Structural biology: Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing

Science

Volumn 309, Issue 5740, 2005, Pages 1534-1539

  Macbeth, Mark R ^a,b   Schubert, Heidi L ^a   VanDemark, Andrew F ^a   Lingam, Arunth T ^a,b   Hill, Christopher P ^a   Bass, Brenda L ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; POSITIVE IONS; RNA; ZINC;

ADENOSINE; COFACTORS; INOSITOL HEXAKISPHOSPHATE; STRUCTURAL BIOLOGY;

ENZYMES;

ADENOSINE; ADENOSINE DEAMINASE; CYTIDINE; DOUBLE STRANDED RNA; PHYTIC ACID; RNA; TRANSFER RNA; ZINC; DSRNA ADENOSINE DEAMINASE;

RNA;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA BINDING; RNA EDITING; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; THIN LAYER CHROMATOGRAPHY; WESTERN BLOTTING; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

ADENOSINE DEAMINASE; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYTIC ACID; RNA EDITING; RNA, TRANSFER;

EID: 24644519954     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113150     Document Type: Article

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44. We thank R. Schackmann for synthesis of oligonucleotides and N-terminal sequencing and C. Nelson for mass spectrometry analysis; both are supported by a Cancer Center Support Grant (2P30CA042014). We also thank P. Beal and S. Wente for helpful discussions. This work was supported by grants from the National Institute of General Medical Sciences, GM44073 and GM56775, to B.L.B. and C.P.H., respectively. A.P.V. is supported by a postdoctoral fellowship from the American Cancer Society. B.L.B. is a Howard Huehes Medical Institute Investigator.