Why to compare absolute numbers of mitochondria

Mitochondrion

Volumn 19, Issue Part A, 2014, Pages 113-123

  Schmitt, Sabine ^a   Schulz, Sabine ^a   Schropp, Eva Maria ^a   Eberhagen, Carola ^a   Simmons, Alisha ^a   Beisker, Wolfgang ^a   Aichler, Michaela ^a   Zischka, Hans ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Metabolic shift; Mitochondria; Mitochondrial number; Mitochondrial protein content; Respiratory complex II

Indexed keywords

MITOCHONDRIAL PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; FLOW CYTOMETRY; HEART MITOCHONDRION; HEPATOCELLULAR CARCINOMA CELL LINE; KIDNEY MITOCHONDRION; LIVER; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; MITOCHONDRION; NONHUMAN; PROTEIN CONTENT; RAT; ANIMAL; CYTOLOGY; HUMAN; LIVER TUMOR; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; LIVER; LIVER NEOPLASMS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; RATS;

EID: 84911419264     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2014.06.005     Document Type: Article

References (58)

1. Ahmadzadeh H., Johnson R.D., Thompson L., Arriaga E.A. Direct sampling from muscle cross sections for electrophoretic analysis of individual mitochondria. Anal. Chem. 2004, 76:315-321.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
3. Brown G.C. Total cell protein concentration as an evolutionary constraint on the metabolic control distribution in cells. J. Theor. Biol. 1991, 153:195-203.
4. Criddle R.S., Schatz G. Promitochondria of anaerobically grown yeast. I. Isolation and biochemical properties. Biochemistry 1969, 8:322-334.
5. Cuezva J.M., Krajewska M., de Heredia M.L., Krajewski S., Santamaria G., Kim H., Zapata J.M., Marusawa H., Chamorro M., Reed J.C. The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res. 2002, 62:6674-6681.
6. Dalziel A.C., Moore S.E., Moyes C.D. Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R163-R172.
7. Dejean L., Beauvoit B., Alonso A.P., Bunoust O., Guerin B., Rigoulet M. cAMP-induced modulation of the growth yield of Saccharomyces cerevisiae during respiratory and respiro-fermentative metabolism. Biochim. Biophys. Acta 2002, 1554:159-169.
8. DeRisi J.L., Iyer V.R., Brown P.O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 1997, 278:680-686.
9. Dong L.F., Jameson V.J., Tilly D., Cerny J., Mahdavian E., Marin-Hernandez A., Hernandez-Esquivel L., Rodriguez-Enriquez S., Stursa J., Witting P.K., Stantic B., Rohlena J., Truksa J., Kluckova K., Dyason J.C., Ledvina M., Salvatore B.A., Moreno-Sanchez R., Coster M.J., Ralph S.J., Smith R.A., Neuzil J. Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. J. Biol. Chem. 2011, 286:3717-3728.
10. Dykens J.A., Will Y. The significance of mitochondrial toxicity testing in drug development. Drug Discov. Today 2007, 12:777-785.
11. Ernster L., Schatz G. Mitochondria: a historical review. J. Cell Biol. 1981, 91:227s-255s.
12. Fuller K.M., Arriaga E.A. Capillary electrophoresis monitors changes in the electrophoretic behavior of mitochondrial preparations. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2004, 806:151-159.
13. Gallet P.F., Maftah A., Petit J.M., Denis-Gay M., Julien R. Direct cardiolipin assay in yeast using the red fluorescence emission of 10-N-nonyl acridine orange. Eur. J. Biochem. 1995, 228:113-119.
14. Galluzzi L., Morselli E., Kepp O., Vitale I., Rigoni A., Vacchelli E., Michaud M., Zischka H., Castedo M., Kroemer G. Mitochondrial gateways to cancer. Mol. Asp. Med. 2010, 31:1-20.
