Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility

Journal of Biological Chemistry

Volumn 290, Issue 23, 2015, Pages 14668-14678

  Ingold, Irina ^a   Aichler, Michaela ^a   Yefremova, Elena ^a   Roveri, Antonella ^b   Buday, Katalin ^a   Doll, Sebastian ^a   Tasdemir, Adrianne ^a   Hoffard, Nils ^a   Wurst, Wolfgang ^a,c,d,e   Walch, Axel ^a   Ursini, Fulvio ^b   Angeli, José Pedro Friedmann ^a   Conrad, Marcus ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF PADOVA   (Italy)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d Germany 3 Munich Cluster for Systems Neurology   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; MITOCHONDRIA; PHOSPHOLIPIDS; PROTEINS;

APOPTOTIC CELL DEATH; CELL VIABILITY; DOMINANT NEGATIVE; EMBRYONIC STAGES; GLUTATHIONE PEROXIDASE; INACTIVE MUTANTS; POLYPEPTIDE CHAIN; STRUCTURAL PROTEINS;

MAMMALS;

PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SELENOCYSTEINE; SERINE; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CODON; CONTROLLED STUDY; EMBRYO; FERTILIZATION; GENE; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE STRUCTURE; GPX4 GENE; IN VITRO STUDY; MALE; MALE FERTILITY; MOUSE; NONHUMAN; OOCYTE; OXIDATION; POLYMERIZATION; PRIORITY JOURNAL; SPERM; SPERMATOZOON MIDPIECE; SUBFERTILITY; AMINO ACID SUBSTITUTION; ANIMAL; CELL CULTURE; EMBRYO DEATH; ENZYME ACTIVE SITE; FEMALE; GENETICS; HETEROZYGOTE; HOMOZYGOTE; MALE INFERTILITY; METABOLISM; PATHOLOGY; SPERMATOGENESIS; SPERMATOZOON; TRANSGENIC MOUSE; ULTRASTRUCTURE;

MUS; RODENTIA;

AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CELLS, CULTURED; EMBRYO LOSS; FEMALE; GLUTATHIONE PEROXIDASE; HETEROZYGOTE; HOMOZYGOTE; INFERTILITY, MALE; MALE; MICE; MICE, TRANSGENIC; SELENOCYSTEINE; SERINE; SPERMATOGENESIS; SPERMATOZOA;

EID: 84930623244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.656363     Document Type: Article

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