-
1
-
-
33746302753
-
Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
-
Malloy VL, Krajcik RA, Bailey SJ, Hristopoulos G, Plummer JD, Orentreich N. Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell 2006;5:305-314
-
(2006)
Aging Cell
, vol.5
, pp. 305-314
-
-
Malloy, V.L.1
Krajcik, R.A.2
Bailey, S.J.3
Hristopoulos, G.4
Plummer, J.D.5
Orentreich, N.6
-
2
-
-
77956678381
-
Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states
-
Hasek BE, Stewart LK, Henagan TM, et al. Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Am J Physiol Regul Integr Comp Physiol 2010;299:R728-R739
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.299
, pp. R728-R739
-
-
Hasek, B.E.1
Stewart, L.K.2
Henagan, T.M.3
-
3
-
-
77956674231
-
Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction
-
Plaisance EP, Henagan TM, Echlin H, et al. Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction. Am J Physiol Regul Integr Comp Physiol 2010;299:R740-R750
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.299
, pp. R740-R750
-
-
Plaisance, E.P.1
Henagan, T.M.2
Echlin, H.3
-
4
-
-
84891516963
-
Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats
-
Hasek BE, Boudreau A, Shin J, et al. Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes 2013;62:3362-3372
-
(2013)
Diabetes
, vol.62
, pp. 3362-3372
-
-
Hasek, B.E.1
Boudreau, A.2
Shin, J.3
-
5
-
-
77952852503
-
Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats
-
Perrone CE, Mattocks DA, Jarvis-Morar M, Plummer JD, Orentreich N. Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats. Metabolism 2010;59:1000-1011
-
(2010)
Metabolism
, vol.59
, pp. 1000-1011
-
-
Perrone, C.E.1
Mattocks, D.A.2
Jarvis-Morar, M.3
Plummer, J.D.4
Orentreich, N.5
-
6
-
-
38049141111
-
Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue
-
Perrone CE, Mattocks DA, Hristopoulos G, Plummer JD, Krajcik RA, Orentreich N. Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue. J Lipid Res 2008;49:12-23
-
(2008)
J Lipid Res
, vol.49
, pp. 12-23
-
-
Perrone, C.E.1
Mattocks, D.A.2
Hristopoulos, G.3
Plummer, J.D.4
Krajcik, R.A.5
Orentreich, N.6
-
7
-
-
0033962298
-
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha
-
Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 2000;154:787-801
-
(2000)
Genetics
, vol.154
, pp. 787-801
-
-
Sood, R.1
Porter, A.C.2
Olsen, D.A.3
Cavener, D.R.4
Wek, R.C.5
-
8
-
-
80054689381
-
Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity
-
Visweswaraiah J, Lageix S, Castilho BA, et al. Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem 2011;286:36568-36579
-
(2011)
J Biol Chem
, vol.286
, pp. 36568-36579
-
-
Visweswaraiah, J.1
Lageix, S.2
Castilho, B.A.3
-
9
-
-
70350539531
-
Atf4 regulates obesity, glucose homeostasis, and energy expenditure
-
Seo J, Fortuno ES 3rd, Suh JM, et al. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes 2009;58:2565-2573
-
(2009)
Diabetes
, vol.58
, pp. 2565-2573
-
-
Seo, J.1
Fortuno, E.S.2
Suh, J.M.3
-
10
-
-
70349226800
-
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
-
Yoshizawa T, Hinoi E, Jung DY, et al. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 2009;119:2807-2817
-
(2009)
J Clin Invest
, vol.119
, pp. 2807-2817
-
-
Yoshizawa, T.1
Hinoi, E.2
Jung, D.Y.3
-
11
-
-
84858311217
-
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
-
De Sousa-Coelho AL, Marrero PF, Haro D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J 2012;443:165-171
-
(2012)
Biochem J
, vol.443
, pp. 165-171
-
-
De Sousa-Coelho, A.L.1
Marrero, P.F.2
Haro, D.3
-
12
-
-
72049124015
-
ATF4-dependent transcription mediates signaling of amino acid limitation
-
Kilberg MS, Shan J, Su N. ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab 2009;20:436-443
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 436-443
-
-
Kilberg, M.S.1
Shan, J.2
Su, N.3
-
13
-
-
20144374658
-
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
-
Hao S, Sharp JW, Ross-Inta CM, et al. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 2005;307:1776-1778
-
(2005)
Science
, vol.307
, pp. 1776-1778
-
-
Hao, S.1
Sharp, J.W.2
Ross-Inta, C.M.3
-
14
-
-
84871919301
-
Detection of amino acid deprivation in the central nervous system
-
Anthony TG, Gietzen DW. Detection of amino acid deprivation in the central nervous system. Curr Opin Clin Nutr Metab Care 2013;16:96-101
-
(2013)
Curr Opin Clin Nutr Metab Care
, vol.16
, pp. 96-101
-
-
Anthony, T.G.1
Gietzen, D.W.2
-
15
