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Volumn 11, Issue 3, 2016, Pages 287-299

From mice to men and back: An assessment of preclinical model systems for the study of lung cancers

Author keywords

Cell lines; Cell Lines; Genetically Engineered Mouse Models; Lung Cancer; Neuroendocrine Carcinomas; Non Small Cell Lung Cancer; Patient Derived Xenografts; Preclinical Models; Small Cell Lung Cancer

Indexed keywords

CANCER RESEARCH; DISEASE MODEL; GENETICALLY ENGINEERED MOUSE STRAIN; HISTOPATHOLOGY; HUMAN; LUNG CANCER; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; REVIEW; SMALL CELL LUNG CANCER; TUMOR CELL LINE; TUMOR XENOGRAFT; ANIMAL; LUNG TUMOR; MOUSE; PATHOLOGY; SCID MOUSE; TRANSGENIC MOUSE;

EID: 84962522570     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2015.10.009     Document Type: Review
Times cited : (43)

References (72)
  • 1
    • 84929989581 scopus 로고    scopus 로고
    • Preclinical murine models for lung cancer: Clinical trial applications
    • Kellar A, Egan C, Morris D. Preclinical murine models for lung cancer: Clinical trial applications. Biomed Res Int. 2015; 2015: 621324.
    • (2015) Biomed Res Int , vol.2015 , pp. 621324
    • Kellar, A.1    Egan, C.2    Morris, D.3
  • 2
    • 77956570532 scopus 로고    scopus 로고
    • Lung cancer cell lines as tools for biomedical discovery and research
    • Gazdar AF, Girard L, Lockwood WW, et al. Lung cancer cell lines as tools for biomedical discovery and research. J Natl Cancer Inst. 2010; 102: 1310-1321.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1310-1321
    • Gazdar, A.F.1    Girard, L.2    Lockwood, W.W.3
  • 3
    • 77952542786 scopus 로고    scopus 로고
    • Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?
    • Gazdar AF, Gao B, Minna JD. Lung cancer cell lines: useless artifacts or invaluable tools for medical science? Lung Cancer. 2010; 68: 309-318.
    • (2010) Lung Cancer , vol.68 , pp. 309-318
    • Gazdar, A.F.1    Gao, B.2    Minna, J.D.3
  • 5
    • 84935894028 scopus 로고    scopus 로고
    • Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours
    • Ince TA, Sousa AD, Jones MA, et al. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nat Commun. 2015; 6: 7419.
    • (2015) Nat Commun , vol.6 , pp. 7419
    • Ince, T.A.1    Sousa, A.D.2    Jones, M.A.3
  • 6
    • 0015187933 scopus 로고
    • A new floating cell line derived from human pulmonary carcinoma of oat cell type
    • Oboshi S, Tsugawa S, Seido T, et al. A new floating cell line derived from human pulmonary carcinoma of oat cell type. Gan. 1971; 62: 505-514.
    • (1971) Gan , vol.62 , pp. 505-514
    • Oboshi, S.1    Tsugawa, S.2    Seido, T.3
  • 7
    • 85025402749 scopus 로고
    • Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix
    • Scherer WF, Syverton JT, Gey GO. Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix. J Exp Med. 1953; 97: 695-710.
    • (1953) J Exp Med , vol.97 , pp. 695-710
    • Scherer, W.F.1    Syverton, J.T.2    Gey, G.O.3
  • 8
    • 84873769697 scopus 로고
    • Cultivation of normal and malignant human lung tissue i the establishment of three adenocarcinoma cell strains
    • Reed MV, Gey GO. Cultivation of normal and malignant human lung tissue. I. The establishment of three adenocarcinoma cell strains. Lab Invest. 1962; 11: 638-652.
    • (1962) Lab Invest , Issue.11 , pp. 638-652
    • Reed, M.V.1    Gey, G.O.2
  • 9
    • 67749108202 scopus 로고    scopus 로고
    • A gene-Alteration profile of human lung cancer cell lines
    • Blanco R, Iwakawa R, Tang M, et al. A gene-Alteration profile of human lung cancer cell lines. Hum Mutat. 2009; 30: 1199-1206.
