Flavonoids in modulation of cell survival signalling pathways

Genes and Nutrition

Volumn 9, Issue 3, 2014, Pages

  Mansuri, Mohammad Lukman ^a   Parihar, Priyanka ^a   Solanki, Isha ^a   Parihar, Mordhwaj S ^a  

^a VIKRAM UNIVERSITY   (India)

Author keywords

3 kinase; Akt protein kinase B; Cell survival; Mitogen activated protein kinase; Phosphoinositide; Plant polyphenols; Protein kinase C

Indexed keywords

CHRYSIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPIGALLOCATECHIN GALLATE; FLAVONOID; GENISTEIN; HESPERETIN; KAEMPFEROL; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MYRICETIN; NARIRUTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PINOCEMBRINE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE;

ACUTE LUNG INJURY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL FUNCTION; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; INFLAMMATORY PAIN; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION;

LYTHRACEAE; RUBUS GLAUCUS; VACCINIUM;

EID: 84899490033     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-014-0400-z     Document Type: Review

References (71)

1. Arany I, Megyesi JK, Reusch JE, Safirstein RL (2005) CREB mediates ERK-induced survival of mouse renal tubular cells after oxidant stress. Kidney Int 68:1573-1582 (Pubitemid 43169902)
2. Behrens A, Sibilia M, Wagner EF (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 21:326-329 (Pubitemid 29124945)
3. Belguise K, Guo S, Sonenshein GE (2007) Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells. Cancer Res 67:5763-5770 (Pubitemid 46985009)
4. Brazil DP, Hemmings BA (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26:657-664
5. Carpenter CL, Cantley LC (1990) Phosphoinositide kinases. Biochemistry 29:11147-11156
6. Chen C, Yu R, Owuor ED, Kong AN (2000) Activation of antioxidant response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 23:605-612
7. Chen X, Yang X, Liu T, Guan M, Feng X, Dong W, Chu X, Liu J, Tian X, Ci X, Li H, Wei J, Deng Y, Deng X, Chi G, Sun Z (2012) Kaempferol regulates MAPKs and NF-κB signalling pathways to attenuate LPS-induced acute lung injury in mice. Int Immunopharmacol 14:209-216
8. Choi EM (2011) Kaempferol protects MC3T3-E1 cells through antioxidant effect and regulation of mitochondrial function. Food Chem Toxicol 49:1800-1805
9. Choi YJ, Jeong YJ, Lee YJ, Kwon HM, Kang YH (2005) (-)Epigallocatechin gallate and quercetin enhance survival signalling in response to oxidant-induced human endothelial apoptosis. J Nutr 135:707-713
10. Clifford M (2001) A nomenclature for phenols with special reference to tea. Crit Rev Food Sci Nutr 41:393-397
11. Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927
12. Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103:239-252
13. Dutil EM, Toker A, Newton AC (1998) Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol 8:1366-1375 (Pubitemid 29020145)
14. Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT (1991) cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell 65:75
15. Fruman DA, Meyers RE, Cantley LC (1998) Phosphoinositide kinases. Annu Rev Biochem 67:481-507 (Pubitemid 28411136)
16. Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D (2010) Genistein induces pancreatic bcell proliferation through activation of multiple signalling pathways and prevents insulin-deficient diabetes in mice. Endocrinology 151:3026-3037
17. Ha SK, Park HY, Eom H, Kim Y, Choi I (2012) Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation. Food Chem Toxicol 50:3498-3504
18. Halliwell B, Rafter J, Jenner A (2005) Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr 81:268S-276S
19. Hazgui S, Bonnomet A, Nawrocki-Raby B, Milliot M, Terryn C, Cutrona J, Polette M, Birembaut P, Zahm JM (2008) Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells. Respir Res 9:33
20. He D, Ma X, Chen Y, Cai Y, Ru X, Bruce IC, Xia Q, Shi G, Jin J (2012) Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinase signalling pathway. FEBS J 279:1834-1843