-
-
33846602706
-
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
-
Guo F, Cavener DR. The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab 2007;5:103-114
-
(2007)
Cell Metab
, vol.5
, pp. 103-114
-
-
Guo, F.1
Cavener, D.R.2
-
16
-
-
4344650113
-
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2
-
Anthony TG, McDaniel BJ, Byerley RL, et al. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem 2004;279:36553-36561
-
(2004)
J Biol Chem
, vol.279
, pp. 36553-36561
-
-
Anthony, T.G.1
McDaniel, B.J.2
Byerley, R.L.3
-
17
-
-
84891693313
-
Remodeling of lipid metabolism by dietary restriction of essential amino acids
-
Anthony TG, Morrison CD, Gettys TW. Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes 2013;62:2635-2644
-
(2013)
Diabetes
, vol.62
, pp. 2635-2644
-
-
Anthony, T.G.1
Morrison, C.D.2
Gettys, T.W.3
-
18
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
Harding HP, Zhang Y, Zeng H, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003;11:619-633
-
(2003)
Mol Cell
, vol.11
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
-
20
-
-
68849087185
-
Jefferson LS. EIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver
-
Dang Do AN, Kimball SR, Cavener DR, Jefferson LS. eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics 2009;38:328-341
-
(2009)
Physiol Genomics
, vol.38
, pp. 328-341
-
-
Dang Do, A.N.1
Kimball, S.R.2
Cavener, D.R.3
-
21
-
-
32544446451
-
Coping with stress: eIF2 kinases and translational control
-
Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 2006;34:7-11
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 7-11
-
-
Wek, R.C.1
Jiang, H.Y.2
Anthony, T.G.3
-
22
-
-
84938746309
-
ERK2 mediates metabolic stress response to regulate cell fate
-
Shin S, Buel GR, Wolgamott L, et al. ERK2 mediates metabolic stress response to regulate cell fate. Mol Cell 2015;59:382-398
-
(2015)
Mol Cell
, vol.59
, pp. 382-398
-
-
Shin, S.1
Buel, G.R.2
Wolgamott, L.3
-
23
-
-
28644441875
-
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway
-
Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA. PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell 2005;16:5493-5501
-
(2005)
Mol Biol Cell
, vol.16
, pp. 5493-5501
-
-
Hamanaka, R.B.1
Bennett, B.S.2
Cullinan, S.B.3
Diehl, J.A.4
-
24
-
-
73949120145
-
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation
-
Liu Y, László C, Liu Y, et al. Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation. Neoplasia 2010;12:61-68
-
(2010)
Neoplasia
, vol.12
, pp. 61-68
-
-
Liu, Y.1
László, C.2
Liu, Y.3
-
25
-
-
84892646801
-
Unfolded protein response signaling and metabolic diseases
-
Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem 2014;289:1203-1211
-
(2014)
J Biol Chem
, vol.289
, pp. 1203-1211
-
-
Lee, J.1
Ozcan, U.2
-
26
-
-
84907015381
-
FGF21 is an endocrine signal of protein restriction
-
Laeger T, Henagan TM, Albarado DC, et al. FGF21 is an endocrine signal of protein restriction. J Clin Invest 2014;124:3913-3922
-
(2014)
J Clin Invest
, vol.124
, pp. 3913-3922
-
-
Laeger, T.1
Henagan, T.M.2
Albarado, D.C.3
-
27
-
-
84908610776
-
Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice
-
Stone KP, Wanders D, Orgeron M, Cortez CC, Gettys TW. Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes 2014;63:3721-3733
-
(2014)
Diabetes
, vol.63
, pp. 3721-3733
-
-
Stone, K.P.1
Wanders, D.2
Orgeron, M.3
Cortez, C.C.4
Gettys, T.W.5
-
28
-
-
33644778829
-
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
-
Ayala JE, Bracy DP, McGuinness OP, Wasserman DH. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes 2006;55:390-397
-
(2006)
Diabetes
, vol.55
, pp. 390-397
-
-
Ayala, J.E.1
Bracy, D.P.2
McGuinness, O.P.3
Wasserman, D.H.4
-
29
-
-
36048985768
-
Mechanisms of food intake repression in indispensable amino acid deficiency
-
Gietzen DW, Hao S, Anthony TG. Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr 2007;27:63-78
-
(2007)
Annu Rev Nutr
, vol.27
, pp. 63-78
-
-
Gietzen, D.W.1
Hao, S.2
Anthony, T.G.3
-
30
-
-
1842583027
-
Phosphorylation of eIF2alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats
-
Gietzen DW, Ross CM, Hao S, Sharp JW. Phosphorylation of eIF2alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats. J Nutr 2004;134:717-723
-
(2004)
J Nutr
, vol.134
, pp. 717-723
-
-
Gietzen, D.W.1
Ross, C.M.2
Hao, S.3
Sharp, J.W.4
-
31
-
-
84873518501
-
Adaptive thermogenesis in adipocytes: Is beige the new brown?
