The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes

Cancer Research

Volumn 60, Issue 21, 2000, Pages 6116-6133

  Lerman, Michael I ^b   Minna, John D ^a   Sekido, Yoshitaka ^a   Bader, Scott ^a   Burbee, David ^a   Fong, Kwun ^a   Forgacs, Eva ^a   Gao, Boning ^a   Garner, Harold ^a   Gazdar, Adi F ^a   Girard, Luc ^a   Kamibayashi, Craig ^a   Kondo, Masashi ^a   Pande, Ashwini ^a   Persemlidis, Alex ^a   Ramalingam, Vivek ^a   Randle, Dwight ^a   Tomizawa, Yoshio ^a   Virmani, Arvind ^a   Wistuba, Ivan ^a   Zeng, Grace ^a   Macartney, Donia ^c   Honorio, Sofia ^c   Maher, Eamonn ^c   Latif, Farida ^c   Kashuba, Vladimir ^d   Protopopov, Alexei ^d   Li, Jingfeng ^d   Klein, George ^d   Zabarovsky, Eugene ^d   Duh, Fuh Mei ^b   Wei, Ming Hui ^b   Geil, Laura ^b   Kuzmin, Igor ^b   Ivanov, Sergei ^b   Angeloni, Debora ^b   Ivanova, Alla ^b   Zbar, Bert ^b   Johnson, Bruce E ^e   more..

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 3P; CONTROLLED STUDY; GENE ASSIGNMENT; GENE DELETION; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0034327412     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (132)

1. Cancer surveillance series: Changing geographic patterns of lung cancer mortality in the United States, 1950 through 1994
2. Cancer statistics, 1999
3. Global cancer statistics
4. Progress in understanding the molecular pathogenesis of human lung cancer
5. Evidence for Mendelian inheritance in the pathogenesis of lung cancer
6. Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types
7. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes
8. Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene
9. Homozygous deletions at 3p12 in breast and lung cancer
10. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma
11. Analysis of loss of heterozygosity in 399 premalignant breast lesions at 15 genetic loci
12. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
13. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus
14. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
15. A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes
16. Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: Progress toward the isolation of a lung cancer TSG
17. Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin
18. A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity
19. Human Gi protein α-subunit: Deduction of amino acid structure from a cloned cDNA
20. Nucleotide sequence for a cDNA encoding the α subunit of retinal transducin (GNATI) isolated from the human eye
21. Alterations in DNA methylation: A fundamental aspect of neoplasia
22. NCI-Navy Medical Oncology Branch cell line data base
23. A combined approach of conventional and molecular cytogenetics for detailed karyotypic analysis of the small cell lung carcinoma cell line U2020
24. myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines
25. Prediction of complete gene structures in human genomic DNA
26. Human chromosome 3: High-resolution fluorescence in situ hybridization mapping of 40 unique NotI linking clones homologous to genes and cDNAs
27. Von Hippel-Lindau disease: Identification of deletion mutations by pulsed-field gel electrophoresis
28. Local alignment statistics
29. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines
30. Mutation analysis of the PTEN/MMAC1 gene in lung cancer
31. Molecular biology database list
32. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
33. Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins
34. SMART, a simple modular architecture research tool: Identification of signaling domains
35. Better prediction of protein cellular localization sites with the k nearest neighbors classifier
36. Highly specific protein sequence motifs for genome analysis
37. The PROSITE database, its status in 1999
38. Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs
39. Large-scale taxonomic profiling of eukaryotic model organisms: A comparison of orthologous proteins encoded by the human, fly, nematode, and yeast genomes
40. Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences
41. Towards detection of orthologues in sequence databases
42. The Yeast Proteome Database (YPD): A model for the organization and presentation of genome-wide functional data
43. Homozygous deletions of human chromosome 3p in lung tumors
44. An 80 Kb P1 clone from chromosome 3p21.3 suppresses tumor growth in vivo
45. Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3
46. Definition of a tumor suppressor locus within human chromosome 3p21-p22
47. 3PK, a new map kinase activated protein kinase, located in the small cell lung cancer tumor suppressor gene region
48. The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21
49. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns
50. Collection of mRNA-like non-coding RNAs
51. PipMakerA web server for aligning two genomic DNA sequences
52. The mouse Aire gene: Comparative genomic sequencing, gene organization, and expression
53. Complete genomic sequence and analysis of the prion protein gene region from three mammalian species
54. Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues
55. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer
56. The mutation rate and cancer
57. Cancer cells exhibit a mutator phenotype
58. The FlyBase database of the Drosophila Genome Projects and community literature. The FlyBase Consortium
59. 2+ channel α2δ subunit in current stimulation and subunit interaction
60. Functional properties of a new voltage-dependent calcium channel α2δ auxiliary subunit gene (CACNA2D2)
61. Structure and expression of the human MTG8/ETO gene
62. Molecular cloning, sequence analysis, expression, and tissue distribution of suppressin, a novel suppressor of cell cycle entry
63. Identification of Nore1 as a potential Ras effector
64. Substrate specificities and identification of putative substrates of ATM kinase family members
65. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity
66. Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase
67. Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX
68. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus
69. New features of the Blocks Database servers
70. The putative tumour suppressor Fus-2 is an N-acetyltransferase
71. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31
72. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes
73. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3
74. DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC
75. Human lung cancer antigens recognized by autologous antibodies: Definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3
76. Nonrandom structural and numerical chromosome changes in non-small-cell lung cancer
77. Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)
78. A nonrandom chromosomal abnormality, de1 3p(14-23), in human small cell lung cancer (SCLC)
79. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer
80. Molecular analysis of the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung
81. Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors
82. Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer
83. Three distinct regions involved in 3p deletion in human lung cancer
84. The FHIT gene at 3p14.2 is abnormal in lung cancer
85. Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22
86. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer related FHIT cDNA splicing aberrations
87. A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma
88. Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: A strategy for cloning the putative tumor suppressor gene
89. Characterization of the submicroscopic deletion in the small-cell lung carcinoma (SCLC) cell line U2020
90. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line
91. Molecular damage in the bronchial epithelium of current and former smokers
92. Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer
93. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
94. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
95. Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region
96. Genetic mechanisms of tumor suppression by the human p53 gene
97. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
98. p53: A frequent target for genetic abnormalities in lung cancer
99. Mechanisms of p16INK4A inactivation in non small-cell lung cancers
100. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between SCLC and NSCLC, and loci clustering
101. Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors
102. Inactivation of CACNAIG, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors
103. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
104. The molecular basis of oncogenes and tumor suppressor genes
105. Tumor suppressing pathways
106. The murine gene p27Kip1 is haplo-insufficient for tumour suppression
107. Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency
108. Evidence that haploinsufficiency of ptch leads to medulloblastoma in mice
109. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
110. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
111. Human cancer syndromes: Clues to the origin and nature of cancer
112. Cancer-susceptibility genes. Gatekeepers and caretakers
113. Mutation and cancer: A personal odyssey
114. Mutation and cancer: A model for human carcinogenesis
115. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
116. Comparison of features of human lung cancer cell lines and their corresponding tumors
117. Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer
118. Lung cancer
119. Neuroendocrine tumors of the lung. Pathology and molecular biology
120. Non-ocular cancer in relatives of retinoblastoma patients
121. Increased cancer risk among relatives of nonsmoking lung cancer cases
122. Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis