메뉴 건너뛰기




Volumn 17, Issue 12, 2017, Pages 725-737

Small-cell lung cancer: What we know, what we need to know and the path forward

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOMODULATING AGENT; MYC PROTEIN; NOTCH RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN P53; TRANSCRIPTION FACTOR EZH2; RB1 PROTEIN, HUMAN; RETINOBLASTOMA BINDING PROTEIN; TP53 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

EID: 85034813206     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc.2017.87     Document Type: Review
Times cited : (596)

References (186)
  • 1
    • 84856425976 scopus 로고    scopus 로고
    • American Cancer Society American Cancer Society
    • American Cancer Society. Global Cancer Facts & Figures 3rd edn (American Cancer Society, 2015).
    • (2015) Global Cancer Facts & Figures 3rd Edn
  • 2
    • 85003815084 scopus 로고    scopus 로고
    • Small-cell lung cancer in 2016: Shining light on novel targets and therapies
    • Rudin, C. M. & Poirier, J. T. Small-cell lung cancer in 2016: shining light on novel targets and therapies. Nat. Rev. Clin. Oncol. 14, 75-76 (2017).
    • (2017) Nat. Rev. Clin. Oncol. , vol.14 , pp. 75-76
    • Rudin, C.M.1    Poirier, J.T.2
  • 3
    • 84994470617 scopus 로고    scopus 로고
    • Mutational signatures associated with tobacco smoking in human cancer
    • Alexandrov, L. B. et al. Mutational signatures associated with tobacco smoking in human cancer. Science 354, 618-622 (2016).
    • (2016) Science , vol.354 , pp. 618-622
    • Alexandrov, L.B.1
  • 4
    • 84938132350 scopus 로고    scopus 로고
    • Comprehensive genomic profiles of small cell lung cancer
    • George, J. et al. Comprehensive genomic profiles of small cell lung cancer. Nature 524, 47-53 (2015).
    • (2015) Nature , vol.524 , pp. 47-53
    • George, J.1
  • 5
    • 84962812153 scopus 로고    scopus 로고
    • Small cell lung cancer: Can recent advances in biology and molecular biology be translated into improved outcomes?
    • Bunn, P. A. Jr et al. Small cell lung cancer: can recent advances in biology and molecular biology be translated into improved outcomes? J. Thorac Oncol. 11, 453-474 (2016).
    • (2016) J. Thorac Oncol. , vol.11 , pp. 453-474
    • Bunn, P.A.1
  • 6
    • 7344228962 scopus 로고    scopus 로고
    • Second primary tumours in more than 2-year disease-free survivors of small-cell lung cancer in Japan: The role of smoking cessation
    • Kawahara, M. et al. Second primary tumours in more than 2-year disease-free survivors of small-cell lung cancer in Japan: the role of smoking cessation. Br. J. Cancer 78, 409-412 (1998).
    • (1998) Br. J. Cancer , vol.78 , pp. 409-412
    • Kawahara, M.1
  • 8
    • 85034864658 scopus 로고    scopus 로고
    • Cancer Research UK. Lung cancer incidence statistics. Cancer Research UK
    • Cancer Research UK. Lung cancer incidence statistics. Cancer Research UK http://www.cancerresearchuk. org/health-professional/cancer-statistics/statistics-by-cancer-type/lung-cancer/incidence (2014).
    • (2014)
  • 9
    • 85034862392 scopus 로고    scopus 로고
    • Current status of small cell lung cancer in China
    • Liu, J., Cheng, Y., Li, H. & Zhang, S. Current status of small cell lung cancer in China. J. Cancer Biol. Res. 2, 1032 (2014).
    • (2014) J. Cancer Biol. Res. , vol.2 , pp. 1032
    • Liu, J.1    Cheng, Y.2    Li, H.3    Zhang, S.4
  • 11
    • 84964350752 scopus 로고    scopus 로고
    • Epidemiology of Lung cancer in Korea: Recent trends
    • Park, J. Y. & Jang, S. H. Epidemiology of Lung cancer in Korea: recent trends. Tuberc Respir. Dis. 79, 58-69 (2016).
    • (2016) Tuberc Respir. Dis. , vol.79 , pp. 58-69
    • Park, J.Y.1    Jang, S.H.2
  • 12
    • 33750603100 scopus 로고    scopus 로고
    • Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database
    • Govindan, R. et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J. Clin. Oncol. 24, 4539-4544 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4539-4544
    • Govindan, R.1
  • 13
    • 85034864787 scopus 로고    scopus 로고
    • US Congress. H.R.733-Recalcitrant Cancer Research Act of 2012. Congress.gov
    • US Congress. H.R.733-Recalcitrant Cancer Research Act of 2012. Congress.gov https://www.congress.gov/bill/112th-congress/house-bill/733 (2012).
    • (2012)
  • 14
    • 0001248220 scopus 로고
    • The nature of the "oat celled" sarcoma of the mediastinum
    • Barnard, W. The nature of the "oat celled" sarcoma of the mediastinum. J. Pathol. Bacteriol. 29, 241-244 (1926).
    • (1926) J. Pathol. Bacteriol. , vol.29 , pp. 241-244
    • Barnard, W.1
  • 15
    • 0000513167 scopus 로고
    • Oat-cell carcinoma of the bronchus
    • Azzopardi, J. G. Oat-cell carcinoma of the bronchus. J. Pathol. Bacteriol. 78, 513-519 (1959).
    • (1959) J. Pathol. Bacteriol. , vol.78 , pp. 513-519
    • Azzopardi, J.G.1
  • 16
    • 67651068682 scopus 로고    scopus 로고
    • The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970-2004
    • Wong, Y. N., Jack, R. H., Mak, V., Henrik, M. & Davies, E. A. The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970-2004. BMC Cancer 9, 209 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 209
    • Wong, Y.N.1    Jack, R.H.2    Mak, V.3    Henrik, M.4    Davies, E.A.5
  • 17
    • 0015890021 scopus 로고
    • Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer
    • Matthews, M. J., Kanhouwa, S., Pickren, J. & Robinette, D. Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer. Cancer Chemother. Rep. 3 4, 63-67 (1973).
    • (1973) Cancer Chemother. Rep. , vol.34 , pp. 63-67
    • Matthews, M.J.1    Kanhouwa, S.2    Pickren, J.3    Robinette, D.4
  • 18
    • 0014375114 scopus 로고
    • Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid
    • Bensch, K. G., Corrin, B., Pariente, R. & Spencer, H. Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid. Cancer 22, 1163-1172 (1968).
    • (1968) Cancer , vol.22 , pp. 1163-1172
    • Bensch, K.G.1    Corrin, B.2    Pariente, R.3    Spencer, H.4
  • 19
    • 0014007530 scopus 로고
    • 5-Hydroxytryptophan uptake by dog thyroid 'C' cells, and its possible significance in polypeptide hormone production
    • Pearse, A. G. 5-Hydroxytryptophan uptake by dog thyroid 'C' cells, and its possible significance in polypeptide hormone production. Nature 211, 598-600 (1966).
    • (1966) Nature , vol.211 , pp. 598-600
    • Pearse, A.G.1
  • 20
    • 0022855207 scopus 로고
    • The diffuse neuroendocrine system: Peptides, amines, placodes and the APUD theory
    • Pearse, A. G. The diffuse neuroendocrine system: peptides, amines, placodes and the APUD theory. Prog. Brain Res. 68, 25-31 (1986).
    • (1986) Prog. Brain Res. , vol.68 , pp. 25-31
    • Pearse, A.G.1
  • 21
    • 0025347331 scopus 로고
    • "aPUD" cells: Fact and fiction
    • Baylin, S. B. "APUD" cells: fact and fiction. Trends Endocrinol. Metab. 1, 198-204 (1990).
    • (1990) Trends Endocrinol. Metab. , vol.1 , pp. 198-204
    • Baylin, S.B.1
  • 22
    • 79953306029 scopus 로고    scopus 로고
    • The origin of neuroendocrine tumors and the neural crest saga
    • Rosai, J. The origin of neuroendocrine tumors and the neural crest saga. Mod. Pathol. 24, S53-S57 (2011).
