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Volumn 70, Issue , 2017, Pages 34-44

Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies

Author keywords

Antioxidant activity; Fisetin; Flavonoids; Oxidative stress

Indexed keywords

AGENTS; CELL MEMBRANES; FLAVONOIDS; FREE RADICALS; MEDICAL APPLICATIONS; METAL IONS; METALS; OXIDATIVE STRESS; PIGMENTS; REINFORCEMENT; TRANSITION METAL COMPOUNDS; TRANSITION METALS;

EID: 85031741762     PISSN: 09242244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tifs.2017.10.003     Document Type: Review
Times cited : (104)

References (100)
  • 1
    • 77955097118 scopus 로고    scopus 로고
    • After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
    • Arredondo, F., Echeverry, C., Abin-Carriquiry, J.A., Blasina, F., Antunez, K., Jones, D.P., et al. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radical Biology & Medicine 49 (2010), 738–747.
    • (2010) Free Radical Biology & Medicine , vol.49 , pp. 738-747
    • Arredondo, F.1    Echeverry, C.2    Abin-Carriquiry, J.A.3    Blasina, F.4    Antunez, K.5    Jones, D.P.6
  • 3
    • 44449133306 scopus 로고    scopus 로고
    • Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons
    • Burdo, J., Schubert, D., Maher, P., Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. Brain Research 1189 (2008), 12–22.
    • (2008) Brain Research , vol.1189 , pp. 12-22
    • Burdo, J.1    Schubert, D.2    Maher, P.3
  • 4
    • 0031020195 scopus 로고    scopus 로고
    • Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships
    • Cao, G., Sofic, E., Prior, R.L., Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships. Free Radical Biology & Medicine 22 (1997), 749–760.
    • (1997) Free Radical Biology & Medicine , vol.22 , pp. 749-760
    • Cao, G.1    Sofic, E.2    Prior, R.L.3
  • 5
    • 84928159063 scopus 로고    scopus 로고
    • Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells
    • Chen, P.Y., Ho, Y.R., Wu, M.J., Huang, S.P., Chen, P.K., Tai, M.H., et al. Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells. Food & Function 6 (2015), 287–296.
    • (2015) Food & Function , vol.6 , pp. 287-296
    • Chen, P.Y.1    Ho, Y.R.2    Wu, M.J.3    Huang, S.P.4    Chen, P.K.5    Tai, M.H.6
  • 6
    • 84929179325 scopus 로고    scopus 로고
    • Fisetin ameliorated photodamage by suppressing the mitogen-activated protein kinase/matrix metalloproteinase pathway and nuclear factor-kappaB pathways
    • Chiang, H.M., Chan, S.Y., Chu, Y., Wen, K.C., Fisetin ameliorated photodamage by suppressing the mitogen-activated protein kinase/matrix metalloproteinase pathway and nuclear factor-kappaB pathways. Journal of Agricultural and Food Chemistry 63 (2015), 4551–4560.
    • (2015) Journal of Agricultural and Food Chemistry , vol.63 , pp. 4551-4560
    • Chiang, H.M.1    Chan, S.Y.2    Chu, Y.3    Wen, K.C.4
  • 7
    • 84855854014 scopus 로고    scopus 로고
    • Chemical modification of the multitarget neuroprotective compound fisetin
    • Chiruta, C., Schubert, D., Dargusch, R., Maher, P., Chemical modification of the multitarget neuroprotective compound fisetin. Journal of Medicinal Chemistry 55 (2012), 378–389.
    • (2012) Journal of Medicinal Chemistry , vol.55 , pp. 378-389
    • Chiruta, C.1    Schubert, D.2    Dargusch, R.3    Maher, P.4
  • 9
    • 0031886669 scopus 로고    scopus 로고
    • Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers
    • Cos, P., Ying, L., Calomme, M., Hu, J.P., Cimanga, K., Van Poel, B., et al. Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. Journal of Natural Products 61 (1998), 71–76.
    • (1998) Journal of Natural Products , vol.61 , pp. 71-76
    • Cos, P.1    Ying, L.2    Calomme, M.3    Hu, J.P.4    Cimanga, K.5    Van Poel, B.6
  • 10
    • 84895780810 scopus 로고    scopus 로고
    • Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice
    • Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell 13 (2014), 379–390.
