메뉴 건너뛰기




Volumn 2, Issue 4, 2012, Pages 287-302

The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease

Author keywords

1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine (MPTP); Apoptosis; Fisetin; MPP+; neurodegeneration; NF B inhibitor; Parkinson's disease; PC12 cells; pro inflammatory cytokines

Indexed keywords

ALPHA SYNUCLEIN; FISETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84874850775     PISSN: 18777171     EISSN: 1877718X     Source Type: Journal    
DOI: 10.3233/JPD-012110     Document Type: Article
Times cited : (49)

References (74)
  • 1
    • 34147181610 scopus 로고    scopus 로고
    • The progression of Parkinson disease: A hypothesis
    • DOI 10.1212/01.wnl.0000257110.91041.5d, PII 0000611420070320000017
    • Lang AE (2007) The progression of Parkinson disease: A hypothesis. Neurology, 68, 948-952. (Pubitemid 46568509)
    • (2007) Neurology , vol.68 , Issue.12 , pp. 948-952
    • Lang, A.E.1
  • 2
    • 33745847479 scopus 로고    scopus 로고
    • Diagnosis and treatment of Parkinson disease: Molecules to medicine
    • DOI 10.1172/JCI29178
    • Savitt JM, Dawson VL, & Dawson TM (2006) Diagnosis and treatment of Parkinson disease: Molecules to medicine. J Clin Invest, 116, 1744-1754. (Pubitemid 44033293)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1744-1754
    • Savitt, J.M.1    Dawson, V.L.2    Dawson, T.M.3
  • 3
    • 0034613450 scopus 로고    scopus 로고
    • Characterization of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain
    • Crowther RA, Daniel SE, & Goedert M (2000) Characterization of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain. Neurosci Lett, 92(2), 128-130.
    • (2000) Neurosci Lett , vol.92 , Issue.2 , pp. 128-130
    • Crowther, R.A.1    Daniel, S.E.2    Goedert, M.3
  • 4
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • DOI 10.1038/nm0602-600
    • Xu J, Kao SY, Lee FJ, Song W, Jin LW, & Yanker BA (2002) Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease. Nat Med, 8, 600-606. (Pubitemid 34633438)
    • (2002) Nature Medicine , vol.8 , Issue.6 , pp. 600-606
    • Xu, J.1    Kao, S.-Y.2    Lee, F.J.S.3    Song, W.4    Jin, L.-W.5    Yankner, B.A.6
  • 5
    • 0033825627 scopus 로고    scopus 로고
    • Oxidative stress andgenetics in the pathogenesis of Parkinson's disease
    • Zhang Y, Dawson VL, & Dawson TM (2000) Oxidative stress andgenetics in the pathogenesis of Parkinson's disease. Neu-robiol Dis, 7(4), 240-250.
    • (2000) Neu-robiol Dis , vol.7 , Issue.4 , pp. 240-250
    • Zhang, Y.1    Dawson, V.L.2    Dawson, T.M.3
  • 6
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative Stress in Parkinson's Disease: A mechanism of pathogenic and therapeutic significance
    • Zhou C, Huang Y, & Przedborski (2008) Oxidative Stress in Parkinson's Disease: A mechanism of pathogenic and therapeutic significance. Annals of the New York Academy of Sciences, 1147, 93-104.
    • (2008) Annals of the New York Academy of Sciences , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski3
  • 7
    • 25144468525 scopus 로고    scopus 로고
    • To be or not to be (inflamed) - Is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?
    • DOI 10.1016/j.tips.2005.08.007, PII S0165614705002051
    • Marchetti B, & Abbracchio MP (2005) To be or not to be (inflamed) Is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? Trends Pharmacol Sci, 26, 517-525. (Pubitemid 41338562)
    • (2005) Trends in Pharmacological Sciences , vol.26 , Issue.10 , pp. 517-525
    • Marchetti, B.1    Abbracchio, M.P.2
  • 10
    • 0028967848 scopus 로고
    • Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apopto-sis
    • Slater AF, Nobel CS, Maellaro E, Bustamante J, Kimland M, & Orrenius S (1995) Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apopto-sis. Biochem J, 306, 771-778.