    • (2011) Mod. Pathol. , vol.24 , pp. S53-S57
    • Rosai, J.1
  • 23
    • 0018954542 scopus 로고
    • Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties
    • Gazdar, A. F. et al. Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res. 40, 3502-3507 (1980).
    • (1980) Cancer Res. , vol.40 , pp. 3502-3507
    • Gazdar, A.F.1
  • 24
    • 84989936333 scopus 로고    scopus 로고
    • ASCL1 and NEUROD1 reveal heterogeneity in pulmonary neuroendocrine tumors and regulate distinct genetic programs
    • Borromeo, M. D. et al. ASCL1 and NEUROD1 reveal heterogeneity in pulmonary neuroendocrine tumors and regulate distinct genetic programs. Cell Rep. 16, 1259-1272 (2016).
    • (2016) Cell Rep. , vol.16 , pp. 1259-1272
    • Borromeo, M.D.1
  • 25
    • 0030936265 scopus 로고    scopus 로고
    • An achaete-scute homologue essential for neuroendocrine differentiation in the lung
    • Borges, M. et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 386, 852-855 (1997).
    • (1997) Nature , vol.386 , pp. 852-855
    • Borges, M.1
  • 26
    • 84914172949 scopus 로고    scopus 로고
    • Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1
    • Vasconcelos, F. F. & Castro, D. S. Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1. Front. Cell. Neurosci. 8, 412 (2014).
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 412
    • Vasconcelos, F.F.1    Castro, D.S.2
  • 27
    • 84907938536 scopus 로고    scopus 로고
    • ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
    • Augustyn, A. et al. ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc. Natl Acad. Sci. USA 111, 14788-14793 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 14788-14793
    • Augustyn, A.1
  • 28
    • 85019546383 scopus 로고    scopus 로고
    • Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
    • Lim, J. S. et al. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature 545, 360-364 (2017).
    • (2017) Nature , vol.545 , pp. 360-364
    • Lim, J.S.1
  • 29
    • 0022006760 scopus 로고
    • Establishment and identification of small cell lung cancer cell lines having classic and variant features
    • Carney, D. N. et al. Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res. 45, 2913-2923 (1985).
    • (1985) Cancer Res. , vol.45 , pp. 2913-2923
    • Carney, D.N.1
  • 30
    • 85009505564 scopus 로고    scopus 로고
    • MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to Aurora kinase inhibition
    • Mollaoglu, G. et al. MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to Aurora kinase inhibition. Cancer Cell 31, 270-285 (2017).
    • (2017) Cancer Cell , vol.31 , pp. 270-285
    • Mollaoglu, G.1
  • 31
    • 77957969699 scopus 로고    scopus 로고
    • TTF1 expression in normal lung neuroendocrine cells and related tumors: Immunohistochemical study comparing two different monoclonal antibodies
    • La Rosa, S. et al. TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies. Virchows Arch. 457, 497-507 (2010).
    • (2010) Virchows Arch. , vol.457 , pp. 497-507
    • La Rosa, S.1
  • 32
    • 84878965845 scopus 로고    scopus 로고
    • NKX2-1/TTF-1: An enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression
    • Yamaguchi, T., Hosono, Y., Yanagisawa, K. & Takahashi, T. NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression. Cancer Cell 23, 718-723 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 718-723
    • Yamaguchi, T.1    Hosono, Y.2    Yanagisawa, K.3    Takahashi, T.4
  • 33
    • 84951812171 scopus 로고    scopus 로고
    • Treatment of small-cell lung cancer: American Society of Clinical Oncology endorsement of the American College of Chest Physicians guideline
    • Rudin, C. M. et al. Treatment of small-cell lung cancer: American Society of Clinical Oncology endorsement of the American College of Chest Physicians guideline. J. Clin. Oncol. 33, 4106-4111 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 4106-4111
    • Rudin, C.M.1
  • 34
    • 0021968689 scopus 로고
    • Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties
    • Gazdar, A. F., Carney, D. N., Nau, M. M. & Minna, J. D. Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties. Cancer Res. 45, 2924-2930 (1985).
    • (1985) Cancer Res. , vol.45 , pp. 2924-2930
    • Gazdar, A.F.1    Carney, D.N.2    Nau, M.M.3    Minna, J.D.4
  • 35
    • 0025907433 scopus 로고
    • Myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens
    • Brennan, J. et al. myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens. Cancer Res. 51, 1708-1712 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 1708-1712
    • Brennan, J.1
  • 36
    • 0020535311 scopus 로고
    • In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants
    • Carney, D. N., Mitchell, J. B. & Kinsella, T. J. In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants. Cancer Res. 43, 2806-2811 (1983).
    • (1983) Cancer Res. , vol.43 , pp. 2806-2811
    • Carney, D.N.1    Mitchell, J.B.2    Kinsella, T.J.3
  • 37
    • 84880559818 scopus 로고    scopus 로고
    • Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer
    • Poirier, J. T. et al. Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer. J. Natl Cancer Inst. 105, 1059-1065 (2013).
    • (2013) J. Natl Cancer Inst. , vol.105 , pp. 1059-1065
    • Poirier, J.T.1
  • 38
    • 0029681702 scopus 로고    scopus 로고
    • MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer
    • Johnson, B. E. et al. MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer. J. Cell. Biochem. Suppl. 24, 210-217 (1996).
    • (1996) J. Cell. Biochem. Suppl. , vol.24 , pp. 210-217
    • Johnson, B.E.1
  • 39
    • 79751511326 scopus 로고    scopus 로고
    • A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer
    • Calbo, J. et al. A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer. Cancer Cell 19, 244-256 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 244-256
    • Calbo, J.1
  • 40
    • 84938209433 scopus 로고    scopus 로고
    • Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: Clinical update
    • Takebe, N. et al. Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat. Rev. Clin. Oncol. 12, 445-464 (2015).
    • (2015) Nat. Rev. Clin. Oncol. , vol.12 , pp. 445-464
    • Takebe, N.1
  • 42
    • 77349109478 scopus 로고    scopus 로고
    • Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy
    • Sullivan, J. P., Minna, J. D. & Shay, J. W. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev. 29, 61-72 (2010).
    • (2010) Cancer Metastasis Rev. , vol.29 , pp. 61-72
    • Sullivan, J.P.1    Minna, J.D.2    Shay, J.W.3
  • 43
    • 84938097346 scopus 로고    scopus 로고
    • Origins, genetic landscape, and emerging therapies of small cell lung cancer
    • Semenova, E. A., Nagel, R. & Berns, A. Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes Dev. 29, 1447-1462 (2015).
    • (2015) Genes Dev. , vol.29 , pp. 1447-1462
    • Semenova, E.A.1    Nagel, R.2    Berns, A.3
  • 44
    • 84949534082 scopus 로고    scopus 로고
    • Sox2, a key factor in the regulation of pluripotency and neural differentiation
    • Zhang, S. & Cui, W. Sox2, a key factor in the regulation of pluripotency and neural differentiation. World J. Stem Cells 6, 305-311 (2014).
    • (2014) World J. Stem Cells , vol.6 , pp. 305-311
    • Zhang, S.1    Cui, W.2
  • 45
    • 84866849548 scopus 로고    scopus 로고
    • Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
    • Rudin, C. M. et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat. Genet. 44, 1111-1116 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 1111-1116
    • Rudin, C.M.1
  • 46
    • 84978437311 scopus 로고    scopus 로고
    • Identification and targeting of long-term tumor-propagating cells in small cell lung cancer
    • Jahchan, N. S. et al. Identification and targeting of long-term tumor-propagating cells in small cell lung cancer. Cell Rep. 16, 644-656 (2016).
    • (2016) Cell Rep. , vol.16 , pp. 644-656
    • Jahchan, N.S.1
  • 47
    • 54249112735 scopus 로고    scopus 로고
    • Small cell, big problem! Stem cells, root cause? Clin
    • Subramanian, J. & Govindan, R. Small cell, big problem! Stem cells, root cause? Clin. Lung Cancer 9, 252-253 (2008).
