-
1
-
-
0037115911
-
Uracil in DNA-occurrence, consequences and repair
-
Krokan, H. E., Drabløs, F., Slupphaug, G. Uracil in DNA-occurrence, consequences and repair. Oncogene 21, 8935-8948 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 8935-8948
-
-
Krokan, H.E.1
Drabløs, F.2
Slupphaug, G.3
-
2
-
-
84978910909
-
Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history
-
Lewis, C. A. Jr, Crayle, J., Zhou, S., Swanstrom, R., Wolfenden, R. Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history. Proc. Natl Acad. Sci. USA 113, 8194-8199 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 8194-8199
-
-
Lewis, C.A.1
Crayle, J.2
Zhou, S.3
Swanstrom, R.4
Wolfenden, R.5
-
3
-
-
84971006562
-
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
-
Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A., Liu, D. R. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533, 420-424 (2016).
-
(2016)
Nature
, vol.533
, pp. 420-424
-
-
Komor, A.C.1
Kim, Y.B.2
Packer, M.S.3
Zuris, J.A.4
Liu, D.R.5
-
4
-
-
84981516964
-
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
-
Nishida, K. et al. Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems. Science 353, aaf8729 (2016).
-
(2016)
Science
, vol.353
, pp. 8729
-
-
Nishida, K.1
-
5
-
-
85030701188
-
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
-
Komor, A. C. et al. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci. Adv. 3, eaao4774 (2017).
-
(2017)
Sci. Adv.
, vol.3
, pp. 4774
-
-
Komor, A.C.1
-
7
-
-
85017397628
-
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
-
Kim, Y. B. et al. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat. Biotechnol. 35, 371-376 (2017).
-
(2017)
Nat. Biotechnol.
, vol.35
, pp. 371-376
-
-
Kim, Y.B.1
-
8
-
-
85020458044
-
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery
-
Rees, H. A. et al. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat. Commun. 8, 15790 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 15790
-
-
Rees, H.A.1
-
9
-
-
85019844083
-
Precise genome-wide base editing by the CRISPR Nickase system in yeast
-
Satomura, A. et al. Precise genome-wide base editing by the CRISPR Nickase system in yeast. Sci. Rep. 7, 2095 (2017).
-
(2017)
Sci. Rep.
, vol.7
, pp. 2095
-
-
Satomura, A.1
-
10
-
-
85009355218
-
Precise editing of a target base in the rice genome using a modified CRISPR/Cas9 system
-
Lu, Y., Zhu, J.-K. Precise editing of a target base in the rice genome using a modified CRISPR/Cas9 system. Mol. Plant 10, 523-525 (2017).
-
(2017)
Mol. Plant
, vol.10
, pp. 523-525
-
-
Lu, Y.1
Zhu, J.-K.2
-
11
-
-
85018618268
-
Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion
-
Zong, Y. et al. Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion. Nat. Biotechnol. 35, 438-440 (2017).
-
(2017)
Nat. Biotechnol.
, vol.35
, pp. 438-440
-
-
Zong, Y.1
-
12
-
-
85025611746
-
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
-
Zhang, Y. et al. Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. Nat. Commun. 8, 118 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 118
-
-
Zhang, Y.1
-
13
-
-
85030254880
-
CRISPR-mediated base editing enables efficient disruption of eukaryotic genes through induction of STOP codons
-
Billon, P. et al. CRISPR-mediated base editing enables efficient disruption of eukaryotic genes through induction of STOP codons. Mol. Cell 67, 1068-1079 (2017).
-
(2017)
Mol. Cell
, vol.67
, pp. 1068-1079
-
-
Billon, P.1
-
14
-
-
85027502168
-
CRISPR-STOP: Gene silencing through base-editing-induced nonsense mutations
-
Kuscu, C. et al. CRISPR-STOP: Gene silencing through base-editing-induced nonsense mutations. Nat. Methods 14, 710-712 (2017).
-
(2017)
Nat. Methods
, vol.14
, pp. 710-712
-
-
Kuscu, C.1
-
15
-
-
85018918215
-
Highly efficient RNA-guided base editing in mouse embryos
-
Kim, K. et al. Highly efficient RNA-guided base editing in mouse embryos. Nat. Biotechnol. 35, 435-437 (2017).
-
(2017)
Nat. Biotechnol.
, vol.35
, pp. 435-437
-
-
Kim, K.1
-
16
-
-
85030690032
-
In vivo base editing of PCSK9 (proprotein convertase subtilisin/kexin Type 9) as a therapeutic alternative to genome editing
-
Chadwick, A. C., Wang, X., Musunuru, K. In vivo base editing of PCSK9 (proprotein convertase subtilisin/kexin Type 9) as a therapeutic alternative to genome editing. Arterioscler. Thromb. Vasc. Biol. 37, 1741-1747 (2017).
