KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Nature

Volumn 543, Issue 7645, 2017, Pages 438-442

  Wolfson, Rachel L ^a,b,c   Chantranupong, Lynne ^a,b,c   Wyant, Gregory A ^a,b,c   Gu, Xin ^a,b,c   Orozco, Jose M ^a,b,c   Shen, Kuang ^a,b,c   Condon, Kendall J ^a,b,c   Petri, Sabrina ^d   Kedir, Jibril ^a,b,c   Scaria, Sonia M ^a,b,c   Abu Remaileh, Monther ^a,b,c   Frankel, Wayne N ^d   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; C12ORF66 PROTEIN; GLUCOSE; ITFG2 PROTEIN; KICSTOR PROTEIN; KPTN PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN; SZT2 PROTEIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; C12ORF66 PROTEIN, HUMAN; CARRIER PROTEIN; DEPDC5 PROTEIN, HUMAN; ITFG2 PROTEIN, HUMAN; KPTN PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; NERVE PROTEIN; PROTEIN BINDING; REPRESSOR PROTEIN; SZT2 PROTEIN, HUMAN; SZT2 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

AMINO ACID; BRAIN; CANCER; CELL ORGANELLE; CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; ENZYME; ENZYME ACTIVITY; NERVOUS SYSTEM DISORDER; PROTEIN; RODENT; TRANSLOCATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; FEMALE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; LYSOSOME; MALE; MOUSE; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; REGULATORY MECHANISM; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DEFICIENCY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MUTATION; NERVE CELL; SIGNAL TRANSDUCTION;

MUS;

AMINO ACIDS; ANIMALS; CARRIER PROTEINS; CELL LINE; FEMALE; GLUCOSE; HUMANS; LYSOSOMES; MALE; MICE; MICROFILAMENT PROTEINS; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TOR SERINE-THREONINE KINASES;

EID: 85014816345     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21423     Document Type: Article

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