    • (2008) Lung Cancer , vol.9 , pp. 252-253
    • Subramanian, J.1    Govindan, R.2
  • 49
    • 84882995953 scopus 로고    scopus 로고
    • Cancer stem cells and tumor transdifferentiation: Implications for novel therapeutic strategies
    • Shekhani, M. T., Jayanthy, A. S., Maddodi, N. & Setaluri, V. Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies. Am. J. Stem Cells 2, 52-61 (2013).
    • (2013) Am. J. Stem Cells , vol.2 , pp. 52-61
    • Shekhani, M.T.1    Jayanthy, A.S.2    Maddodi, N.3    Setaluri, V.4
  • 50
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histolgical evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist, L. et al. Genotypic and histolgical evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl Med. 3, 75ra26 (2011).
    • (2011) Sci. Transl Med. , vol.3 , pp. 75ra26
    • Sequist, L.1
  • 51
    • 84924590266 scopus 로고    scopus 로고
    • RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
    • Niederst, M. J. et al. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nature Commun. 6, 6377 (2015).
    • (2015) Nature Commun. , vol.6 , pp. 6377
    • Niederst, M.J.1
  • 52
    • 84929949436 scopus 로고    scopus 로고
    • The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung
    • Gazdar, A. F. et al. The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J. Thorac Oncol. 10, 553-564 (2015).
    • (2015) J. Thorac Oncol. , vol.10 , pp. 553-564
    • Gazdar, A.F.1
  • 53
    • 0033927099 scopus 로고    scopus 로고
    • Molecular changes in the bronchial epithelium of patients with small cell lung cancer
    • Wistuba, I. I. et al. Molecular changes in the bronchial epithelium of patients with small cell lung cancer. Clin. Cancer Res. 6, 2604-2610 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2604-2610
    • Wistuba, I.I.1
  • 54
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 55
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance, E. D. et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463, 184-190 (2010).
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1
  • 56
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • Govindan, R. et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150, 1121-1134 (2012).
    • (2012) Cell , vol.150 , pp. 1121-1134
    • Govindan, R.1
  • 57
    • 84883432724 scopus 로고    scopus 로고
    • An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
    • Roberts, S. A. et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45, 970-976 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 970-976
    • Roberts, S.A.1
  • 58
    • 0141523025 scopus 로고    scopus 로고
    • Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
    • Meuwissen, R. et al. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 4, 181-189 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 181-189
    • Meuwissen, R.1
  • 59
    • 84896333670 scopus 로고    scopus 로고
    • Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
    • McFadden, D. G. et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell 156, 1298-1311 (2014).
    • (2014) Cell , vol.156 , pp. 1298-1311
    • McFadden, D.G.1
  • 60
    • 84875813017 scopus 로고    scopus 로고
    • Mouse models for lung cancer
    • Kwon, M. C. & Berns, A. Mouse models for lung cancer. Mol. Oncol. 7, 165-177 (2013).
    • (2013) Mol. Oncol. , vol.7 , pp. 165-177
    • Kwon, M.C.1    Berns, A.2
  • 61
    • 0020038032 scopus 로고
    • Specific chromosome defect associated with human small-cell lung cancer; Deletion 3p(14-23)
    • Whang-Peng, J. et al. Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23). Science 215, 181-182 (1982).
    • (1982) Science , vol.215 , pp. 181-182
    • Whang-Peng, J.1
  • 62
    • 19244370711 scopus 로고    scopus 로고
    • High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
    • Wistuba, I. I. et al. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res. 60, 1949-1960 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1949-1960
    • Wistuba, I.I.1
  • 63
    • 33751100403 scopus 로고    scopus 로고
    • Functional analysis of lung tumor suppressor activity at 3p21.3
    • ter Elst, A. et al. Functional analysis of lung tumor suppressor activity at 3p21.3. Genes Chromosomes Cancer 45, 1077-1093 (2006).
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 1077-1093
    • Ter Elst, A.1
  • 64
    • 0037037787 scopus 로고    scopus 로고
    • Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
    • Zabarovsky, E. R., Lerman, M. I. & Minna, J. D. Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21, 6915-6935 (2002).
    • (2002) Oncogene , vol.21 , pp. 6915-6935
    • Zabarovsky, E.R.1    Lerman, M.I.2    Minna, J.D.3
  • 66
    • 77449123163 scopus 로고    scopus 로고
    • Chromosomal and genomic changes in lung cancer
    • Varella-Garcia, M. Chromosomal and genomic changes in lung cancer. Cell Adh. Migr. 4, 100-106 (2010).
    • (2010) Cell Adh. Migr. , vol.4 , pp. 100-106
    • Varella-Garcia, M.1
  • 67
    • 0034327412 scopus 로고    scopus 로고
    • The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes
    • Lerman, M. I. & Minna, J. D. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. Cancer Res. 60, 6116-6133 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6116-6133
    • Lerman, M.I.1    Minna, J.D.2
  • 69
    • 0028234984 scopus 로고
    • Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines
    • Sekido, Y. et al. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. Oncogene 9, 1599-1604 (1994).
    • (1994) Oncogene , vol.9 , pp. 1599-1604
    • Sekido, Y.1
  • 70
    • 84954403082 scopus 로고    scopus 로고
    • NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas
    • Meder, L. et al. NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas. Int. J. Cancer 138, 927-938 (2016).
    • (2016) Int. J. Cancer , vol.138 , pp. 927-938
    • Meder, L.1
  • 71
    • 84940403711 scopus 로고    scopus 로고
    • A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo
    • Saunders, L. R. et al. A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. Sci. Transl Med. 7, 302ra136 (2015).
    • (2015) Sci. Transl Med. , vol.7 , pp. 302ra136
    • Saunders, L.R.1
  • 72
    • 84896082963 scopus 로고    scopus 로고
    • From fly wings to targeted cancer therapies: A centennial for notch signaling
    • Ntziachristos, P., Lim, J. S., Sage, J. & Aifantis, I. From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell 25, 318-334 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 318-334
    • Ntziachristos, P.1    Lim, J.S.2    Sage, J.3    Aifantis, I.4
  • 73
    • 85021448605 scopus 로고    scopus 로고
    • Toppling high-grade pulmonary neuroendocrine tumors with a DLL3-targeted trojan horse
    • Dylla, S. J. Toppling high-grade pulmonary neuroendocrine tumors with a DLL3-targeted trojan horse. Mol. Cell. Oncol. 3, e1101515 (2016).
    • (2016) Mol. Cell. Oncol. , vol.3 , pp. e1101515
    • Dylla, S.J.1
  • 74
    • 0021053735 scopus 로고
    • Amplification and expression of the c-myc oncogene in human lung cancer cell lines
    • Little, C. D., Nau, M. M., Carney, D. N., Gazdar, A. F. & Minna, J. D. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306, 194-196 (1983).
    • (1983) Nature , vol.306 , pp. 194-196
    • Little, C.D.1    Nau, M.M.2    Carney, D.N.3    Gazdar, A.F.4    Minna, J.D.5
  • 75
    • 0022392771 scopus 로고
    • L-Myc, a new myc-related gene amplified and expressed in human small cell lung cancer
    • Nau, M. M. et al. L-Myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature 318, 69-73 (1985).
    • (1985) Nature , vol.318 , pp. 69-73
    • Nau, M.M.1
  • 76
    • 0026494173 scopus 로고
    • Myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer
    • Johnson, B. E., Brennan, J. F., Ihde, D. C. & Gazdar, A. F. myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer. J. Natl Cancer Inst. Monogr. (13), 39-43 (1992).
    • (1992) J. Natl Cancer Inst. Monogr. , Issue.13 , pp. 39-43
    • Johnson, B.E.1    Brennan, J.F.2    Ihde, D.C.3    Gazdar, A.F.4
  • 77
    • 84925229549 scopus 로고    scopus 로고
    • MYC amplification is associated with poor survival in small cell lung cancer: A chromogenic in situ hybridization study
    • Alves Rde, C., Meurer, R. T. & Roehe, A. V. MYC amplification is associated with poor survival in small cell lung cancer: a chromogenic in situ hybridization study. J. Cancer Res. Clin. Oncol. 140, 2021-2025 (2014).
