Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Nature

Volumn 545, Issue 7654, 2017, Pages 360-364

  Lim, Jing Shan ^a   Ibaseta, Alvaro ^a   Fischer, Marcus M ^b   Cancilla, Belinda ^b   O'Young, Gilbert ^b   Cristea, Sandra ^a   Luca, Vincent C ^a   Yang, DIan ^a   Jahchan, Nadine S ^a   Hamard, Cécile ^c,d   Antoine, Martine ^c,d   Wislez, Marie ^c,d   Kong, Christina ^a   Cain, Jennifer ^b   Liu, Yu Wang ^b   Kapoun, Ann M ^b   Garcia, K Christopher ^a   Hoey, Timothy ^b   Murriel, Christopher L ^b   Sage, Julien ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OncoMed Pharmaceuticals Inc   (United States)

^c SORBONNE UNIVERSITÉ   (France)

^d HÔPITAL TENON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; IRINOTECAN; NOTCH RECEPTOR; TAREXTUMAB; RE1-SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ANATOMY; BIOLOGICAL DEVELOPMENT; BIOMARKER; CANCER; CELLS AND CELL COMPONENTS; CHEMOTHERAPY; GENE EXPRESSION; GROWTH; INHIBITION; INHIBITOR; PHYSIOLOGY; RODENT; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER PATIENT; CANCER RECURRENCE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROENDOCRINE TUMOR; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL CELL LUNG CANCER; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CELL PROLIFERATION; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; FEMALE; LUNG NEOPLASMS; MALE; METABOLISM; PATHOLOGY; PREVENTION AND CONTROL; SIGNAL TRANSDUCTION; SMALL CELL LUNG CARCINOMA; TUMOR RECURRENCE;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICE; NEOPLASM RECURRENCE, LOCAL; RECEPTORS, NOTCH; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SMALL CELL LUNG CARCINOMA; TUMOR MICROENVIRONMENT;

EID: 85019546383     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature22323     Document Type: Article

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