    • (2009) Hum Mutat , vol.30 , pp. 1199-1206
    • Blanco, R.1    Iwakawa, R.2    Tang, M.3
  • 10
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance ED, Stephens PJ, OMeara S, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature. 2010; 463: 184-190.
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1    Stephens, P.J.2    Omeara, S.3
  • 11
    • 84930163431 scopus 로고    scopus 로고
    • Reproducibility: Changing the policies and culture of cell line authentication
    • Freedman LP, Gibson MC, Ethier SP, et al. Reproducibility: changing the policies and culture of cell line authentication. Nat Methods. 2015; 12: 493-497.
    • (2015) Nat Methods , vol.12 , pp. 493-497
    • Freedman, L.P.1    Gibson, M.C.2    Ethier, S.P.3
  • 12
    • 0015759232 scopus 로고
    • Vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors
    • Giard DJ, Aaronson SA, Todaro GJ, et al. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst. 1973; 51: 1417-1423.
    • (1973) J Natl Cancer Inst , vol.51 , pp. 1417-1423
    • Giard, D.J.1    Aaronson, S.A.2    Todaro, G.J.3
  • 13
    • 84887212361 scopus 로고    scopus 로고
    • Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
    • Gandhi J, Zhang J, Xie Y, et al. Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One. 2009; 4: e4576.
    • (2009) PLoS One , vol.4 , pp. e4576
    • Gandhi, J.1    Zhang, J.2    Xie, Y.3
  • 14
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011; 71: 6051-6060.
    • (2011) Cancer Res , vol.71 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3
  • 15
    • 0018889149 scopus 로고
    • Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung
    • Pettengill OS, Sorenson GD, Wurster-Hill DH, et al. Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung. Cancer. 1980; 45: 906-918.
    • (1980) Cancer , vol.45 , pp. 906-918
    • Pettengill, O.S.1    Sorenson, G.D.2    Wurster-Hill, D.H.3
  • 16
    • 0018954542 scopus 로고
    • Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties
    • Gazdar AF, Carney DN, Russell EK, et al. Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res. 1980; 40: 3502-3507.
    • (1980) Cancer Res , vol.40 , pp. 3502-3507
    • Gazdar, A.F.1    Carney, D.N.2    Russell, E.K.3
  • 17
    • 33646953271 scopus 로고    scopus 로고
    • NCI-Navy Medical Oncology Branch cell line data base
    • Phelps RM, Johnson BE, Ihde DC, et al. NCI-Navy Medical Oncology Branch cell line data base. J Cell Biochem Suppl. 1996; 24: 32-91.
    • (1996) J Cell Biochem Suppl , vol.24 , pp. 32-91
    • Phelps, R.M.1    Johnson, B.E.2    Ihde, D.C.3
  • 18
    • 0021968689 scopus 로고
    • Characterization of variant subclasses of cell lines derived fromsmall cell lung cancer having distinctive biochemical, morphological, and growth properties
    • Gazdar AF, Carney DN, Nau MM, et al. Characterization of variant subclasses of cell lines derived fromsmall cell lung cancer having distinctive biochemical, morphological, and growth properties. Cancer Res. 1985; 45: 2924-2930.
    • (1985) Cancer Res , vol.45 , pp. 2924-2930
    • Gazdar, A.F.1    Carney, D.N.2    Nau, M.M.3
  • 19
    • 84906790811 scopus 로고    scopus 로고
    • Advances in patientderived tumor xenografts: From target identification to predicting clinical response rates in oncology
    • Rosfjord E, Lucas J, Li G, et al. Advances in patientderived tumor xenografts: from target identification to predicting clinical response rates in oncology. Biochem Pharmacol. 2014; 91: 135-143.