    • (2014) J. Cancer Res. Clin. Oncol. , vol.140 , pp. 2021-2025
    • Alves Rde, C.1    Meurer, R.T.2    Roehe, A.V.3
  • 78
    • 84974605091 scopus 로고    scopus 로고
    • Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer
    • Kim, D. W. et al. Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev. 30, 1289-1299 (2016).
    • (2016) Genes Dev. , vol.30 , pp. 1289-1299
    • Kim, D.W.1
  • 79
    • 84971508916 scopus 로고    scopus 로고
    • Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation
    • Fiorentino, F. P. et al. Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation. Oncotarget 7, 31014-31028 (2016).
    • (2016) Oncotarget , vol.7 , pp. 31014-31028
    • Fiorentino, F.P.1
  • 80
    • 84867627577 scopus 로고    scopus 로고
    • A framework for identification of actionable cancer genome dependencies in small cell lung cancer
    • Sos, M. L. et al. A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc. Natl Acad. Sci. USA 109, 17034-17039 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 17034-17039
    • Sos, M.L.1
  • 81
    • 84990988111 scopus 로고    scopus 로고
    • Barasertib (AZD1152), a small molecule Aurora B Inhibitor, inhibits the growth of SCLC cell lines in vitro and in vivo
    • Helfrich, B. A. et al. Barasertib (AZD1152), a small molecule Aurora B Inhibitor, inhibits the growth of SCLC cell lines in vitro and in vivo. Mol. Cancer Ther. 15, 2314-2322 (2016).
    • (2016) Mol. Cancer Ther. , vol.15 , pp. 2314-2322
    • Helfrich, B.A.1
  • 82
    • 84895821044 scopus 로고    scopus 로고
    • MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1
    • Romero, O. A. et al. MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1. Cancer Discov. 4, 292-303 (2014).
    • (2014) Cancer Discov. , vol.4 , pp. 292-303
    • Romero, O.A.1
  • 83
    • 69849115509 scopus 로고    scopus 로고
    • Oncogenic mutation of PIK3CA in small cell lung carcinoma: A potential therapeutic target pathway for chemotherapy-resistant lung cancer
    • Shibata, T., Kokubu, A., Tsuta, K. & Hirohashi, S. Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer. Cancer Lett. 283, 203-211 (2009).
    • (2009) Cancer Lett. , vol.283 , pp. 203-211
    • Shibata, T.1    Kokubu, A.2    Tsuta, K.3    Hirohashi, S.4
  • 84
    • 84900437332 scopus 로고    scopus 로고
    • PTEN is a potent suppressor of small cell lung cancer
    • Cui, M. et al. PTEN is a potent suppressor of small cell lung cancer. Mol. Cancer Res. 12, 654-659 (2014).
    • (2014) Mol. Cancer Res. , vol.12 , pp. 654-659
    • Cui, M.1
  • 85
    • 84902669919 scopus 로고    scopus 로고
    • FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies
    • Wynes, M. W. et al. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clin. Cancer Res. 20, 3299-3309 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 3299-3309
    • Wynes, M.W.1
  • 86
    • 84893717646 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer
    • Schultheis, A. M. et al. Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. Mod. Pathol. 27, 214-221 (2014).
    • (2014) Mod. Pathol. , vol.27 , pp. 214-221
    • Schultheis, A.M.1
  • 87
    • 84982135138 scopus 로고    scopus 로고
    • Is the canonical RAF/MEK/ERK signaling pathway a therapeutic target in SCLC?
    • Cristea, S. & Sage, J. Is the canonical RAF/MEK/ERK signaling pathway a therapeutic target in SCLC? J. Thorac Oncol. 11, 1233-1241 (2016).
    • (2016) J. Thorac Oncol. , vol.11 , pp. 1233-1241
    • Cristea, S.1    Sage, J.2
  • 88
    • 84987781487 scopus 로고    scopus 로고
    • Targeting the cancer epigenome for therapy
    • Jones, P. A., Issa, J. P. & Baylin, S. Targeting the cancer epigenome for therapy. Nat. Rev. Genet. 17, 630-641 (2016).
    • (2016) Nat. Rev. Genet. , vol.17 , pp. 630-641
    • Jones, P.A.1    Issa, J.P.2    Baylin, S.3
  • 89
    • 84963959599 scopus 로고    scopus 로고
    • Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
    • Kazanets, A., Shorstova, T., Hilmi, K., Marques, M. & Witcher, M. Epigenetic silencing of tumor suppressor genes: paradigms, puzzles, and potential. Biochim. Biophys. Acta 1865, 275-288 (2016).
    • (2016) Biochim. Biophys. Acta , vol.1865 , pp. 275-288
    • Kazanets, A.1    Shorstova, T.2    Hilmi, K.3    Marques, M.4    Witcher, M.5
  • 90
    • 84880921962 scopus 로고    scopus 로고
    • The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells
    • Kalari, S., Jung, M., Kernstine, K. H., Takahashi, T. & Pfeifer, G. P. The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells. Oncogene 32, 3559-3568 (2013).
    • (2013) Oncogene , vol.32 , pp. 3559-3568
    • Kalari, S.1    Jung, M.2    Kernstine, K.H.3    Takahashi, T.4    Pfeifer, G.P.5
  • 91
    • 84948570001 scopus 로고    scopus 로고
    • DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2
    • Poirier, J. T. et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene 34, 5869-5878 (2015).
    • (2015) Oncogene , vol.34 , pp. 5869-5878
    • Poirier, J.T.1
  • 92
    • 84981322711 scopus 로고    scopus 로고
    • EZH2 promotes progression of small cell lung cancer by suppressing the TGF-ß-Smad-ASCL1 pathway
    • Murai, F. et al. EZH2 promotes progression of small cell lung cancer by suppressing the TGF-ß-Smad-ASCL1 pathway. Cell Discov. 1, 15026 (2015).
    • (2015) Cell Discov. , vol.1 , pp. 15026
    • Murai, F.1
  • 93
    • 0035932393 scopus 로고    scopus 로고
    • Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
    • Agathanggelou, A. et al. Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene 20, 1509-1518. (2001).
    • (2001) Oncogene , vol.20 , pp. 1509-1518
    • Agathanggelou, A.1
  • 94
    • 0035795676 scopus 로고    scopus 로고
    • Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
    • Burbee, D. G. et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl Cancer Inst. 93, 691-699 (2001).
    • (2001) J. Natl Cancer Inst. , vol.93 , pp. 691-699
    • Burbee, D.G.1
  • 95
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon, J. A. & Lange, C. A. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat. Res. 647, 21-29 (2008).
    • (2008) Mutat. Res. , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 96
    • 84957998842 scopus 로고    scopus 로고
    • Prognostic value of high EZH2 expression in patients with different types of cancer: A systematic review with meta-analysis
    • Jiang, T. et al. Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysis. Oncotarget 7, 4584-4597 (2016).
    • (2016) Oncotarget , vol.7 , pp. 4584-4597
    • Jiang, T.1
  • 97
    • 84957555628 scopus 로고    scopus 로고
    • Targeting EZH2 in cancer
    • Kim, K. H. & Roberts, C. W. Targeting EZH2 in cancer. Nat. Med. 22, 128-134 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 128-134
    • Kim, K.H.1    Roberts, C.W.2
  • 98
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer, M. et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat. Genet. 44, 1104-1110 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 1104-1110
    • Peifer, M.1
  • 99
    • 85015959352 scopus 로고    scopus 로고
    • Small cell lung cancer exhibits frequent inactivating mutations in the histone methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance)
    • Augert, A. et al. Small cell lung cancer exhibits frequent inactivating mutations in the histone methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance). J. Thorac Oncol. 12, 704-713 (2017).