    • (2014) Aging Cell , vol.13 , pp. 379-390
    • Currais, A.1    Prior, M.2    Dargusch, R.3    Armando, A.4    Ehren, J.5    Schubert, D.6
  • 11
    • 84978521854 scopus 로고    scopus 로고
    • Antiepileptic effect of fisetin in iron-induced experimental model of traumatic epilepsy in rats in the light of electrophysiological, biochemical, and behavioral observations
    • Das, J., Singh, R., Sharma, D., Antiepileptic effect of fisetin in iron-induced experimental model of traumatic epilepsy in rats in the light of electrophysiological, biochemical, and behavioral observations. Nutritional Neuroscience 20 (2017), 1–10.
    • (2017) Nutritional Neuroscience , vol.20 , pp. 1-10
    • Das, J.1    Singh, R.2    Sharma, D.3
  • 14
    • 84962406561 scopus 로고    scopus 로고
    • Comparative spectroscopic and mechanistic study of chelation properties of fisetin with iron in aqueous buffered solutions. Implications on in vitro antioxidant activity
    • Dimitric Markovic, J.M., Markovic, Z.S., Brdaric, T.P., Filipovic, N.D., Comparative spectroscopic and mechanistic study of chelation properties of fisetin with iron in aqueous buffered solutions. Implications on in vitro antioxidant activity. Dalton transactions 40 (2011), 4560–4571.
    • (2011) Dalton transactions , vol.40 , pp. 4560-4571
    • Dimitric Markovic, J.M.1    Markovic, Z.S.2    Brdaric, T.P.3    Filipovic, N.D.4
  • 17
    • 0024550507 scopus 로고
    • Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
    • Ferriola, P.C., Cody, V., Middleton, E. Jr., Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochemical Pharmacology 38 (1989), 1617–1624.
    • (1989) Biochemical Pharmacology , vol.38 , pp. 1617-1624
    • Ferriola, P.C.1    Cody, V.2    Middleton, E.3
  • 18
    • 26044481983 scopus 로고    scopus 로고
    • Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity
    • Fiorani, M., Accorsi, A., Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity. The British Journal of Nutrition 94 (2005), 338–345.
    • (2005) The British Journal of Nutrition , vol.94 , pp. 338-345
    • Fiorani, M.1    Accorsi, A.2
  • 19
    • 0036139979 scopus 로고    scopus 로고
    • Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes
    • Fiorani, M., De Sanctis, R., De Bellis, R., Dacha, M., Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. Free Radical Biology & Medicine 32 (2002), 64–72.
    • (2002) Free Radical Biology & Medicine , vol.32 , pp. 64-72
    • Fiorani, M.1    De Sanctis, R.2    De Bellis, R.3    Dacha, M.4
  • 20
    • 11844293406 scopus 로고    scopus 로고
    • Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry
    • Firuzi, O., Lacanna, A., Petrucci, R., Marrosu, G., Saso, L., Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry. Biochimica et biophysica acta 1721 (2005), 174–184.
    • (2005) Biochimica et biophysica acta , vol.1721 , pp. 174-184
    • Firuzi, O.1    Lacanna, A.2    Petrucci, R.3    Marrosu, G.4    Saso, L.5
  • 22
    • 84858069261 scopus 로고    scopus 로고
    • Antioxidant activity of food constituents: An overview
    • Gulcin, I., Antioxidant activity of food constituents: An overview. Archives of Toxicology 86 (2012), 345–391.
    • (2012) Archives of Toxicology , vol.86 , pp. 345-391
    • Gulcin, I.1
  • 23
    • 33746736380 scopus 로고    scopus 로고
    • Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death
    • Hanneken, A., Lin, F.F., Johnson, J., Maher, P., Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Investigative Ophthalmology & Visual Science 47 (2006), 3164–3177.
    • (2006) Investigative Ophthalmology & Visual Science , vol.47 , pp. 3164-3177
    • Hanneken, A.1    Lin, F.F.2    Johnson, J.3    Maher, P.4
  • 24
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medical significance of the flavonoids
    • Havsteen, B.H., The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics 96 (2002), 67–202.
    • (2002) Pharmacology & Therapeutics , vol.96 , pp. 67-202
    • Havsteen, B.H.1
  • 25
    • 84949257810 scopus 로고    scopus 로고
    • Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
    • Hytti, M., Piippo, N., Korhonen, E., Honkakoski, P., Kaarniranta, K., Kauppinen, A., Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation. Scientific Reports, 5, 2015, 17645.