    • (1995) Biochem J , vol.306 , pp. 771-778
    • Slater, A.F.1    Nobel, C.S.2    Maellaro, E.3    Bustamante, J.4    Kimland, M.5    Orrenius, S.6
  • 11
    • 0033956743 scopus 로고    scopus 로고
    • Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: Modulatory effects of phytochemicals
    • O'Brien NM, Woods JA, Aherne SA, & O'Callaghan YC (2000) Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: Modulatory effects of phytochemicals. Biochem Soc Trans, 28, 22-26. (Pubitemid 30103207)
    • (2000) Biochemical Society Transactions , vol.28 , Issue.2 , pp. 22-26
    • O'Brien, N.M.1    Woods, J.A.2    Aherne, S.A.3    O'Callaghan, Y.C.4
  • 12
    • 0035815285 scopus 로고    scopus 로고
    • Release and aggregation of cytochrome c and α-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole
    • DOI 10.1016/S0014-2999(01)00902-5, PII S0014299901009025
    • Kakimura J, Kitamura Y, Takata K, Kohno Y, Nomura Y, & Taniguchi T (2001) Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. Eur J Pharmacol, 417(1-2), 59-67. (Pubitemid 32299869)
    • (2001) European Journal of Pharmacology , vol.417 , Issue.1-2 , pp. 59-67
    • Kakimura, J.-I.1    Kitamura, Y.2    Takata, K.3    Kohno, Y.4    Nomura, Y.5    Taniguchi, T.6
  • 13
    • 65549098614 scopus 로고    scopus 로고
    • Apop-totic mechanisms after cerebral ischemia
    • Broughton BR, Reutens DC, & Sobey CG (2009) Apop-totic mechanisms after cerebral ischemia. Stroke, 40, e331-e339.
    • (2009) Stroke , vol.40
    • Broughton, B.R.1    Reutens, D.C.2    Sobey, C.G.3
  • 14
    • 0032879452 scopus 로고    scopus 로고
    • Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease
    • Hashimoto M, Takeda A, Hsu LJ, Takenouchi T, & Masliah E (1999) Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease. J Biol Chem, 274(41), 28849-28852.
    • (1999) J Biol Chem , vol.274 , Issue.41 , pp. 28849-28852
    • Hashimoto, M.1    Takeda, A.2    Hsu, L.J.3    Takenouchi, T.4    Masliah, E.5
  • 15
    • 0031036896 scopus 로고    scopus 로고
    • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
    • Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, & Agid Y (1997) Apoptosis and autophagy in nigral neurons of patientswith Parkinson's disease. Histol Histopathol, 12, 25-31. (Pubitemid 27106916)
    • (1997) Histology and Histopathology , vol.12 , Issue.1 , pp. 25-31
    • Anglade, P.1
  • 16
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • DOI 10.1016/0022-510X(95)00336-Z
    • Mochizuki H, Goto K, Mori H, & Mizuno Y (1996) His-tochemical detection of apoptosis in Parkinson's disease. J Neurol Sci, 137, 120-123. (Pubitemid 26172041)
    • (1996) Journal of the Neurological Sciences , vol.137 , Issue.2 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 17
    • 0028222824 scopus 로고
    • +) in ventral mesencephalic-striatal co-culture in rat
    • DOI 10.1016/0304-3940(94)90271-2
    • Mochizuki H, Nakamura N, Nishi K, & Mizuno Y (1994) Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat. Neurosci Lett, 170, 191-194. (Pubitemid 24117319)
    • (1994) Neuroscience Letters , vol.170 , Issue.1 , pp. 191-194
    • Mochizuki, H.1    Nakamura, N.2    Nishi, K.3    Mizuno, Y.4
  • 18
    • 0036716889 scopus 로고    scopus 로고
    • MPTP: Insights into parkinsonian neu-rodegeneration
    • Speciale SG (2002) MPTP: Insights into parkinsonian neu-rodegeneration. Neurotoxicol Teratol, 24, 607-620.
    • (2002) Neurotoxicol Teratol , vol.24 , pp. 607-620
    • Speciale, S.G.1
  • 19
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining
    • Tatton NA, & Kish SJ (1997) In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience, 77, 1037-1048.
    • (1997) Neuroscience , vol.77 , pp. 1037-1048
    • Tatton, N.A.1    Kish, S.J.2
  • 20
    • 0025116342 scopus 로고
    • Mechanism of the neuro-toxicity of MPTP, an update
    • Singer TP, & Ramsay RR (1990) Mechanism of the neuro-toxicity of MPTP, an update. FEBS Lett, 274, 1-8.
    • (1990) FEBS Lett , vol.274 , pp. 1-8
    • Singer, T.P.1    Ramsay, R.R.2
  • 21
    • 0035022949 scopus 로고    scopus 로고
    • + neurotoxicity in mice
    • DOI 10.1023/A:1007680616056
    • Alcaraz-Zubeldia M, Rojas P, Boll C, & Rios C (2001) Neuro-protective effect of acute and chronic administration of copper (II) sulfate against MPP+ neurotoxicity in mice. Neurochem Res, 26, 59-64. (Pubitemid 32428814)
    • (2001) Neurochemical Research , vol.26 , Issue.1 , pp. 59-64
    • Alcaraz-Zubeldia, M.1    Rojas, P.2    Boll, C.3    Rios, C.4
  • 22
    • 0033840581 scopus 로고    scopus 로고
    • 2-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
    • DOI 10.1046/j.1471-4159.2000.0751200.x
    • Saporito MS, Thomas BA, Scott RW (2000) MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J Neurochem, 75, 1200-1208. (Pubitemid 30660510)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.3 , pp. 1200-1208
    • Saporito, M.S.1    Thomas, B.A.2    Scott, R.W.3
  • 24
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of α-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • DOI 10.1074/jbc.M105326200
    • Lee HJ, Shin SY, Choi C, Lee YH, & Lee SJ (2002) Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem, 277, 5411-5417. (Pubitemid 34968588)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.7 , pp. 5411-5417
    • Lee, H.-J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.-J.5
  • 25
    • 2442494278 scopus 로고    scopus 로고
    • +-induced apoptosis in neuroblastoma cells. Intermediacy of transferrin receptor iron and hydrogen peroxide
    • DOI 10.1074/jbc.M312497200
    • Kalivendi SV, Cunningham S, Kotamraju S, Joseph J, Hillard CJ, & Kalyanaraman B (2004) Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neurob-lastoma cells: Intermediacy of transferrin receptor iron and hydrogen peroxide. J Biol Chem, 279, 15240-15247. (Pubitemid 38618920)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.15 , pp. 15240-15247
    • Kalivendi, S.V.1    Cunningham, S.2    Kotamraju, S.3    Joseph, J.4    Hillard, C.J.5    Kalyanaraman, B.6
  • 26
    • 56349089470 scopus 로고    scopus 로고
    • Role of nitric oxide synthases in Parkinson's disease: A review on the antioxidantand anti-inflammatory activityofpolyphenols
    • Aquilano K, Baldelli S, Rotilio G, & Ciriolo MR (2008) Role of nitric oxide synthases in Parkinson's disease: A review on the antioxidantand anti-inflammatory activityofpolyphenols. Neurochem Res, 33, 2416-2426.
    • (2008) Neurochem Res , vol.33 , pp. 2416-2426
    • Aquilano, K.1    Baldelli, S.2    Rotilio, G.3    Ciriolo, M.R.4
  • 27
    • 33750465142 scopus 로고    scopus 로고
    • Nitric oxide synthase regulation and diversity: Implications in Parkinson's disease
    • DOI 10.1016/j.niox.2006.07.003, PII S1089860306003764
    • Kavya R, Saluja R, Singh, & Dikshit SM (2006) Nitric oxide synthase regulation and diversity: Implications in Parkinson's disease. Nitric Oxide, 15, 280-294. (Pubitemid 44647899)
    • (2006) Nitric Oxide - Biology and Chemistry , vol.15 , Issue.4 , pp. 280-294
    • Kavya, R.1    Saluja, R.2    Singh, S.3    Dikshit, M.4
  • 30
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • DOI 10.1016/S0896-6273(03)00568-3
    • Dauer W, & Przedborski S (2003) Parkinson's disease: Mechanisms and models. Neuron, 39, 889-909. (Pubitemid 37130207)
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 31
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: Where are we now?
