ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis

Genes and Development

Volumn 31, Issue 23-24, 2017, Pages 2343-2360

  Leong, Wei Zhong ^a   Tan, Shi Hao ^a   Ngoc, Phuong Cao Thi ^a   Amanda, Stella ^a   Yam, Alice Wei Yee ^a   Liau, Wei Siang ^a   Gong, Zhiyuan ^b   Lawton, Lee N ^a   Tenen, Daniel G ^a,c,d   Sanda, Takaomi ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Dept Medicine Endocrinol Diabet   (Singapore)

Author keywords

ARID5B; Core regulatory circuit; MYC; T cell acute lymphoblastic leukemia; TAL1

Indexed keywords

T CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1; ARID5B PROTEIN, HUMAN; DNA BINDING PROTEIN; PROTEIN BINDING; TAL1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; AT RICH INTERACTIVE DOMAIN 5B; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; LEUKEMOGENESIS; ONCOGENE; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; THYMOCYTE; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; METABOLISM; PROTEIN DOMAIN; THYMUS; TRANSCRIPTION INITIATION; TUMOR CELL LINE; ZEBRA FISH;

ANIMALS; CARCINOGENESIS; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HEK293 CELLS; HUMANS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN BINDING; PROTEIN DOMAINS; T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1; THYMOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; ZEBRAFISH;

EID: 85040904810     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.302646.117     Document Type: Article

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