    • (2017) J. Thorac Oncol. , vol.12 , pp. 704-713
    • Augert, A.1
  • 100
    • 84962019891 scopus 로고    scopus 로고
    • Bromodomain and hedgehog pathway targets in small cell lung cancer
    • Kaur, G. et al. Bromodomain and hedgehog pathway targets in small cell lung cancer. Cancer Lett. 3 71, 225-239 (2016).
    • (2016) Cancer Lett. , vol.371 , pp. 225-239
    • Kaur, G.1
  • 101
    • 84866324536 scopus 로고    scopus 로고
    • Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
    • Byers, L. A. et al. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov. 2, 798-811 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 798-811
    • Byers, L.A.1
  • 102
    • 85012931265 scopus 로고    scopus 로고
    • Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis
    • Gardner, E. E. et al. Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis. Cancer Cell 31, 286-299 (2017).
    • (2017) Cancer Cell , vol.31 , pp. 286-299
    • Gardner, E.E.1
  • 103
    • 84880893647 scopus 로고    scopus 로고
    • EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation
    • Hubaux, R. et al. EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation. J. Thorac Oncol. 8, 1102-1106 (2013).
    • (2013) J. Thorac Oncol. , vol.8 , pp. 1102-1106
    • Hubaux, R.1
  • 104
    • 85020202044 scopus 로고    scopus 로고
    • Role of EZH2 in cancer stem cells: From biological insight to a therapeutic target
    • Wen, Y., Cai, J., Hou, Y., Huang, Z. & Wang, Z. Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target. Oncotarget 8, 37974-37990 (2017).
    • (2017) Oncotarget , vol.8 , pp. 37974-37990
    • Wen, Y.1    Cai, J.2    Hou, Y.3    Huang, Z.4    Wang, Z.5
  • 105
    • 85012024585 scopus 로고    scopus 로고
    • Developing EZH2-targeted therapy for lung cancer
    • Frankel, A. E., Liu, X. & Minna, J. D. Developing EZH2-targeted therapy for lung cancer. Cancer Discov. 6, 949-952 (2016).
    • (2016) Cancer Discov. , vol.6 , pp. 949-952
    • Frankel, A.E.1    Liu, X.2    Minna, J.D.3
  • 106
    • 85008679957 scopus 로고    scopus 로고
    • Antitumor activity of LSD1 inhibitors in lung cancer
    • Mohammad, H. P. & Kruger, R. G. Antitumor activity of LSD1 inhibitors in lung cancer. Mol. Cell. Oncol. 3, e1117700 (2016).
    • (2016) Mol. Cell. Oncol. , vol.3 , pp. e1117700
    • Mohammad, H.P.1    Kruger, R.G.2
  • 107
    • 84937429405 scopus 로고    scopus 로고
    • A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC
    • Mohammad, H. P. et al. A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell 28, 57-69 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 57-69
    • Mohammad, H.P.1
  • 108
    • 84919495606 scopus 로고    scopus 로고
    • Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor
    • Christensen, C. L. et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell 26, 909-922 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 909-922
    • Christensen, C.L.1
  • 109
    • 84988355089 scopus 로고    scopus 로고
    • NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer
    • Wu, N. et al. NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer. Oncotarget 7, 57514-57524 (2016).
    • (2016) Oncotarget , vol.7 , pp. 57514-57524
    • Wu, N.1
  • 110
    • 84978388629 scopus 로고    scopus 로고
    • Transcription factor NFIB is a driver of small cell lung cancer progression in mice and marks metastatic disease in patients
    • Semenova, E. A. et al. Transcription factor NFIB is a driver of small cell lung cancer progression in mice and marks metastatic disease in patients. Cell Rep. 16, 631-643 (2016).
    • (2016) Cell Rep. , vol.16 , pp. 631-643
    • Semenova, E.A.1
  • 111
    • 84978379634 scopus 로고    scopus 로고
    • Nfib promotes metastasis through a widespread increase in chromatin accessibility
    • Denny, S. K. et al. Nfib promotes metastasis through a widespread increase in chromatin accessibility. Cell 166, 328-342 (2016).
    • (2016) Cell , vol.166 , pp. 328-342
    • Denny, S.K.1
  • 112
    • 84982162351 scopus 로고    scopus 로고
    • Opening a chromatin gate to metastasis
    • Minna, J. D. & Johnson, J. E. Opening a chromatin gate to metastasis. Cell 166, 275-276 (2016).
    • (2016) Cell , vol.166 , pp. 275-276
    • Minna, J.D.1    Johnson, J.E.2
  • 113
    • 84994238857 scopus 로고    scopus 로고
    • Small cell lung cancer cell line screen of oncology drugs and investigational agents identifies patterns with gene and microRNA expression
    • Polley, E. et al. Small cell lung cancer cell line screen of oncology drugs and investigational agents identifies patterns with gene and microRNA expression. J. Natl Cancer Inst. 108, djw122 (2016).
    • (2016) J. Natl Cancer Inst. , vol.108 , pp. djw122
    • Polley, E.1
  • 114
    • 84996844180 scopus 로고    scopus 로고
    • Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer
    • Carter, L. et al. Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nat. Med. 23, 114-119 (2017).
    • (2017) Nat. Med. , vol.23 , pp. 114-119
    • Carter, L.1
  • 115
    • 84876146708 scopus 로고    scopus 로고
    • The schlafen family of proteins and their regulation by interferons
    • Mavrommatis, E., Fish, E. N. & Platanias, L. C. The schlafen family of proteins and their regulation by interferons. J. Interferon Cytokine Res. 33, 206-210 (2013).
    • (2013) J. Interferon Cytokine Res. , vol.33 , pp. 206-210
    • Mavrommatis, E.1    Fish, E.N.2    Platanias, L.C.3
  • 116
    • 84998827879 scopus 로고    scopus 로고
    • Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition
    • Murai, J. et al. Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. Oncotarget 7, 76534-76550 (2016).
    • (2016) Oncotarget , vol.7 , pp. 76534-76550
    • Murai, J.1
  • 117
    • 85012890398 scopus 로고    scopus 로고
    • Awakening of "schlafen11" to tackle chemotherapy resistance in SCLC
    • Berns, K. & Berns, A. Awakening of "Schlafen11" to tackle chemotherapy resistance in SCLC. Cancer Cell 31, 169-171 (2017).
    • (2017) Cancer Cell , vol.31 , pp. 169-171
    • Berns, K.1    Berns, A.2
  • 118
    • 85020775070 scopus 로고    scopus 로고
    • Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer
    • He, T. et al. Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer. Epigenomics 9, 849-862 (2017).
    • (2017) Epigenomics , vol.9 , pp. 849-862
    • He, T.1
  • 119
    • 85028352113 scopus 로고    scopus 로고
    • MCAM mediates chemoresistance in small cell lung cancer via the PI3K/AKT/SOX2 signaling pathway
    • Tripathi, S. C. et al. MCAM mediates chemoresistance in small cell lung cancer via the PI3K/AKT/SOX2 signaling pathway. Cancer Res. 77, 4414-4425 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 4414-4425
    • Tripathi, S.C.1
  • 120
    • 85023745986 scopus 로고    scopus 로고
    • CHK1 inhibition in small cell lung cancer produces single-agent activity in biomarker-defined disease subsets and combination activity with cisplatin or olaparib
    • Sen, T. et al. CHK1 inhibition in small cell lung cancer produces single-agent activity in biomarker-defined disease subsets and combination activity with cisplatin or olaparib. Cancer Res. 77, 3870-3884 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 3870-3884
    • Sen, T.1
  • 121
    • 84963610096 scopus 로고    scopus 로고
    • Activation of the PI3K/mTOR pathway following PARP inhibition in small cell lung cancer
    • Cardnell, R. J. et al. Activation of the PI3K/mTOR pathway following PARP inhibition in small cell lung cancer. PLoS ONE 11, e0152584 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0152584
    • Cardnell, R.J.1
  • 122
    • 84941986957 scopus 로고    scopus 로고
    • Small cell lung cancer: Will recent progress lead to improved outcomes? Clin
    • Pietanza, M. C., Byers, L. A., Minna, J. D. & Rudin, C. M. Small cell lung cancer: will recent progress lead to improved outcomes? Clin. Cancer Res. 21, 2244-2255 (2015).
