A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives

Free Radical Research

Volumn 40, Issue 10, 2006, Pages 1105-1111

  Maher, Pamela ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Differentiation; Extracellular signal regulated kinase (ERK); Flavonoids; Glutathione; Neuroprotection; Oxidative stress

Indexed keywords

3',4' DIHYDROXYFLAVONE; 3,3' DIHYDROXYFLAVONE; 3,3',4' TETRAHYDROXYFLAVONE; 3,4' DIHYDROXYFLAVONE; 3,7,3' TETRAHYDROXYFLAVONE; 3,7,4' TETRAHYDROXYFLAVONE; 7,3',4' TETRAHYDROXYFLAVONE; FISETIN; FLAVONE DERIVATIVE; FLAVONOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTROPISM; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; CELL DIFFERENTIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONES; FLAVONOIDS; MAP KINASE KINASE KINASES; NERVE GROWTH FACTORS; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749255399     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760600672509     Document Type: Conference Paper

References (19)

1. Levy, YS and Gilgun-Sherki, Y and Melamed, E and Offen, D. (2005) Therapeutic potential of neurotrophic factors in neurodegenerative diseases BioDrugs, 19, pp. 97-127.
2. Sagara, Y and Vahnnasy, J and Maher, P. (2004) Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation J Neurochem, 90, pp. 1144-1155.
3. Ishige, K and Schubert, D and Sagara, Y. (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms Free Radic Biol Med, 30, pp. 433-446.
4. Davis, JB and Maher, P. (1994) Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell lines Brain Res, 652, pp. 169-173.
5. Maher, P and Davis, JB. (1996) The role of monoamine metabolism in oxidative glutamate toxicity J Neurosci, 16, pp. 6394-6401.
6. Greene, L and Tischler, AS. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proc Natl Acad Sci USA, 73, pp. 2424-2428.
7. Kimura, H and Schubert, D. (1992) Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells J Cell Biol, 116, pp. 777-783.
8. Hansen, MB and Nielsen, SE and Berg, K. (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill J Immunol Methods, 119, pp. 203-210.
9. Schreiber, E and Matthias, P and Muller, MM and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells Nuc Acids Res, 17, pp. 6419.
10. Maher, P and Hanneken, A. (2005) The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line Invest Ophthalmol Vis Sci, 46, pp. 749-757.
11. Re, R and Pellegrini, N and Proteggente, A and Pannala, A and Yang, M and Rice-Evans, C. (1999) Antioxidant activity applying an improved ABTS radical cation depolarization assay Free Rad Biol Med, 26, pp. 1231-1237.
12. Tan, S and Schubert, D and Maher, P. (2001) Oxytosis: A novel form of programmed cell death Curr Top Med Chem, 1, pp. 497-506.
13. Valerio, LG and Kepa, JK and Pickwell, GV and Quattrochi, LC. (2001) Induction of human NAD(P)H: Quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin Toxicol Lett, 119, pp. 49-57.
14. Hou, D-X and Fukuda, M and Johnson, JA and Miyamori, K and Ushikai, M and Fujii, M. (2001) Fisetin induces transcription of NADPH: Quinone oxidoreductase gene through an antioxidant responsive element-involved activation Int J Oncol, 18, pp. 1175-1179.
15. Myhrstad, MCW and Carlsen, H and Nordstrom, O and Blomhoff, R and Moskaug, JO. (2002) Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter Free Rad Biol Med, 32, pp. 386-393.
16. Hayes, JD and McLellan, LI. (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress Free Rad Res, 31, pp. 273-300.
17. Nguyen, T and Sherratt, PJ and Pickett, CB. (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element Annu Rev Pharmacol Toxicol, 43, pp. 233-260.
18. Keegan, K and Halegoua, S. (1993) Signal transduction pathways in neuronal differentiation Curr Opin Neurobiol, 3, pp. 14-19.
19. Dringen, R and Gutterer, JM and Hirrlinger, J. (2000) Glutathione metabolism in brain Eur J Biochem, 267, pp. 4912-4916.