    • DOI 10.1111/j.1471-4159.2006.03907.x
    • Halliwell B (2006) Oxidative stress and neurodegeneration: Where are we now? J Neurochem, 97(6), 1634-1658. (Pubitemid 43873658)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.6 , pp. 1634-1658
    • Halliwell, B.1
  • 32
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms Underlying Inflammation in Neurodegeneration
    • Glass CK, Saijo K, Winner B, Marchetto MC, & Gage FH (2010) Mechanisms Underlying Inflammation in Neurodegeneration. Cell, 140(6), 918-934.
    • (2010) Cell , vol.140 , Issue.6 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 33
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C, & Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev, 52, 673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 34
  • 35
    • 0035235476 scopus 로고    scopus 로고
    • Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons
    • Bastianetto S, Zheng WH, & Quirion R (2000) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol, 131(4), 711-720.
    • (2000) Br J Pharmacol , vol.131 , Issue.4 , pp. 711-720
    • Bastianetto, S.1    Zheng, W.H.2    Quirion, R.3
  • 36
    • 3142540615 scopus 로고    scopus 로고
    • Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes
    • DOI 10.1016/j.febslet.2004.06.027, PII S0014579304007483
    • Sengupta B, Banerjee A, & Sengupta PK (2004) Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes. FEBS Letters, 570, 77-81. (Pubitemid 38900960)
    • (2004) FEBS Letters , vol.570 , Issue.1-3 , pp. 77-81
    • Sengupta, B.1    Banerjee, A.2    Sengupta, P.K.3
  • 37
    • 0033850592 scopus 로고    scopus 로고
    • Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration
    • Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, & Kinae N (2000) Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr, 130(9), 2243-2250.
    • (2000) J Nutr , vol.130 , Issue.9 , pp. 2243-2250
    • Arai, Y.1    Watanabe, S.2    Kimira, M.3    Shimoi, K.4    Mochizuki, R.5    Kinae, N.6
  • 38
    • 71949125029 scopus 로고    scopus 로고
    • Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
    • Maher P (2009) Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr, 4(4), 297-307.
    • (2009) Genes Nutr , vol.4 , Issue.4 , pp. 297-307
    • Maher, P.1
  • 39
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • DOI 10.1080/10715760500233113
    • Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, & Dexter DT (2005) Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res, 39(10), 1119-1125. (Pubitemid 41358566)
    • (2005) Free Radical Research , vol.39 , Issue.10 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 40
    • 4043089112 scopus 로고    scopus 로고
    • Pharmacokinetics and Metabolism of dietary fiavonoids
    • Manach C, & Donovan J (2004) Pharmacokinetics and Metabolism of dietary fiavonoids. Free Rad Res, 38, 771-785.
    • (2004) Free Rad Res , vol.38 , pp. 771-785
    • Manach, C.1    Donovan, J.2
  • 41
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • DOI 10.1016/S0891-5849(00)00498-6, PII S0891584900004986
    • Ishige K, Schubert D, & Sagara Y (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med, 30(4), 433-446. (Pubitemid 32155542)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.4 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 42
    • 4444360215 scopus 로고    scopus 로고
    • Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation
    • DOI 10.1111/j.1471-4159.2004.02563.x
    • Sagara Y, Vanhnasy J, & Maher P. (2004) Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation. J Neurochem, 90(5), 1144-1155. (Pubitemid 39167347)
    • (2004) Journal of Neurochemistry , vol.90 , Issue.5 , pp. 1144-1155
    • Sagara, Y.1    Vanhnasy, J.2    Maher, P.3
  • 43
    • 33749255399 scopus 로고    scopus 로고
    • A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives
    • DOI 10.1080/10715760600672509, PII W1255U116263V742, Polyphenols and Health
    • Maher P (2006) A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. Free Radic Res, 40(10), 1105-1111. (Pubitemid 44480551)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1105-1111
    • Maher, P.1
  • 44
    • 48149095229 scopus 로고    scopus 로고
    • The flavonoid fisetin promotes nerve cell survival from trophic withdrawal by enhancement of proteasome activity
    • Maher P (2008) The flavonoid fisetin promotes nerve cell survival from trophic withdrawal by enhancement of proteasome activity. Arch Biochem Biophys, 476, 139-144.