15. Garrabou G., Soriano A., Lopez S., Guallar J.P., Giralt M., Villarroya F., Martinez J.A., Casademont J., Cardellach F., Mensa J., Miro O. Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. Antimicrob. Agents Chemother. 2007, 51:962-967.
16. Gear A.R., Bednarek J.M. Direct counting and sizing of mitochondria in solution. J. Cell Biol. 1972, 54:325-345.
17. Gogvadze V., Orrenius S., Zhivotovsky B. Mitochondria in cancer cells: what is so special about them?. Trends Cell Biol. 2008, 18:165-173.
18. Gogvadze V., Orrenius S., Zhivotovsky B. Mitochondria as targets for chemotherapy. Apoptosis 2009, 14:624-640.
19. Green D.R., Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004, 305:626-629.
20. Hackenbrock C.R. Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria. J. Cell Biol. 1966, 30:269-297.
21. Hackenbrock C.R. Chemical and physical fixation of isolated mitochondria in low-energy and high-energy states. Proc. Natl. Acad. Sci. U. S. A. 1968, 61:598-605.
22. Hackenbrock C.R. Ultrastructural bases for metabolically linked mechanical activity in mitochondria. II. Electron transport-linked ultrastructural transformations in mitochondria. J. Cell Biol. 1968, 37:345-369.
23. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
24. Hostetler K.Y., Zenner B.D., Morris H.P. Abnormal membrane phospholipid content in subcellular fractions from the Morris 7777 hepatoma. Biochim. Biophys. Acta 1976, 441:231-238.
25. Hsu C.C., Lee H.C., Wei Y.H. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J. Gastroenterol. 2013, 19:8880-8886.
26. Kiebish M.A., Han X., Cheng H., Chuang J.H., Seyfried T.N. Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J. Lipid Res. 2008, 49:2545-2556.
27. Kluckova K., Bezawork-Geleta A., Rohlena J., Dong L., Neuzil J. Mitochondrial complex II, a novel target for anti-cancer agents. Biochim. Biophys. Acta 2013, 1827:552-564.
28. Lemarie A., Grimm S. Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?. Oncogene 2011, 30:3985-4003.
29. Lemarie A., Huc L., Pazarentzos E., Mahul-Mellier A.L., Grimm S. Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction. Cell Death Differ. 2011, 18:338-349.
30. Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
31. Löffler G., Petrides P.E. Biochemie und Pathobiochemie 1990, Springer-Verlag, Berlin Heidelberg New York. 5th edn.
32. Maftah A., Petit J.M., Ratinaud M.H., Julien R. 10-N nonyl-acridine orange: a fluorescent probe which stains mitochondria independently of their energetic state. Biochem. Biophys. Res. Commun. 1989, 164:185-190.
33. Marroquin L.D., Hynes J., Dykens J.A., Jamieson J.D., Will Y. Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. Toxicol. Sci. 2007, 97:539-547.
34. Mattiasson G. Flow cytometric analysis of isolated liver mitochondria to detect changes relevant to cell death. Cytometry A 2004, 60:145-154.
35. Mintz H.A., Yawn D.H., Safer B., Bresnick E., Liebelt A.G., Blailock Z.R., Rabin E.R., Schwartz A. Morphological and biochemical studies of isolated mitochondria from fetal, neonatal, and adult liver and from neoplastic tissues. J. Cell Biol. 1967, 34:513-523.
36. Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M., Patterson N., Lander E.S., Mann M. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 2003, 115:629-640.
37. Morton R., Cunningham C., Jester R., Waite M., Miller N., Morris H.P. Alteration of mitochondrial function and lipid composition in Morris 7777 hepatoma. Cancer Res. 1976, 36:3246-3254.
38. Mulisch M., Welsch U. Romeis Mikroskopische Technik 2010, Spektrum Akademischer Verlag Heidelberg, Heidelberg. 18th edn.