-
Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev 2013;27:234-250
-
(2013)
Genes Dev
, vol.27
, pp. 234-250
-
-
Wu, J.1
Cohen, P.2
Spiegelman, B.M.3
-
32
-
-
84933556258
-
UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity
-
Wanders D, Burk DH, Cortez CC, et al. UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity. FASEB J 2015;29:2603-2615
-
(2015)
FASEB J
, vol.29
, pp. 2603-2615
-
-
Wanders, D.1
Burk, D.H.2
Cortez, C.C.3
-
33
-
-
84922918736
-
GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment
-
Wilson GJ, Lennox BA, She P, et al. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab 2015;308:E283-E293
-
(2015)
Am J Physiol Endocrinol Metab
, vol.308
, pp. E283-E293
-
-
Wilson, G.J.1
Lennox, B.A.2
She, P.3
-
34
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 2008;149:6018-6027
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
Bina, H.A.2
Schneider, M.A.3
-
35
-
-
77954277205
-
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
-
Sarruf DA, Thaler JP, Morton GJ, et al. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 2010;59:1817-1824
-
(2010)
Diabetes
, vol.59
, pp. 1817-1824
-
-
Sarruf, D.A.1
Thaler, J.P.2
Morton, G.J.3
-
36
-
-
84908018672
-
FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
-
Owen BM, Ding X, Morgan DA, et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab 2014;20:670-677
-
(2014)
Cell Metab
, vol.20
, pp. 670-677
-
-
Owen, B.M.1
Ding, X.2
Morgan, D.A.3
-
37
-
-
84901196741
-
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice
-
Xiao F, Yu J, Guo Y, et al. Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice. Metabolism 2014;63:841-850
-
(2014)
Metabolism
, vol.63
, pp. 841-850
-
-
Xiao, F.1
Yu, J.2
Guo, Y.3
-
38
-
-
79952374033
-
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
-
Xiao F, Huang Z, Li H, et al. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes 2011;60:746-756
-
(2011)
Diabetes
, vol.60
, pp. 746-756
-
-
Xiao, F.1
Huang, Z.2
Li, H.3
-
39
-
-
0036771638
-
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice
-
Zhang P, McGrath BC, Reinert J, et al. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 2002;22:6681-6688
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6681-6688
-
-
Zhang, P.1
McGrath, B.C.2
Reinert, J.3
-
40
-
-
70549094335
-
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase
-
Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem 2009;284:32742-32749
-
(2009)
J Biol Chem
, vol.284
, pp. 32742-32749
-
-
Bunpo, P.1
Dudley, A.2
Cundiff, J.K.3
Cavener, D.R.4
Wek, R.C.5
Anthony, T.G.6
-
41
-
-
2442542312
-
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
-
Cullinan SB, Diehl JA. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 2004;279:20108-20117
-
(2004)
J Biol Chem
, vol.279
, pp. 20108-20117
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
42
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003;23:7198-7209
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
44
-
-
0028557442
-
Methionine restriction increases blood glutathione and longevity in F344 rats
-
Richie JP Jr, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA. Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J 1994;8:1302-1307
-
(1994)
FASEB J
, vol.8
, pp. 1302-1307
-
-
Richie, J.P.1
Leutzinger, Y.2
Parthasarathy, S.3
Malloy, V.4
Orentreich, N.5
Zimmerman, J.A.6
-
45
-
-
67649660052
-
Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
-
Sun L, Sadighi Akha AA, Miller RA, Harper JM. Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci 2009;64:711-722
-
(2009)
J Gerontol A Biol Sci Med Sci
, vol.64
, pp. 711-722
-
-
Sun, L.1
Sadighi Akha, A.A.2
Miller, R.A.3
Harper, J.M.4
-
46
-
-
84901341167
-
Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells
-
Johnson JE, Johnson FB. Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells. PLoS One 2014;9:e97729
-
(2014)
PLoS One
, vol.9
-
-
Johnson, J.E.1
Johnson, F.B.2
-
47
-
-
0036256246
-
Regulation of global and specific mRNA translation by amino acids
-
Kimball SR. Regulation of global and specific mRNA translation by amino acids. J Nutr 2002;132:883-886
-
(2002)
J Nutr
, vol.132