    • (2015) Cancer Res. , vol.21 , pp. 2244-2255
    • Pietanza, M.C.1    Byers, L.A.2    Minna, J.D.3    Rudin, C.M.4
  • 123
    • 85018417226 scopus 로고    scopus 로고
    • Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer
    • Stewart, C. A. et al. Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer. Oncotarget 8, 28575-28587 (2017).
    • (2017) Oncotarget , vol.8 , pp. 28575-28587
    • Stewart, C.A.1
  • 124
    • 85007579435 scopus 로고    scopus 로고
    • Cancer therapy due to apoptosis: Galectin-9
    • Fujita, K. et al. Cancer therapy due to apoptosis: galectin-9. Int. J. Mol. Sci. 18, 74 (2017).
    • (2017) Int. J. Mol. Sci. , vol.18 , pp. 74
    • Fujita, K.1
  • 125
    • 0024452546 scopus 로고
    • P53: A frequent target for genetic abnormalities in lung cancer
    • Takahashi, T. et al. p53: a frequent target for genetic abnormalities in lung cancer. Science 246, 491-494 (1989).
    • (1989) Science , vol.246 , pp. 491-494
    • Takahashi, T.1
  • 126
    • 69249132204 scopus 로고    scopus 로고
    • Pathogenesis of lung cancer signalling pathways: Roadmap for therapies
    • Brambilla, E. & Gazdar, A. Pathogenesis of lung cancer signalling pathways: roadmap for therapies. Eur. Respir. J. 33, 1485-1497 (2009).
    • (2009) Eur. Respir. J. , vol.33 , pp. 1485-1497
    • Brambilla, E.1    Gazdar, A.2
  • 127
    • 84944166647 scopus 로고    scopus 로고
    • Targeting BCL2-proteins for the treatment of solid tumours
    • Vogler, M. Targeting BCL2-proteins for the treatment of solid tumours. Adv. Med. 2014, 943648 (2014).
    • (2014) Adv. Med. , vol.2014 , pp. 943648
    • Vogler, M.1
  • 128
    • 84866343458 scopus 로고    scopus 로고
    • A genetic snapshot of small cell lung cancer
    • Rosell, R. & Wannesson, L. A genetic snapshot of small cell lung cancer. Cancer Discov. 2, 769-771 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 769-771
    • Rosell, R.1    Wannesson, L.2
  • 129
    • 84928761118 scopus 로고    scopus 로고
    • Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A. et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1
  • 130
    • 84981554895 scopus 로고    scopus 로고
    • The future of immunotherapy in the treatment of small cell lung cancer
    • Horn, L., Reck, M. & Spigel, D. R. The future of immunotherapy in the treatment of small cell lung cancer. Oncologist 21, 910-921 (2016).
    • (2016) Oncologist , vol.21 , pp. 910-921
    • Horn, L.1    Reck, M.2    Spigel, D.R.3
  • 131
    • 84962254409 scopus 로고    scopus 로고
    • Immunotherapy for small-cell lung cancer: Emerging evidence
    • Reck, M., Heigener, D. & Reinmuth, N. Immunotherapy for small-cell lung cancer: emerging evidence. Future Oncol. 12, 931-943 (2016).
    • (2016) Future Oncol. , vol.12 , pp. 931-943
    • Reck, M.1    Heigener, D.2    Reinmuth, N.3
  • 132
    • 84938416174 scopus 로고    scopus 로고
    • Vaccine immunotherapy in lung cancer: Clinical experience and future directions
    • Freeman-Keller, M., Goldman, J. & Gray, J. Vaccine immunotherapy in lung cancer: clinical experience and future directions. Pharmacol. Ther. 153, 1-9 (2015).
    • (2015) Pharmacol. Ther. , vol.153 , pp. 1-9
    • Freeman-Keller, M.1    Goldman, J.2    Gray, J.3
  • 133
    • 84928659261 scopus 로고    scopus 로고
    • Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma
    • Ehrlich, D., Wang, B., Lu, W., Dowling, P. & Yuan, R. Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma. J. Hematol. Oncol. 7, 91 (2014).
    • (2014) J. Hematol. Oncol. , vol.7 , pp. 91
    • Ehrlich, D.1    Wang, B.2    Lu, W.3    Dowling, P.4    Yuan, R.5
  • 134
    • 84978381315 scopus 로고    scopus 로고
    • CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
    • Weiskopf, K. et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J. Clin. Invest. 126, 2610-2620 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 2610-2620
    • Weiskopf, K.1
  • 135
    • 84908343167 scopus 로고    scopus 로고
    • Liquid biopsies in lung cancer: The new ambrosia of researchers
    • Rolfo, C. et al. Liquid biopsies in lung cancer: the new ambrosia of researchers. Biochim. Biophys. Acta 1846, 539-546 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1846 , pp. 539-546
    • Rolfo, C.1
  • 137
    • 84873866902 scopus 로고    scopus 로고
    • Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation
    • Endo, H. et al. Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation. J. Thorac Oncol. 8, 131-139 (2013).
    • (2013) J. Thorac Oncol. , vol.8 , pp. 131-139
    • Endo, H.1
  • 138
    • 84884281697 scopus 로고    scopus 로고
    • Lung cancer-initiating cells: A novel target for cancer therapy
    • Morrison, B. J., Morris, J. C. & Steel, J. C. Lung cancer-initiating cells: a novel target for cancer therapy. Target Oncol. 8, 159-172 (2013).
    • (2013) Target Oncol. , vol.8 , pp. 159-172
    • Morrison, B.J.1    Morris, J.C.2    Steel, J.C.3
  • 139
    • 84936940261 scopus 로고    scopus 로고
    • Paraneoplastic syndromes: The way to an early diagnosis of lung cancer
    • Paraschiv, B., Diaconu, C. C., Toma, C. L. & Bogdan, M. A. Paraneoplastic syndromes: the way to an early diagnosis of lung cancer. Pneumologia 64, 14-19 (2015).
    • (2015) Pneumologia , vol.64 , pp. 14-19
    • Paraschiv, B.1    Diaconu, C.C.2    Toma, C.L.3    Bogdan, M.A.4
  • 140
    • 84916204173 scopus 로고    scopus 로고
    • Paraneoplastic syndromes associated with lung cancer
    • Kanaji, N. et al. Paraneoplastic syndromes associated with lung cancer. World J. Clin. Oncol. 5, 197-223 (2014).
    • (2014) World J. Clin. Oncol. , vol.5 , pp. 197-223
    • Kanaji, N.1
  • 141
    • 49749189195 scopus 로고
    • A case of pluriglandular syndrome: "diabetes of bearded women"
    • Brown, W. A case of pluriglandular syndrome: "Diabetes of bearded women". Lancet 212, 1022-1023 (1928).
    • (1928) Lancet , vol.212 , pp. 1022-1023
    • Brown, W.1
  • 142
    • 0021807624 scopus 로고
    • Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer
    • Cuttitta, F. et al. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature 316, 823-826 (1985).
    • (1985) Nature , vol.316 , pp. 823-826
    • Cuttitta, F.1
  • 143
    • 84962822743 scopus 로고    scopus 로고
    • Somatostatin receptors in lung cancer: From function to molecular imaging and therapeutics
    • Callison, J. C. Jr, Walker, R. C. & Massion, P. P. Somatostatin receptors in lung cancer: from function to molecular imaging and therapeutics. J. Lung Cancer 10, 69-76 (2011).
    • (2011) J. Lung Cancer , vol.10 , pp. 69-76
    • Callison, J.C.1    Walker, R.C.2    Massion, P.P.3
  • 144
    • 81255211667 scopus 로고    scopus 로고
    • Lambert-Eaton myasthenic syndrome: From clinical characteristics to therapeutic strategies
    • Titulaer, M. J., Lang, B. & Verschuuren, J. J. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 10, 1098-1107 (2011).
