FHIT in human cancer

Advances in Cancer Research

Volumn 74, Issue , 1998, Pages 141-165

  Sozzi, G ^a   Huebner, K ^a   Croce, C M ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; CHROMOSOME 3P; CHROMOSOME REARRANGEMENT; DIGESTIVE SYSTEM CANCER; HETEROZYGOSITY LOSS; HUMAN; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; RESPIRATORY TRACT CANCER; REVIEW;

EID: 0031900879     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0065-230x(08)60766-6     Document Type: Review

References (115)

1. Baffa, R., Veronese, M. L., Fu, T. B., Mandes, B., Santoro, R., Santoro, E., Croce, C. M., and Heubner, K. (1997). The FHIT gene is deleted in intestinal type human gastric cancer. Submitted for publication
2. 3-triphosphate hydrolase Biochemistry 35 36 1996 11529 11535
3. Boldog E. Gemmill R.M. West J. Robinson M. Robinson L. Li E. Roche J. Todd S. Waggoner B. Lundstrom R. Jacobson J. Mullokandov M.R. Klinger H. Drabkin H.A. Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B Hum. Mol. Genet 6 2 1997 193 203
4. Boldog E.L. Waggoner B. Glover T.W. Chumakov I. Le Plasier D. Cohen D. Gemmill R.M. Drabkin H.A. Integrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B Genes Chrom. Cancer 11 1994 216 221
5. Brauch H. Johnson B. Hovis J. Yano T. Gazdar A. Pettengill O.S. Graziano S. Sorenson G.D. Poiesz B.J. Minna J. Molecular analysis of the short arm of chromosome 3 in small-cell and nonsmall-cell carcinoma of the lung N. Engl. J. Med 317 1987 1109 1113
6. Brauch H. Tory K. Kotler E Gazdar A. Pettengill E.O.S. Johnson B. Graziano S. Winton T. Buys C.H. Sorenson G.D. Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer Genes Chrom. Cancer 1 1990 240 246
7. Brenner C. Garrison P. Gilmour J. Peisach D. Ringe D. Petsko G.A. Lowenstein J.M. Crystal structures of HINT demonstrate that histidine triad proteins are GaIT-related nucleotide-binding proteins Nature Struct. Biol 4 3 1997 231 238
8. Buchhagen D.L. Qiu L. Etkind P. Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3–3p21.3 in sporadic breast-cancer development Int. J. Cancer 57 1994 473 479
9. Cattoretti G. Pilotti S. Lombardi L. Rilke F. Cutaneous neuroendocrine (Merkel cell) carcinoma: Phenotypic analysis for tissue restricted markers, growth factor receptors, and ultrastructure Am. J. Surg. Pathol 2 1989 293 304
10. Chen L.C. Matsumura K. Deng G. Kurisu W. Ljung B.M. Lerman M.I. Waldman F.M. Smith H.S. Deletion of two separate regions on chromosome 3p in breast cancers Cancer Res 54 1994 3021 3024
11. Cohen A.J. Li F.P. Berg S. Marchetto D.J. Tsai S. Jacobs S.C. Brown R.S. Hereditary renal-cell carcinoma associated with a chromosomal translocation N Engl. J. Med 301 1979 592 595
12. Correa P. Sasano N. Stemmermann G.N. Haenszel W. Pathology of gastric carcinoma in Japanese populations: Comparisons between Miyagi prefecture, Japan, and Hawaii J. Natl. Cancer Inst 51 1973 1449 1459
13. Devilee P. Van den Broek M. Kuipers-Dijkshoorn N. Kolluri R. Khan P.M. Pearson P.L. Cornelisse C.J. At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma Genomics 5 1989 554 560