-
(2017)
Arterioscler. Thromb. Vasc. Biol.
, vol.37
, pp. 1741-1747
-
-
Chadwick, A.C.1
Wang, X.2
Musunuru, K.3
-
17
-
-
85029749445
-
Correction of-thalassemia mutant by base editor in human embryos
-
Liang, P. et al. Correction of-thalassemia mutant by base editor in human embryos. Protein Cell https://doi.org/10.1007/s13238-017-0475-6 (2017).
-
(2017)
Protein Cell
-
-
Liang, P.1
-
18
-
-
85027830826
-
Highly efficient and precise base editing in discarded human tripronuclear embryos
-
Li, G. et al. Highly efficient and precise base editing in discarded human tripronuclear embryos. Protein Cell 8, 776-779 (2017).
-
(2017)
Protein Cell
, vol.8
, pp. 776-779
-
-
Li, G.1
-
19
-
-
85021648932
-
Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
-
Tang, W., Hu, J. H., Liu, D. R. Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation. Nat. Commun. 8, 15939 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 15939
-
-
Tang, W.1
Hu, J.H.2
Liu, D.R.3
-
20
-
-
40849097298
-
Miscoding properties of 2-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases
-
Yasui, M. et al. Miscoding properties of 2-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. J. Mol. Biol. 377, 1015-1023 (2008).
-
(2008)
J. Mol. Biol.
, vol.377
, pp. 1015-1023
-
-
Yasui, M.1
-
21
-
-
85018254357
-
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA
-
Zheng, Y., Lorenzo, C., Beal, P. A. DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. Nucleic Acids Res. 45, 3369-3377 (2017).
-
(2017)
Nucleic Acids Res
, vol.45
, pp. 3369-3377
-
-
Zheng, Y.1
Lorenzo, C.2
Beal, P.A.3
-
22
-
-
33646888184
-
Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase
-
Kim, J. et al. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. Biochemistry 45, 6407-6416 (2006).
-
(2006)
Biochemistry
, vol.45
, pp. 6407-6416
-
-
Kim, J.1
-
23
-
-
0037099742
-
TadA, an essential tRNA-specific adenosine deaminase from Escherichia coli
-
Wolf, J., Gerber, A. P., Keller, W. tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J. 21, 3841-3851 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 3841-3851
-
-
Wolf, J.1
Gerber, A.P.2
Keller, W.3
-
24
-
-
84963603761
-
Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
-
Matthews, M. M. et al. Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat. Struct. Mol. Biol. 23, 426-433 (2016).
-
(2016)
Nat. Struct. Mol. Biol.
, vol.23
, pp. 426-433
-
-
Matthews, M.M.1
-
25
-
-
84889880502
-
Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies
-
Grunebaum, E., Cohen, A., Roifman, C. M. Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies. Curr. Opin. Allergy Clin. Immunol. 13, 630-638 (2013).
-
(2013)
Curr. Opin. Allergy Clin. Immunol.
, vol.13
, pp. 630-638
-
-
Grunebaum, E.1
Cohen, A.2
Roifman, C.M.3
-
26
-
-
0033527628
-
An adenosine deaminase that generates inosine at the wobble position of tRNAs
-
Gerber, A. P., Keller, W. An adenosine deaminase that generates inosine at the wobble position of tRNAs. Science 286, 1146-1149 (1999).
-
(1999)
Science
, vol.286
, pp. 1146-1149
-
-
Gerber, A.P.1
Keller, W.2
-
27
-
-
79955739303
-
DNA mismatch repair in eukaryotes and bacteria
-
Fukui, K. DNA mismatch repair in eukaryotes and bacteria. J. Nucleic Acids 2010, 260512 (2010).
-
(2010)
J. Nucleic Acids
, vol.2010
, pp. 260512
-
-
Fukui, K.1
-
28
-
-
85006341729
-
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
-
Shi, K. et al. Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nat. Struct. Mol. Biol. 24, 131-139 (2017).
-
(2017)
Nat. Struct. Mol. Biol.
, vol.24
, pp. 131-139
-
-
Shi, K.1
-
29
-
-
24644519954
-
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing
-
Macbeth, M. R. et al. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science 309, 1534-1539 (2005).
-
(2005)
Science
, vol.309
, pp. 1534-1539
-
-
MacBeth, M.R.1
-
30
-
-
32244445417
-
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA
-
Losey, H. C., Ruthenburg, A. J., Verdine, G. L. Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. Nat. Struct. Mol. Biol. 13, 153-159 (2006).