    • (2008) Arch Biochem Biophys , vol.476 , pp. 139-144
    • Maher, P.1
  • 45
    • 2442507000 scopus 로고    scopus 로고
    • Affordable image analysis using NIH image/imageJ
    • Girish V, & Vijayalakshmi A (2004) Affordable image analysis using NIH Image/ImageJ. Indian J Cancer, 41, 47. (Pubitemid 38623932)
    • (2004) Indian Journal of Cancer , vol.41 , Issue.1 , pp. 47
    • Girish, V.1    Vijayalakshmi, A.2
  • 48
    • 2342650150 scopus 로고    scopus 로고
    • 2, Hydrogen Peroxide, and a Nitric Oxide Donor in Differentiated Neuroblastoma Cells
    • DOI 10.1002/jnr.20058
    • Prasad JE, Kumar B, Andreatta C, Nahreini P, Hanson AJ, Yan XD, & Prasad KN (2004) Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells. J Neurosci Res, 76, 415-422. (Pubitemid 38580137)
    • (2004) Journal of Neuroscience Research , vol.76 , Issue.3 , pp. 415-422
    • Prasad, J.E.1    Kumar, B.2    Andreatta, C.3    Nahreini, P.4    Hanson, A.J.5    Yan, X.D.6    Prasad, K.N.7
  • 49
    • 0031172065 scopus 로고    scopus 로고
    • NF-κB: A crucial transcription factor for glial and neuronal cell function
    • DOI 10.1016/S0166-2236(96)01035-1
    • O'Neill Luke AJ, & Kaltschmidt C (1997) NF-kB: A crucial transcription factor for glial and neuronal cell function. Trends Neurosci, 20, 252-258. (Pubitemid 27261456)
    • (1997) Trends in Neurosciences , vol.20 , Issue.6 , pp. 252-258
    • O'Neill, L.A.J.1    Kaltschmidt, C.2
  • 50
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-kB in nerve cell survival, plasticity, and disease
    • Mattson MP, & Meffert MK (2006) Roles for NF-kB in nerve cell survival, plasticity, and disease. Cell Death Differ, 13, 852-860.
    • (2006) Cell Death Differ , vol.13 , pp. 852-860
    • Mattson, M.P.1    Meffert, M.K.2
  • 51
    • 34250016055 scopus 로고    scopus 로고
    • Apoptotic neuronal death in Parkinson's disease: Involvement of nitric oxide
    • DOI 10.1016/j.brainresrev.2007.02.001, PII S0165017307000276
    • Singh S, & Dikshit M (2007) Apoptotic neuronal death in Parkinson's disease: Involvement of nitric oxide. Brain Research Reviews, 54(2), 233-250. (Pubitemid 46891075)
    • (2007) Brain Research Reviews , vol.54 , Issue.2 , pp. 233-250
    • Singh, S.1    Dikshit, M.2
  • 53
    • 84975751684 scopus 로고
    • Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
    • Hartley A, Stone JM, Heron C, Cooper JM, & Schapira AH (1994) Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease. JNeurochem, 63, 1987-1990. (Pubitemid 24326248)
    • (1994) Journal of Neurochemistry , vol.63 , Issue.5 , pp. 1987-1990
    • Hartley, A.1    Stone, J.M.2    Heron, C.3    Cooper, J.M.4    Schapira, A.H.V.5
  • 54
    • 79953869870 scopus 로고    scopus 로고
    • Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-kB pathway and regulation of cellular redox status by an oxazine derivative
    • Ansari N, Khodagholi F, Amini M, & Shaerzadeh F (2011) Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-kB pathway and regulation of cellular redox status by an oxazine derivative. Biochimie, 93(5), 899-908.