    • (2014) Biochem Pharmacol , vol.91 , pp. 135-143
    • Rosfjord, E.1    Lucas, J.2    Li, G.3
  • 20
    • 84873808119 scopus 로고    scopus 로고
    • Evaluation of novel orthotopic nude mouse models for human smallcell lung cancer
    • Isobe T, Onn A, Morgensztern D, et al. Evaluation of novel orthotopic nude mouse models for human smallcell lung cancer. J Thorac Oncol. 2013; 8: 140-146.
    • (2013) J Thorac Oncol , vol.8 , pp. 140-146
    • Isobe, T.1    Onn, A.2    Morgensztern, D.3
  • 21
    • 0019847006 scopus 로고
    • Heterotransplantation of small-cell carcinoma of the lung into nude mice: Comparison of intracranial and subcutaneous routes
    • Gazdar AF, Carney DN, Sims HL, et al. Heterotransplantation of small-cell carcinoma of the lung into nude mice: comparison of intracranial and subcutaneous routes. Int J Cancer. 1981; 28: 777-783.
    • (1981) Int J Cancer , vol.28 , pp. 777-783
    • Gazdar, A.F.1    Carney, D.N.2    Sims, H.L.3
  • 22
    • 84920374898 scopus 로고    scopus 로고
    • Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer
    • Hao C, Wang L, Peng S, et al. Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett. 2015; 357: 179-185.
    • (2015) Cancer Lett , vol.357 , pp. 179-185
    • Hao, C.1    Wang, L.2    Peng, S.3
  • 23
    • 84937634186 scopus 로고    scopus 로고
    • Clinical utility of patient-derived xenografts to determine biomarkers of prognosis and map resistance pathways in EGFRmutant lung adenocarcinoma
    • Stewart EL, Mascaux C, Pham NA, et al. Clinical utility of patient-derived xenografts to determine biomarkers of prognosis and map resistance pathways in EGFRmutant lung adenocarcinoma. J Clin Oncol. 2015; 33: 2472-2480.
    • (2015) J Clin Oncol , vol.33 , pp. 2472-2480
    • Stewart, E.L.1    Mascaux, C.2    Pham, N.A.3
  • 24
    • 84964693948 scopus 로고    scopus 로고
    • Patient-derived xenografts for investigation of acquired resistance in oncogene-driven cancers: Building a better mousetrap
    • Gandara DR, Lara Jr PN, Mack PC. Patient-derived xenografts for investigation of acquired resistance in oncogene-driven cancers: building a better mousetrap. J Clin Oncol. 2015; 33: 2839-2840.
    • (2015) J Clin Oncol , vol.33 , pp. 2839-2840
    • Gandara, D.R.1    Lara, P.N.2    Mack, P.C.3
  • 25
    • 84906895091 scopus 로고    scopus 로고
    • Patient-derived xenograft models: An emerging platform for translational cancer research
    • Hidalgo M, Amant F, Biankin AV, et al. Patient-derived xenograft models: An emerging platform for translational cancer research. Cancer Discov. 2014; 4: 998-1013.
    • (2014) Cancer Discov , vol.4 , pp. 998-1013
    • Hidalgo, M.1    Amant, F.2    Biankin, A.V.3
  • 26
    • 84893637270 scopus 로고    scopus 로고
    • One mouse, one patient paradigm: New avatars of personalized cancer therapy
    • Malaney P, Nicosia SV, Dave V. One mouse, one patient paradigm: new avatars of personalized cancer therapy. Cancer Lett. 2014; 344: 1-12.
    • (2014) Cancer Lett , vol.344 , pp. 1-12
    • Malaney, P.1    Nicosia, S.V.2    Dave, V.3
  • 27
    • 80053405084 scopus 로고    scopus 로고
    • Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
    • Zhang YA, Maitra A, Hsieh JT, et al. Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther. 2011; 12: 617-628.
