메뉴 건너뛰기




Volumn 4, Issue 6, 2014, Pages

MYC activation is a hallmark of cancer initiation and maintenance

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; MYC PROTEIN, HUMAN; TUMOR MARKER;

EID: 84887147170     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a014241     Document Type: Article
Times cited : (617)

References (128)
  • 2
    • 22844444945 scopus 로고    scopus 로고
    • Conditionally MYC: Insights from novel transgenic models
    • Arvanitis C, Felsher DW. 2005. Conditionally MYC: Insights from novel transgenic models. Cancer Lett 226: 95-99.
    • (2005) Cancer Lett , vol.226 , pp. 95-99
    • Arvanitis, C.1    Felsher, D.W.2
  • 3
    • 84855795795 scopus 로고    scopus 로고
    • Immunology in the clinic review series; focus on cancer: Multiple roles for the immune system in oncogene addiction
    • Bachireddy P, Rakhra K, Felsher DW. 2012. Immunology in the clinic review series; focus on cancer: Multiple roles for the immune system in oncogene addiction. Clin Exp Immunol 167: 188-194.
    • (2012) Clin Exp Immunol , vol.167 , pp. 188-194
    • Bachireddy, P.1    Rakhra, K.2    Felsher, D.W.3
  • 6
    • 0028203632 scopus 로고
    • Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis
    • Bowden GT, Schneider B, Domann R, Kulesz-Martin M. 1994. Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis. Cancer Res 54: 1882s-1885s.
    • (1994) Cancer Res , vol.54
    • Bowden, G.T.1    Schneider, B.2    Domann, R.3    Kulesz-Martin, M.4
  • 7
    • 0035839844 scopus 로고    scopus 로고
    • Translocations involving c-myc and c-myc function
    • Boxer LM, Dang CV. 2001. Translocations involving c-myc and c-myc function. Oncogene 20: 5595-5610.
    • (2001) Oncogene , vol.20 , pp. 5595-5610
    • Boxer, L.M.1    Dang, C.V.2
  • 8
    • 10944258521 scopus 로고    scopus 로고
    • Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation
    • Boxer RB, Jang JW, Sintasath L, Chodosh LA. 2004. Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation. Cancer Cell 6: 577-586.
    • (2004) Cancer Cell , vol.6 , pp. 577-586
    • Boxer, R.B.1    Jang, J.W.2    Sintasath, L.3    Chodosh, L.A.4
  • 9
    • 13444292555 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer
    • Calvisi DF, Thorgeirsson SS. 2005. Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer. Toxicologic Pathol 33: 181-184.
    • (2005) Toxicologic Pathol , vol.33 , pp. 181-184
    • Calvisi, D.F.1    Thorgeirsson, S.S.2
  • 10
  • 11
    • 22944470236 scopus 로고    scopus 로고
    • Transforming growth factor-a inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kB in murine hepatocellular carcinomas
    • Cavin LG, Wang F, Factor VM, Kaur S, Venkatraman M, Thorgeirsson SS, Arsura M. 2005. Transforming growth factor-a inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kB in murine hepatocellular carcinomas. Mol Cancer Res 3: 403-412.
    • (2005) Mol Cancer Res , vol.3 , pp. 403-412
    • Cavin, L.G.1    Wang, F.2    Factor, V.M.3    Kaur, S.4    Venkatraman, M.5    Thorgeirsson, S.S.6    Arsura, M.7
  • 13
    • 0022999622 scopus 로고
    • C-myc and functionally related oncogenes induce both high rates of sister chromatid exchange and abnormal karyotypes in rat fibroblasts
    • Cerni C, Mougneau E, Zerlin M, Julius M, Marcu KB, Cuzin F. 1986. c-myc and functionally related oncogenes induce both high rates of sister chromatid exchange and abnormal karyotypes in rat fibroblasts. Curr Top Microbiol Immunol 132: 193-201.
    • (1986) Curr Top Microbiol Immunol , vol.132 , pp. 193-201
    • Cerni, C.1    Mougneau, E.2    Zerlin, M.3    Julius, M.4    Marcu, K.B.5    Cuzin, F.6
  • 18
    • 0024507110 scopus 로고
    • The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors
    • Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R. 1989. The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. Proc Natl Acad Sci 86: 2224-2228.