    • (2011) Biochimie , vol.93 , Issue.5 , pp. 899-908
    • Ansari, N.1    Khodagholi, F.2    Amini, M.3    Shaerzadeh, F.4
  • 55
    • 79957939863 scopus 로고    scopus 로고
    • Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-a expression
    • Dholakiya SL, & Benzeroual KE (2011) Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-a expression. Toxicology In Vitro, 25(5), 1039-1044.
    • (2011) Toxicology in Vitro , vol.25 , Issue.5 , pp. 1039-1044
    • Dholakiya, S.L.1    Benzeroual, K.E.2
  • 56
    • 0035894881 scopus 로고    scopus 로고
    • Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    • Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F, Yang L, Flint Beal M, & Andersen JK (2001) Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinson's disease. The Journal of Neuroscience, 21(24), 9519-9528. (Pubitemid 34184040)
    • (2001) Journal of Neuroscience , vol.21 , Issue.24 , pp. 9519-9528
    • Viswanath, V.1    Wu, Y.2    Boonplueang, R.3    Chen, S.4    Stevenson, F.F.5    Yantiri, F.6    Yang, L.7    Flint Beal, M.8    Andersen, J.K.9
  • 58
    • 33847265732 scopus 로고    scopus 로고
    • Rifampicin protects PC12 cells against MPP+ induced apoptosis and inhibits expression of alpha-Synuclein oligomers
    • Xua J, Weib C, Xuc C, Bennettc CM, Zhanga G, Lia F, & Taoa E (2007) Rifampicin protects PC12 cells against MPP+ induced apoptosis and inhibits expression of alpha-Synuclein oligomers. Brain Research, 1139, 220-225.
    • (2007) Brain Research , vol.1139 , pp. 220-225
    • Xua, J.1    Weib, C.2    Xuc, C.3    Bennettc, C.M.4    Zhanga, G.5    Lia, F.6    Taoa, E.7
  • 59
    • 0033966487 scopus 로고    scopus 로고
    • α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • DOI 10.1046/j.1471-4159.2000.740721.x
    • Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, & Przedborski S (2000) a-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP J Neurochem, 74, 721-729. (Pubitemid 30053745)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.2 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 61
    • 12244300931 scopus 로고    scopus 로고
    • Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease
    • Watanabe Y, Himeda T, & Araki T (2005) Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease. Med Sci Monit, 11, RA17-RA23. (Pubitemid 40116407)
    • (2005) Medical Science Monitor , vol.11 , Issue.1
    • Watanabe, Y.1    Himeda, T.2    Araki, T.3
  • 63
    • 29644434199 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
    • DOI 10.1093/hmg/ddi396
    • Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, & Ross CA (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet, 14, 3801-3811. (Pubitemid 43020082)
    • (2005) Human Molecular Genetics , vol.14 , Issue.24 , pp. 3801-3811
    • Smith, W.W.1    Jiang, H.2    Pei, Z.3    Tanaka, Y.4    Morita, H.5    Sawa, A.6    Dawson, V.L.7    Dawson, T.M.8    Ross, C.A.9
  • 64
    • 0032006868 scopus 로고    scopus 로고
    • Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells
    • DOI 10.1002/(SICI)1097-4547(19980201)51:3<293::AID-JNR3>3.0.CO;2-B
    • Kruman I, Guo Q, & Mattson MP (1998) Calcium andreactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res, 51, 293-308. (Pubitemid 28078461)
    • (1998) Journal of Neuroscience Research , vol.51 , Issue.3 , pp. 293-308
    • Kruman, I.1    Guo, Q.2    Mattson, M.P.3
  • 65
    • 0037441753 scopus 로고    scopus 로고
    • The establishment of a reliable cytotoxic system with SK-N-SH neuroblastoma cell culture
    • DOI 10.1016/S0165-0270(02)00324-2, PII S0165027002003242
    • Ba F, Pang PKT, & Benishin CG (2003) The establishment of a reliable cytotoxic system with SK-N-SH neuroblastoma cell culture. Journal of Neuroscience Methods, 123(1), 11-22. (Pubitemid 36173648)
    • (2003) Journal of Neuroscience Methods , vol.123 , Issue.1 , pp. 11-22
    • Ba, F.1    Pang, P.K.T.2    Benishin, C.G.3
  • 66
    • 79953150761 scopus 로고    scopus 로고
    • Parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and a-synuclein mutations promote tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in Vitro
    • Qureshi HY, & Paudel HK (2011) Parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and a-synuclein mutations promote tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in Vitro. J Biol Chem, 286(7), 5055-5068.