    • (2011) Lancet Neurol. , vol.10 , pp. 1098-1107
    • Titulaer, M.J.1    Lang, B.2    Verschuuren, J.J.3
  • 145
    • 84861742450 scopus 로고    scopus 로고
    • Molecular and cellular biology of neuroendocrine lung tumors: Evidence for separate biological entities
    • Swarts, D. R., Ramaekers, F. C. & Speel, E. J. Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities. Biochim. Biophys. Acta 1826, 255-271 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1826 , pp. 255-271
    • Swarts, D.R.1    Ramaekers, F.C.2    Speel, E.J.3
  • 146
    • 84978505017 scopus 로고    scopus 로고
    • Next-generation sequencing of pulmonary large cell neuroendocrine carcinoma reveals small cell carcinoma-like and non-small cell carcinoma-like subsets
    • Rekhtman, N. et al. Next-generation sequencing of pulmonary large cell neuroendocrine carcinoma reveals small cell carcinoma-like and non-small cell carcinoma-like subsets. Clin. Cancer Res. 22, 3618-3629 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 3618-3629
    • Rekhtman, N.1
  • 147
    • 0001949065 scopus 로고
    • Keynote address on biostatistics and data retrieval
    • Zelen, M. Keynote address on biostatistics and data retrieval. Cancer Chemother. Rep. 3, 31-42 (1973).
    • (1973) Cancer Chemother. Rep. , vol.3 , pp. 31-42
    • Zelen, M.1
  • 148
    • 0014413596 scopus 로고
    • Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin
    • Pearse, A. G. Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin. Proc. R. Soc. Lond. B Biol. Sci. 170, 71-80 (1968).
    • (1968) Proc. R. Soc. Lond. B Biol. Sci. , vol.170 , pp. 71-80
    • Pearse, A.G.1
  • 149
    • 79959360314 scopus 로고    scopus 로고
    • History of small-cell lung cancer
    • Haddadin, S. & Perry, M. C. History of small-cell lung cancer. Clin. Lung Cancer 12, 87-93 (2011).
    • (2011) Clin. Lung Cancer , vol.12 , pp. 87-93
    • Haddadin, S.1    Perry, M.C.2
  • 150
    • 0015187933 scopus 로고
    • A new floating cell line derived from human pulmonary carcinoma of oat cell type
    • Oboshi, S. et al. A new floating cell line derived from human pulmonary carcinoma of oat cell type. Jpn. J. Cancer Res. 62, 505-514 (1971).
    • (1971) Jpn. J. Cancer Res. , vol.62 , pp. 505-514
    • Oboshi, S.1
  • 151
    • 0016382152 scopus 로고
    • Ectopic ACTH production in carcinoma of the lung
    • Gewirtz, G. & Yalow, R. S. Ectopic ACTH production in carcinoma of the lung. J. Clin. Invest. 53, 1022-1032 (1974).
    • (1974) J. Clin. Invest. , vol.53 , pp. 1022-1032
    • Gewirtz, G.1    Yalow, R.S.2
  • 152
    • 0018889149 scopus 로고
    • Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung
    • Pettengill, O. S. et al. Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung. Cancer 45, 906-918 (1980).
    • (1980) Cancer , vol.45 , pp. 906-918
    • Pettengill, O.S.1
  • 153
    • 0023686773 scopus 로고
    • Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
    • Harbour, J. W. et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241, 353-357 (1988).
    • (1988) Science , vol.241 , pp. 353-357
    • Harbour, J.W.1
  • 154
    • 15444374561 scopus 로고    scopus 로고
    • Mouse models for human lung cancer
    • Meuwissen, R. & Berns, A. Mouse models for human lung cancer. Genes Dev. 19, 643-664 (2005).
    • (2005) Genes Dev. , vol.19 , pp. 643-664
    • Meuwissen, R.1    Berns, A.2
  • 155
    • 37349068491 scopus 로고    scopus 로고
    • The International Association for the Study of Lung Cancer lung cancer staging project: Proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer
    • Shepherd, F. A. et al. The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer. J. Thorac Oncol. 2, 1067-1077 (2007).
    • (2007) J. Thorac Oncol. , vol.2 , pp. 1067-1077
    • Shepherd, F.A.1
  • 156
    • 84876412243 scopus 로고    scopus 로고
    • Rationale for chemotherapy, immunotherapy, and checkpoint blockade in SCLC: Beyond traditional treatment approaches
    • Spigel, D. R. & Socinski, M. A. Rationale for chemotherapy, immunotherapy, and checkpoint blockade in SCLC: beyond traditional treatment approaches. J. Thorac Oncol. 8, 587-598 (2013).
    • (2013) J. Thorac Oncol. , vol.8 , pp. 587-598
    • Spigel, D.R.1    Socinski, M.A.2
  • 157
    • 85007506761 scopus 로고    scopus 로고
    • Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: A first-in-human, first-in-class, open-label, phase 1 study
    • Rudin, C. M. et al. Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study. Lancet Oncol. 18, 42-51 (2017).
    • (2017) Lancet Oncol. , vol.18 , pp. 42-51
    • Rudin, C.M.1
  • 158
    • 79958761641 scopus 로고    scopus 로고
    • Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung
    • Sutherland, K. D. et al. Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 19, 754-764 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 754-764
    • Sutherland, K.D.1
  • 159
    • 84944472659 scopus 로고    scopus 로고
    • Roles of NOTCH1 as a therapeutic target and a biomarker for lung cancer: Controversies and perspectives
    • Guo, L., Zhang, T., Xiong, Y. & Yang, Y. Roles of NOTCH1 as a therapeutic target and a biomarker for lung cancer: controversies and perspectives. Dis. Markers 2015, 520590 (2015).
    • (2015) Dis. Markers , vol.2015 , pp. 520590
    • Guo, L.1    Zhang, T.2    Xiong, Y.3    Yang, Y.4
  • 160
    • 84938694305 scopus 로고    scopus 로고
    • Notch signaling in cancer: Rationale and strategies for targeting
    • Alketbi, A. & Attoub, S. Notch signaling in cancer: rationale and strategies for targeting. Curr. Cancer Drug Targets 15, 364-374 (2015).
    • (2015) Curr. Cancer Drug Targets , vol.15 , pp. 364-374
    • Alketbi, A.1    Attoub, S.2
  • 161
    • 84859098510 scopus 로고    scopus 로고
    • Possible roles of DLK1 in the Notch pathway during development and disease
    • Falix, F. A., Aronson, D. C., Lamers, W. H. & Gaemers, I. C. Possible roles of DLK1 in the Notch pathway during development and disease. Biochim. Biophys. Acta 1822, 988-995 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 988-995
    • Falix, F.A.1    Aronson, D.C.2    Lamers, W.H.3    Gaemers, I.C.4
  • 162
    • 84905963021 scopus 로고    scopus 로고
    • The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells
    • Nueda, M. L., Naranjo, A. I., Baladron, V. & Laborda, J. The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells. Biochim. Biophys. Acta 1843, 2674-2684 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1843 , pp. 2674-2684
    • Nueda, M.L.1    Naranjo, A.I.2    Baladron, V.3    Laborda, J.4
  • 163
    • 0033918563 scopus 로고    scopus 로고
    • Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
    • Dammann, R. et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat. Genet. 25, 315-319 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 315-319
    • Dammann, R.1
  • 164
    • 84987842794 scopus 로고    scopus 로고
    • ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers
    • Wang, Y. W. et al. ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers. J. Thorac Oncol. 11, 1469-1481 (2016).
    • (2016) J. Thorac Oncol. , vol.11 , pp. 1469-1481
    • Wang, Y.W.1
  • 165
    • 85008697782 scopus 로고    scopus 로고
    • Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2
    • Niu, Y. et al. Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2. Mol. Cancer 16, 5 (2017).
    • (2017) Mol. Cancer , vol.16 , pp. 5
    • Niu, Y.1
  • 166
    • 84952035123 scopus 로고    scopus 로고
    • Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells
    • Fang, S. et al. Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells. Lab. Invest. 96, 60-68 (2016).
