Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial

European Journal of Nutrition

Volumn 57, Issue 3, 2018, Pages 1169-1180

  Miller, Marshall G ^a   Hamilton, Derek A ^b   Joseph, James A ^a   Shukitt Hale, Barbara ^a  

^a TUFTS UNIVERSITY   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Aging; Blueberry; Cognition; Gait; Postural Sway

Indexed keywords

ANTHOCYANIN; PLACEBO;

ADULT; AGED; ARTICLE; BLUEBERRY; CALIFORNIA VERBAL LEARNING TEST; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; EXECUTIVE FUNCTION; FEMALE; FREEZE DRYING; GAIT; HUMAN; LONG TERM MEMORY; MALE; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; SHORT TERM MEMORY; TREATMENT DURATION; BODY EQUILIBRIUM; COGNITIVE DEFECT; DIET THERAPY; FRUIT; FUNCTIONAL FOOD; GERIATRIC NUTRITION; MIDDLE AGED; NEUROLOGIC GAIT DISORDER; PATHOPHYSIOLOGY; PRESERVED FOOD; SENSORY DYSFUNCTION; SEVERITY OF ILLNESS INDEX;

AGED; BLUEBERRY PLANTS; COGNITION; COGNITIVE DYSFUNCTION; DOUBLE-BLIND METHOD; ELDER NUTRITIONAL PHYSIOLOGICAL PHENOMENA; EXECUTIVE FUNCTION; FEMALE; FOOD, PRESERVED; FREEZE DRYING; FRUIT; FUNCTIONAL FOOD; GAIT; GAIT DISORDERS, NEUROLOGIC; HUMANS; MALE; MIDDLE AGED; POSTURAL BALANCE; SENSATION DISORDERS; SEVERITY OF ILLNESS INDEX;

EID: 85014802279     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-017-1400-8     Document Type: Article

References (40)