14. Dietrich C.U. Pandis N. Teixeira M.R. Bardi G. Gerdes A.M. Andersen J.A. Heim S. Chromosome abnormalities in benign hyperproliferative disorders of epithelial and stromal breast tissue Int. J. Cancer 60 1995 49 53
15. Druck T. Hadaczek P. Fu T.B. Ohta M. Siprashvili Z. Baffa R. Negrini M. Kastury K. Veronese M.L. Rosen D. Rothstein J. McCue P. Cotticelli MG Inoue H. Croce C.M. Huebner K. Structure and expression of the human FHIT gene in normal and tumor cells Cancer Res 57 1997 504 512
16. Druck T. Kastury K. Hadaczek P. Podolski J. Toloczko A. Sikorski A. Ohta M. LaForgia S. Lasota J. McCue P. Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas Cancer Res 55 1995 5348 5353
17. Fong K.M. Biesterveld E.J. Virmani A. Wistuba I. Sekido Y. Bader S. Ahmadian M. Ong S.T. Rassool F.V. Zimmerman P.V. Giaccone G. Gazdar A. Minna J.D. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations Cancer Res 57 1997 2256 2267
18. Fu Y.H. Kuhl D.P. Pizzuti A. Pieretti M. Sutcliffe J.S. Richards S. Verkerk A.J. Holden J.J. Fenwick R.G. Jr. Warren S.T. Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox Cell 67 1991 1047 1058
19. Gemma A. Hagiwara K. Ke Y. Burke L.M. Khan M.A. Nagashima M. Bennet W.P. Harris C.C. FHIT mutations in human primary gastric cancer Cancer Res 57 1997 1435 1437
20. Geurts J.M. Schoenmakers E.E. Roijer E. Stenman G. Van de Ven W.J. Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland Cancer Res 57 1997 13 17
21. Glover T.W. Berger C. Coyle J. Echo B. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes Hum. Genet 67 1984 136 142
22. Glover T.W. Stein C.K. Chromosome breakage and recombination at fragile sites Am. J. Hum. Genet 43 1988 265 273
23. Gnarra J.R. Tory K. Weng Y. Schmidt L. Wei M.H. Li H. Latif E Liu S. Chen E Duh E.M. Mutations of the VHL tumour suppressor gene in renal carcinoma Nature Genet 7 1994 85 90
24. Gomez L.G. DiMaio S. Silva E.G. Mackay B. Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skin Am. J. Surg. Pathol 7 1983 171 177
25. Gould V.E. Lee I. Hammar S.P. Neuroendocrine skin carcinoma coexpressing cytokeratin and neurofilament proteins Ultrastruct. Pathol 9 1985 83 90
26. Hibi K. Takahashi T. Yamakawa K. Ueda R. Sekido Y. Ariyoshi Y. Suyama M. Takagi H. Nakamura Y. Three distinct regions involved in 3p deletion in human lung cancer Oncogene 7 1992 445 449
27. Huang Y. Garrison P.N. Barnes L.D. Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5′,5′-P1, P4-tetraphosphate (Ap4A) asymmetrical hydrolase: Sequence similarity with the histidine triad (HIT) protein family Biochem. J 312 1995 925 932
28. Hung J. Kishimoto Y. Sugio K. Virmani A. McIntire D. Minna J.D. Gazdar A.F. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma J. Am. Med. Soc 273 1995 558 563
29. Hung J. Kishimoto Y. Sugio K. Virmani A. McIntire D.D. Minna J.D. Gazdar A.F. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma [published erratum appears in J. Am. Med. Soc J. Am. Med. Soc 273 1995 558 563 1995 273 (24), 1908]
30. Ishwad C.S. Ferrell R.E. Rossie K.N. Appel B.N. Johnson J.T. Myers E.N. Law J.C. Srivastava S. Gollin S.M. Loss of heterozygosity of the short arm of chromosomes 3 and 9 in oral cancer Int. J. Cancer 69 1996 1 4
