Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects

British Journal of Nutrition

Volumn 110, Issue 3, 2013, Pages 420-425

  Reyes Izquierdo, Tania ^a   Nemzer, Boris ^b   Shu, Cynthia ^a   Huynh, Lan ^a   Argumedo, Ruby ^a   Keller, Robert ^c   Pietrzkowski, Zb ^a  

^a Applied BioClinical Inc   (United States)

^b FutureCeuticals Inc   (United States)

^c NutraClinical Inc   (United States)

Author keywords

Brain derived growth factor; Caffeine; Coffee fruit extract; Polyphenols; Procyanidins

Indexed keywords

3,4 O ICAFFEOYLQUINIC ACID; 3,5 O DICAFFEOYLQUINIC ACID; 4 FERULOYLQUINIC ACID; 4 O CAFFEOYL 5 O FEOYLQUINIC; 4,5 O DICAFFEOYLQUINIC ACID; 5 FERULOYLQUINIC ACID; 5 O CAFFEOYLQUINIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CAFFEINE DERIVATIVE; CATECHIN; CHLOROGENIC ACID; COFFEE FRUIT EXTRACT; EPICATECHIN; GRAPE SEED EXTRACT; GREEN COFFEE BEAN EXTRACT; GREEN COFFEE CAFFEINE; NATURAL PRODUCT; PLACEBO; POLYPHENOL DERIVATIVE; PROCYANIDIN DIMMER B2; PROCYANIDIN TETRAMER B2; PROCYANIDIN TRIMER B2; RUTOSIDE; TRIGONELLINE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR BLOOD LEVEL; COFFEE; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; FRUIT; NONHUMAN; PILOT STUDY; POWDER; PROTEIN BLOOD LEVEL; SINGLE DRUG DOSE; WHOLE COFFEE FRUIT CONCENTRATE POWDER;

BRAIN-DERIVED NEUROTROPHIC FACTOR; CAFFEINE; COFFEA; FRUIT; HUMANS; PLANT EXTRACTS; SEEDS; SILICON DIOXIDE; VITIS;

EID: 84880782055     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512005338     Document Type: Article

References (53)