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 2224-2228
    • Compere, S.J.1    Baldacci, P.2    Sharpe, A.H.3    Thompson, T.4    Land, H.5    Jaenisch, R.6
  • 20
    • 0032905924 scopus 로고    scopus 로고
    • C-Myc target genes involved in cell growth, apoptosis, and metabolism
    • Dang CV. 1999. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19: 1-11.
    • (1999) Mol Cell Biol , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 21
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. 2012. MYC on the path to cancer. Cell 149: 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 22
    • 84881056831 scopus 로고    scopus 로고
    • MYC, metabolism, cell growth, and tumorigenesis
    • Dang CV. 2013. MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb Perspect Med 3: a014217.
    • (2013) Cold Spring Harb Perspect Med , vol.3
    • Dang, C.V.1
  • 24
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A, Gao P. 2009. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 15: 6479-6483.
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 27
    • 0033624011 scopus 로고    scopus 로고
    • Cooperation of bcl-2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated intercellular communication
    • DeoCampo ND, Wilson MR, Trosko JE. 2000. Cooperation of bcl-2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated intercellular communication. Carcinogenesis 21: 1501-1506.
    • (2000) Carcinogenesis , vol.21 , pp. 1501-1506
    • Deocampo, N.D.1    Wilson, M.R.2    Trosko, J.E.3
  • 28
    • 0000015743 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Basic concepts and mechanisms
    • Dias N, Stein CA. 2002. Antisense oligonucleotides: Basic concepts and mechanisms. Mol Cancer Ther 1: 347-355.
    • (2002) Mol Cancer Ther , vol.1 , pp. 347-355
    • Dias, N.1    Stein, C.A.2
  • 31
    • 54349087788 scopus 로고    scopus 로고
    • Myc’s broad reach
    • Eilers M, Eisenman RN. 2008. Myc’s broad reach. Genes Dev 22: 2755-2766.
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 34
    • 0038387495 scopus 로고    scopus 로고
    • Cancer revoked: Oncogenes as therapeutic targets
    • Felsher DW. 2003. Cancer revoked: Oncogenes as therapeutic targets. Nat Rev Cancer 3: 375-380.
    • (2003) Nat Rev Cancer , vol.3 , pp. 375-380
    • Felsher, D.W.1
  • 35
    • 33748934199 scopus 로고    scopus 로고
    • Tumor dormancy: Death and resurrection of cancer as seen through transgenic mouse models
    • Felsher DW. 2006. Tumor dormancy: Death and resurrection of cancer as seen through transgenic mouse models. Cell Cycle 5: 1808-1811.
    • (2006) Cell Cycle , vol.5 , pp. 1808-1811
    • Felsher, D.W.1
  • 36
    • 44849137232 scopus 로고    scopus 로고
    • Oncogene addiction versus oncogene amnesia: Perhaps more than just a bad habit?
    • Felsher DW. 2008. Oncogene addiction versus oncogene amnesia: Perhaps more than just a bad habit? Cancer Res 68: 3081-3086.
    • (2008) Cancer Res , vol.68 , pp. 3081-3086
    • Felsher, D.W.1
  • 37
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher DW, Bishop JM. 1999a. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4: 199-207.
    • (1999) Mol Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 38
    • 0033616602 scopus 로고    scopus 로고
    • Transient excess of MYC activity can elicit genomic instability and tumorigenesis
    • Felsher DW, Bishop JM. 1999b. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci 96: 3940-3944.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 3940-3944
    • Felsher, D.W.1    Bishop, J.M.2
  • 39
    • 0034641720 scopus 로고    scopus 로고
    • Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
    • Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM. 2000. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci 97: 10544-10548.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 10544-10548
    • Felsher, D.W.1    Zetterberg, A.2    Zhu, J.3    Tlsty, T.4    Bishop, J.M.5
  • 43
    • 64749116346 scopus 로고    scopus 로고
    • Mendell JT, et al. 2009. C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, et al. 2009. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458: 762-765.
    • Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6    Zeller, K.I.7    De Marzo, A.M.8    Van Eyk, J.E.9
  • 44
    • 0029040537 scopus 로고
    • Apoptosis induced by c-myc overexpression is dependent on growth conditions
    • Gibson AW, Cheng T, Johnston RN. 1995. Apoptosis induced by c-myc overexpression is dependent on growth conditions. Exp Cell Res 218: 351-358.
    • (1995) Exp Cell Res , vol.218 , pp. 351-358
    • Gibson, A.W.1    Cheng, T.2    Johnston, R.N.3
  • 45
    • 0742287062 scopus 로고    scopus 로고
    • Conditional animal models: A strategy to define when oncogenes will be effective targets to treat cancer
    • Giuriato S, Rabin K, Fan AC, Shachaf CM, Felsher DW. 2004. Conditional animal models: A strategy to define when oncogenes will be effective targets to treat cancer. Semin Cancer Biol 14: 3-11.
    • (2004) Semin Cancer Biol , vol.14 , pp. 3-11
    • Giuriato, S.1    Rabin, K.2    Fan, A.C.3    Shachaf, C.M.4    Felsher, D.W.5
  • 48
    • 0030680117 scopus 로고    scopus 로고
    • A Myc-induced apoptosis pathway surfaces
    • Green DR. 1997. A Myc-induced apoptosis pathway surfaces. Science 278: 1246-1247.
    • (1997) Science , vol.278 , pp. 1246-1247
    • Green, D.R.1
  • 49
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. 2010. Immunity, inflammation, and cancer. Cell 140: 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 50
    • 0037541152 scopus 로고    scopus 로고
    • The MYC oncogene as a cancer drug target
    • Hermeking H. 2003. The MYC oncogene as a cancer drug target. Curr Cancer Drug Targets 3: 163-175.
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 163-175
    • Hermeking, H.1
  • 51
    • 54949149565 scopus 로고    scopus 로고
    • Apoptotic signaling by c-MYC
    • Hoffman B, Liebermann DA. 2008. Apoptotic signaling by c-MYC. Oncogene 27: 6462-6472.
    • (2008) Oncogene , vol.27 , pp. 6462-6472
    • Hoffman, B.1    Liebermann, D.A.2
  • 52
    • 0033987718 scopus 로고    scopus 로고
    • Reversibility of acute B-cell leukaemia induced by BCR-ABL1
    • Huettner CS, Zhang P, Van Etten RA, Tenen DG. 2000. Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet 24: 57-60.
    • (2000) Nat Genet , vol.24 , pp. 57-60
    • Huettner, C.S.1    Zhang, P.2    Van Etten, R.A.3    Tenen, D.G.4
  • 53
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    • Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M. 1999. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev 13: 2678-2690.
    • (1999) Genes Dev , vol.13 , pp. 2678-2690
    • Jacobs, J.J.1    Scheijen, B.2    Voncken, J.W.3    Kieboom, K.4    Berns, A.5    Van Lohuizen, M.6
  • 55
    • 34250340783 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS converge on activation of the mitogenactivated protein kinase pathway in lung cancer mouse models
    • Ji H, Wang Z, Perera SA, Li D, Liang MC, Zaghlul S, McNamara K, Chen L, Albert M, Sun Y, et al. 2007. Mutations in BRAF and KRAS converge on activation of the mitogenactivated protein kinase pathway in lung cancer mouse models. Cancer Res 67: 4933-4939.
    • (2007) Cancer Res , vol.67 , pp. 4933-4939
    • Ji, H.1    Wang, Z.2    Perera, S.A.3    Li, D.4    Liang, M.C.5    Zaghlul, S.6    McNamara, K.7    Chen, L.8    Albert, M.9    Sun, Y.10
  • 57
    • 0029892554 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis as a strategy to identify cancer genes
    • Jonkers J, Berns A. 1996. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta 1287: 29-57.
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 29-57
    • Jonkers, J.1    Berns, A.2
  • 59
    • 0038107350 scopus 로고    scopus 로고
    • Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations
    • Karlsson A, Giuriato S, Tang F, Fung-Weier J, Levan G, Felsher DW. 2003b. Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations. Blood 101: 2797-2803.