    • (2015) Scientific Reports , vol.5 , pp. 17645
    • Hytti, M.1    Piippo, N.2    Korhonen, E.3    Honkakoski, P.4    Kaarniranta, K.5    Kauppinen, A.6
  • 27
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • Ishige, K., Schubert, D., Sagara, Y., Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radical Biology & Medicine 30 (2001), 433–446.
    • (2001) Free Radical Biology & Medicine , vol.30 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 28
    • 84862819739 scopus 로고    scopus 로고
    • Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
    • Jang, K.Y., Jeong, S.J., Kim, S.H., Jung, J.H., Kim, J.H., Koh, W., et al. Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells. Cancer Letters 319 (2012), 197–202.
    • (2012) Cancer Letters , vol.319 , pp. 197-202
    • Jang, K.Y.1    Jeong, S.J.2    Kim, S.H.3    Jung, J.H.4    Kim, J.H.5    Koh, W.6
  • 29
    • 84895077134 scopus 로고    scopus 로고
    • Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system
    • Kang, K.A., Piao, M.J., Kim, K.C., Cha, J.W., Zheng, J., Yao, C.W., et al. Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system. In Vitro Cellular & Developmental Biology. Animal 50 (2014), 66–74.
    • (2014) In Vitro Cellular & Developmental Biology. Animal , vol.50 , pp. 66-74
    • Kang, K.A.1    Piao, M.J.2    Kim, K.C.3    Cha, J.W.4    Zheng, J.5    Yao, C.W.6
  • 30
    • 84930645183 scopus 로고    scopus 로고
    • Properties and applications of flavonoid metal complexes
    • Kasprzak, M.M., Erxleben, A., Ochocki, J., Properties and applications of flavonoid metal complexes. RSC Advances 5 (2015), 45853–45877.
    • (2015) RSC Advances , vol.5 , pp. 45853-45877
    • Kasprzak, M.M.1    Erxleben, A.2    Ochocki, J.3
  • 31
    • 47249134657 scopus 로고    scopus 로고
    • Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
    • Khan, N., Afaq, F., Syed, D.N., Mukhtar, H., Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells. Carcinogenesis 29 (2008), 1049–1056.
    • (2008) Carcinogenesis , vol.29 , pp. 1049-1056
    • Khan, N.1    Afaq, F.2    Syed, D.N.3    Mukhtar, H.4
  • 32
    • 5444268453 scopus 로고    scopus 로고
    • Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids
    • Khanduja, K.L., Bhardwaj, A., Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids. Indian Journal of Biochemistry & Biophysics 40 (2003), 416–422.
    • (2003) Indian Journal of Biochemistry & Biophysics , vol.40 , pp. 416-422
    • Khanduja, K.L.1    Bhardwaj, A.2
  • 33
    • 0008589879 scopus 로고    scopus 로고
    • Japanese intake of flavonoids and isoflavonoids from foods
    • Kimira, M., Arai, Y., Shimoi, K., Watanabe, S., Japanese intake of flavonoids and isoflavonoids from foods. Journal of Epidemiology 8 (1998), 168–175.
    • (1998) Journal of Epidemiology , vol.8 , pp. 168-175
    • Kimira, M.1    Arai, Y.2    Shimoi, K.3    Watanabe, S.4
  • 35
    • 84959016805 scopus 로고    scopus 로고
    • Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress
    • Koneru, M., Sahu, B.D., Kumar, J.M., Kuncha, M., Kadari, A., Kilari, E.K., et al. Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress. Journal of Functional Foods 22 (2016), 588–601.
    • (2016) Journal of Functional Foods , vol.22 , pp. 588-601
    • Koneru, M.1    Sahu, B.D.2    Kumar, J.M.3    Kuncha, M.4    Kadari, A.5    Kilari, E.K.6
  • 39
    • 84860389879 scopus 로고    scopus 로고
    • Fisetin induces Nrf2-mediated HO-1 expression through PKC-delta and p38 in human umbilical vein endothelial cells
    • Lee, S.E., Jeong, S.I., Yang, H., Park, C.S., Jin, Y.H., Park, Y.S., Fisetin induces Nrf2-mediated HO-1 expression through PKC-delta and p38 in human umbilical vein endothelial cells. Journal of Cellular Biochemistry 112 (2011), 2352–2360.