    • (2011) Cancer Biol Ther , vol.12 , pp. 617-628
    • Zhang, Y.A.1    Maitra, A.2    Hsieh, J.T.3
  • 29
    • 84875813017 scopus 로고    scopus 로고
    • Mouse models for lung cancer
    • Kwon MC, Berns A. Mouse models for lung cancer. Mol Oncol. 2013; 7: 165-177.
    • (2013) Mol Oncol , vol.7 , pp. 165-177
    • Kwon, M.C.1    Berns, A.2
  • 30
    • 79957936388 scopus 로고    scopus 로고
    • How genetically engineered mouse tumor models provide insights into human cancers
    • Politi K, Pao W. How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol. 2011; 29: 2273-2281.
    • (2011) J Clin Oncol , vol.29 , pp. 2273-2281
    • Politi, K.1    Pao, W.2
  • 31
    • 84861728922 scopus 로고    scopus 로고
    • SnapShot: Lung cancer models
    • Farago AF, Snyder EL, Jacks T. SnapShot: lung cancer models. Cell. 2012; 149: 246-246.e241.
    • (2012) Cell , vol.149 , pp. 246
    • Farago, A.F.1    Snyder, E.L.2    Jacks, T.3
  • 32
    • 80052581514 scopus 로고    scopus 로고
    • Lung cancer signatures in plasma based on proteome profiling of mouse tumor models
    • Taguchi A, Politi K, Pitteri SJ, et al. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011; 20: 289-299.
    • (2011) Cancer Cell , vol.20 , pp. 289-299
    • Taguchi, A.1    Politi, K.2    Pitteri, S.J.3
  • 33
    • 77952251380 scopus 로고    scopus 로고
    • The new IASLC/ATS/ERS international multidisciplinary lung adenocarcinoma classification
    • Travis W, Brambilla E, Noguchi M, et al. The new IASLC/ATS/ERS international multidisciplinary lung adenocarcinoma classification. J Thorac Oncol. 2009; 4: 244-285.
    • (2009) J Thorac Oncol , vol.4 , pp. 244-285
    • Travis, W.1    Brambilla, E.2    Noguchi, M.3
  • 34
    • 84938794719 scopus 로고    scopus 로고
    • Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities
    • Skoulidis F, Byers LA, Diao L, et al. Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities. Cancer Discov. 2015; 5: 860-877.
    • (2015) Cancer Discov , vol.5 , pp. 860-877
    • Skoulidis, F.1    Byers, L.A.2    Diao, L.3
  • 35
    • 84925536961 scopus 로고    scopus 로고
    • The mutational landscapes of genetic and chemical models of Krasdriven lung cancer
    • Westcott PM, Halliwill KD, To MD, et al. The mutational landscapes of genetic and chemical models of Krasdriven lung cancer. Nature. 2015; 517: 489-492.
    • (2015) Nature , vol.517 , pp. 489-492
    • Westcott, P.M.1    Halliwill, K.D.2    To, M.D.3
  • 36
    • 0141523025 scopus 로고    scopus 로고
    • Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
    • Meuwissen R, Linn SC, Linnoila RI, et al. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell. 2003; 4: 181-189.
    • (2003) Cancer Cell , vol.4 , pp. 181-189
    • Meuwissen, R.1    Linn, S.C.2    Linnoila, R.I.3
  • 37
    • 84929949436 scopus 로고    scopus 로고
    • The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung
    • Gazdar AF, Savage TK, Johnson JE, et al. The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol. 2015; 10: 553-564.
    • (2015) J Thorac Oncol , vol.10 , pp. 553-564
    • Gazdar, A.F.1    Savage, T.K.2    Johnson, J.E.3
  • 38
    • 84896333670 scopus 로고    scopus 로고
    • Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
    • McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell. 2014; 156: 1298-1311.
    • (2014) Cell , vol.156 , pp. 1298-1311
    • McFadden, D.G.1    Papagiannakopoulos, T.2    Taylor-Weiner, A.3
  • 39
    • 84878115679 scopus 로고    scopus 로고
    • Mouse models of lung squamous cell carcinomas
    • You MS, Rouggly LC, You M, et al. Mouse models of lung squamous cell carcinomas. Cancer Metastasis Rev. 2013; 32: 77-82.
