Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

Nature Communications

Volumn 8, Issue , 2017, Pages

  Tang, Weixin ^a,b,c   Hu, Johnny H ^a,b,c   Liu, David R ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUIDE RNA; LIGAND; NUCLEASE; RIBOZYME;

CATALYSIS; CELLS AND CELL COMPONENTS; ENZYME; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; LIGAND; MAMMAL; RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EDITING; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; TRANSCRIPTION INITIATION; CHEMISTRY; CONFORMATION; CRISPR CAS SYSTEM; GENETICS; HEK293 CELL LINE; METABOLISM;

MAMMALIA;

CRISPR-CAS SYSTEMS; GENE EDITING; HEK293 CELLS; HUMANS; LIGANDS; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; RNA, GUIDE; TRANSCRIPTIONAL ACTIVATION;

EID: 85021648932     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15939     Document Type: Article

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