메뉴 건너뛰기




Volumn 6, Issue 9, 2016, Pages 949-952

Developing EZH2-targeted therapy for lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CPI 1205; GSK 2816126; TAZEMETOSTAT; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

EID: 85012024585     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-16-0800     Document Type: Article
Times cited : (24)

References (14)
  • 1
    • 85011961667 scopus 로고    scopus 로고
    • Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer
    • Zhang H, Qi J, Reyes JM, Li L, Rao PK, Li F, et al. Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer. Cancer Discov 2016;6:1006-21.
    • (2016) Cancer Discov , vol.6 , pp. 1006-1021
    • Zhang, H.1    Qi, J.2    Reyes, J.M.3    Li, L.4    Rao, P.K.5    Li, F.6
  • 3
    • 85000543831 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
    • Brooun A, Gajiwala KS, Deng YL, Liu W, Bolanos B, Bingham P, et al. Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat Commun 2016;7: 11384.
    • (2016) Nat Commun , vol.7 , pp. 11384
    • Brooun, A.1    Gajiwala, K.S.2    Deng, Y.L.3    Liu, W.4    Bolanos, B.5    Bingham, P.6
  • 4
    • 84945186017 scopus 로고    scopus 로고
    • Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
    • aac4383
    • Jiao L, Liu X. Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2. Science 2015;350:aac4383.
    • (2015) Science , vol.350
    • Jiao, L.1    Liu, X.2
  • 5
    • 85016328392 scopus 로고    scopus 로고
    • S tructural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
    • Justin N, Zhang Y, Tarricone C, Martin SR, Chen S, Underwood E, et al. S tructural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun 2016;7:11316.
    • (2016) Nat Commun , vol.7 , pp. 11316
    • Justin, N.1    Zhang, Y.2    Tarricone, C.3    Martin, S.R.4    Chen, S.5    Underwood, E.6
  • 6
    • 84885016465 scopus 로고    scopus 로고
    • Enzyme-dependent lysine deprotonation in EZH2 catalysis
    • Kipp DR, Quinn CM, Fortin PD. Enzyme-dependent lysine deprotonation in EZH2 catalysis. Biochemistry 2013;52:6866-78.
    • (2013) Biochemistry , vol.52 , pp. 6866-6878
    • Kipp, D.R.1    Quinn, C.M.2    Fortin, P.D.3
  • 7
    • 84962688557 scopus 로고    scopus 로고
    • Exploiting the epigenome to control cancer-promoting gene-expression programs
    • Brien GL, Valerio DG, Armstrong SA. Exploiting the epigenome to control cancer-promoting gene-expression programs. Cancer Cell 2016; 29: 464-76.
    • (2016) Cancer Cell , vol.29 , pp. 464-476
    • Brien, G.L.1    Valerio, D.G.2    Armstrong, S.A.3
  • 8
    • 84957555628 scopus 로고    scopus 로고
    • Targeting EZH2 in cancer
    • Kim KH, Roberts CW. Targeting EZH2 in cancer. Nat Med 2016;22: 128-34.
    • (2016) Nat Med , vol.22 , pp. 128-134
    • Kim, K.H.1    Roberts, C.W.2
  • 9
    • 84923899867 scopus 로고    scopus 로고
    • Selective inhibitors of protein methyl- transferases
    • Kaniskan HU, Konze KD, Jin J. Selective inhibitors of protein methyl- transferases. J Med Chem 2015;58:1596-629.
    • (2015) J Med Chem , vol.58 , pp. 1596-1629
    • Kaniskan, H.U.1    Konze, K.D.2    Jin, J.3
  • 10
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 2012;109:21360-5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3    Li, L.4    Chuai, S.5    Zhang, R.6
  • 11
    • 84959440141 scopus 로고    scopus 로고
    • The importance of being me: Magic methyls, methyltransferase inhibitors, and the discovery of tazemetostat
    • Kuntz KW, Campbell JE, Keilhack H, Pollock RM, Knutson SK, Porter-Scott M, et al. The importance of being me: magic methyls, methyltransferase inhibitors, and the discovery of tazemetostat. J Med Chem 2016;59:1556-64.
    • (2016) J Med Chem , vol.59 , pp. 1556-1564
    • Kuntz, K.W.1    Campbell, J.E.2    Keilhack, H.3    Pollock, R.M.4    Knutson, S.K.5    Porter-Scott, M.6
  • 12
    • 84994908511 scopus 로고    scopus 로고
    • Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
    • Morera L, Lubbert M, Jung M. Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy. Clin Epigenetics 2016;8:57.
    • (2016) Clin Epigenetics , vol.8 , pp. 57
    • Morera, L.1    Lubbert, M.2    Jung, M.3
  • 13
    • 85012032072 scopus 로고    scopus 로고
    • A phase 1, open-label study of GSK2816126, an enhancer of zeste homolog 2 (EZH2) inhibitor, in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), transformed follicular lymphoma (tFL), other non-Hodgkin’s lymphomas (NHL), multiple myeloma (MM) and solid tumor
    • Abstr TPS2595
    • Yap T. A phase 1, open-label study of GSK2816126, an enhancer of zeste homolog 2 (EZH2) inhibitor, in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), transformed follicular lymphoma (tFL), other non-Hodgkin’s lymphomas (NHL), multiple myeloma (MM) and solid tumor. J Clin Oncol 2016; 34: Abstr TPS2595.
    • (2016) J Clin Oncol , vol.34
    • Yap, T.1
  • 14
    • 84957441064 scopus 로고    scopus 로고
    • Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
    • Gibaja V, Shen F, Harari J, Korn J, Ruddy D, Saenz-Vash V, et al. Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors. Oncogene 2016;35:558-66.
    • (2016) Oncogene , vol.35 , pp. 558-566
    • Gibaja, V.1    Shen, F.2    Harari, J.3    Korn, J.4    Ruddy, D.5    Saenz-Vash, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.