Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 249-255

  Prasath, Gopalan Sriram ^a   Subramanian, Sorimuthu Pillai ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidant; Fisetin; Hepatocytes; Hyperglycemia; Oxidative stress; Tissue protective nature

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; FISETIN; GLICLAZIDE; GLUCOSE; GLUTATHIONE; HEMOGLOBIN A1C; HYDROPEROXIDE; INSULIN; LIPID PEROXIDE; STREPTOZOCIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; INSULIN BLOOD LEVEL; LIVER INJURY; LIVER PROTECTION; LIVER STRUCTURE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS;

ANTIOXIDANT; CAT; CATALASE; DIMETHYL SULPHOXIDE; DMSO; FISETIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE S TRANSFERASE; GLYCOSYLATED HEMOGLOBIN; GPX; GR; GSH; GST; HBALC; HEPATOCYTES; HYPERGLYCEMIA; LEAST SIGNIFICANT DIFFERENCE; LSD; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; ROS; SD; SOD; STANDARD DEVIATION; STREPTOZOTOCIN; STZ; SUPEROXIDE DISMUTASE; TBARS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TISSUE PROTECTIVE NATURE;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; DIABETES MELLITUS, EXPERIMENTAL; FLAVONOIDS; GLUTATHIONE; HEPATIC INSUFFICIENCY; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; LIPID PEROXIDES; LIVER; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDOREDUCTASES; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 84880127162     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.05.062     Document Type: Article

References (56)

