Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Cell

Volumn 172, Issue 3, 2018, Pages 409-422.e21

  Ingold, Irina ^a   Berndt, Carsten ^b   Schmitt, Sabine ^c   Doll, Sebastian ^a   Poschmann, Gereon ^b   Buday, Katalin ^a   Roveri, Antonella ^d   Peng, Xiaoxiao ^e   Porto Freitas, Florencio ^a   Seibt, Tobias ^f   Mehr, Lisa ^a   Aichler, Michaela ^a   Walch, Axel ^a   Lamp, Daniel ^a,g   Jastroch, Martin ^a,g   Miyamoto, Sayuri ^h   Wurst, Wolfgang ^a,c,i   Ursini, Fulvio ^d   Arnér, Elias S J ^j   Fradejas Villar, Noelia ^k   Schweizer, Ulrich ^k   Zischka, Hans ^a,c   Friedmann Angeli, José Pedro ^a,l   Conrad, Marcus ^a   more..

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF PADOVA   (Italy)

^e ASTRAZENECA R AND D   (Sweden)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^h UNIVERSITY OF SÃO PAULO   (Brazil)

ⁱ GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^j KAROLINSKA INSTITUTE   (Sweden)

^k UNIVERSITY OF BONN   (Germany)

^l UNIVERSITY OF WÜRZBURG   (Germany)

more..

Author keywords

ACSL4; ferroptosis; glutathione peroxidase; GPX4; lipid peroxidation; mouse genetics; selenium; selenocysteine; selenoproteins; Trsp

Indexed keywords

CALBINDIN; CALRETININ; CYSTEINE; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; PEROXIREDOXIN 3; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SELENOCYSTEINE; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 4, MOUSE; HYDROGEN PEROXIDE; SELENIUM;

ADULT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT LOSS; CATALYSIS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FEMALE; FERROPTOSIS; FIBROBLAST; HETEROZYGOSITY; HUMAN; HUMAN CELL; INTERNEURON; LETHALITY; LIPID PEROXIDATION; MALE; MOLECULAR CLONING; MOUSE; MUTANT; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL CULTURE; GENETICS; HEK293 CELL LINE; METABOLISM; SEIZURE;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; FEMALE; GLUTATHIONE PEROXIDASE; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; INTERNEURONS; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; SEIZURES; SELENIUM;

EID: 85041924851     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.11.048     Document Type: Article

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