SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

Science

Volumn 358, Issue 6364, 2017, Pages 813-818

  Gu, Xin ^a,b   Orozco, Jose M ^a,b   Saxton, Robert A ^a,b   Condon, Kendall J ^a,b   Liu, Grace Y ^a,b   Krawczyk, Patrycja A ^a,b   Scaria, Sonia M ^a,b   Wade Harper, J ^c   Gygi, Steven P ^c   Sabatini, David M ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5 METHYLTHIOADENOSINE; ADENOSINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ARGININE; DEPDC5 PROTEIN; GATOR1 PROTEIN; GATOR2 PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HOMOCYSTEINE; ISOLEUCINE; KAPTIN PROTEIN; KICSTOR PROTEIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; METHIONYL AMINOPEPTIDASE 2; METHYLTRANSFERASE; NPRL3 PROTEIN; PEPTIDES AND PROTEINS; RAGA PROTEIN; RAGB PROTEIN; RAPTOR PROTEIN; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; S6 KINASE; SAMTOR PROTEIN; SZT2 PROTEIN; UNCLASSIFIED DRUG; WDR24 PROTEIN; WDR59 PROTEIN;

CELLS AND CELL COMPONENTS; ENVIRONMENTAL CUE; ENZYME; ENZYME ACTIVITY; METABOLISM; PROTEIN; SENSOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBON METABOLISM; CONTROLLED STUDY; DISSOCIATION CONSTANT; EPISTASIS; GENE DISRUPTION; GENE OVEREXPRESSION; HEK293T CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STABLE EXPRESSION; ENZYMOLOGY; HEK293 CELL LINE; LYSOSOME; METABOLISM; PROTEIN DOMAIN;

HEK293 CELLS; HUMANS; LYSOSOMES; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN DOMAINS; PROTEIN INTERACTION MAPS; S-ADENOSYLMETHIONINE; SIGNAL TRANSDUCTION;

EID: 85033482466     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aao3265     Document Type: Article

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