    • (2003) Blood , vol.101 , pp. 2797-2803
    • Karlsson, A.1    Giuriato, S.2    Tang, F.3    Fung-Weier, J.4    Levan, G.5    Felsher, D.W.6
  • 60
    • 0032820507 scopus 로고    scopus 로고
    • Amplification of c-myc in hepatocellular carcinoma: Correlation with clinicopathologic features, proliferative activity and p53 overexpression
    • Kawate S, Fukusato T, Ohwada S, Watanuki A, Morishita Y. 1999. Amplification of c-myc in hepatocellular carcinoma: Correlation with clinicopathologic features, proliferative activity and p53 overexpression. Oncology 57: 157-163.
    • (1999) Oncology , vol.57 , pp. 157-163
    • Kawate, S.1    Fukusato, T.2    Ohwada, S.3    Watanuki, A.4    Morishita, Y.5
  • 62
    • 67649450275 scopus 로고    scopus 로고
    • High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
    • Kool J, Berns A. 2009. High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nat Rev Cancer 9: 389-399.
    • (2009) Nat Rev Cancer , vol.9 , pp. 389-399
    • Kool, J.1    Berns, A.2
  • 65
    • 33646422463 scopus 로고    scopus 로고
    • Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis
    • Lawlor ER, Soucek L, Brown-Swigart L, Shchors K, Bialucha CU, Evan GI. 2006. Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. Cancer Res 66: 4591-4601.
    • (2006) Cancer Res , vol.66 , pp. 4591-4601
    • Lawlor, E.R.1    Soucek, L.2    Brown-Swigart, L.3    Shchors, K.4    Bialucha, C.U.5    Evan, G.I.6
  • 66
    • 84887191036 scopus 로고    scopus 로고
    • Cellular MYCRo economics: Balancing MYC function with MYC expression
    • Levens D. 2013. Cellular MYCRo economics: Balancing MYC function with MYC expression. Cold Spring Harb Perspect Med 3: a014233.
    • (2013) Cold Spring Harb Perspect Med , vol.3
    • Levens, D.1
  • 69
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • Lowe SW, Cepero E, Evan G. 2004. Intrinsic tumour suppression. Nature 432: 307-315.
    • (2004) Nature , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 70
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ. 2009. Principles of cancer therapy: Oncogene and non-oncogene addiction. Cell 136: 823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 71
    • 0030061949 scopus 로고    scopus 로고
    • C-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines
    • Mai S, Hanley-Hyde J, Fluri M. 1996. c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines. Oncogene 12: 277-288.
    • (1996) Oncogene , vol.12 , pp. 277-288
    • Mai, S.1    Hanley-Hyde, J.2    Fluri, M.3
  • 72
    • 0021135561 scopus 로고
    • C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment
    • Makino R, Hayashi K, Sugimura T. 1984. C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature 310: 697-698.
    • (1984) Nature , vol.310 , pp. 697-698
    • Makino, R.1    Hayashi, K.2    Sugimura, T.3
  • 73
    • 23644447581 scopus 로고    scopus 로고
    • Oncogene-targeted antisense oligonucleotides for the treatment of Ewing sarcoma
    • Maksimenko A, Malvy C. 2005. Oncogene-targeted antisense oligonucleotides for the treatment of Ewing sarcoma. Expert Opin Ther Targets 9: 825-830.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 825-830
    • Maksimenko, A.1    Malvy, C.2
  • 74
  • 76
    • 79952852787 scopus 로고    scopus 로고
    • An integrated geneticgenomic approach for the identification of novel cancer loci in mice sensitized to c-Myc-induced apoptosis
    • Mendrysa SM, Akagi K, Roayaei J, Lien WH, Copeland NG, Jenkins NA, Eisenman RN. 2010. An integrated geneticgenomic approach for the identification of novel cancer loci in mice sensitized to c-Myc-induced apoptosis. Genes Cancer 1: 465-479.