21. Hollenbach E, Vieth M, Roessner A, Neumann M, Malfertheiner P, Naumann M (2005) Inhibition of RICK/nuclear factor-kappaB and p38 signalling attenuates the inflammatory response in a murine model of Crohn disease. J Biol Chem 280:14981-14988 (Pubitemid 40562850)
22. Hommes DW, Peppelenbosch MP, Von Deventer SJH (2003) Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52:144-151 (Pubitemid 36020783)
23. Huang CC, Wu WB, Fang JY, Chiang HS, Chen SK, Chen BH, Chen YT, Hung CF (2007) (-)-Epicatechin-3-gallate, a green tea polyphenol is a potent agent against UVB-induced damage in HaCaT keratinocytes. Molecules 12:1845-1858
24. Huang CS, Lii CK, Lin AH, Yeh YW, Yao HT, Li CC, Wang TS, Chen HW (2013) Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes. Arch Toxicol 87:167-178
25. Hwang SL, Yen GC (2009) Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide. J Agric Food Chem 57:2576-2582
26. Isaac AB, George IN, Oladimeji TA, James DH (2011) A bioactive flavonoid from Pavetta crassipes K. Schum. Org Med Chem Lett 1:14
27. Jimenez C, Hernandez C, Pimentel B, Carrera AC (2002) The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras. J Biol Chem 277:41556-41562 (Pubitemid 35257459)
28. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912 (Pubitemid 35425238)
29. Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP, Blenis J (1997) Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Mol Cell Biol 17:24-35 (Pubitemid 26425591)
30. Kawasaki H, Morooka T, Shimohama S, Kimura J, Hirano T, Gotoh Y, Nishida E (1997) Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J Biol Chem 272:18518-18521 (Pubitemid 27318185)
31. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, Hay N (1997) The PI 3-kinase/Akt signalling pathway delivers an anti-apoptotic signal. Genes Dev 11:701-713 (Pubitemid 27157159)
32. Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T, Aromaa A (2002) Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76:560-568 (Pubitemid 34920833)
33. Kohl R, Prei S, Knethen AV, Brune B (2006) Oxidized low-density lipoprotein depletes PKCa and attenuates reactive oxygen species formation in monocytes/macrophages. Cardiovasc Res 71:574-585 (Pubitemid 44107871)
34. Kummer JL, Rao PK, Heidenreich KA (1997) Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem 272:20490-20494 (Pubitemid 27355604)
35. Kyoung AK, Zhi HW, Rui Z, Mei JP, Ki CK, Sam SK, Young WK, Jongsung L, Deokhoon P, Jin WH (2010) Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signalling pathways. Int J Mol Sci 11:4348-4360
36. Lakatta EG, Levy D (2003a) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation 107:346-354 (Pubitemid 36135235)
37. Lakatta EG, Levy D (2003b) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a "set up" for vascular disease. Circulation 107:139-146 (Pubitemid 36070946)
38. Lin CW, Wu MJ, Liu I, Su JD, Yen JH (2010) Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. J Agric Food Chem 58:4477-4486
39. Lin CY, Ni CC, Yin MC, Lii CK (2012) Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway. Cytokine 59:65-71
40. Liu R, Wu CX, Zhou D, Yang F, Tian S, Zhang L, Zhang TT, Du GH (2012) Pinocembrin protects against b-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signalling pathways and regulating mitochondrion-mediated apoptosis. BMC Med 10:105
41. 25-35-induced neurotoxicity in PC12 cells via PKC signalling pathway. Neurochem Res 37:2787-2794
42. Manal AEM, Joanne M, Gunter K, Kevin M, Edward D, Srai SK, Catherine RE, Spencer JPE (2006) Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. Br J Nutr 95:51-58 (Pubitemid 43250711)
43. Meotti FC, Posser T, Missau FC, Pizzolatti MG, Leal RB, Santos AR (2007) Involvement of p38MAPK on the antinociceptive action of myricitrin in mice. Biochem Pharmacol 74:924-931 (Pubitemid 47212079)
44. Miyamoto N, Pham LDD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K (2013) Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke 44:2573-2578