1. Ahmad F.K., Zhiheng H., King G.L. Molecular targets of diabetic cardiovascular complications. Curr. Drug. Targets 2005, 6:487-494.
2. Ahn M.Y., Jung Y.S., Jee S.D., Han J.W., Hwang J.S., Yun E.Y., Lee B.M. Blood-pressure-lowering effect of glycosaminoglycan derived from Isaria sinclairii in spontaneously hypertensive rats. J. Toxicol. Environ. Health A 2013, 76(6):391-399.
3. Ahn M.Y., Jee S.D., Lee B.M., Yeon J.H., Park K.K., Hwang J.S., Yun E.Y. Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period. J. Toxicol. Environ. Health A 2010, 73(21-22):1511-1520.
4. Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Aspects Med. 2008, 29:9-16.
5. Alper G., Irer S., Duman E., Caglayan O., Yilmaz C. Effect of I-deprenyl and gliclazide on oxidant stress/antioxidant status and DNA damage in a diabetic rat model. Endocr. Res. 2005, 31:199-212.
6. Arai Y., Watanabe S., Kimira M., Shimoi K., Mochizuki R., Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J. Nutr. 2000, 130:2243-2250.
7. Atli T., Keven K., Avci A., Kutlay S., Turkcapar N., Varli M., Aras S., Ertug E., Canbolat O. Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients. Arch. Gerontol. Geriatr. 2004, 39:269-275.
8. Babujanarthanam R., Kavitha P., Mahadeva Rao U.S., Pandian M.R. Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. Mol. Cell. Biochem. 2011, 358:121-129.
9. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813-820.
10. Carlberg I., Mannervik B. Glutathione reductase. Methods Enzymol. 1985, 113:484-490.
11. Chang C.L., Chen Y.C., Chen H.M., Yang N.S., Yang W.C. Natural cures for type 1 diabetes: a review of phytochemicals, biological actions, and clinical potential. Curr. Med. Chem. 2013, 20(7):899-907.
12. Constantin R.P., Constantin J., Pagadigorria C.L., Ishii-Iwamoto E.L., Bracht A., Ono Mde K., Yamamoto N.S. The actions of fisetin on glucose metabolism in the rat liver. Cell. Biochem. Funct. 2010, 28(2):149-158.
13. de Groot H., Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam. Clin. Pharmacol. 1998, 12:249-255.
14. El-Demerdash F.M., Yousef M.I., El-Naga N.I. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem. Toxicol. 2005, 43(1):57-63.
15. Evans J.L., Goldfine I.D., Maddux B.A., Grodsky G.M. Oxidative stress and stress activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 2002, 23:599-622.
16. Finley J.W., Kong A.N., Hintze K.J., Jeffery E.H., Ji L.L., Lei X.G. Antioxidants in foods: state of the science important to the food industry. J. Agric. Food Chem. 2011, 59(13):6837-6846.
17. Fischer L.J., Rickert D.E. Pancreatic islet cell toxicity. Crit. Rev. Toxicol. 1975, 3:231-263.
18. Fotsis T., Pepper M.S., Montesano R., Aktas E., Breit S., Schweigerer L., Rasku S., Wähälä K., Adlercreutz H. Baillieres Clin. Endocrinol. Metab. 1998, 12:649-666.
19. Garg M.C., Bansal D.D. Protective antioxidant effect of vitamins C and E in streptozocin induced diabetic rats. Indian J. Exp. Biol. 2000, 38:101-104.
20. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
21. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 2002, 96:67-202.
22. Higa S., Hirano T., Kotani M., Matsumoto M., Fujita A., Suemura M., Kawase I., Tanaka T. Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J. Allergy Clin. Immunol. 2003, 111:1299-1306.
23. Jiang Z.Y., Hunt J.V., Wolff S.P. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal. Biochem. 1992, 202:384-389.
24. Jung U.J., Lee M.K., Park Y.B., Kang M.A., Choi M.S. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int. J. Biochem. Cell Biol. 2006, 38:1134-1145.
25. Khan N., Syed D.N., Ahmad N., Mukhtar H. Fisetin a dietary antioxidant for health promotion. Antioxid. Redox. Signal 2012, Epub ahead of print.
26. King, J., 1965a. The transaminases: alanine and aspartate transaminases, In: Van, D., Nostrand, Co. (Ed.), Practical Clinical Enzymology. London, pp. 363-395.
27. King, J., 1965b. The hydrolases-acid and alkaline phosphatases, In: Practical clinical enzymology. Van, D. Nostrand Co. (Ed.), London, pp. 199-208.
28. Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., Ferrell L.D., Liu Y.C., Torbenson M.S., Unalp-Arida A., Yeh M., McCullough A.J., Sanyal A.J. Nonalcoholic steatohepatitis clinical research network, design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
29. Kristal B.S., Jackson C.T., Chung H.Y., Matsuda M., Nguyen H.D., Yu B.P. Defects at center P underlie diabetes-associated mitochondrial dysfunction. Free Radic. Biol. Med. 1997, 22(5):823-833.
30. Kume E., Fujimura H., Matsuki N., Ito M., Aruga C., Toriumi W., Kitamura K., Doi K. Hepatic changes in the acute phase of streptozotocin (SZ)-induced diabetes in mice. Exp. Toxicol. Pathol. 2004, 55:467-480.
31. Long J., Liu C., Sun L., Gao H., Liu J. Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem. Res. 2009, 34:786-794.
32. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
33. Maher P., Dargusch R., Ehren J.L., Okada S., Sharma K., Schubert D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One 2011, 6(6):e21226.
34. Maher P. A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. Free Radic. Res. 2006, 40:1105-1111.
35. Maritim A.C., Sandres R.A., Watkins J.B. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 2003, 17:24-39.
36. Misra H.P., Fridrovich T. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 1972, 247:3170-3175.
37. Mori M. Electron microscopic and new microscopic studies of hepatocyte cytoskeleton: physiological and pathological relevance. J. Electron. Microsc. (Tokyo) 1994, 43:347-355.
38. Nayak S.S., Pattabiraman T.N. A new colorimetric method for the estimation of glycosylated hemoglobin. Clin. Chim. Acta 1981, 109:267-274.
39. Nicolle E., Souard F., Faure P., Boumendjel A. Flavonoids as promising lead compounds in type 2 diabetes mellitus: molecules of interest and structure-activity relationship. Curr. Med. Chem. 2011, 18(17):2661-2672.
40. O'Brien R.M., Granner D.K. Regulation of gene expression by insulin. Biochem. J. 1991, 278:609-619.
41. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
42. Ozgová S., Hermánek J., Gut I. Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-Fe-ascorbate- and Fe-microsomal systems. Biochem. Pharmacol. 2003, 66(7):1127-1137.
43. Prasath G.S., Subramanian S.P. Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2011, 668(3):492-496.
44. Prasath G.S., Sundaram C.S., Subramanian S.P. Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats. Endocrine. Jan 1. 2013, Epub ahead of print.
45. Rakieten N., Rakieten M.L., Nadkarni M.V. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother. Rep. 1963, 29:91-98.
46. Rashid K., Das J., Sil P.C. Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food Chem. Toxicol. 2013, 51:317-329.
47. Rice-Evans C.A., Miller N.J., Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad. Biol. Med. 1996, 20:933-956.
48. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
49. Sedlak J., Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 1968, 25:192-205.
50. Sriram Prasath G., Subramanian S. Fistein, a bioflavonoid ameliorates hyperglycemia in STZ induced experimental diabetes in rats. Int. J. Pharm. Sci. Rev. Res. 2011, 6:68-74.
51. Stadler K., Jenei V., von Bölcsházy G., Somogyi A., Jakus J. Increased nitric oxide levels as an early sign of premature aging in diabetes. Free Rad. Biol. Med. 2003, 35:1240-1251.
52. Suh Y., Afaq F., Khan N., Johnson J.J., Khusro F.H., Mukhtar H. Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis 2010, 31:1424-1433.
53. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 2001, 50(6):537-546.
54. Takahara S., Hamilton H.B., Neel J.V., Kobara T.Y., Ogura Y., Nishimura E.T. Hypocatalasemia: a new genetic carrier state. J. Clin. Invest. 1960, 39:610-619.
55. Wiernsperger N.F. Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes Metab. 2003, 29(6):579-585.
56. Yun K.U., Ryu C.S., Lee J.Y., Noh J.R., Lee C.H., Lee H.S., Kang J.S., Park S.K., Kim B.H., Kim S.K. Hepatic metabolism of sulfur amino acids in db/db mice. Food Chem. Toxicol. 2013, 53:180-186.