31. Jones C. Penny L. Mattina T. Yu S. Baker E. Voullaire L. Langdon W.Y. Sutherland G.R. Richards R.I. Tunnacliffe A. Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2 Nature 376 1995 145 149
32. Kao-Shan C.S. Fine R.L. Whang-Peng J. Lee E.C. Chabner B.A. Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers Cancer Res 47 1987 6278 6282
33. Kastury K. Baffa R. Druck T. Ohta M. Cotticelli M.G. Inoue H. Negrini M. Rugge M. Huang D. Croce C.M. Palazzo J. Huebner K. Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines Cancer Res 56 1996 978 983
34. Killary A.M. Wolf M.E. Giambernardi T.A. Naylor S.L. Definition of a tumor suppressor locus within human chromosome 3p21-p22 Proc. Natl. Acad. Sci. USA 89 1992 10877 10881
35. Kitzler J.W. Farr S.B. Ames B.N. Intracellular functions of ApnN: Prokaryotes: In “Ap4A and Other Dinucleoside Polyphosphates” A.G. McLennan 1992 CRC Press Boca Raton, FL
36. Knight S.J. Flannery A.V. Hirst M.C. Campbell L. Christodoulou Z. Phelps S.R. Pointon J. Middleton-Price H.R. Barnicoat A. Pembrey M.E. Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation Cell 74 1993 127 134
37. Kohno T. Takayama H. Hamaguchi M. Takano H. Yamaguchi N. Tsuda H. Hirohashi S. Vissing H. Shimizu M. Oshimura M. Deletion mapping of chromosome 3p in human uterine cervical cancer Oncogene 8 1993 1825 1832
38. Kremer E.J. Pritchard M. Lynch M. Yu S. Holman K. Baker E. Warren S.T. Schlessinger D. Sutherland G.R. Richards R.I. Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n Science 252 1991 1711 1714
39. Kusyk C.J. Romsdahl M.M. Cytogenetic study of a Merkel cell carcinoma Cancer Genet. Cytogenet 20 1986 311 316
40. Kuwano A. Kajii T. Synergistic effect of aphidicolin and ethanol on the induction of common fragile sites Hum. Genet 75 1987 75 78
41. Latif F. Tory K. Gnarra J. Yao M. Duh E.M. Orcutt M.L. Stackhouse T. Kuzmin I. Modi W. Geil L. Identification of the von Hippel-Lindau disease tumor suppressor gene Science 260 1993 1317 1320
42. Le Beau M.M. Chromosomal fragile sites and cancer-specific rearrangements Blood 67 1986 849 858 [Review]
43. Leonard, J. H., Williams, G., Walters, M. K., Nancarrow, D. J., and Rabbitts, P. H. (1996).
44. Deletion mapping of the short arm of chromosome 3 in Merkel cell carcinoma Genes Chrom. Cancer., 15, 102–107.
45. Lisitsyn N. Wigler M. Representational difference analysis in detection of genetic lesions in cancer Methods Enzymol 254 1995 291 304
46. Lothe R.A. Fossa S.D. Stenwig A.E. Nakamura Y. White R. Borresen A.L. Brogger A. Loss of 3p or 11p alleles is associated with testicular cancer tumors Genomics 5 1989 134 138
47. Lubinski J. Hadaczek P. Podolski J. Toloczko A. Sikorski A. McCue P. Druck T. Huebner K. Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas Cancer Res 54 1994 3710 3713
48. Maestro R. Gasparotto D. Vukosavljevic T. Barzan L. Sulfaro S. Boiocchi M. Three discrete regions of deletion at 3p in head and neck cancers Cancer Res 53 1993 5775 5779
49. Mao L. Fan Y.H. Lotan R. Hong W.K. Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines Cancer Res 56 1996 5128 5131
50. Mao L. Lee J.S. Fan Y.H. Ro J.Y. Batsakis J.G. Lippman S. Hittelman W. Hong W.K. Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment Nature Med 2 1996 682 685
51. Mercer D. Brander P. Liddell K. Merkel cell carcinoma: The clinical course Ann. Plastic Surg 25 1990 136 141
52. Michaelis S.C. Bardenheuer W. Lux A. Schramm A. Gockel A. Siebert R. Willers C. Schmidtke K. Todt B. van der Hout A.H. Characterization and chromosomal assignment of yeast artificial chromosomes containing human 3p13–3p21-specific sequence tagged sites Cancer Genet. Cytogenet 81 1995 1 12
53. Mori N. Yokota J. Oshimura M. Cavenee W.K. Mizoguchi H. Noguchi M. Shimosato Y. Sugimura T. Terada M. Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma Cancer Res 49 1989 5130 5135
54. Mulley J.C. Yu S. Loesch D.Z. Hay D.A. Donnelly A. Gedeon A.K. Carbonell P. Lopez I. Glover G. Gabarron I. FRAXE and mental retardation J. Med. Genet 32 1995 162 169
55. Musio A. Sbrana I. Common and rare fragile sites on human chromosomes. The cytogenetic expression of active and inactive genes? Cancer Genet. Cytogenet 88 1996 184 185 [Letter]
56. Nawroz H. van der Riet P. Hruban R.H. Koch W. Ruppert J.M. Sidransky D. Allelotype of head and neck squamous cell carcinoma Cancer Res 54 1994 1152 1155
57. Naylor S.L. Johnson B.E. Minna J.D. Sakaguchi A.Y. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer Nature 329 1987 451 454
58. Negrini M. Monaco C. Vorechovsky I. Ohta M. Druck T. Baffa R. Huebner K. Croce C.M. The FHIT gene at 3p14.2 is abnormal in breast carcinomas Cancer Res 56 1996 3173 3179
59. Ogawa O. Kakehi Y. Ogawa K. Koshiba M. Sugiyama T. Yoshida O. Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma Cancer Res 51 1991 949 953
60. Ohta M. Inoue H. Cotticelli M.G. Kastury K. Baffa R. Palazzo J. Siprashvili Z. Mori M. McCue P. Druck T. Croce C.M. Huebner K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancer Cell 84 1996 587 597
61. Panagopoulos I. Pandis N. Thelin S. Petersson C. Mertens F. Borg A. Kristoffersson U. Mitelman F. Arnan P. The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14 Cancer Res 56 1996 4871 4875
62. Pandis N. Idvall I. Bardi G. Jin Y. Gorunova L. Mertens E Olsson H. Ingvar C. Beroukas K. Mitelman E. Heim S. Correlation between karyotypic pattern and clinicopathologic features in 125 breast cancer cases Int. J. Cancer 66 1996 191 196
63. Pandis N. Jin Y. Limon J. Bardi G. Idvall I. Mandahl N. Mitelman E. Heim S. Interstitial deletion of the short arm of chromosome 3 as a primary chromosome abnormality in carcinomas of the breast Genes Chrom. Cancer 6 1993 151 155
64. Pandis N. Jin Y. Gorunova L. Petersson C. Bardi G. Idvall I. Johansson B. Ingvar C. Mandahl N. Mitelman E. Chromosome analysis of 97 primary breast carcinomas: Identification of eight karyotypic subgroups Genes Chrom. Cancer 12 1995 173 185
65. Paradee J.D. Mullins C. He Z. Glover T. Wilke C. Opalka B. Schutte J. Smith D. Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3 Genomics 27 1995 358 361
66. Pennisi E. New gene forges link between fragile site and many cancers Science 272 1996 649
