12/15-Lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 36, 2010, Pages 15774-15779

  Conrad, Marcus ^a,e,f   Sandin, Åsa ^b   Förster, Heidi ^a   Seiler, Alexander ^a   Frijhoff, Jeroen ^b   Dagnell, Markus ^b   Bornkamm, Georg W ^a   Rådmark, Olof ^b   Van Huijsduijnen, Rob Hooft ^c   Aspenström, Pontus ^b   Böhmer, Frank ^d   Östman, Arne ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MERCK SERONO S A   (Switzerland)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

PDGF; Phospholipid hydroperoxide glutathione peroxidase; Redox regulation; Reversible oxidation

Indexed keywords

15 HYDROPEROXYARACHIDONIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; CYTOSKELETON PROTEIN; HYDROGEN PEROXIDE; LIPID PEROXIDE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; TYROSINE KINASE RECEPTOR; 12 15 LIPOXYGENASE; 12-15-LIPOXYGENASE; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; ENZYME ACTIVITY; IN VITRO STUDY; LIPID PEROXIDATION; OXIDATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; ENZYME ACTIVATION; GENETICS; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; PHOSPHORYLATION;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ENZYME ACTIVATION; GLUTATHIONE PEROXIDASE; LIPID PEROXIDES; MICE; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASES; REACTIVE OXYGEN SPECIES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

EID: 77957660973     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007909107     Document Type: Article

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