Progressive stages of mitochondrial destruction caused by cell toxic bile salts

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 9, 2013, Pages 2121-2133

  Schulz, Sabine ^a   Schmitt, Sabine ^a   Wimmer, Ralf ^b   Aichler, Michaela ^a   Eisenhofer, Sabine ^a   Lichtmannegger, Josef ^a   Eberhagen, Carola ^a   Artmann, Renate ^b   Tookos, Ferenc ^a   Walch, Axel ^a   Krappmann, Daniel ^a   Brenner, Catherine ^c   Rust, Christian ^b   Zischka, Hans ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c Universite Paris Sud   (France)

Author keywords

Bile salts; Cholestasis; Liver; Mitochondria; Mitochondrial permeability transition

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; BILE SALT; CALCIUM; GLYCOCHENODEOXYCHOLIC ACID; LIPOSOME; TAUROCHENODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; 4-METHYLUMBELLIFERYL PHOSPHATE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CARRIER PROTEIN; CYCLOSPORIN A; CYTOCHROME C; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATIDYLCHOLINE; REACTIVE OXYGEN METABOLITE; RHODAMINE 123; ROS; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL CELL; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; CYTOTOXICITY; LIVER MITOCHONDRION; MEMBRANE BINDING; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; RAT; 4-MUP; ANIMAL; ANT; BILE SALTS; CARBONYLCYANIDE-P-(TRIFLUOROMETHOXY) PHENYL-HYDRAZONE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CHOLESTASIS; CYS A; CYT C; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; GCDCA; HEART MITOCHONDRION; HEART MUSCLE; IM; INNER MEMBRANE; ISOLATION AND PURIFICATION; LIVER; MΒCD; METABOLISM; METHYL-Β-CYCLODEXTRIN; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL OUTER MEMBRANE RUPTURE; MITOCHONDRION; MMP; MOMP; MPT; OD; OM; OPTICAL DENSITY; PATHOLOGY; PC; RH123; TCDCA; TUDCA; VDAC; VOLTAGE-DEPENDENT ANION CHANNEL; ZE-FFE; ZONE ELECTROPHORESIS IN A FREE FLOW ELECTROPHORESIS DEVICE;

4-METHYLUMBELLIFERYL PHOSPHATE; 4-MUP; ADENINE NUCLEOTIDE TRANSLOCATOR; ANT; BILE SALTS; CARBONYLCYANIDE-P-(TRIFLUOROMETHOXY) PHENYL-HYDRAZONE; CHOLESTASIS; CYCLOSPORINE A; CYS A; CYT C; CYTOCHROME C; FCCP; GCDCA; GLYCOCHENODEOXYCHOLIC ACID; IM; INNER MEMBRANE; LIVER; MΒCD; METHYL-Β-CYCLODEXTRIN; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL OUTER MEMBRANE RUPTURE; MITOCHONDRIAL PERMEABILITY TRANSITION; MMP; MOMP; MPT; OD; OM; OPTICAL DENSITY; OUTER MEMBRANE; PC; PHOSPHATIDYLCHOLINE; REACTIVE OXYGEN SPECIES; RH123; RHODAMINE 123; ROS; TAUROCHENODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; TCDCA; TUDCA; VDAC; VOLTAGE-DEPENDENT ANION CHANNEL; ZE-FFE; ZONE ELECTROPHORESIS IN A FREE FLOW ELECTROPHORESIS DEVICE;

ANIMALS; CELL MEMBRANE PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOCHENODEOXYCHOLIC ACID; LIPOSOMES; LIVER; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIA, LIVER; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MYOCARDIUM; RATS; TAUROCHENODEOXYCHOLIC ACID; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 84879234547     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.05.007     Document Type: Article

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