Enhancer redundancy provides phenotypic robustness in mammalian development

Nature

Volumn 554, Issue 7691, 2018, Pages 239-243

  Osterwalder, Marco ^a   Barozzi, Iros ^a   Tissiéres, Virginie ^b,c   Fukuda Yuzawa, Yoko ^a   Mannion, Brandon J ^a   Afzal, Sarah Y ^a   Lee, Elizabeth A ^a   Zhu, Yiwen ^a   Plajzer Frick, Ingrid ^a   Pickle, Catherine S ^a   Kato, Momoe ^a   Garvin, Tyler H ^a   Pham, Quan T ^a   Harrington, Anne N ^a   Akiyama, Jennifer A ^a   Afzal, Veena ^a   Lopez Rios, Javier ^b,c   Dickel, Diane E ^a   Visel, Axel ^a,d,e   Pennacchio, Len A ^a,d,f  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^d DOE JOINT GENOME INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMALITY; BRAIN; COMPLEXITY; DEVELOPMENTAL BIOLOGY; GENE; GENE EXPRESSION; LIMB; PHENOTYPE; PROTEIN;

ADULT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; EPIGENETICS; FEMALE; GENE DELETION; GENE EDITING; GENE EXPRESSION; GENE FUNCTION; GENETIC BACKGROUND; HEART; LIMB DEVELOPMENT; LOSS OF FUNCTION MUTATION; MALE; MAMMAL; MAMMALIAN EMBRYO; MAMMALIAN GENETICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSCRIPTOMICS; ANIMAL; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETICS; GENOME; LIMB; LIMB MALFORMATION; SPATIOTEMPORAL ANALYSIS;

MAMMALIA;

ANIMALS; BRAIN; ENHANCER ELEMENTS, GENETIC; EXTREMITIES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME; HEART; LIMB DEFORMITIES, CONGENITAL; MALE; MICE; PHENOTYPE; SEQUENCE DELETION; SPATIO-TEMPORAL ANALYSIS;

EID: 85041712124     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature25461     Document Type: Article

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