The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-κB and MAPK signaling in human lens epithelial cells

Molecular Vision

Volumn 14, Issue , 2008, Pages 1865-1871

  Yao, Ke ^a   Zhang, Li ^a   Zhang, Yi Dong ^a   Ye, Pan Pan ^a   Zhu, Ning ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FISETIN; FLAVONOID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA;

ARTICLE; CATARACTOGENESIS; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; EYE PROTECTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LENS EPITHELIUM; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION ATTENUATION; RADIATION PROTECTION; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION; WESTERN BLOTTING;

CELL LINE; CELL SURVIVAL; EPITHELIAL CELLS; FLAVONOIDS; HUMANS; I-KAPPA B PROTEINS; LENS, CRYSTALLINE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; ULTRAVIOLET RAYS;

EID: 55349129283     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Foster A, Resnikoff S. The impact of Vision 2020 on global blindness. Eye 2005; 19:1133-5.
2. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, Mariotti SP. Global data on visual impairment in the year 2002. Bull World Health Organ 2004; 82:944-51.
3. Taylor HR. Epidemiology of age-related cataract. Eye 1999; 13:445-8.
4. Sasaki K, Sasaki H, Kojima M, Shui YB, Hockwin O, Jonasson F, Cheng HM, Ono M, Katoh N. Epidemiological studies on UV-related cataract in climatically different countries. J Epidemiol 1999; 9:S33-8.
5. West S. Ocular ultraviolet B exposure and lens opacities: a review. J Epidemiol 1999; 9:S97-101.
6. Andley UP, Walsh A, Kochevar IE, Reddan JR. Effect of ultraviolet-B radiation on protein synthesis in cultured lens epithelial cells. Curr Eye Res 1990; 9:1099-106.
7. Linetsky M, James HL, Ortwerth BJ. The generation of superoxide anion by the UVA irradiation of human lens proteins. Exp Eye Res 1996; 63:67-74.
8. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J 1995; 9:1173-82.
9. Truscott RJ. Age-related nuclear cataract-oxidation is the key. Exp Eye Res 2005; 80:709-25.
10. Jiang Q, Zhou C, Healey S, Chu W, Kouttab N, Bi Z, Wan Y. UV radiation down-regulates Dsg-2 via Rac/NADPH oxidasemediated generation of ROS in human lens epithelial cells. Int J Mol Med 2006; 18:381-7.
11. Kalbina I, Strid A. The role of NADPH oxidase and MAP kinase phosphatase in UV-B-dependent gene expression in Arabidopsis. Plant Cell Environ 2006; 29:1783-93.
12. Boileau TW, Bray TM, Bomser JA. Bomser.Ultraviolet Radiation Modulates Nuclear Factor Kappa B Activation in Human Lens Epithelial Cells. J Biochem Mol Toxicol 2003; 17:108-13.
13. Lee DH, Cho KS, Park SG, Kim EK, Jon CK. Cellular death mediated by nuclear factor kappa B(NF-κB) translocation in cultured human lensepithelial cells after ultraviolet-B irradiation. J Cataract Refract Surg 2005; 31:614-9.
14. Halliwell B, Gutteridge JMC, editors. Free Radicals in Biology and Medicine. 3rd ed. London: Oxford University Press; 1999.
15. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 2000; 130:2243-50.
16. Maher P. Comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. Free Radic Res 2006; 40:1105-11.
17. Higa S, Hirano T, Kotani M, Matsumoto M, Fujita A, Suemura M, Kawase I, Tanake T. Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J Allergy Clin Immunol 2003; 111: 1299-306.
18. Fotsis T, Pepper MS, Montesano R, Aktas E, Breit S, Schweigerer L, Rasku S, Wahala K, Adlercreutz H. Phytoestrogens and inhibition of angiogenesis. Baillieres Clin Endocrinol Metab 1998; 12:649-66.
19. Hanneken A, Lin FF, Johnson J, Maher P. Flavonoids Protect Human Retinal Pigment Epithelial Cells from Oxidative-Stress-Induced Death. Invest Ophthalmol Vis Sci 2006; 47:3164-77.
20. Ibaraki N, Chen SC, Lin LR, Okamoto H, Pipas JM, Reddy VN. Human lens epithelial cell line. Exp Eye Res 1998; 67:577-85.
21. McCarty CA, Taylor HR. A review of the epidemiologic evidence linking ultraviolet radiation and cataracts. Dev Ophthalmol 2002; 35:21-31.
22. Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signaling molecules. Free Radic Biol Med 2004; 36:838-49.
23. Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, Coso OA. Phosphorylation of c-Fos by members of the p38 MAPK family: role in the AP-1 response to UV light. J Biol Chem 2005; 280:18842-52.
24. Mantena SK, Katiyar SK. Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-κB signaling in human epidermal keratinocytes. Free Radic Biol Med 2006; 40:1603-14.
25. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 2001; 30:433-46.
26. Wätjen W, Michels G, Steffan B, Niering P, Chovolou Y, Kampkötter A, Tran-Thi QH, Proksch P, Kahl R. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J Nutr 2005; 135:525-31.
27. Schreck R, Albermann K, Baeuerle PA. Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 1992; 17:221-37.
28. Boileau TW, Bray TM, Bomser JA. Ultraviolet radiation modulates nuclear factor kappa B activation in human lens epithelial cells. J Biochem Mol Toxicol 2003; 17:108-13.
29. Maniatis T. Catalysis by a multiprotein IkappaB kinase complex. Science 1997; 278:818-9.
30. Bacuerle PA, Baltimore D. NF-kappa B: ten Cell 1996; 87:13-20.
31. Helenius M, Makelainen L, Salminen A. Attenuation of NF-kappaB signaling response to UVB light during cellular senescence. Exp Cell Res 1999; 248:194-202.
32. Saliou C, Kitazawa M, McLaughlin L, Yang JP, Lodge JK, Tetsuka T, Iwasaki K, Cillard J, Okamoto T, Packer L. Antioxidants modulate acute solar ultraviolet radiation-induced NF-kappa-B activation in a human keratinocyte cell line. Free Radic Biol Med 1999; 26:174-83.
33. Torres M, Forman HJ. Redox signaling and the MAP kinase pathways. Biofactors 2003; 17:287-96.
34. Chen Z, Gibson TB, Robinson F, Silvestro L, Person G, Xu B, Wright A, Vanderbilt C, Cobb MH. MAP kinases. Chem Rev 2001; 101:2449-76.
35. Kyriakis JM, Avruch J. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 1996; 271:24313-6.
36. Yao K, Ye PP, Zhang L, Tan J, Tang XJ, Zhang YD. Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent aproptpsis in human lens epithelial cells. Mol Vis 2008; 14:217-23.
37. Wang D, Richmond A. Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway. J Biol Chem 2001; 276:3650-9.
38. Bonvin C, Guillon A, van Bemmelen MX, Gerwins P, Johnson GL, Widmann C. Role of the N-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis. Cell Signal 2002; 14:123-31.
39. Ravi D, Muniyappa H, Das KC. Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Mol Cell Biochem 2008; 308:193-200.