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 153-159
-
-
Losey, H.C.1
Ruthenburg, A.J.2
Verdine, G.L.3
-
31
-
-
0034610336
-
Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase
-
Lau, A. Y., Wyatt, M. D., Glassner, B. J., Samson, L. D., Ellenberger, T. Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG. Proc. Natl Acad. Sci. USA 97, 13573-13578 (2000).
-
(2000)
AAG. Proc. Natl Acad. Sci. USA
, vol.97
, pp. 13573-13578
-
-
Lau, A.Y.1
Wyatt, M.D.2
Glassner, B.J.3
Samson, L.D.4
Ellenberger, T.5
-
32
-
-
84881460714
-
Endonuclease V cleaves at inosines in RNA
-
Vik, E. S. et al. Endonuclease V cleaves at inosines in RNA. Nat. Commun. 4, 2271 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2271
-
-
Vik, E.S.1
-
33
-
-
84971299957
-
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
-
Paquet, D. et al. Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9. Nature 533, 125-129 (2016).
-
(2016)
Nature
, vol.533
, pp. 125-129
-
-
Paquet, D.1
-
34
-
-
85018935232
-
Genome-wide target specificities of CRISPR RNA-guided programmable deaminases
-
Kim, D. et al. Genome-wide target specificities of CRISPR RNA-guided programmable deaminases. Nat. Biotechnol. 35, 475-480 (2017).
-
(2017)
Nat. Biotechnol.
, vol.35
, pp. 475-480
-
-
Kim, D.1
-
35
-
-
84923266604
-
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
-
Tsai, S. Q. et al. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat. Biotechnol. 33, 187-197 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 187-197
-
-
Tsai, S.Q.1
-
36
-
-
84982181938
-
A genome-editing strategy to treat-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
-
Traxler, E. A. et al. A genome-editing strategy to treat-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Nat. Med. 22, 987-990 (2016).
-
(2016)
Nat. Med.
, vol.22
, pp. 987-990
-
-
Traxler, E.A.1
-
37
-
-
85028324684
-
KLF1 drives the expression of fetal hemoglobin in British HPFH
-
Wienert, B. et al. KLF1 drives the expression of fetal hemoglobin in British HPFH. Blood 130, 803-807 (2017).
-
(2017)
Blood
, vol.130
, pp. 803-807
-
-
Wienert, B.1
-
38
-
-
67249111755
-
HFE-associated hereditary hemochromatosis
-
Alexander, J., Kowdley, K. V. HFE-associated hereditary hemochromatosis. Genet. Med. 11, 307-313 (2009).
-
(2009)
Genet. Med.
, vol.11
, pp. 307-313
-
-
Alexander, J.1
Kowdley, K.V.2
-
39
-
-
84976904305
-
Clin Var: Public archive of interpretations of clinically relevant variants
-
Landrum, M. J. et al. ClinVar: Public archive of interpretations of clinically relevant variants. Nucleic Acids Res. 44, D862-D868 (2016).
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. D862-D868
-
-
Landrum, M.J.1
-
40
-
-
84969786561
-
Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance
-
Badran, A. H. et al. Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance. Nature 533, 58-63 (2016).
-
(2016)
Nature
, vol.533
, pp. 58-63
-
-
Badran, A.H.1
-
41
-
-
27144471889
-
Nucleotide exchange and excision technology (NExT) DNA shuffling: A robust method for DNA fragmentation and directed evolution
-
Müller, K. M. et al. Nucleotide exchange and excision technology (NExT) DNA shuffling: A robust method for DNA fragmentation and directed evolution. Nucleic Acids Res. 33, e117 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
, pp. e117
-
-
Müller, K.M.1
-
42
-
-
79955534060
-
A system for the continuous directed evolution of biomolecules
-
Esvelt, K. M., Carlson, J. C., Liu, D. R. A system for the continuous directed evolution of biomolecules. Nature 472, 499-503 (2011).
-
(2011)
Nature
, vol.472
, pp. 499-503
-
-
Esvelt, K.M.1
Carlson, J.C.2
Liu, D.R.3
-
43
-
-
85010953630
-
Precise and efficient scarless genome editing in stem cells using CORRECT
-
Kwart, D., Paquet, D., Teo, S., Tessier-Lavigne, M. Precise and efficient scarless genome editing in stem cells using CORRECT. Nat. Protocols 12, 329-354 (2017).
-
(2017)
Nat. Protocols
, vol.12
, pp. 329-354
-
-
Kwart, D.1
Paquet, D.2
Teo, S.3
Tessier-Lavigne, M.4
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