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 77-82
    • You, M.S.1    Rouggly, L.C.2    You, M.3
  • 40
    • 84876355029 scopus 로고    scopus 로고
    • The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas
    • Xiao Z, Jiang Q, Willette-Brown J, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell. 2013; 23: 527-540.
    • (2013) Cancer Cell , vol.23 , pp. 527-540
    • Xiao, Z.1    Jiang, Q.2    Willette-Brown, J.3
  • 41
    • 84900393562 scopus 로고    scopus 로고
    • Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PDL1 expression
    • Xu C, Fillmore CM, Koyama S, et al. Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PDL1 expression. Cancer Cell. 2014; 25: 590-604.
    • (2014) Cancer Cell , vol.25 , pp. 590-604
    • Xu, C.1    Fillmore, C.M.2    Koyama, S.3
  • 42
    • 84862908154 scopus 로고    scopus 로고
    • ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells
    • Liu X, Ory V, Chapman S, et al. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am J Pathol. 2012; 180: 599-607.
    • (2012) Am J Pathol , vol.180 , pp. 599-607
    • Liu, X.1    Ory, V.2    Chapman, S.3
  • 43
    • 84905819148 scopus 로고    scopus 로고
    • Tumorigenicity and genetic profiling of circulating tumor cells in smallcell lung cancer
    • Hodgkinson CL, Morrow CJ, Li Y, et al. Tumorigenicity and genetic profiling of circulating tumor cells in smallcell lung cancer. Nat Med. 2014; 20: 897-903.
    • (2014) Nat Med , vol.20 , pp. 897-903
    • Hodgkinson, C.L.1    Morrow, C.J.2    Li, Y.3
  • 44
    • 84874700631 scopus 로고    scopus 로고
    • Three-dimensional cell culture: The missing link in drug discovery
    • Breslin S, ODriscoll L. Three-dimensional cell culture: The missing link in drug discovery. Drug Discov Today. 2013; 18: 240-249.
    • (2013) Drug Discov Today , vol.18 , pp. 240-249
    • Breslin, S.1    Odriscoll, L.2
  • 45
    • 84870569410 scopus 로고    scopus 로고
    • Three-dimensional culture of human breast epithelial cells: The how and the why
    • Vidi PA, Bissell MJ, Lelievre SA. Three-dimensional culture of human breast epithelial cells: The how and the why. Methods Mol Biol. 2013; 945: 193-219.
    • (2013) Methods Mol Biol , vol.945 , pp. 193-219
    • Vidi, P.A.1    Bissell, M.J.2    Lelievre, S.A.3
  • 46
    • 84901749083 scopus 로고    scopus 로고
    • Advanced cell culture techniques for cancer drug discovery
    • Lovitt CJ, Shelper TB, Avery VM. Advanced cell culture techniques for cancer drug discovery. Biology (Basel). 2014; 3: 345-367.
    • (2014) Biology (Basel , vol.3 , pp. 345-367
    • Lovitt, C.J.1    Shelper, T.B.2    Avery, V.M.3
  • 47
    • 84873866902 scopus 로고    scopus 로고
    • Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation
    • Endo H, Okami J, Okuyama H, et al. Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation. J Thorac Oncol. 2013; 8: 131-139.
    • (2013) J Thorac Oncol , vol.8 , pp. 131-139
    • Endo, H.1    Okami, J.2    Okuyama, H.3
  • 48
    • 78649960144 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling
    • Sullivan JP, Spinola M, Dodge M, et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res. 2010; 70: 9937-9948.
    • (2010) Cancer Res , vol.70 , pp. 9937-9948
    • Sullivan, J.P.1    Spinola, M.2    Dodge, M.3
  • 49
    • 10844284696 scopus 로고    scopus 로고
    • Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    • Ramirez RD, Sheridan S, Girard L, et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 2004; 64: 9027-9034.
