NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

International Journal of Cancer

Volumn 138, Issue 4, 2016, Pages 927-938

  Meder, Lydia ^a,b   König, Katharina ^a,b   Ozretic, Luka ^a,b   Schultheis, Anne M ^a,b   Ueckeroth, Frank ^a,b   Ade, Carsten P ^c   Albus, Kerstin ^a,b   Boehm, Diana ^a,b   Rommerscheidt Fuss, Ursula ^a   Florin, Alexandra ^a   Buhl, Theresa ^a,b   Hartmann, Wolfgang ^a   Wolf, Jürgen ^a,b   Merkelbach Bruse, Sabine ^a,b   Eilers, Martin ^c   Perner, Sven ^a,b,c   Heukamp, Lukas C ^a,b   Buettner, Reinhard ^a,b  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

achaete scute homolog 1; Lung cancer; neurogenic locus notch homolog; retinoblastoma protein; small cell lung cancer

Indexed keywords

CYCLIN DEPENDENT KINASE 5; NOTCH RECEPTOR; PROTEIN P53; PROTEIN RB1; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR MASH1; UNCLASSIFIED DRUG; ASCL1 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; TP53 PROTEIN, HUMAN;

AMPLICON; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LARGE CELL LUNG CARCINOMA; LUNG ADENOCARCINOMA; NEUROENDOCRINE TUMOR; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMALL CELL LUNG CANCER; WNT SIGNALING PATHWAY; CARCINOMA; DNA MUTATIONAL ANALYSIS; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; HIGH THROUGHPUT SEQUENCING; LUNG TUMOR; METABOLISM; PATHOLOGY;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, NEUROENDOCRINE; DNA MUTATIONAL ANALYSIS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG NEOPLASMS; RECEPTORS, NOTCH; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; SMALL CELL LUNG CARCINOMA; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84954403082     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29835     Document Type: Article

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