Correction of β-thalassemia mutant by base editor in human embryos

Protein and Cell

Volumn 8, Issue 11, 2017, Pages 811-822

  Liang, Puping ^a   Ding, Chenhui ^a   Sun, Hongwei ^a   Xie, Xiaowei ^a   Xu, Yanwen ^a   Zhang, Xiya ^a   Sun, Ying ^a   Xiong, Yuanyan ^a   Ma, Wenbin ^a   Liu, Yongxiang ^a   Wang, Yali ^a   Fang, Jianpei ^a   Liu, Dan ^b   Songyang, Zhou ^a,b   Zhou, Canquan ^a   Huang, Junjiu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

base editor; HBB 28 (A>G); human embryo; thalassemia

Indexed keywords

ARTICLE; BETA THALASSEMIA; CELL MATURATION; EMBRYO; FIBROBLAST; GENE AMPLIFICATION; GENE EDITING; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; OOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TARGETED GENE REPAIR; BLASTOMA; CRISPR CAS SYSTEM; CYTOLOGY; DNA SEQUENCE; FEMALE; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HETEROZYGOTE; HOMOZYGOTE; MAMMALIAN EMBRYO; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; POINT MUTATION; PRIMARY CELL CULTURE; PROCEDURES; PROMOTER REGION;

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; HEMOGLOBIN BETA CHAIN;

APOBEC-1 DEAMINASE; BASE SEQUENCE; BETA-GLOBINS; BETA-THALASSEMIA; BLASTOMERES; CRISPR-CAS SYSTEMS; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; GENE EDITING; GENE EXPRESSION; HEK293 CELLS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; POINT MUTATION; PRIMARY CELL CULTURE; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 85029749445     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-017-0475-6     Document Type: Article

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