    • (2010) Genes Cancer , vol.1 , pp. 465-479
    • Mendrysa, S.M.1    Akagi, K.2    Roayaei, J.3    Lien, W.H.4    Copeland, N.G.5    Jenkins, N.A.6    Eisenman, R.N.7
  • 77
    • 0037235453 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: Tagging cancer pathways
    • Mikkers H, Berns A. 2003. Retroviral insertional mutagenesis: Tagging cancer pathways. Adv Cancer Res 88: 53-99.
    • (2003) Adv Cancer Res , vol.88 , pp. 53-99
    • Mikkers, H.1    Berns, A.2
  • 78
    • 0036729878 scopus 로고    scopus 로고
    • High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
    • Mikkers H, Allen J, Knipscheer P, Romeijn L, Hart A, Vink E, Berns A. 2002. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 32: 153-159.
    • (2002) Nat Genet , vol.32 , pp. 153-159
    • Mikkers, H.1    Allen, J.2    Knipscheer, P.3    Romeijn, L.4    Hart, A.5    Vink, E.6    Berns, A.7
  • 81
    • 0020530338 scopus 로고
    • The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors
    • Murray MJ, Cunningham JM, Parada LF, Dautry F, Lebowitz P, Weinberg RA. 1983. The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell 33: 749-757.
    • (1983) Cell , vol.33 , pp. 749-757
    • Murray, M.J.1    Cunningham, J.M.2    Parada, L.F.3    Dautry, F.4    Lebowitz, P.5    Weinberg, R.A.6
  • 82
    • 77957881882 scopus 로고    scopus 로고
    • Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap
    • Neto-Silva RM, de Beco S, Johnston LA. 2010. Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell 19: 507-520.
    • (2010) Dev Cell , vol.19 , pp. 507-520
    • Neto-Silva, R.M.1    De Beco, S.2    Johnston, L.A.3
  • 83
    • 84867010006 scopus 로고    scopus 로고
    • Casellas R, et al. 2012. C-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    • Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green DR, Tessarollo L, Casellas R, et al. 2012. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 151: 68-79.
    • Cell , vol.151 , pp. 68-79
    • Nie, Z.1    Hu, G.2    Wei, G.3    Cui, K.4    Yamane, A.5    Resch, W.6    Wang, R.7    Green, D.R.8    Tessarollo, L.9
  • 84
    • 1642430733 scopus 로고    scopus 로고
    • Myc pathways provoking cell suicide and cancer
    • Nilsson JA, Cleveland JL. 2003. Myc pathways provoking cell suicide and cancer. Oncogene 22: 9007-9021.
    • (2003) Oncogene , vol.22 , pp. 9007-9021
    • Nilsson, J.A.1    Cleveland, J.L.2
  • 85
    • 84883779605 scopus 로고    scopus 로고
    • Coordination of nutrient availability and utilization by MAX-and MLX-centered transcription networks
    • O’Shea JM, Ayer DE. 2013. Coordination of nutrient availability and utilization by MAX-and MLX-centered transcription networks. Cold Spring Harb Perspect Med 3: a014258.
    • (2013) Cold Spring Harb Perspect Med , vol.3
    • O’Shea, J.M.1    Ayer, D.E.2
  • 86
    • 14944381961 scopus 로고    scopus 로고
    • Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: Therapeutic implications
    • Pastorino F, Brignole C, Marimpietri D, Di Paolo D, Zancolli M, Pagnan G, Ponzoni M. 2004. Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: Therapeutic implications. Ann N Y Acad Sci 1028: 90-103.
    • (2004) Ann N Y Acad Sci , vol.1028 , pp. 90-103
    • Pastorino, F.1    Brignole, C.2    Marimpietri, D.3    Di Paolo, D.4    Zancolli, M.5    Pagnan, G.6    Ponzoni, M.7
  • 87
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Mycinduced apoptosis in b cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • Pelengaris S, Khan M, Evan GI. 2002. Suppression of Mycinduced apoptosis in b cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109: 321-334.
    • (2002) Cell , vol.109 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 92
    • 78249239770 scopus 로고    scopus 로고
    • Can antitumor immunity help to explain “oncogene addiction?”