    • (2011) J Biol Chem , vol.286 , Issue.7 , pp. 5055-5068
    • Qureshi, H.Y.1    Paudel, H.K.2
  • 67
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM, & Korsmeyer SJ (1999) Bcl-2 family members and the mitochondria in apoptosis. Genes Dev, 13, 1899-1911. (Pubitemid 29407357)
    • (1999) Genes and Development , vol.13 , Issue.15 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 69
    • 0043162103 scopus 로고    scopus 로고
    • Novel anti-inflammatory therapy for Parkinson's disease
    • DOI 10.1016/S0165-6147(03)00176-7
    • Gao HM, Liu B, Zhang W, & Hong JS (200) (2003) Novel anti-inflammatory therapy for Parkinson's disease. Trends in Pharmacological Sciences, 24(8), 395-401. (Pubitemid 36952555)
    • (2003) Trends in Pharmacological Sciences , vol.24 , Issue.8 , pp. 395-401
    • Gao, H.-M.1    Liu, B.2    Zhang, W.3    Hong, J.-S.4
  • 70
    • 1942454250 scopus 로고    scopus 로고
    • Inflammation and neu-rodegeneration in Parkinson's disease
    • McGeer PL, & McGeer EG (2004) Inflammation and neu-rodegeneration in Parkinson's disease. Parkinsonism Relat Disord, 10(1), S3-S7.
    • (2004) Parkinsonism Relat Disord , vol.10 , Issue.1
    • McGeer, P.L.1    McGeer, E.G.2
  • 71
    • 35348966882 scopus 로고    scopus 로고
    • Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
    • DOI 10.1016/j.expneurol.2007.07.004, PII S0014488607002701
    • Tansey MG, McCoy MK, & Frank-Cannon TC (2007) Neu-roinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol, 208(1), 1-25. (Pubitemid 47603240)
    • (2007) Experimental Neurology , vol.208 , Issue.1 , pp. 1-25
    • Tansey, M.G.1    McCoy, M.K.2    Frank-Cannon, T.C.3
  • 72
    • 0037031609 scopus 로고    scopus 로고
    • Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra
    • DOI 10.1016/S0304-3940(02)00704-8, PII S0304394002007048
    • Feng ZH, Wang TG, Li DD, Fung P, Wilson BC, Liu B, Ali SF, Langenbach R, & Hong JS (2002) Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra. Neurosci Lett, 329, 354-358. (Pubitemid 35245358)
    • (2002) Neuroscience Letters , vol.329 , Issue.3 , pp. 354-358
    • Feng, Z.-H.1    Wang, T.-G.2    Li, D.-D.3    Fung, P.4    Wilson, B.C.5    Liu, B.6    Ali, S.F.7    Langenbach, R.8    Hong, J.-S.9
  • 73
    • 1642395294 scopus 로고    scopus 로고
    • Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- treated mice
    • DOI 10.1016/j.brainres.2004.01.065, PII S0006899304001726
    • Chera B, Schaecher KE, Rocchini A, Imam SZ, Sribnick EA, Ray SK, Ali SF, & Banik NL (2004) Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated mice. Brain Res, 1006, 150-156. (Pubitemid 38393759)
    • (2004) Brain Research , vol.1006 , Issue.2 , pp. 150-156
    • Chera, B.1    Schaecher, K.E.2    Rocchini, A.3    Imam, S.Z.4    Sribnick, E.A.5    Ray, S.K.6    Ali, S.F.7    Banik, N.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.