, pp. 883-886
-
-
Kimball, S.R.1
-
48
-
-
0037369215
-
Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B
-
Kobayashi H, Børsheim E, Anthony TG, et al. Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab 2003;284:E488-E498
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
, pp. E488-E498
-
-
Kobayashi, H.1
Børsheim, E.2
Anthony, T.G.3
-
49
-
-
0034618364
-
Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
-
Pham PTT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS Jr, Lynch CJ. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J Cell Biochem 2000;79:427-441
-
(2000)
J Cell Biochem
, vol.79
, pp. 427-441
-
-
Pham, P.T.T.1
Heydrick, S.J.2
Fox, H.L.3
Kimball, S.R.4
Jefferson, L.S.5
Lynch, C.J.6
-
50
-
-
0027529511
-
Neural mechanisms in the responses to amino acid deficiency
-
Gietzen DW. Neural mechanisms in the responses to amino acid deficiency. J Nutr 1993;123:610-625
-
(1993)
J Nutr
, vol.123
, pp. 610-625
-
-
Gietzen, D.W.1
-
51
-
-
58449089596
-
Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways
-
Deval C, Chaveroux C, Maurin AC, et al. Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS J 2009;276:707-718
-
(2009)
FEBS J
, vol.276
, pp. 707-718
-
-
Deval, C.1
Chaveroux, C.2
Maurin, A.C.3
-
52
-
-
0037025396
-
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
-
Siu F, Bain PJ, LeBlanc-Chaffin R, Chen H, Kilberg MS. ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem 2002;277:24120-24127
-
(2002)
J Biol Chem
, vol.277
, pp. 24120-24127
-
-
Siu, F.1
Bain, P.J.2
LeBlanc-Chaffin, R.3
Chen, H.4
Kilberg, M.S.5
-
53
-
-
0141866865
-
Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter
-
Pan Y, Chen H, Siu F, Kilberg MS. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. J Biol Chem 2003;278:38402-38412
-
(2003)
J Biol Chem
, vol.278
, pp. 38402-38412
-
-
Pan, Y.1
Chen, H.2
Siu, F.3
Kilberg, M.S.4
-
54
-
-
84954365064
-
Metabolic responses to dietary leucine restriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling
-
Wanders D, Stone KP, Dille K, Simon J, Pierse A, Gettys TW. Metabolic responses to dietary leucine restriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling. Biofactors 2015;41:391-402
-
(2015)
Biofactors
, vol.41
, pp. 391-402
-
-
Wanders, D.1
Stone, K.P.2
Dille, K.3
Simon, J.4
Pierse, A.5
Gettys, T.W.6
-
55
-
-
84952915479
-
Sestrin2 is a leucine sensor for the mTORC1 pathway
-
Wolfson RL, Chantranupong L, Saxton RA, et al. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 2016;351:43-48
-
(2016)
Science
, vol.351
, pp. 43-48
-
-
Wolfson, R.L.1
Chantranupong, L.2
Saxton, R.A.3
-
56
-
-
84930361385
-
Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis
-
Tang X, Keenan MM, Wu J, et al. Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis. PLoS Genet 2015;11:e1005158
-
(2015)
PLoS Genet
, vol.11
-
-
Tang, X.1
Keenan, M.M.2
Wu, J.3
-
57
-
-
84922743269
-
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
-
Wang S, Tsun ZY, Wolfson RL, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science 2015;347:188-194
-
(2015)
Science
, vol.347
, pp. 188-194
-
-
Wang, S.1
Tsun, Z.Y.2
Wolfson, R.L.3
-
58
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999;397:271-274
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
59
-
-
67649402187
-
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
-
Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009;284:13291-13295
-
(2009)
J Biol Chem
, vol.284
, pp. 13291-13295
-
-
Nguyen, T.1
Nioi, P.2
Pickett, C.B.3
-
60
-
-
84937604339
-
Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice
-
Douris N, Stevanovic DM, Fisher FM, et al. Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice. Endocrinology 2015;156:2470-2481
-
(2015)
Endocrinology
, vol.156
, pp. 2470-2481
-
-
Douris, N.1
Stevanovic, D.M.2
Fisher, F.M.3
-
62
-
-
84946481310
-
Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction
-
Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW. Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 2015;26:1235-1247
-
(2015)
J Nutr Biochem
, vol.26
, pp. 1235-1247
-
-
Patil, Y.N.1
Dille, K.N.2
Burk, D.H.3
Cortez, C.C.4
Gettys, T.W.5
|