Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 34, 2016, Pages E4966-E4975

  Yang, Wan Seok ^a   Kim, Katherine J ^b   Gaschler, Michael M ^b   Patel, Milesh ^c   Shchepinov, Mikhail S ^d   Stockwell, Brent R ^b  

^a ST JOHN'S UNIVERSITY   (United States)

^b Columbia University ^*  (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Retrotope Inc   (United States)

Author keywords

Ferroptosis; Gpx4; Lipoxygenase; PHKG2; PUFAs

Indexed keywords

DEUTERIUM; HYDROPEROXIDE; IRON; LIPOXYGENASE; PHOSPHORYLASE KINASE; PHOSPHORYLASE KINASE G2; POLYUNSATURATED FATTY ACID; SELENOCYSTEINE; UNCLASSIFIED DRUG; GLUTATHIONE PEROXIDASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LIPID PEROXIDE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; UNSATURATED FATTY ACID;

ARTICLE; CATALYSIS; CELL DEATH; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME REGULATION; FERROPTOSIS; LIPID PEROXIDATION; LIPIDOMICS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CATALYTIC DOMAIN; CELL DEATH; CELL LINE, TUMOR; DEUTERIUM; EPITHELIAL CELLS; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION; GLUTATHIONE PEROXIDASE; GREEN FLUORESCENT PROTEINS; HUMANS; IRON; LIPID PEROXIDATION; LIPID PEROXIDES; LIPOXYGENASES; PHOSPHORYLASE KINASE; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SELENOCYSTEINE; SIGNAL TRANSDUCTION;

EID: 84983666736     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603244113     Document Type: Article

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