    • (2011) Journal of Cellular Biochemistry , vol.112 , pp. 2352-2360
    • Lee, S.E.1    Jeong, S.I.2    Yang, H.3    Park, C.S.4    Jin, Y.H.5    Park, Y.S.6
  • 40
    • 0037081782 scopus 로고    scopus 로고
    • Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease
    • Lee, W.R., Shen, S.C., Lin, H.Y., Hou, W.C., Yang, L.L., Chen, Y.C., Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Biochemical Pharmacology 63 (2002), 225–236.
    • (2002) Biochemical Pharmacology , vol.63 , pp. 225-236
    • Lee, W.R.1    Shen, S.C.2    Lin, H.Y.3    Hou, W.C.4    Yang, L.L.5    Chen, Y.C.6
  • 41
    • 0242691712 scopus 로고    scopus 로고
    • Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate
    • Lee, K.G., Shibamoto, T., Takeoka, G.R., Lee, S.E., Kim, J.H., Park, B.S., Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate. Journal of Agricultural and Food Chemistry 51 (2003), 7203–7207.
    • (2003) Journal of Agricultural and Food Chemistry , vol.51 , pp. 7203-7207
    • Lee, K.G.1    Shibamoto, T.2    Takeoka, G.R.3    Lee, S.E.4    Kim, J.H.5    Park, B.S.6
  • 44
    • 84879835492 scopus 로고    scopus 로고
    • The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts
    • Léotoing, L., Wauquier, F., Guicheux, J., Miot-Noirault, E., Wittrant, Y., Coxam, V., The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. PloS One, 8, 2013, e68388.
    • (2013) PloS One , vol.8 , pp. e68388
    • Léotoing, L.1    Wauquier, F.2    Guicheux, J.3    Miot-Noirault, E.4    Wittrant, Y.5    Coxam, V.6
  • 45
    • 52049097043 scopus 로고    scopus 로고
    • Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages
    • Lian, T.W., Wang, L., Lo, Y.H., Huang, I.J., Wu, M.J., Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochimica et biophysica acta 1781 (2008), 601–609.
    • (2008) Biochimica et biophysica acta , vol.1781 , pp. 601-609
    • Lian, T.W.1    Wang, L.2    Lo, Y.H.3    Huang, I.J.4    Wu, M.J.5
  • 46
    • 84943393440 scopus 로고    scopus 로고
    • Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
    • Li, J.-M., Li, W.-Y., Huang, M.-Y., Zhang, X.-Q., Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells. Bangladesh Journal of Pharmacology 10 (2015), 820–829.
    • (2015) Bangladesh Journal of Pharmacology , vol.10 , pp. 820-829
    • Li, J.-M.1    Li, W.-Y.2    Huang, M.-Y.3    Zhang, X.-Q.4
  • 47
    • 84977482058 scopus 로고    scopus 로고
    • Influence of environmental factors on the active substance production and antioxidant activity in Potentilla fruticosa L. and its quality assessment
    • Liu, W., Yin, D., Li, N., Hou, X., Wang, D., Li, D., et al. Influence of environmental factors on the active substance production and antioxidant activity in Potentilla fruticosa L. and its quality assessment. Scientific Reports, 6, 2016, 28591.
    • (2016) Scientific Reports , vol.6 , pp. 28591
    • Liu, W.1    Yin, D.2    Li, N.3    Hou, X.4    Wang, D.5    Li, D.6
  • 48
    • 33749255399 scopus 로고    scopus 로고
    • A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives
    • Maher, P., A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. Free Radical Research 40 (2006), 1105–1111.
    • (2006) Free Radical Research , vol.40 , pp. 1105-1111
    • Maher, P.1
  • 49
    • 71949125029 scopus 로고    scopus 로고
    • Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
    • Maher, P., Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes & Nutrition 4 (2009), 297–307.
    • (2009) Genes & Nutrition , vol.4 , pp. 297-307
    • Maher, P.1
  • 50
    • 33644793240 scopus 로고    scopus 로고
    • Flavonoids protect retinal ganglion cells from oxidative stress-induced death
    • Maher, P., Hanneken, A., Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Investigative Ophthalmology & Visual Science 46 (2005), 4796–4803.
    • (2005) Investigative Ophthalmology & Visual Science , vol.46 , pp. 4796-4803
    • Maher, P.1    Hanneken, A.2
  • 51
    • 34548855340 scopus 로고    scopus 로고
    • A novel approach to screening for new neuroprotective compounds for the treatment of stroke
    • Maher, P., Salgado, K.F., Zivin, J.A., Lapchak, P.A., A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Research 1173 (2007), 117–125.