    • (2016) Lab. Invest. , vol.96 , pp. 60-68
    • Fang, S.1
  • 168
    • 33646953271 scopus 로고    scopus 로고
    • NCI-Navy Medical Oncology Branch cell line data base
    • Phelps, R. M. et al. NCI-Navy Medical Oncology Branch cell line data base. J. Cell. Biochem. Suppl. 24, 32-91 (1996).
    • (1996) J. Cell. Biochem. Suppl. , vol.24 , pp. 32-91
    • Phelps, R.M.1
  • 169
    • 33646962490 scopus 로고    scopus 로고
    • NCI series of cell lines: An historical perspective
    • Gazdar, A. F. & Minna, J. D. NCI series of cell lines: an historical perspective. J. Cell. Biochem. Suppl. 24, 1-11 (1996).
    • (1996) J. Cell. Biochem. Suppl. , vol.24 , pp. 1-11
    • Gazdar, A.F.1    Minna, J.D.2
  • 170
    • 0019279209 scopus 로고
    • Growth of human small cell (oat cell) carcinoma of the lung in serum-free growth factor-supplemented medium
    • Simms, E., Gazdar, A. F., Abrams, P. G. & Minna, J. D. Growth of human small cell (oat cell) carcinoma of the lung in serum-free growth factor-supplemented medium. Cancer Res. 40, 4356-4363 (1980).
    • (1980) Cancer Res. , vol.40 , pp. 4356-4363
    • Simms, E.1    Gazdar, A.F.2    Abrams, P.G.3    Minna, J.D.4
  • 171
    • 0022335729 scopus 로고
    • The serum-free establishment and in vitro growth properties of classic and variant small cell lung cancer cell lines
    • Carney, D. N., Bepler, G. & Gazdar, A. F. The serum-free establishment and in vitro growth properties of classic and variant small cell lung cancer cell lines. Recent Results Cancer Res. 99, 157-166 (1985).
    • (1985) Recent Results Cancer Res. , vol.99 , pp. 157-166
    • Carney, D.N.1    Bepler, G.2    Gazdar, A.F.3
  • 172
    • 10844284696 scopus 로고    scopus 로고
    • Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    • Ramirez, R. D. et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 64, 9027-9034 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 9027-9034
    • Ramirez, R.D.1
  • 173
    • 84876207852 scopus 로고    scopus 로고
    • Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
    • Sato, M. et al. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol. Cancer Res. 11, 638-650 (2013).
    • (2013) Mol. Cancer Res. , vol.11 , pp. 638-650
    • Sato, M.1
  • 174
    • 84875803391 scopus 로고    scopus 로고
    • Mouse models of cancer
    • Berns, A. & Barbacid, M. Mouse models of cancer. Mol. Oncol. 7, 143-145 (2013).
    • (2013) Mol. Oncol. , vol.7 , pp. 143-145
    • Berns, A.1    Barbacid, M.2
  • 175
    • 84962522570 scopus 로고    scopus 로고
    • From mice to men and back: An assessment of preclinical model systems for the study of lung cancers
    • Gazdar, A. F., Hirsch, F. R. & Minna, J. D. From mice to men and back: an assessment of preclinical model systems for the study of lung cancers. J. Thorac Oncol. 11, 287-299 (2016).
    • (2016) J. Thorac Oncol. , vol.11 , pp. 287-299
    • Gazdar, A.F.1    Hirsch, F.R.2    Minna, J.D.3
  • 176
    • 84861879404 scopus 로고    scopus 로고
    • Genetically engineered mouse models: Closing the gap between preclinical data and trial outcomes
    • Singh, M., Murriel, C. L. & Johnson, L. Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes. Cancer Res. 72, 2695-2700 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2695-2700
    • Singh, M.1    Murriel, C.L.2    Johnson, L.3
  • 177
    • 84929989581 scopus 로고    scopus 로고
    • Preclinical murine models for lung cancer: Clinical trial applications
    • Kellar, A., Egan, C. & Morris, D. Preclinical murine models for lung cancer: clinical trial applications. BioMed Res. Int. 2015, 621324 (2015).
    • (2015) BioMed Res. Int. , vol.2015 , pp. 621324
    • Kellar, A.1    Egan, C.2    Morris, D.3
  • 178
    • 84884318689 scopus 로고    scopus 로고
    • Mouse models of chemically-induced lung carcinogenesis
    • Vikis, H. G., Rymaszewski, A. L. & Tichelaar, J. W. Mouse models of chemically-induced lung carcinogenesis. Front. Biosci. 5, 939-946 (2013).
    • (2013) Front. Biosci. , vol.5 , pp. 939-946
    • Vikis, H.G.1    Rymaszewski, A.L.2    Tichelaar, J.W.3
  • 179
    • 77952794331 scopus 로고    scopus 로고
    • Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma
    • Schaffer, B. E. et al. Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res. 70, 3877-3883 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3877-3883
    • Schaffer, B.E.1
  • 180
    • 85012031704 scopus 로고    scopus 로고
    • Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation
    • Lázaro, S. et al. Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation. Oncotarget 8, 4373-4386 (2016).
    • (2016) Oncotarget , vol.8 , pp. 4373-4386
    • Lázaro, S.1
  • 181
    • 84873808119 scopus 로고    scopus 로고
    • Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer
    • Isobe, T. et al. Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer. J. Thorac Oncol. 8, 140-146 (2013).
    • (2013) J. Thorac Oncol. , vol.8 , pp. 140-146
    • Isobe, T.1
  • 182
    • 74349117865 scopus 로고    scopus 로고
    • Clinical relevance of human cancer xenografts as a tool for preclinical assessment: Example of in-vivo evaluation of topotecan-based chemotherapy in a panel of human small-cell lung cancer xenografts
    • Némati, F. et al. Clinical relevance of human cancer xenografts as a tool for preclinical assessment: example of in-vivo evaluation of topotecan-based chemotherapy in a panel of human small-cell lung cancer xenografts. Anticancer Drugs 21, 25-32 (2010).
    • (2010) Anticancer Drugs , vol.21 , pp. 25-32
    • Némati, F.1
  • 183
    • 84928092645 scopus 로고    scopus 로고
    • New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice
    • Sakamoto, S. et al. New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice. Cancer Sci. 106, 367-374 (2015).
    • (2015) Cancer Sci. , vol.106 , pp. 367-374
    • Sakamoto, S.1
  • 184
    • 0019378229 scopus 로고
    • Intracranial growth of pulmonary small cell carcinoma cells in nude athymic mice
    • Chambers, W. F., Pettengill, O. S. & Sorenson, G. D. Intracranial growth of pulmonary small cell carcinoma cells in nude athymic mice. Exp. Cell Biol. 49, 90-97 (1981).
    • (1981) Exp. Cell Biol. , vol.49 , pp. 90-97
    • Chambers, W.F.1    Pettengill, O.S.2    Sorenson, G.D.3
  • 185
    • 0019847006 scopus 로고
    • Heterotransplantation of small-cell carcinoma of the lung into nude mice: Comparison of intracranial and subcutaneous routes
    • Gazdar, A. F., Carney, D. N., Sims, H. L. & Simmons, A. Heterotransplantation of small-cell carcinoma of the lung into nude mice: comparison of intracranial and subcutaneous routes. Int. J. Cancer 28, 777-783 (1981).
    • (1981) Int. J. Cancer , vol.28 , pp. 777-783
    • Gazdar, A.F.1    Carney, D.N.2    Sims, H.L.3    Simmons, A.4
  • 186
    • 84893637270 scopus 로고    scopus 로고
    • One mouse, one patient paradigm: New avatars of personalized cancer therapy
    • Malaney, P., Nicosia, S. V. & Dave, V. One mouse, one patient paradigm: new avatars of personalized cancer therapy. Cancer Lett. 344, 1-12 (2014).
    • (2014) Cancer Lett. , vol.344 , pp. 1-12
    • Malaney, P.1    Nicosia, S.V.2    Dave, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.