Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice

Antioxidants and Redox Signaling

Volumn 22, Issue 4, 2015, Pages 281-293

  Brütsch, Simone Hanna ^a   Wang, Chi Chiu ^b   Li, Lu ^b,c   Stender, Hannelore ^a   Neziroglu, Nilgün ^a   Richter, Constanze ^d   Kuhn, Hartmut ^a   Borchert, Astrid ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALOX15 PROTEIN; LIPOXYGENASE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG; ALOX15 PROTEIN, MOUSE; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; FERTILITY; GENE EXPRESSION; GENE INACTIVATION; HETEROZYGOTE; LETHALITY; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; 129 MOUSE; ANIMAL; C57BL MOUSE; FEMALE; GENE TARGETING; GENETICS; LETHAL GENE; MALE; METABOLISM; OXIDATION REDUCTION REACTION; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACID; FEMALE; GENE EXPRESSION; GENE KNOCK-IN TECHNIQUES; GENES, LETHAL; GLUTATHIONE PEROXIDASE; HETEROZYGOTE; MALE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; OXIDATION-REDUCTION;

EID: 84921357948     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.5967     Document Type: Article

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