    • (2007) Brain Research , vol.1173 , pp. 117-125
    • Maher, P.1    Salgado, K.F.2    Zivin, J.A.3    Lapchak, P.A.4
  • 53
    • 73349117489 scopus 로고    scopus 로고
    • Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: Implications on in vitro antioxidant activity
    • Markovic, Z.S., Mentus, S.V., Dimitric Markovic, J.M., Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: Implications on in vitro antioxidant activity. The Journal of Physical Chemistry. A 113 (2009), 14170–14179.
    • (2009) The Journal of Physical Chemistry. A , vol.113 , pp. 14170-14179
    • Markovic, Z.S.1    Mentus, S.V.2    Dimitric Markovic, J.M.3
  • 54
    • 84949293844 scopus 로고    scopus 로고
    • Fisetin modulates antioxidant enzymes and inflammatory factors to inhibit Aflatoxin-B1 induced hepatocellular carcinoma in rats
    • Maurya, B.K., Trigun, S.K., Fisetin modulates antioxidant enzymes and inflammatory factors to inhibit Aflatoxin-B1 induced hepatocellular carcinoma in rats. Oxidative Medicine and Cellular Longevity, 2016, 2016, 1972793.
    • (2016) Oxidative Medicine and Cellular Longevity , vol.2016 , pp. 1972793
    • Maurya, B.K.1    Trigun, S.K.2
  • 57
    • 0034665067 scopus 로고    scopus 로고
    • Interaction of the antioxidant flavonoid quercetin with planar lipid bilayers
    • Movileanu, L., Neagoe, I., Flonta, M.L., Interaction of the antioxidant flavonoid quercetin with planar lipid bilayers. International Journal of Pharmaceutics 205 (2000), 135–146.
    • (2000) International Journal of Pharmaceutics , vol.205 , pp. 135-146
    • Movileanu, L.1    Neagoe, I.2    Flonta, M.L.3
  • 58
    • 0027487109 scopus 로고
    • A method to screen for the antioxidant effect of compounds on low-density lipoprotein (LDL): Illustration with flavonoids
    • Myara, I., Pico, I., Vedie, B., Moatti, N., A method to screen for the antioxidant effect of compounds on low-density lipoprotein (LDL): Illustration with flavonoids. Journal of Pharmacological and Toxicological Methods 30 (1993), 69–73.
    • (1993) Journal of Pharmacological and Toxicological Methods , vol.30 , pp. 69-73
    • Myara, I.1    Pico, I.2    Vedie, B.3    Moatti, N.4
  • 59
  • 60
    • 84921456864 scopus 로고    scopus 로고
    • Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFkappaB signaling pathways in SKH-1 hairless mice
    • Pal, H.C., Athar, M., Elmets, C.A., Afaq, F., Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFkappaB signaling pathways in SKH-1 hairless mice. Photochemistry and Photobiology 91 (2015), 225–234.
    • (2015) Photochemistry and Photobiology , vol.91 , pp. 225-234
    • Pal, H.C.1    Athar, M.2    Elmets, C.A.3    Afaq, F.4
  • 62
    • 84878440823 scopus 로고    scopus 로고
    • Protective effect of fisetin (3,7,3',4'-tetrahydroxyflavone) against gamma-irradiation-induced oxidative stress and cell damage
    • Piao, M.J., Kim, K.C., Chae, S., Keum, Y.S., Kim, H.S., Hyun, J.W., Protective effect of fisetin (3,7,3',4'-tetrahydroxyflavone) against gamma-irradiation-induced oxidative stress and cell damage. Biomolecules & Therapeutics 21 (2013), 210–215.
    • (2013) Biomolecules & Therapeutics , vol.21 , pp. 210-215
    • Piao, M.J.1    Kim, K.C.2    Chae, S.3    Keum, Y.S.4    Kim, H.S.5    Hyun, J.W.6
  • 64
    • 84874703613 scopus 로고    scopus 로고
    • Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity
    • Prakash, D., Gopinath, K., Sudhandiran, G., Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity. Neuromolecular Medicine 15 (2013), 192–208.
    • (2013) Neuromolecular Medicine , vol.15 , pp. 192-208
    • Prakash, D.1    Gopinath, K.2    Sudhandiran, G.3
  • 65
    • 84880127162 scopus 로고    scopus 로고
    • Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats
    • Prasath, G.S., Subramanian, S.P., Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 59 (2013), 249–255.