    • Restifo NP. 2010. Can antitumor immunity help to explain “oncogene addiction?” Cancer Cell 18: 403-405.
    • (2010) Cancer Cell , vol.18 , pp. 403-405
    • Restifo, N.P.1
  • 93
    • 0022342072 scopus 로고
    • Epstein-Barr virus-positive Burkitt’s lymphoma cells not recognized by virus-specific T-cell surveillance
    • Rooney CM, Rowe M, Wallace LE, Rickinson AB. 1985. Epstein-Barr virus-positive Burkitt’s lymphoma cells not recognized by virus-specific T-cell surveillance. Nature 317: 629-631.
    • (1985) Nature , vol.317 , pp. 629-631
    • Rooney, C.M.1    Rowe, M.2    Wallace, L.E.3    Rickinson, A.B.4
  • 94
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • Ruggero D, Pandolfi PP. 2003. Does the ribosome translate cancer? Nat Rev Cancer 3: 179-192.
    • (2003) Nat Rev Cancer , vol.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 95
    • 79960623998 scopus 로고    scopus 로고
    • The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy
    • Savino M, Annibali D, Carucci N, Favuzzi E, Cole MD, Evan GI, Soucek L, Nasi S. 2011. The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. PloS ONE 6: e22284.
    • (2011) Plos ONE , vol.6
    • Savino, M.1    Annibali, D.2    Carucci, N.3    Favuzzi, E.4    Cole, M.D.5    Evan, G.I.6    Soucek, L.7    Nasi, S.8
  • 96
    • 0035049735 scopus 로고    scopus 로고
    • Bcl-2 mediates chemoresistance in matched pairs of primary Em-myc lymphomas in vivo
    • Schmitt CA, Lowe SW. 2001. Bcl-2 mediates chemoresistance in matched pairs of primary Em-myc lymphomas in vivo. Blood Cells Mol Dis 27: 206-216.
    • (2001) Blood Cells Mol Dis , vol.27 , pp. 206-216
    • Schmitt, C.A.1    Lowe, S.W.2
  • 97
  • 98
    • 19644376774 scopus 로고    scopus 로고
    • Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy
    • Shachaf CM, Felsher DW. 2005. Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy. Cancer Res 65: 4471-4474.
    • (2005) Cancer Res , vol.65 , pp. 4471-4474
    • Shachaf, C.M.1    Felsher, D.W.2
  • 102
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
    • Sharma SV, Settleman J. 2007. Oncogene addiction: Setting the stage for molecularly targeted cancer therapy. Genes Dev 21: 3214-3231.
    • (2007) Genes Dev , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 104
    • 0018182764 scopus 로고
    • Identification of nucleotide sequences which may encode the oncogenic capacity of avian retrovirus MC29
    • Sheiness D, Fanshier L, Bishop JM. 1978. Identification of nucleotide sequences which may encode the oncogenic capacity of avian retrovirus MC29. J Virol 28: 600-610.
    • (1978) J Virol , vol.28 , pp. 600-610
    • Sheiness, D.1    Fanshier, L.2    Bishop, J.M.3
  • 106
    • 34948852371 scopus 로고    scopus 로고
    • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
    • Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI. 2007. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 13: 1211-1218.
    • (2007) Nat Med , vol.13 , pp. 1211-1218
    • Soucek, L.1    Lawlor, E.R.2    Soto, D.3    Shchors, K.4    Swigart, L.B.5    Evan, G.I.6
  • 109
    • 0026096540 scopus 로고
    • Control of c-myc regulation in normal and neoplastic cells
    • Spencer CA, Groudine M. 1991. Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res 56: 1-48.
    • (1991) Adv Cancer Res , vol.56 , pp. 1-48
    • Spencer, C.A.1    Groudine, M.2
  • 111
    • 28844454167 scopus 로고    scopus 로고
    • Antisense strategies for oncogene inactivation
    • Stein CA, Benimetskaya L, Mani S. 2005. Antisense strategies for oncogene inactivation. Semin Oncol 32: 563-572.
    • (2005) Semin Oncol , vol.32 , pp. 563-572
    • Stein, C.A.1    Benimetskaya, L.2    Mani, S.3
  • 113
    • 0035845318 scopus 로고    scopus 로고
    • Antisense therapy in oncology: New hope for an old idea?