67. Petersson C. Pandis N. Mertens F. Adeyinka A. Ingvar C. Ringberg A. Idvall I. Bondeson L. Borg A. Olsson H. Kristoffersson U. Mitelman F. Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families Genes Chrom. Cancer 16 1996 185 188
68. Pieretti M. Zhang F.P. Fu Y.H. Warren S.T. Oostra B.A. Caskey C.T. Nelson D.L. Absence of expression of the FMR-1 gene in fragile X syndrome Cell 66 1991 817 822
69. Pilotti S. Rilke E Bartoli C. Grisotti A. Clinicopathologic correlations of cutaneous neuroendocrine Merkel cell carcinoma J. Clin. Oncol 6 1988 1863 1873
70. Pilotti S. Rilke F. Lombardi L. Neuroendocrine (Merkel cell) carcinoma of the skin Am. J. Surg. Pathol 6 1982 243 254
71. Rabbitts P. Douglas J. Daly M. Sundaresan V. Fox B. Haselton P. Wells E Albertson D. Waters J. Bergh J. Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall-cell lung cancer Genes Chrom. Cancer 1 1989 95 105
72. Rassool F.V. McKeithan T.W. Neilly M.E. van melle E. Espinosa R. III Le Beau M.M. Preferential integration of marker DNA into the chromosomal fragile site at 3p14: An approach to cloning fragile sites Proc. Natl. Acad. Sci. USA 88 1991 6657 6661
73. Rimessi P. Gualandi F. Morelli C. Trabanelli C. Wu Q. Possati L. Montesi M. Barrett J.C. Barbanti-Brodano G. Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer Oncogene 9 1994 3467 3474
74. Robinson A.K. de la Pena C.E. Barnes L.D. Isolation and characterization of diadenosine tetraphosphate (Ap4A) hydrolase from Schizosaccharomyces pombe. Biochem. Biophys. Acta 1161 1993 139 148
75. Roth J.A. Nguyen D. Lawrence D.D. Kemp B.L. Carrasco C.H. Ferson D.Z. Hong W.K. Komaki R. Lee J.J. Nesbitt J.C. Pisters K.M. Putnam J.B. Schea R. Shin D.M. Walsh G.L. Dolormente M.M. Han C.I. Martin F.D. Yen N. Xu K Stephens L.C. McDonnell T.J. Mukhopadhyay T. Cai D. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer [see comments] Nature Med 2 1996 985 991
76. Roz L. Wu C.L. Porter S. Scully C. Speight P. Read A. Sloan P. Thakker N. Allelic imbalance on chromosome 3p in oral dysplastic lesions: An early event in oral carcinogenesis Cancer Res 56 1996 1228 1231
77. Sanchez Y. el-Naggar A. Pathak S. Killary A.M. A tumor suppressor locus with-in 3p14–p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc. Natl. Acad. Sci. USA 91 1994 3383 3387
78. Sandbrink F. Muller L. Fiebig H.H. Kovacs G. Short communication: deletion 7q, trisomy 6 and 11 in a case of Merkel-cell carcinoma Cancer Genet. Cytogenet 33 1988 305 309
79. Satoh H. Lamb P.W. Dong J.T. Everitt J. Boreiko C. Oshimura M. Barrett J.C. Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer Mol. Carcinog 7 1993 157 164
80. Schmid M. Ott G. Haaf T. Scheres J.M. Evolutionary conservation of fragile sites induced by 5-azacytidine and 5-azadeoxycytidine in man, gorilla, and chimpanzee Hum. Genet 71 1985 342 350
81. Segal E. Le Pecq J.B. Relationship between cellular diadenosine 5′,5′-P1,P4-tetraphosphate level, cell density, cell growth stimulation and toxic stresses Exp. Cell Res 167 1986 119 126
82. Sekido Y. Bader S. Latif F Gnarra J.R. Gazdar A.F. Linehan W.M. Zbar B. Lerman M.I. Minna J.D. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines Oncogene 9 1994 1599 1604