    • (2013) Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association , vol.59 , pp. 249-255
    • Prasath, G.S.1    Subramanian, S.P.2
  • 66
    • 84884988774 scopus 로고    scopus 로고
    • Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats
    • Prasath, G.S., Sundaram, C.S., Subramanian, S.P., Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats. Endocrine 44 (2013), 359–368.
    • (2013) Endocrine , vol.44 , pp. 359-368
    • Prasath, G.S.1    Sundaram, C.S.2    Subramanian, S.P.3
  • 67
    • 84900430879 scopus 로고    scopus 로고
    • Diet antioxidant capacity: Relationships to oxidative stress and health
    • Prior, R.L., Wu, X., Diet antioxidant capacity: Relationships to oxidative stress and health. American Journal of Biomedical Sciences 5 (2013), 126–139.
    • (2013) American Journal of Biomedical Sciences , vol.5 , pp. 126-139
    • Prior, R.L.1    Wu, X.2
  • 68
    • 84959018825 scopus 로고    scopus 로고
    • Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
    • Rani, V., Deep, G., Singh, R.K., Palle, K., Yadav, U.C., Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sciences 148 (2016), 183–193.
    • (2016) Life Sciences , vol.148 , pp. 183-193
    • Rani, V.1    Deep, G.2    Singh, R.K.3    Palle, K.4    Yadav, U.C.5
  • 69
    • 79953059350 scopus 로고    scopus 로고
    • Fisetin, a novel flavonol attenuates benzo (a) pyrene-induced lung carcinogenesis in Swiss albino mice
    • Ravichandran, N., Suresh, G., Ramesh, B., Siva, G.V., Fisetin, a novel flavonol attenuates benzo (a) pyrene-induced lung carcinogenesis in Swiss albino mice. Food and Chemical Toxicology 49 (2011), 1141–1147.
    • (2011) Food and Chemical Toxicology , vol.49 , pp. 1141-1147
    • Ravichandran, N.1    Suresh, G.2    Ramesh, B.3    Siva, G.V.4
  • 71
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Ray, P.D., Huang, B., Tsuji, Y., Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cellular Signalling 24 (2012), 981–990.
    • (2012) Cellular Signalling , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.2    Tsuji, Y.3
  • 73
    • 84906961778 scopus 로고    scopus 로고
    • Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-kappaB activation and antioxidant defence
    • Sahu, B.D., Kalvala, A.K., Koneru, M., Mahesh Kumar, J., Kuncha, M., Rachamalla, S.S., et al. Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-kappaB activation and antioxidant defence. PloS One, 9, 2014, e105070.
    • (2014) PloS One , vol.9 , pp. e105070
    • Sahu, B.D.1    Kalvala, A.K.2    Koneru, M.3    Mahesh Kumar, J.4    Kuncha, M.5    Rachamalla, S.S.6
  • 74
    • 84877623497 scopus 로고    scopus 로고
    • Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes
    • Sakai, E., Shimada-Sugawara, M., Yamaguchi, Y., Sakamoto, H., Fumimoto, R., Fukuma, Y., et al. Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes. Journal of Pharmacological Sciences 121 (2013), 288–298.
    • (2013) Journal of Pharmacological Sciences , vol.121 , pp. 288-298
    • Sakai, E.1    Shimada-Sugawara, M.2    Yamaguchi, Y.3    Sakamoto, H.4    Fumimoto, R.5    Fukuma, Y.6
  • 75
    • 84944585500 scopus 로고    scopus 로고
    • Fisetin imparts neuroprotection in experimental diabetic neuropathy by modulating Nrf2 and NF-kappaB pathways
    • Sandireddy, R., Yerra, V.G., Komirishetti, P., Areti, A., Kumar, A., Fisetin imparts neuroprotection in experimental diabetic neuropathy by modulating Nrf2 and NF-kappaB pathways. Cellular and Molecular Neurobiology 36 (2016), 883–892.
    • (2016) Cellular and Molecular Neurobiology , vol.36 , pp. 883-892
    • Sandireddy, R.1    Yerra, V.G.2    Komirishetti, P.3    Areti, A.4    Kumar, A.5
  • 77
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • Scalbert, A., Williamson, G., Dietary intake and bioavailability of polyphenols. The Journal of Nutrition 130 (2000), 2073s–2085s.
    • (2000) The Journal of Nutrition , vol.130 , pp. 2073s-2085s
    • Scalbert, A.1    Williamson, G.2
  • 78
    • 3142540615 scopus 로고    scopus 로고
    • Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes
    • Sengupta, B., Banerjee, A., Sengupta, P.K., Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes. FEBS Letters 570 (2004), 77–81.