1. Miller M, Shukitt-Hale B (2012) Berry fruit enhances beneficial signaling in the brain. J Agric Food Chem 60(23):5709–5715
2. Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D (2007) Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51(6):675–683
3. Huang W-Y, Liu Y-M, Wang J, Wang X-N, Li C-Y (2014) Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin-3-galactoside in endothelial cells. Molecules 19(8):12827–12841
4. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, Bickford PC (1999) Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. The Journal of Neuroscience 19(18):8114–8121
5. Morris RG (1981) Spatial localization does not require the presence of local cues. Learn Motiv 12(2):239–260
6. Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA (2005) Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 8(2):111–120
7. Shukitt-Hale B, Bielinski DF, Lau FC, Willis LM, Carey AN, Joseph JA (2015) The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. Br J Nutr 114(10):1542–1549
8. Kent K, Charlton K, Roodenrys S, Batterham M, Potter J, Traynor V, Gilbert H, Morgan O, Richards R (2015) Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. Eur J Nutr:1–9
9. Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA (2010) Blueberry supplementation improves memory in older adults†. J Agric Food Chem 58(7):3996–4000
10. Schrager MA, Hilton J, Gould R, Kelly VE (2015) Effects of blueberry supplementation on measures of functional mobility in older adults. Appl Physiol Nutr Metab 40(6):543–549
11. Miller MG, Hamilton DA, Joseph JA, Shukitt-Hale B (2014) Mobility and cognition: end points for dietary interventions in aging. Nutrition Aging 2(4):213–222
12. Laugero KD, Falcon LM, Tucker KL (2011) Relationship between perceived stress and dietary and activity patterns in older adults participating in the Boston Puerto Rican Health Study. Appetite 56(1):194–204
13. Paffenbarger RS Jr, Hyde RT, Wing AL, Lee I-M, Jung DL, Kampert JB (1993) The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 328(8):538–545
14. Yardley L, Beyer N, Hauer K, Kempen G, Piot-Ziegler C, Todd C (2005) Development and initial validation of the Falls Efficacy Scale-International (FES-I). Age Ageing 34(6):614–619
15. Rogers RD, Monsell S (1995) Costs of a predictible switch between simple cognitive tasks. J Exp Psychol Gen 124(2):207
16. Monsell S, Yeung N, Azuma R (2000) Reconfiguration of task-set: Is it easier to switch to the weaker task? Psychol Res 63(3–4):250–264
17. Monsell S, Sumner P, Waters H (2003) Task-set reconfiguration with predictable and unpredictable task switches. Mem Cognit 31(3):327–342
18. Department W (1944) Army Individual Test Battery: Manual of Directions and Scoring. Washington, D.C
19. Delis DC, Kramer J, Kaplan E, Ober BA (2000) CVLT-II: California verbal learning test: adult version. Psychological Corporation
20. Wechsler D (1945) A standardized memory scale for clinical use. J Psychol 19(1):87–95
21. Wechsler D (1955) Wechsler adult intelligence scale: Manual. Psychological Corporation
22. Hamilton DA, Johnson TE, Redhead ES, Verney SP (2009) Control of rodent and human spatial navigation by room and apparatus cues. Behav Processes 81(2):154–169
23. Jacobs WJ, Laurance HE, Thomas KG (1997) Place learning in virtual space I: Acquisition, overshadowing, and transfer. Learn Motiv 28(4):521–541
24. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI (2002) Testing the efficiency and independence of attentional networks. J Cogn Neurosci 14(3):340–347
25. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1983) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17(1):37–49
26. McNair D, Lorr M, Droppleman L (1992) Revised manual for the Profile of Mood States. Educational and Industrial Testing Services, San Diego, CA 731:732–733
27. Lacritz LH, Cullum CM (1998) The hopkins verbal learning test and CVLT: a preliminary comparison. Arch Clin Neuropsychol 13(7):623–628
28. Lacritz LH, Cullum CM, Weiner MF, Rosenberg RN (2001) Comparison of the hopkins verbal learning test-revised to the California verbal learning test in Alzheimer’s disease. Appl Neuropsychol 8(3):180–184
29. Kaltreider LB, Cullum CM, Lacritz LH, Brewer K, Filley CM (1999) Brief Recall tasks and memory assessment in Alzheimer’s disease. Appl Neuropsychol 6(3):165–169
30. Vanderploeg RD, Schinka JA, Retzlaff P (1994) Relationships between measures of auditory verbal learning and executive functioning. J Clin Exp Neuropsychol 16(2):243–252
31. Tremont G, Halpert S, Javorsky DJ, Stern RA (2000) Differential impact of executive dysfunction on verbal list learning and story recall. Clin Neuropsychol 14(3):295–302
32. Hill BD, Alosco M, Bauer L, Tremont G (2012) The relation of executive functioning to CVLT-II learning, memory, and process indexes. Appl Neuropsychol Adult 19(3):198–206
33. Alexander M, Stuss D, Fansabedian N (2003) California Verbal Learning Test: performance by patients with focal frontal and non-frontal lesions. Brain 126(6):1493–1503
34. Stuss DT, Alexander MP, Palumbo CL, Buckle L, Sayer L, Pogue J (1994) Organizational strategies with unilateral or bilateral frontal lobe injury in word learning tasks. Neuropsychology 8(3):355
35. Brickman AM, Buchsbaum MS, Shihabuddin L, Hazlett EA, Borod JC, Mohs RC (2003) Striatal size, glucose metabolic rate, and verbal learning in normal aging. Cognitive Brain Res 17(1):106–116
36. Wasylyshyn C, Verhaeghen P, Sliwinski MJ (2011) Aging and task switching: a meta-analysis. Psychol Aging 26(1):15
37. Reimers S, Maylor EA (2005) Task switching across the life span: effects of age on general and specific switch costs. Dev Psychol 41(4):661
38. Dove A, Pollmann S, Schubert T, Wiggins CJ, von Cramon DY (2000) Prefrontal cortex activation in task switching: an event-related fMRI study. Cognitive Brain Res 9(1):103–109
39. Sohn M-H, Ursu S, Anderson JR, Stenger VA, Carter CS (2000) The role of prefrontal cortex and posterior parietal cortex in task switching. Proc Natl Acad Sci 97(24):13448–13453
40. Öberg T, Karsznia A, Öberg K (1993) Basic gait parameters: reference data for normal subjects, 10–79 years of age. J Rehabil Res Dev 30:210–210