Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

Nature

Volumn 536, Issue 7615, 2016, Pages 229-233

  Saxton, Robert A ^a,b,c,d   Chantranupong, Lynne ^a,b,c,d   Knockenhauer, Kevin E ^a   Schwartz, Thomas U ^a   Sabatini, David M ^a,b,c,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; ARGININE; ASPARTATE KINASE; CASTOR1 PROTEIN; CHORISMATE MUTASE; GATOR2 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; TYRA PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CASTOR1 PROTEIN, HUMAN; LYSINE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN BINDING; TARGET OF RAPAMYCIN KINASE;

AMINO ACID; ENZYME; ENZYME ACTIVITY; EUKARYOTE; IMMUNE RESPONSE; MAMMAL; PHYSIOLOGY; PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; DISSOCIATION CONSTANT; HUMAN; HUMAN CELL; IN VITRO STUDY; NUTRIENT; PRIORITY JOURNAL; PROKARYOTE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR MODEL; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

EUKARYOTA; MAMMALIA; PROKARYOTA;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ARGININE; ASPARTATE KINASE; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; HUMANS; LYSINE; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84982124784     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature19079     Document Type: Article

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