83. Shabtai F. Sternberg A. Klar D. Reiss R. Halbrecht I. Involvement of chromosome 22 in a Merkel cell carcinoma in a patient with a previous meningioma Cancer Genet. Cytogenet 38 1989 43 48
84. Shimizu M. Yokota J. Mori N. Shuin T. Shinoda M. Terada M. Oshimura M. Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR Oncogene 5 1990 185 194
85. Silva E.G. Mackay B. Goepfert H. Burgess M.A. Fields R.S. Endocrine carcinoma of the skin (Merkel cell carcinoma) Pathol. Annu 19 2 1984 1 30
86. Smadja N. de Gramont A. Gonzalez-Canali G. Louvet C. Wattel E. Krulik M. Cytogenetic study in a bone marrow metastatic Merkel cell carcinoma Cancer Genet. Cytogenet 51 1991 85 87
87. Sozzi G. Bertoglio M.G. Pilotti S. Rilke E Pierotti M.A. Della Porta G. Cytogenetic studies in primary and metastatic neuroendocrine Merkel cell carcinoma Cancer Genet. Cytogenet 30 1988 151 158
88. Sozzi G. Miozzo M. Tagliabue E. Calderone C. Lombardi L. Pilotti S. Pastorino U. Pierotti M.A. Della Porta G. Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients Cancer Res 51 1991 400 404
89. Sozzi G. Alder H. Tornielli S. Corletto V. Baffa R. Veronese M.L. Negrini M. Pilotti S. Pierotti M.A. Huebner K. Croce C.M. Aberrant FHIT transcripts in Merkel cell carcinoma Cancer Res 56 1996 2472 2474
90. Sozzi G. Veronese M.L. Negrini M. Baffa R. Cotticelli M.G. Inoue H. Tornielli S. Pilotti S. De Gregorio L. Pastorino U. Pierotti M.A. Otha M. Huebner K. Croce C.M. The FHIT gene at 3p14.2 is abnormal in lung cancer Cell 85 1996 17 26
91. Sozzi G. Sard L. De Gregorio L. Marchetti A. Musso K. Buttitta F. Tornielli S. Pellegrini S. Veronese M.L. Manenti G. Incarbone M. Chella A. Angeletti C.A. Pastorino U. Huebner K. Bevilaqua G. Pilotti S. Croce C.M. Pierotti M.A. Association between cigarette smoking and FHIT gene alterations in lung cancer Cancer Res 57 1997 2121 2123
92. Sozzi G. Tornielli S. Tagliabue E. Sard L. Pezzella F. Pastorino U. Minoletti F. Pilotti S. Ratcliffe C. Veronese M.L. Goldstraw P. Huebner K. Croce C.M. Pierotti M.A. Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities Cancer Res 57 1997 5207 5212
93. Sundaresan V. Ganly P. Haselton P. Rudd R. Sinha G. Bleehen N.M. Rabbits P. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus Oncogene 7 1992 1989 1997
94. Sutherland G.R. Chromosomal fragile sites Genet. Anal. Tech. Appl 8 1991 161 166
95. Sutherland G.R. Richards R.I. The molecular basis of fragile sites in human chromosomes Curr. Opin. Genet. Dev 5 1995 323 327
96. Teixeira M.R. Pandis N. Bardi G. Andersen J.A. Heim S. Karyotypic comparisons of multiple tumorous and macroscopically normal surrounding tissue samples from patients with breast cancer Cancer Res 56 1996 855 859
97. Testa J.R. Siegfried J.M. Liu Z. Hunt J.D. Feder M.M. Litwin S. Zhou J.-Y. Taguchi T. Keller S.M. Cytogenetic analysis of 63 non-small cell lung carcinomas: Recurrent chromosome alterations amid frequent and widespread genomic upheaval Gene: Chrom. Cancer 11 1994 178 194
98. Thiagalingam S. Lisitsyn N.A. Hamaguchi M. Wigler M.H. Willson J.K. Markowitz S.D. Leach E.S. Kinzler K.W. Vogelstein B. Evaluation of the FHIT gene in colorectal cancers Cancer Res 56 1996 2936 2939