39. Pallotti F., Lenaz G. Isolation and subfractionation of mitochondria from animal cells and tissue culture lines. Methods Cell Biol. 2007, 80:3-44.
40. Petit J.M., Maftah A., Ratinaud M.H., Julien R. 10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria. Eur. J. Biochem. 1992, 209:267-273.
41. Petit P.X., Goubern M., Diolez P., Susin S.A., Zamzami N., Kroemer G. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett. 1998, 426:111-116.
42. Phillips N.R., Sprouse M.L., Roby R.K. Simultaneous quantification of mitochondrial DNA copy number and deletion ratio: a multiplex real-time PCR assay. Sci. Rep. 2014, 4:3887.
43. Plattner H., Schatz G. Promitochondria of anaerobically grown yeast. 3. Morphology. Biochemistry 1969, 8:339-343.
44. Plattner H., Salpeter M.M., Saltzgaber J., Schatz G. Promitochondria of anaerobically grown yeast. IV. Conversion into respiring mitochondria. Proc. Natl. Acad. Sci. U.S.A. 1970, 66:1252-1259.
45. Ramsay R.R., Ackrell B.A., Coles C.J., Singer T.P., White G.A., Thorn G.D. Reaction site of carboxanilides and of thenoyltrifluoroacetone in complex II. Proc. Natl. Acad. Sci. U. S. A. 1981, 78:825-828.
46. Rossignol R., Gilkerson R., Aggeler R., Yamagata K., Remington S.J., Capaldi R.A. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 2004, 64:985-993.
47. Saggerson E.D., Carpenter C.A. Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism. Biochem. J. 1986, 236:137-141.
48. Schmitt S., Saathoff F., Meissner L., Schropp E.M., Lichtmannegger J., Schulz S., Eberhagen C., Borchard S., Aichler M., Adamski J., Plesnila N., Rothenfusser S., Kroemer G., Zischka H. A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies. Anal. Biochem. 2013, 443:66-74.
49. Schnaitman C., Erwin V.G., Greenawalt J.W. The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria. J. Cell Biol. 1967, 32:719-735.
50. Schwerzmann K., Cruz-Orive L.M., Eggman R., Sanger A., Weibel E.R. Molecular architecture of the inner membrane of mitochondria from rat liver: a combined biochemical and stereological study. J. Cell Biol. 1986, 102:97-103.
51. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U. S. A. 1979, 76:4350-4354.
52. Veltri K.L., Espiritu M., Singh G. Distinct genomic copy number in mitochondria of different mammalian organs. J. Cell. Physiol. 1990, 143:160-164.
53. Vijayasarathy C., Biunno I., Lenka N., Yang M., Basu A., Hall I.P., Avadhani N.G. Variations in the subunit content and catalytic activity of the cytochrome c oxidase complex from different tissues and different cardiac compartments. Biochim. Biophys. Acta 1998, 1371:71-82.
54. Williams A.J., Coakley J., Christodoulou J. Automated analysis of mitochondrial enzymes in cultured skin fibroblasts. Anal. Biochem. 1998, 259:176-180.
55. Winklhofer K.F., Haass C. Mitochondrial dysfunction in Parkinson's disease. Biochim. Biophys. Acta 2010, 1802:29-44.
56. Zhang J.G., Tirmenstein M.A., Nicholls-Grzemski F.A., Fariss M.W. Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants. Arch. Biochem. Biophys. 2001, 393:87-96.
57. Zischka H., Braun R.J., Marantidis E.P., Buringer D., Bornhovd C., Hauck S.M., Demmer O., Gloeckner C.J., Reichert A.S., Madeo F., Ueffing M. Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis. Mol. Cell. Proteomics 2006, 5:2185-2200.
58. Zischka H., Larochette N., Hoffmann F., Hamoller D., Jagemann N., Lichtmannegger J., Jennen L., Muller-Hocker J., Roggel F., Gottlicher M., Vollmar A.M., Kroemer G. Electrophoretic analysis of the mitochondrial outer membrane rupture induced by permeability transition. Anal. Chem. 2008, 80:5051-5058.