Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

Nature Protocols

Volumn 9, Issue 8, 2014, Pages 1956-1968

  Yang, Hui ^a   Wang, Haoyi ^a   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; MESSENGER RNA; NUCLEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAS9 GENE; CONTROLLED STUDY; CRISPR CAS SYSTEM; EMBRYO; EMBRYONIC STEM CELL; FEMALE; GENE; GENE DELETION; GENE LOCUS; GENETIC ENGINEERING; INDEL MUTATION; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; SURVIVAL RATE; ANIMAL; C57BL MOUSE; CELL CULTURE TECHNIQUE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENE TARGETING; GENOTYPING TECHNIQUE; PROCEDURES; TRANSGENIC MOUSE;

ANIMALS; CELL CULTURE TECHNIQUES; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; EMBRYONIC STEM CELLS; GENE TARGETING; GENETIC ENGINEERING; GENOTYPING TECHNIQUES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 84905029498     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2014.134     Document Type: Article

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