Progressive Loss of Function in a Limb Enhancer during Snake Evolution

Cell

Volumn 167, Issue 3, 2016, Pages 633-642.e11

  Kvon, Evgeny Z ^a   Kamneva, Olga K ^b   Melo, Uirá S ^a   Barozzi, Iros ^a   Osterwalder, Marco ^a   Mannion, Brandon J ^a   Tissières, Virginie ^c   Pickle, Catherine S ^a   Plajzer Frick, Ingrid ^a   Lee, Elizabeth A ^a   Kato, Momoe ^a   Garvin, Tyler H ^a   Akiyama, Jennifer A ^a   Afzal, Veena ^a   Lopez Rios, Javier ^c   Rubin, Edward M ^a,d   Dickel, Diane E ^a   Pennacchio, Len A ^a,d   Visel, Axel ^a,d,e  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d DOE JOINT GENOME INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cis regulatory element; CRISPR Cas9; enhancer; evo devo; genome editing; limb development; morphological evolution; snakes; Sonic hedgehog (Shh); ZRS

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL GENETICS; ANIMAL STRUCTURES; ANIMAL TISSUE; ARTICLE; BINDING SITE; BOA CONSTRICTOR CONSTRICTOR; CONTROLLED STUDY; CROTALUS; CROTALUS MITCHELLII PYRRHUS; EMBRYO; ENHANCER REGION; EVOLUTION; EVOLUTIONARY RATE; GENE DELETION; GENOME ANALYSIS; LIMB; LIMB BUD; LIMB DEVELOPMENT; LOSS OF FUNCTION MUTATION; MORPHOLOGICAL ADAPTATION; MOUSE; NAJA; NONHUMAN; OPHIOPHAGUS HANNAH; PHENOTYPE; PHYLOGENETIC TREE; PRIORITY JOURNAL; PYTHON MOLURUS BIVITTATUS; REGULATORY SEQUENCE; SNAKE; ANIMAL; CLASSIFICATION; GENE TARGETING; GENETICS; GROWTH, DEVELOPMENT AND AGING; MOLECULAR EVOLUTION; MUTATION; NUCLEOTIDE SEQUENCE; PHYLOGENY; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BIOLOGICAL EVOLUTION; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; EXTREMITIES; GENE KNOCK-IN TECHNIQUES; HEDGEHOG PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PHYLOGENY; SNAKES;

EID: 84992505836     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.028     Document Type: Article

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