Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Science Advances

Volumn 3, Issue 8, 2017, Pages

  Komor, Alexis C ^a,b,c,d   Zhao, Kevin T ^a,b,c   Packer, Michael S ^a,b,c,e   Gaudelli, Nicole M ^a,b,c   Waterbury, Amanda L ^a   Koblan, Luke W ^a,b,c   Kim, Y Bill ^a,b,c   Badran, Ahmed H ^a,b,c   Liu, David R ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Beam Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGES; EFFICIENCY; PROTEINS; REPAIR;

BASE EXCISION REPAIRS; CYTIDINE DEAMINASE; DOUBLE-STRANDED DNA BREAKS; FOURTH GENERATION; HIGHER EFFICIENCY; PRODUCT DISTRIBUTIONS; STATE OF THE ART; URACIL-N-GLYCOSYLASE;

C (PROGRAMMING LANGUAGE);

DNA BINDING PROTEIN; GAM PROTEIN, COLIPHAGE; URACIL DNA GLYCOSIDASE; VIRAL PROTEIN;

BASE PAIRING; CELL LINE; DNA REPAIR; ENTEROBACTERIA PHAGE MU; ENZYME ACTIVATION; GENE FREQUENCY; GENE ORDER; HUMAN; INDEL MUTATION; METABOLISM; PHYSIOLOGY;

BACTERIOPHAGE MU; BASE PAIRING; CELL LINE; DNA REPAIR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE FREQUENCY; GENE ORDER; HUMANS; INDEL MUTATION; URACIL-DNA GLYCOSIDASE; VIRAL PROTEINS;

EID: 85030701188     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.aao4774     Document Type: Article

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