45. Mursu J, Voutilainen S, Nurmi T, Tuomainen TP, Kurl S, Salonen JT (2008) Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr 100:890-895
46. Na HK, Kim EH, Jung JH, Lee HH, Hyun JW, Surh YJ (2008) (-)-Epigallocatechin gallate induces Nrf2-mediated anti-oxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. Arch Biochem Biophys 476:171-177
47. Naidoo N, Ferber M, Master M, Zhu Y, Pac AI (2008) Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signalling. J Neurosci 28:6539-6548
48. Neri LM, Borgatti P, Capitani S, Martelli AM (2002) The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim Biophys Acta 1584:73-80 (Pubitemid 35217879)
49. Newton AC (2001) Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101:2353-2364
50. Newton AC (2003) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370:361-371
51. Park SE, Sapkota K, Kim S, Kim H, Kim SJ (2011) Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells. Br J Pharmacol 164:1008-1025
52. Rainey SS, Schroetke LW, Bahia P, Fahmi A, Skilton R, Spencer JP, Rice-Evans C, Rattray M, Williams RJ (2008) Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neurosci Lett 438:29-33
53. Rice DS, Curran T (1999) Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev 13:2758-2773
54. Rice-Evans C (1995) Plant polyphenols: free radical scavengers or chain-breaking antioxidants? Biochem Soc Symp 61:103-116 Rice-Evans C (2001) Flavonoid antioxidants. Curr Med Chem 8:797-807
55. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027-1037 (Pubitemid 24292330)
56. Scalbert A, Manach C, Morand C, Remesy C, Jimenez L (2005) Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287-306 (Pubitemid 41657352)
57. Schroeter H, Bahia P, Spencer JP, Sheppard O, Rattray M, Cadenas E, Rice-Evans C, Williams RJ (2007) (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and upregulates GluR2 in cortical neurons. J Neurochem 101:1596-1606 (Pubitemid 46848841)
58. Simpson L, Parsons R (2001) PTEN: life as a tumor suppressor. Exp Cell Res 264:29-41 (Pubitemid 32989079)
59. Song GA, Ouyang GA, Bao S (2005) The activation of Akt/PKB signalling pathway and cell survival. J Cell Mol Med 9:59-71
60. Spencer JPE (2007) The interaction of flavonoids within neuronal signalling pathways. Genes Nutr 2:257-273
61. Spencer JP (2008) Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proc Nutr Soc 67:238-252
62. Vauzour D (2012) Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms under-pinning their beneficial effects. Oxid Med Cell Longev 2012:914273
63. Vauzour D, Vafeiadou K, Rice-Evans C, Williams RJ, Spencer JP (2007) Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. J Neurochem 103:1355-1367 (Pubitemid 47631805)
64. Williams RJ, Spencer JP, Rice-Evans C (2004) Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36:838-849 (Pubitemid 38352901)
65. Xi YD, Yu HL, Ding J, Ma WW, Yuan LH, Feng JF, Xiao YX, Xiao R (2012) Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from β-amyloid peptide-induced oxidative damage. Curr Neurovasc Res 9:32-41
66. Xiao H, Liu M (2013) Atypical protein kinase C in cell motility. Cell Mol Life Sci 70:3057-3066
67. Yang D, Liu J, Tian C, Zeng Y, Zheng YH, Fang Q, Li HH (2010a) Epigallocatechin gallate inhibits angiotensin II-induced endothelial barrier dysfunction via inhibition of the p38 MAPK/HSP27 pathway. Acta Pharmacol Sin 31:1401-1406
68. Yang Y, Nie W, Yuan J, Zhang B, Wang Z, Wu Z, Guo Y (2010b) Genistein activates endothelial nitric oxide synthase in broiler pulmonary arterial endothelial cells by an Akt-dependent mechanism. Exp Mol Med 42:768-776
69. Levites Y, Amit T, Youdim MB, Mandel S (2002) Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. J Biol Chem 277:30574-30580 (Pubitemid 34970751)
70. Zhanga Y, Liu D (2011) Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol 670:325-332
71. Zheng FL, Zhao JH, Zhang HP (2012) The action of PI3K/AKT during genistein promoting the activity of eNOS. Zhonghua Xin Xue Guan Bing Za Zhi 40:327-331