    • (2004) FEBS Letters , vol.570 , pp. 77-81
    • Sengupta, B.1    Banerjee, A.2    Sengupta, P.K.3
  • 79
    • 84948403821 scopus 로고    scopus 로고
    • Fisetin inhibits TNF-alpha-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression
    • Seo, S.H., Jeong, G.S., Fisetin inhibits TNF-alpha-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression. International Immunopharmacology 29 (2015), 246–253.
    • (2015) International Immunopharmacology , vol.29 , pp. 246-253
    • Seo, S.H.1    Jeong, G.S.2
  • 80
    • 85031735379 scopus 로고    scopus 로고
    • Potential of fisetin as a nutri-cosmetics material through evaluating anti-oxidant and anti-adipogenic activities
    • Shon, M., Kim, R., Song, J., Kwon, O.J., Lee, A., Kim, H., et al. Potential of fisetin as a nutri-cosmetics material through evaluating anti-oxidant and anti-adipogenic activities. Asian Journal of Beauty and Cosmetology 14 (2016), 6–17.
    • (2016) Asian Journal of Beauty and Cosmetology , vol.14 , pp. 6-17
    • Shon, M.1    Kim, R.2    Song, J.3    Kwon, O.J.4    Lee, A.5    Kim, H.6
  • 81
    • 84898606042 scopus 로고    scopus 로고
    • In-vitro anti-proliferative and anti-oxidant activity of galangin, fisetin and quercetin: Role of localization and intermolecular interaction in model membrane
    • Sinha, R., Srivastava, S., Joshi, A., Joshi, U.J., Govil, G., In-vitro anti-proliferative and anti-oxidant activity of galangin, fisetin and quercetin: Role of localization and intermolecular interaction in model membrane. European Journal of Medicinal Chemistry 79 (2014), 102–109.
    • (2014) European Journal of Medicinal Chemistry , vol.79 , pp. 102-109
    • Sinha, R.1    Srivastava, S.2    Joshi, A.3    Joshi, U.J.4    Govil, G.5
  • 82
    • 84908691387 scopus 로고    scopus 로고
    • Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats
    • Subramanian, P., Jayakumar, M., Jayapalan, J.J., Hashim, O.H., Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats. Pharmacological Reports: PR 66 (2014), 1037–1042.
    • (2014) Pharmacological Reports: PR , vol.66 , pp. 1037-1042
    • Subramanian, P.1    Jayakumar, M.2    Jayapalan, J.J.3    Hashim, O.H.4
  • 83
    • 84920729103 scopus 로고    scopus 로고
    • Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats
    • Subramanian, P., Jayakumar, M., Singaravel, M., Kumar, D., Basu, P., Jayapalan, J.J., et al. Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats. Journal of Functional Foods 12 (2015), 409–419.
    • (2015) Journal of Functional Foods , vol.12 , pp. 409-419
    • Subramanian, P.1    Jayakumar, M.2    Singaravel, M.3    Kumar, D.4    Basu, P.5    Jayapalan, J.J.6
  • 84
    • 0033410209 scopus 로고    scopus 로고
    • Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid
    • Sugihara, N., Arakawa, T., Ohnishi, M., Furuno, K., Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. Free Radical Biology & Medicine 27 (1999), 1313–1323.
    • (1999) Free Radical Biology & Medicine , vol.27 , pp. 1313-1323
    • Sugihara, N.1    Arakawa, T.2    Ohnishi, M.3    Furuno, K.4
  • 85
    • 60149112516 scopus 로고    scopus 로고
    • A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways
    • Suh, Y., Afaq, F., Johnson, J.J., Mukhtar, H., A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. Carcinogenesis 30 (2009), 300–307.
    • (2009) Carcinogenesis , vol.30 , pp. 300-307
    • Suh, Y.1    Afaq, F.2    Johnson, J.J.3    Mukhtar, H.4
  • 86
  • 88
    • 0028347944 scopus 로고
    • A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation
    • Ursini, F., Maiorino, M., Morazzoni, P., Roveri, A., Pifferi, G., A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation. Free Radical Biology & Medicine 16 (1994), 547–553.