    • (2004) Cancer Res , vol.64 , pp. 9027-9034
    • Ramirez, R.D.1    Sheridan, S.2    Girard, L.3
  • 50
    • 84876207852 scopus 로고    scopus 로고
    • Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
    • Sato M, Larsen JE, Lee W, et al. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res. 2013; 11: 638-650.
    • (2013) Mol Cancer Res , vol.11 , pp. 638-650
    • Sato, M.1    Larsen, J.E.2    Lee, W.3
  • 51
    • 84886787846 scopus 로고    scopus 로고
    • Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer
    • Kim HS, Mendiratta S, Kim J, et al. Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013; 155: 552-566.
    • (2013) Cell , vol.155 , pp. 552-566
    • Kim, H.S.1    Mendiratta, S.2    Kim, J.3
  • 52
    • 84920867879 scopus 로고    scopus 로고
    • A mouse geneticists practical guide to CRISPR applications
    • Singh P, Schimenti JC, Bolcun-Filas E. A mouse geneticists practical guide to CRISPR applications. Genetics. 2015; 199: 1-15.
    • (2015) Genetics , vol.199 , pp. 1-15
    • Singh, P.1    Schimenti, J.C.2    Bolcun-Filas, E.3
  • 53
    • 84933277263 scopus 로고    scopus 로고
    • Applications of the CRISPRCas9 system in cancer biology
    • Sanchez-Rivera FJ, Jacks T. Applications of the CRISPRCas9 system in cancer biology. Nature Rev Cancer. 2015; 15: 387-395.
    • (2015) Nature Rev Cancer , vol.15 , pp. 387-395
    • Sanchez-Rivera, F.J.1    Jacks, T.2
  • 54
    • 84925008880 scopus 로고    scopus 로고
    • Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis
    • Chen S, Sanjana NE, Zheng K, et al. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015; 160: 1246-1260.
    • (2015) Cell , vol.160 , pp. 1246-1260
    • Chen, S.1    Sanjana, N.E.2    Zheng, K.3
  • 55
    • 34147198467 scopus 로고    scopus 로고
    • Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    • Whitehurst AW, Bodemann BO, Cardenas J, et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature. 2007; 446: 815-819.
    • (2007) Nature , vol.446 , pp. 815-819
    • Whitehurst, A.W.1    Bodemann, B.O.2    Cardenas, J.3
  • 56
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • Regales L, Gong Y, Shen R, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009; 119: 3000-3010.
    • (2009) J Clin Invest , vol.119 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3
  • 57
    • 0020038032 scopus 로고
    • Specific chromosome defect associated with human small-cell lung cancer deletion 3p 14-23
    • Whang-Peng J, Kao-Shan CS, Lee EC, et al. Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23). Science. 1982; 215: 181-182.
    • (1982) Science , vol.215 , pp. 181-182
    • Whang-Peng, J.1    Kao-Shan, C.S.2    Lee, E.C.3
  • 58
    • 0026334301 scopus 로고
    • Nonrandom structural and numerical chromosome changes in non-small-cell lung cancer
    • Whang-Peng J, Knutsen T, Gazdar A, et al. Nonrandom structural and numerical chromosome changes in non-small-cell lung cancer. Genes Chromosomes Cancer. 1991; 3: 168-188.
    • (1991) Genes Chromosomes Cancer , vol.3 , pp. 168-188
    • Whang-Peng, J.1    Knutsen, T.2    Gazdar, A.3
  • 59
    • 0035795676 scopus 로고    scopus 로고
    • Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
    • Burbee DG, Forgacs E, Zochbauer-Muller S, et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst. 2001; 93: 691-699.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 691-699
    • Burbee, D.G.1    Forgacs, E.2    Zochbauer-Muller, S.3
  • 60
    • 0037037787 scopus 로고    scopus 로고
    • Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
    • Zabarovsky ER, Lerman MI, Minna JD. Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene. 2002; 21: 6915-6935.