99. Todd M.C. Xiang R.H. Garcia D.K. Kerbacher K.E. Moore S.L. Hensel C.H. Liu P. Siciliano M.J. Kok K. van den Berg A. Veldhuis P. Buys C.H. Killary AM Naylor S.L. An 80 Kb P1 clone from chromosome 3p21.3 suppresses tumor growth in vivo. Oncogene 13 1996 2387 2396
100. Vartanian A. Narovlyansky A. Amchenkova A. Turpaev K. Kisselev L. Interferons induce accumulation of diadenosine triphosphate (Ap3A) in human cultured cells FEBS Lett 381 1996 32 34
101. Verkerk A.J. Pieretti M. Sutcliffe J.S. Fu Y.H. Kuhl D.P. Pizzuti A. Reiner O. Richards S. Victoria M.E. Zhang E.P. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome Cell 65 1991 905 914
102. Virgilio L. Shuster M. Gollin S.M. Veronese M.L. Ohta M. Huebner K. Croce C.M. FHIT gene alterations in head and neck squamous cell carcinomas Proc. Natl. Acad. Sci. USA 93 1996 9770 9775
103. Whang-Peng J. Bunn P.A. Jr. Kao-Shan C.S. Lee E.C. Carney D.N. Gazdar A. Minna J.D. A nonrandom chromosomal abnormality, del 3p(14–23), in human small cell lung cancer (SCLC) Cancer Genet. Cytogenet 6 1982 119 134
104. Wilke C.M. Guo S.W. Hall B.K. Boldog E Gemmill R.M. Chandrasekharappa SC Barcroft C.L. Drabkin H.A. Glover T.W. Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma Genomics 22 1994 319 326
105. Wilke C.M. Hall B.K. Hoge A. Paradee W. Smith D.I. Glover T.W. FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: Direct evidence for the coincidence of viral integration sites and fragile sites Hum. Mol. Genet 5 1996 187 195
106. Wingo P.A. Bolden S. Tong T. Parker S.L. Martin L.M. Heath C.W. Jr. Cancer statistics for African Americans, 1996 Cancer J. Clinicians 46 1996 113 125
107. Yanagisawa K. Kondo M. Osada H. Uchida K. Takagi K. Masuda A. Takahashi T. Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines Cancer Res 56 1996 5579 5582
108. Yang-Feng T.L. Han H. Chen K.C. Li S.B. Claus E.B. Carcangiu M.L. Chambers S.K. Chambers J.T. Schwartz P.E. Allelic loss in ovarian cancer Int. J. Cancer 54 1993 546 551
109. Yokota J. Wada M. Shimosato Y. Terada M. Sugimura T. Loss of heterozygosity on chromosomes, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung Proc. Natl. Acad. Sci. USA 84 1987 9252 9256
110. Yoshida M.A. Shimizu M. Ikeuchi T. Tonomura A. Yokota J. Oshimura M. In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion Mol. Carcinog 9 1994 114 121
111. Yu S. Mangelsdorf M. Hewett D. Hobson L. Baker E. Eyre H.J. Lapsys N. Lepaslier D. Doggett N.A. Sutherland G.R. Richards R.I. Human chromosomal fragile site FRA16B is an amplified at-rich minisatellite repeat Cell 88 3 1997 367 374
112. Yu S. Pritchard M. Kremer E. Lynch M. Nancarrow J. Baker E. Holman K. Mulley J.C. Warren S.T. Schlessinger D. Fragile X genotype characterized by an unstable region of DNA Science 252 1991 1179 1181
113. Yunis J.J. Soreng A.L. Constitutive fragile sites and cancer Science 226 1984 1199 1204
114. Yunis J.J. Soreng A.L. Bowe A.E. Fragile sites are targets of diverse mutagens and carcinogens Oncogene 1 1987 59 69
115. Zimonjic D.B. Druck T. Otha M. Kastury K. Croce C.M. Popescu N.C. Huebner K. Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene Cancer Res 57 1997 1166 1170