1. Fujinami A, Ohta K, Obayashi H, et al. (2008) Serum brainderived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance. Clin Biochem 41, 812-817.
2. Jones KR & Reichardt LF (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci USA 87, 8060-8064.
3. Maisonpierre PC, Le Beau MM, Espinosa R III, et al. (1991) Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 10, 558-568.
4. Tessarollo L (1998) Pleiotropic functions of neurotrophins in development. Cytokine Growth Factor Rev 9, 125-137.
5. Yamamoto M, Sobue G, Yamamoto K, et al. (1996) Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res 21, 929-938.
6. Cunha C, Angelucci A, D'Antoni A, et al. (2009) Brainderived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiol Dis 33, 358-368.
7. Cunha C, Brambilla R & Thomas KL (2010) A simple role for BDNF in learning and memory? Front Mol Neurosci 3, 1.
8. Grothe C & Unsicker K (1987) Neuron-enriched cultures of adult rat dorsal root ganglia: establishment, characterization, survival, and neuropeptide expression in response to trophic factors. J Neurosci Res 18, 539-550.
9. Kalcheim C & Gendreau M (1988) Brain-derived neurotrophic factor stimulates survival and neuronal differentiation in cultured avian neural crest. Brain Res 469, 79-86.
10. Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77, 627-638.
11. Boulanger LM & Poo MM (1999) Presynaptic depolarization facilitates neurotrophin-induced synaptic potentiation. Nat Neurosci 2, 346-351.
12. Li W & Keifer J (2008) Coordinate action of pre-and postsynaptic brain-derived neurotrophic factor is required for AMPAR trafficking and acquisition of in vitro classical conditioning. Neuroscience 155, 686-697.
13. Tanaka J, Horiike Y, Matsuzaki M, et al. (2008) Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science (New York, NY) 319, 1683-1687.
14. Han BH & Holtzman DM (2000) BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 20, 5775-5781.
15. Bifrare Y-D, Kummer J, Joss P, et al. (2005) Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis. J Infect Dis 191, 40-45.
16. Brunoni AR, Lopes M & Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11, 1169-1180.
17. Dwivedi Y (2009) Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat 5, 433-449.
18. Maina G, Rosso G, Zanardini R, et al. (2010) Serum levels of brain-derived neurotrophic factor in drug-naive obsessivecompulsive patients: a case-control study. J Affect Disord 122, 174-178.
19. Zuccato C & Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5, 311-322.
20. Arancio O & Chao MV (2007) Neurotrophins, synaptic plasticity and dementia. Curr Opin Neurobiol 17, 325-330.
21. Fumagalli F, Racagni G & Riva MA (2006) Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease. Pharmacogenomics J 6, 95-104.
22. Chun HS, Son JJ & Son JH (2000) Identification of potential compounds promoting BDNF production in nigral dopaminergic neurons: clinical implication in Parkinson's disease. Neuroreport 11, 511-514.
23. Seifer DB, Feng B, Shelden RM, et al. (2002) Brain-derived neurotrophic factor: a novel human ovarian follicular protein. J Clin Endocrinol Metab 87, 655-659.
24. Pan W, Banks WA, Fasold MB, et al. (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37, 1553-1561.
25. Kramer AF, Colcombe SJ, McAuley E, et al. (2005) Fitness, aging and neurocognitive function. Neurobiol Aging 26, Suppl. 1, 124-127.
26. Colcombe SJ, Kramer AF, McAuley E, et al. (2004) Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci 24, 9-14.
27. Kramer AF, Hahn S, Cohen NJ, et al. (1999) Ageing, fitness and neurocognitive function. Nature 400, 418-419.
28. Connolly SK & Tamy (2010) Caffeine modulates CREBdependent gene expression in developing cortical neurons. Biochem Biophys Res Commun 397, 152-156.
29. Costa MS, Botton PH, Mioranzza S, et al. (2008) Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochem Int 53, 89-94.
30. Alhaider IA, Aleisa AM, Tran TT, et al. (2011) Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. Mol Cell Neurosci 46, 742-751.
31. Heimbach JT, Marone PA, Hunter JM, et al. (2010) Safety studies on products from whole coffee fruit. Food Chem Toxicol 48, 2517-2525.
32. Yashin YI, Nemzer BV, Ryzhnev VY, et al. (2010) Creation of a databank for content of antioxidants in food products by an amperometric method. Molecules 15, 7450-7466.
33. Borecki IB, Higgins M, Schreiner PJ, et al. (1998) Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. Obes Res 6, 107-114.
34. Zolodz JAPA, Majerczak K, Grandys M, et al. (2008) Endurance training increases brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol S17, 59, 199-132.
35. Piccini A, Marazziti D, Del Debbio A, et al. (2008) Diurnal variation of plasma brain-derived neurotrophic growth factor (BDNF) in humans. Chronobiol Int 25, 819-826.
36. Mullen W, Nemzer B, Ou B, et al. (2011) The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. J Agric Food Chem 59, 3754-3762.
37. International Organization for Standardization (ISO) (2005) Determination of Substances Characteristic of Green and Black Tea. Part 1: Content of Total Polyphenols in Tea-Colorimetric Method Using Folin-Ciocalteu Reagent. Geneva: ISO. ISO 14502-1.
38. Chung HY, Choi HR, Park HJ, et al. (2001) Peroxynitrite scavenging and cytoprotective activity of 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether from the marine alga Symphyocladia latiuscula. J Agric Food Chem 49, 3614-3621.
39. Huang D, Ou B, Hampsch-Woodill M, et al. (2002) Highthroughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem 50, 4437-4444.
40. Ou B, Hampsch-Woodill M, Flanagan J, et al. (2002) Novel fluorometric assay for hydroxyl radical prevention capacity using fluorescein as the probe. J Agric Food Chem 50, 2772-2777.
41. Zhang L, Huang D, Kondo M, et al. (2009) Novel highthroughput assay for antioxidant capacity against superoxide anion. J Agric Food Chem 57, 2661-2667.
42. Elzinga BM, Molendijk ML, Oude Voshaar RC, et al. (2011) The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. Psychopharmacology 214, 319-328.
43. Larsen MH, Mikkelsen JD, Hay-Schmidt A, et al. (2010) Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment. J Psychiatr Res 44, 808-816.
44. Advani T, Koek W & Hensler JG (2009) Gender differences in the enhanced vulnerability of BDNF \+/2 mice to mild stress. Int J Neuropsychopharmacol 12, 583-588.
45. Capiotti KM, Menezes FP, Nazario LR, et al. (2011) Early exposure to caffeine affects gene expression of adenosine receptors, DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish (Danio rerio). Neurotoxicol Teratol 33, 680-685.
46. Bairam A, Kinkead R, Lajeunesse Y, et al. (2010) Neonatal caffeine treatment does not induce long-term consequences on TrkB receptors or BDNF expression in chemosensory organs of adult rats. Neurosci Lett 468, 292-296.
47. Xu J, Rong S, Xie B, et al. (2010) Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod. J Gerontol 65, 933-940.
48. Fraga CG & Oteiza PI (2011) Dietary flavonoids: role of (2)-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med 51, 813-823.
49. Terra X, Pallares V, Ardevol A, et al. (2011) Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J Nutr Biochem 22, 380-387.
50. Narita K, Hisamoto M, Okuda T, et al. (2011) Differential neuroprotective activity of two different grape seed extracts. PloS one 6, e14575.
51. Fu W, Lu C & Mattson MP (2002) Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. J Neurosci 22, 10, 710-719.
52. Niu C (2010) The neuroprotective signaling mechanisms of telomerase via the induction by brain-derived neurotrophic factor (BDNF) in nervous system injury. Postgraduate Thesis, University of Hong Kong.
53. Wang CCLT, Liao WC, Yuan SC, et al. (2009) Cigarette smoking and cognitive impairment: a 10 year cohort study in Taiwan. Arch Gerontol Geriatr 1, 143-148.