Hippocampus as a mediator of the role of Vitamin B-12 in memory

American Journal of Clinical Nutrition

Volumn 103, Issue 4, 2016, Pages 959-960

  Smith, A David ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; HOMOCYSTEINE;

BRAIN ATROPHY; BRAIN DAMAGE; COGNITION ASSESSMENT; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; DENTATE GYRUS; DIFFUSION TENSOR IMAGING; DNA REPLICATION; EDITORIAL; ENTORHINAL CORTEX; GRAY MATTER; HIPPOCAMPUS; HUMAN; MEMORY; MEMORY DISORDER; MEMORY TEST; NERVOUS SYSTEM DEVELOPMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PERNICIOUS ANEMIA; VITAMIN SUPPLEMENTATION; BLOOD; DRUG EFFECTS; FEMALE; MALE; MILD COGNITIVE IMPAIRMENT;

FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMORY; MILD COGNITIVE IMPAIRMENT; VITAMIN B 12;

EID: 84962738842     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.116.132266     Document Type: Editorial

References (16)

1. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720-8.
2. Kalita J, Misra UK. Benefit of vitamin B-12 supplementation in asymptomatic elderly: A matter of endpoints. Am J Clin Nutr 2015;102:529-30.
3. Smith AD, Refsum H. Vitamin B-12 and cognition in the elderly. Am J Clin Nutr 2009;89(Suppl):707S-11S.
4. Smith AD, Refsum H. Do we need to reconsider the desirable blood level of vitamin B12? J Intern Med 2012;271:179-82.
5. Vogiatzoglou A, Smith AD, Nurk E, Drevon CA, Ueland PM, Vollset SE, Nygaard HA, Engedal K, Tell GS, Refsum H. Cognitive function in an elderly population: Interaction between vitamin B12 status, depression, and apolipoprotein E E4: The Hordaland Homocysteine Study. Psychosom Med 2013;75:20-9.
6. Selhub J, Rosenberg IH. Excessive folic acid intake and relation to adverse health outcome. Biochimie. In press.
7. Oulhaj A, Jernerén F, Refsum H, Smith AD, De Jager CA. Omega-3 fatty acid status enhances the prevention of cognitive decline by B vitamins in mild cognitive impairment. J Alzheimer's Dis 2016;50(2):547-57.
8. De Lau LM, Smith AD, Refsum H, Johnston C, Breteler MM. Plasma vitamin B12 status and cerebral white matter lesions. J Neurol Neurosurg Psychiatry 2009;80:149-57.
9. Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, De Jager C, Budge MM, Smith AD. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology 2008;71:826-32.
10. Hooshmand B, Mangialasche F, Kalpouzos G, Solomon A, K°areholt I, Smith AD, Refsum H, Wang R, Mühlmann M, Ertl-Wagner B, et al. Vitamin B12, folate and sulfur amino acids in relation to brain MRI measures: A longitudinal population-based study. JAMA Psychiatry. In press.
11. Köbe T, Witte AV, Schnelle A, Grittner U, Tesky VA, Pantel J, Schuchardt JP, Hahn A, Bohlken J, Rujescu D, et al. Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment. Am J Clin Nutr 2016;103:1045-54.
12. Bartsch T, Wulff P. The hippocampus in aging and disease: From plasticity to vulnerability. Neuroscience 2015;309:1-16.
13. Rogalski EJ, Murphy CM, deToledo-Morrell L, Shah RC, Moseley ME, Bammer R, Stebbins GT. Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: A diffusion tensor imaging study. Behav Neurol 2009;21:51-61.
14. Smith AD, Refsum H. Homocysteine, B vitamins and cognitive impairment. Annu Rev Nutr. In press.
15. Gupta PK, Garg RK, Gupta RK, Malhotra HS, Paliwal VK, Rathore RK, Verma R, Singh MK, Rai Y, Pandey CM. Diffusion tensor tractography and neuropsychological assessment in patients with vitamin B12 deficiency. Neuroradiology 2014;56:97-106.
16. Douaud G, Refsum H, De Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci USA 2013;110:9523-8.