    • (2002) Oncogene , vol.21 , pp. 6915-6935
    • Zabarovsky, E.R.1    Lerman, M.I.2    Minna, J.D.3
  • 61
    • 0033918563 scopus 로고    scopus 로고
    • Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
    • Dammann R, Li C, Yoon JH, et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet. 2000; 25: 315-319.
    • (2000) Nat Genet , vol.25 , pp. 315-319
    • Dammann, R.1    Li, C.2    Yoon, J.H.3
  • 62
    • 0023686773 scopus 로고
    • Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
    • Harbour JW, Lai SL, Whang-Peng J, et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science. 1988; 241: 353-357.
    • (1988) Science , vol.241 , pp. 353-357
    • Harbour, J.W.1    Lai, S.L.2    Whang-Peng, J.3
  • 63
    • 0024452546 scopus 로고
    • P53: A frequent target for genetic abnormalities in lung cancer
    • Takahashi T, Nau MM, Chiba I, et al. p53: A frequent target for genetic abnormalities in lung cancer. Science. 1989; 246: 491-494.
    • (1989) Science , Issue.246 , pp. 491-494
    • Takahashi, T.1    Nau, M.M.2    Chiba, I.3
  • 64
    • 0021053735 scopus 로고
    • Amplification and expression of the c-myc oncogene in human lung cancer cell lines
    • Little CD, Nau MM, Carney DN, et al. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature. 1983; 306: 194-196.
    • (1983) Nature , vol.306 , pp. 194-196
    • Little, C.D.1    Nau, M.M.2    Carney, D.N.3
  • 65
    • 0022392771 scopus 로고
    • L-myc, a new mycrelated gene amplified and expressed in human small cell lung cancer
    • Nau MM, Brooks BJ, Battey J, et al. L-myc, a new mycrelated gene amplified and expressed in human small cell lung cancer. Nature. 1985; 318: 69-73.
    • (1985) Nature , vol.318 , pp. 69-73
    • Nau, M.M.1    Brooks, B.J.2    Battey, J.3
  • 66
    • 0023681795 scopus 로고
    • Myc family DNA amplification in small cell lung cancer patients tumors and corresponding cell lines
    • Johnson BE, Makuch RW, Simmons AD, et al. myc family DNA amplification in small cell lung cancer patients tumors and corresponding cell lines. Cancer Res. 1988; 48: 5163-5166.
    • (1988) Cancer Res , vol.48 , pp. 5163-5166
    • Johnson, B.E.1    Makuch, R.W.2    Simmons, A.D.3
  • 67
    • 20144386787 scopus 로고    scopus 로고
    • Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
    • Shigematsu H, Takahashi T, Nomura M, et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res. 2005; 65: 1642-1646.
    • (2005) Cancer Res , vol.65 , pp. 1642-1646
    • Shigematsu, H.1    Takahashi, T.2    Nomura, M.3
  • 68
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004; 304: 1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 69
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004; 304: 554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 70
    • 34250329445 scopus 로고    scopus 로고
    • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    • Vikis H, Sato M, James M, et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res. 2007; 67: 4665-4670.
    • (2007) Cancer Res , vol.67 , pp. 4665-4670
    • Vikis, H.1    Sato, M.2    James, M.3
  • 71
    • 78651260008 scopus 로고    scopus 로고
    • Discovery of selective irreversible inhibitors for EGFR-T790M
    • Zhou W, Ercan D, Janne PA, et al. Discovery of selective irreversible inhibitors for EGFR-T790M. Bioorg Med Chem Lett. 2011; 21: 638-643.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 638-643
    • Zhou, W.1    Ercan, D.2    Janne, P.A.3
  • 72
    • 84866709500 scopus 로고    scopus 로고
    • Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
    • Hammerman PS, Sos ML, Ramos AH, et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011; 1: 78-89.
    • (2011) Cancer Discov , vol.1 , pp. 78-89
    • Hammerman, P.S.1    Sos, M.L.2    Ramos, A.H.3


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