Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase

Journal of Neuroscience

Volumn 28, Issue 28, 2008, Pages 7219-7230

  Kronenberg, Golo ^a   Harms, Christoph ^a   Sobol, Robert W ^b,c,d   Cardozo Pelaez, Fernando ^e   Linhart, Heinz ^f   Winter, Benjamin ^a   Balkaya, Mustafa ^a   Gertz, Karen ^a   Gay, Shanna B ^c   Cox, David ^e   Eckart, Sarah ^a   Ahmadi, Michael ^a   Juckel, Georg ^g   Kempermann, Gerd ^a,h   Hellweg, Rainer ^a   Sohr, Reinhard ^a   Hörtnagl, Heide ^a   Wilson, Samuel H ^d   Jaenisch, Rudolf ^f   Endres, Matthias ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e UNIVERSITY OF MONTANA   (United States)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^g RUHR UNIVERSITY BOCHUM   (Germany)

^h MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Base excision repair; Despair; Folate deficiency; Memory impairment; Neurodegeneration; Neurogenesis

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FOLIC ACID; GLUTATHIONE; HOMOCYSTEINE; URACIL; URACIL DNA GLYCOSIDASE; 2'-DEOXYURIDYLIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DEOXYURIDINE PHOSPHATE; METHIONINE;

ANIMAL CELL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN DISEASE; CELL DEATH; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DEPRESSION; EMBRYO; ENZYME DEFICIENCY; FOLIC ACID DEFICIENCY; GENOTYPE; HIPPOCAMPUS; HOPELESSNESS; MENTAL DISEASE; MONOAMINE METABOLISM; MONOAMINE NERVE CELL; MOOD DISORDER; MOUSE; MUTATION RATE; NERVE CELL CULTURE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; STROKE; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; BLOOD; BRAIN CORTEX; CELL CULTURE; CULTURE TECHNIQUE; CYTOLOGY; EMBRYO (ANATOMY); EXPLORATORY BEHAVIOR; MAZE TEST; METABOLISM; METHODOLOGY; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SWIMMING;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN DISEASES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CEREBRAL CORTEX; DEOXYURACIL NUCLEOTIDES; EMBRYO, MAMMALIAN; EXPLORATORY BEHAVIOR; FOLIC ACID DEFICIENCY; GLUTATHIONE; HIPPOCAMPUS; HOMOCYSTEINE; MAZE LEARNING; METHIONINE; MICE; NERVE DEGENERATION; NEURONS; NEUROTRANSMITTER AGENTS; SWIMMING; URACIL-DNA GLYCOSIDASE;

EID: 49049119125     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0940-08.2008     Document Type: Article

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