    • Tamm I, Dorken B, Hartmann G. 2001. Antisense therapy in oncology: New hope for an old idea? Lancet 358: 489-497.
    • (2001) Lancet , vol.358 , pp. 489-497
    • Tamm, I.1    Dorken, B.2    Hartmann, G.3
  • 116
    • 0036285034 scopus 로고    scopus 로고
    • C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. 2002. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Mol Cell 9: 1031-1044.
    • (2002) Mol Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3    Beeche, M.4    Pandita, T.K.5    Hampton, G.M.6    Wahl, G.M.7
  • 117
    • 77953917870 scopus 로고    scopus 로고
    • The interaction between Myc and Miz1 is required to antagonize TGFb-dependent autocrine signaling during lymphoma formation and maintenance
    • van Riggelen J, Muller J, Otto T, Beuger V, Yetil A, Choi PS, Kosan C, Moroy T, Felsher DW, Eilers M. 2010a. The interaction between Myc and Miz1 is required to antagonize TGFb-dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev 24: 1281-1294.
    • (2010) Genes Dev , vol.24 , pp. 1281-1294
    • Van Riggelen, J.1    Muller, J.2    Otto, T.3    Beuger, V.4    Yetil, A.5    Choi, P.S.6    Kosan, C.7    Moroy, T.8    Felsher, D.W.9    Eilers, M.10
  • 118
    • 77949920493 scopus 로고    scopus 로고
    • MYC as a regulator of ribosome biogenesis and protein synthesis
    • van Riggelen J, Yetil A, Felsher DW. 2010b. MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 10: 301-309.
    • (2010) Nat Rev Cancer , vol.10 , pp. 301-309
    • Van Riggelen, J.1    Yetil, A.2    Felsher, D.W.3
  • 119
    • 37549040575 scopus 로고    scopus 로고
    • The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
    • Verdine GL, Walensky LD. 2007. The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members. Clin Cancer Res 13: 7264-7270.
    • (2007) Clin Cancer Res , vol.13 , pp. 7264-7270
    • Verdine, G.L.1    Walensky, L.D.2
  • 120
    • 33748192942 scopus 로고    scopus 로고
    • The Myc oncoprotein as a therapeutic target for human cancer
    • Vita M, Henriksson M. 2006. The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biol 16: 318-330.
    • (2006) Semin Cancer Biol , vol.16 , pp. 318-330
    • Vita, M.1    Henriksson, M.2
  • 121
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes—The Achilles heal of cancer
    • Weinstein IB. 2002. Cancer. Addiction to oncogenes—The Achilles heal of cancer. Science 297: 63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 122
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • Weinstein IB, Joe A. 2008. Oncogene addiction. Cancer Res 68: 3077-3080.
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 125
    • 46249107676 scopus 로고    scopus 로고
    • Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis
    • Wu CH, Sahoo D, Arvanitis C, Bradon N, Dill DL, Felsher DW. 2008. Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis. PLoS Genet 4: e1000090.
    • (2008) Plos Genet , vol.4
    • Wu, C.H.1    Sahoo, D.2    Arvanitis, C.3    Bradon, N.4    Dill, D.L.5    Felsher, D.W.6
  • 126
    • 84869861385 scopus 로고    scopus 로고
    • Drugging the undruggable: Transcription therapy for cancer
    • Yan C, Higgins PJ. 2013. Drugging the undruggable: Transcription therapy for cancer. Biochim Biophys Acta 1835: 76-85.
    • (2013) Biochim Biophys Acta , vol.1835 , pp. 76-85
    • Yan, C.1    Higgins, P.J.2
  • 127
    • 77956369534 scopus 로고    scopus 로고
    • Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
    • Yang D, Liu H, Goga A, Kim S, Yuneva M, Bishop JM. 2010. Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase. Proc Natl Acad Sci 107: 13836-13841.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 13836-13841
    • Yang, D.1    Liu, H.2    Goga, A.3    Kim, S.4    Yuneva, M.5    Bishop, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.