    • (1994) Free Radical Biology & Medicine , vol.16 , pp. 547-553
    • Ursini, F.1    Maiorino, M.2    Morazzoni, P.3    Roveri, A.4    Pifferi, G.5
  • 90
  • 91
    • 84980391559 scopus 로고    scopus 로고
    • Fisetin protects DNA against oxidative damage and its possible mechanism
    • Wang, T., Lin, H., Tu, Q., Liu, J., Li, X., Fisetin protects DNA against oxidative damage and its possible mechanism. Advanced Pharmaceutical Bulletin 6 (2016), 267–270.
    • (2016) Advanced Pharmaceutical Bulletin , vol.6 , pp. 267-270
    • Wang, T.1    Lin, H.2    Tu, Q.3    Liu, J.4    Li, X.5
  • 93
    • 14944364739 scopus 로고    scopus 로고
    • Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis
    • Watjen, W., Michels, G., Steffan, B., Niering, P., Chovolou, Y., Kampkotter, A., et al. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. The Journal of Nutrition 135 (2005), 525–531.
    • (2005) The Journal of Nutrition , vol.135 , pp. 525-531
    • Watjen, W.1    Michels, G.2    Steffan, B.3    Niering, P.4    Chovolou, Y.5    Kampkotter, A.6
  • 94
    • 84890040004 scopus 로고    scopus 로고
    • Density functional theory study of the structure-antioxidant activity of polyphenolic deoxybenzoins
    • Xue, Y., Zheng, Y., An, L., Dou, Y., Liu, Y., Density functional theory study of the structure-antioxidant activity of polyphenolic deoxybenzoins. Food Chemistry 151 (2014), 198–206.
    • (2014) Food Chemistry , vol.151 , pp. 198-206
    • Xue, Y.1    Zheng, Y.2    An, L.3    Dou, Y.4    Liu, Y.5
  • 95
    • 55349129283 scopus 로고    scopus 로고
    • The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells
    • Yao, K., Zhang, L., Zhang, Y., Ye, P., Zhu, N., The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells. Molecular Vision 14 (2008), 1865–1871.
    • (2008) Molecular Vision , vol.14 , pp. 1865-1871
    • Yao, K.1    Zhang, L.2    Zhang, Y.3    Ye, P.4    Zhu, N.5
  • 96
    • 85018479003 scopus 로고    scopus 로고
    • Fisetin protects PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling in PC12 cells
    • Yen, J.H., Wu, P.S., Chen, S.F., Wu, M.J., Fisetin protects PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling in PC12 cells. International Journal of Molecular Sciences, 18, 2017, 852.
    • (2017) International Journal of Molecular Sciences , vol.18 , pp. 852
    • Yen, J.H.1    Wu, P.S.2    Chen, S.F.3    Wu, M.J.4
  • 97
    • 84971670314 scopus 로고    scopus 로고
    • The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice
    • Yu, X., Jiang, X., Zhang, X., Chen, Z., Xu, L., Chen, L., et al. The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice. Metabolic Brain Disease 31 (2016), 1011–1021.
    • (2016) Metabolic Brain Disease , vol.31 , pp. 1011-1021
    • Yu, X.1    Jiang, X.2    Zhang, X.3    Chen, Z.4    Xu, L.5    Chen, L.6
  • 98
    • 84870902532 scopus 로고    scopus 로고
    • Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    • Zhang, M., An, C., Gao, Y., Leak, R.K., Chen, J., Zhang, F., Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Progress in Neurobiology 100 (2013), 30–47.
    • (2013) Progress in Neurobiology , vol.100 , pp. 30-47
    • Zhang, M.1    An, C.2    Gao, Y.3    Leak, R.K.4    Chen, J.5    Zhang, F.6
  • 99
    • 84989249048 scopus 로고    scopus 로고
    • Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-kappaB/mTOR and ERK1/2 signaling pathways
    • Zhang, X.J., Jia, S.S., Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-kappaB/mTOR and ERK1/2 signaling pathways. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 83 (2016), 1164–1174.
    • (2016) Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie , vol.83 , pp. 1164-1174
    • Zhang, X.J.1    Jia, S.S.2
  • 100
    • 84947224625 scopus 로고    scopus 로고
    • Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors
    • Zhao, X., Li, X.L., Liu, X., Wang, C., Zhou, D.S., Ma, Q., et al. Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors. Pharmacological Research 102 (2015), 286–297.
    • (2015) Pharmacological Research , vol.102 , pp. 286-297
    • Zhao, X.1    Li, X.L.2    Liu, X.3    Wang, C.4    Zhou, D.S.5    Ma, Q.6


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