메뉴 건너뛰기




Volumn 83, Issue , 2016, Pages 1164-1174

Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mTOR and ERK1/2 signaling pathways

Author keywords

AKT NF B mTOR; ERK1 2; Fisetin; Laryngeal cancer; Proliferation

Indexed keywords

CASPASE 3; FISETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; FLAVONOID; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TARGET OF RAPAMYCIN KINASE;

EID: 84989249048     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.08.035     Document Type: Article
Times cited : (72)

References (61)
  • 3
    • 33750485395 scopus 로고    scopus 로고
    • Staging of laryngeal and hypopharyngeal cancer: value of imaging studies
    • [3] Hermans, R., Staging of laryngeal and hypopharyngeal cancer: value of imaging studies. Eur. Radiol. 16 (2006), 2386–2400.
    • (2006) Eur. Radiol. , vol.16 , pp. 2386-2400
    • Hermans, R.1
  • 4
    • 33748341688 scopus 로고    scopus 로고
    • Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival
    • [4] Hoffman, H.T., Porter, K., Karnell, L.H., Cooper, J.S., Weber, R.S., Langer, C.J., et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 116 (2006), 1–13.
    • (2006) Laryngoscope , vol.116 , pp. 1-13
    • Hoffman, H.T.1    Porter, K.2    Karnell, L.H.3    Cooper, J.S.4    Weber, R.S.5    Langer, C.J.6
  • 5
    • 66949128922 scopus 로고    scopus 로고
    • Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients
    • [5] Pignon, J.P., le Maître, A., Maillard, E., Bourhis, J., Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother. Oncol. 92 (2009), 4–14.
    • (2009) Radiother. Oncol. , vol.92 , pp. 4-14
    • Pignon, J.P.1    le Maître, A.2    Maillard, E.3    Bourhis, J.4
  • 6
    • 84875743953 scopus 로고    scopus 로고
    • Competing roads to larynx preservation
    • [6] Vokes, E.E., Competing roads to larynx preservation. J. Clin. Oncol. 31 (2013), 833–836.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 833-836
    • Vokes, E.E.1
  • 7
    • 84875264233 scopus 로고    scopus 로고
    • Chemoradiotherapy vs. total laryngectomy for primary treatment of advanced laryngeal squamous cell carcinoma
    • [7] Strojan, P., Haigentz, M., Bradford, C.R., Wolf, G.T., Hartl, D.M., Langendijk, J.A., et al. Chemoradiotherapy vs. total laryngectomy for primary treatment of advanced laryngeal squamous cell carcinoma. Oral. Oncol. 49 (2013), 283–286.
    • (2013) Oral. Oncol. , vol.49 , pp. 283-286
    • Strojan, P.1    Haigentz, M.2    Bradford, C.R.3    Wolf, G.T.4    Hartl, D.M.5    Langendijk, J.A.6
  • 8
    • 84874480711 scopus 로고    scopus 로고
    • Influential factors, complications and survival rate of primary and salvage total laryngectomy for advanced laryngeal cancer
    • [8] Stanković, M., Milisavljević, D., Stojanov, D., Zivić, M., Zivaljević, S., Stanković, I., et al. Influential factors, complications and survival rate of primary and salvage total laryngectomy for advanced laryngeal cancer. Coll. Antropol. 36 (2012), 7–12.
    • (2012) Coll. Antropol. , vol.36 , pp. 7-12
    • Stanković, M.1    Milisavljević, D.2    Stojanov, D.3    Zivić, M.4    Zivaljević, S.5    Stanković, I.6
  • 9
    • 79960427057 scopus 로고    scopus 로고
    • Selective killing of cancer cells by a small molecule targeting the stress response to ROS
    • [9] Raj, L., Ide, T., Gurkar, A.U., Foley, M., Schenone, M., Li, X., et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475 (2011), 231–234.
    • (2011) Nature , vol.475 , pp. 231-234
    • Raj, L.1    Ide, T.2    Gurkar, A.U.3    Foley, M.4    Schenone, M.5    Li, X.6
  • 10
    • 84856196727 scopus 로고    scopus 로고
    • Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy
    • [10] Lee, Y.R., Wu, W.C., Ji, W.T., Chen, J.Y., Cheng, Y.P., Chiang, M.K., et al. Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy. J. Biomed. Sci., 19, 2012, 9.
    • (2012) J. Biomed. Sci. , vol.19 , pp. 9
    • Lee, Y.R.1    Wu, W.C.2    Ji, W.T.3    Chen, J.Y.4    Cheng, Y.P.5    Chiang, M.K.6
  • 11
    • 84866514150 scopus 로고    scopus 로고
    • The silver bullet for cancer prevention: chemopreventive effects of carotenoids
    • [11] Tang, F.Y., The silver bullet for cancer prevention: chemopreventive effects of carotenoids. Biomedicine 2 (2012), 117–121.
    • (2012) Biomedicine , vol.2 , pp. 117-121
    • Tang, F.Y.1
  • 12
    • 84867865103 scopus 로고    scopus 로고
    • Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management
    • [12] Adhami, V.M., Syed, D.N., Khan, N., Mukhtar, H., Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem. Pharmacol. 84 (2012), 1277–1281.
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 1277-1281
    • Adhami, V.M.1    Syed, D.N.2    Khan, N.3    Mukhtar, H.4
  • 13
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • [13] Ishige, K., Schubert, D., Sagara, Y., Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic. Biol. Med. 30 (2001), 433–446.
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 14
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • [14] Zbarsky, V., Datla, K.P., Parkar, S., Rai, D.K., Aruoma, O.I., Dexter, D.T., Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic. Res. 39 (2005), 1119–1125.
    • (2005) Free Radic. Res. , vol.39 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 15
    • 85014088612 scopus 로고    scopus 로고
    • The dietary flavonoid fisetin causes cell cycle arrest caspase-dependent apoptosis, and enhanced cytotoxicity of chemotherapeutic drugs in triple-negative breast cancer cells
    • [15] Smith, M.L., Murphy, K., Doucette, C.D., Greenshields, A.L., Hoskin, D.W., The dietary flavonoid fisetin causes cell cycle arrest caspase-dependent apoptosis, and enhanced cytotoxicity of chemotherapeutic drugs in triple-negative breast cancer cells. J. Cell Biochem. 117 (2016), 1913–1925.
    • (2016) J. Cell Biochem. , vol.117 , pp. 1913-1925
    • Smith, M.L.1    Murphy, K.2    Doucette, C.D.3    Greenshields, A.L.4    Hoskin, D.W.5
  • 16
    • 84949636227 scopus 로고    scopus 로고
    • Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway
    • [16] Lin, M.T., Lin, C.L., Lin, T.Y., Cheng, C.W., Yang, S.F., et al. Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway. Tumour Biol. 37 (2016), 6987–6996.
    • (2016) Tumour Biol. , vol.37 , pp. 6987-6996
    • Lin, M.T.1    Lin, C.L.2    Lin, T.Y.3    Cheng, C.W.4    Yang, S.F.5
  • 17
    • 84964265142 scopus 로고    scopus 로고
    • Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation
    • [17] Choi, H.S., Kim, M.K., Choi, Y.K., Shin, Y.C., Cho, S.G., Ko, S.G., Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement. Altern. Med., 16, 2016, 122.
    • (2016) BMC Complement. Altern. Med. , vol.16 , pp. 122
    • Choi, H.S.1    Kim, M.K.2    Choi, Y.K.3    Shin, Y.C.4    Cho, S.G.5    Ko, S.G.6
  • 18
    • 84957977297 scopus 로고    scopus 로고
    • Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
    • [18] Klimaszewska-Wisniewska, A., Halas-Wisniewska, M., Tadrowski, T., Gagat, M., Grzanka, D., Grzanka, A., Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells. Cancer Cell Int., 16, 2016, 10.
    • (2016) Cancer Cell Int. , vol.16 , pp. 10
    • Klimaszewska-Wisniewska, A.1    Halas-Wisniewska, M.2    Tadrowski, T.3    Gagat, M.4    Grzanka, D.5    Grzanka, A.6
  • 19
    • 84944463065 scopus 로고    scopus 로고
    • Fisetin a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymicnude mice implanted with BRAF-mutated melanoma cells
    • [19] Pal, H.C., Baxter, R.D., Hunt, K.M., Agarwal, J., Elmets, C.A., Athar, M., et al. Fisetin a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymicnude mice implanted with BRAF-mutated melanoma cells. Oncotarget 6 (2015), 28296–282311.
    • (2015) Oncotarget , vol.6 , pp. 28296-282311
    • Pal, H.C.1    Baxter, R.D.2    Hunt, K.M.3    Agarwal, J.4    Elmets, C.A.5    Athar, M.6
  • 20
    • 84957624452 scopus 로고    scopus 로고
    • Fisetin a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
    • [20] Pal, H.C., Diamond, A.C., Strickland, L.R., Kappes, J.C., Katiyar, S.K., Elmets, C.A., et al. Fisetin a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma. Oncotarget 7 (2016), 1227–1241.
    • (2016) Oncotarget , vol.7 , pp. 1227-1241
    • Pal, H.C.1    Diamond, A.C.2    Strickland, L.R.3    Kappes, J.C.4    Katiyar, S.K.5    Elmets, C.A.6
  • 21
    • 79952700828 scopus 로고    scopus 로고
    • Bcl-2 proteins and mitochondria—specificity in membrane targeting for death
    • [21] Lindsay, J., Esposti, M.D., Gilmore, A.P., Bcl-2 proteins and mitochondria—specificity in membrane targeting for death. Biochim. Biophys. Acta 1813 (2011), 532–539.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 532-539
    • Lindsay, J.1    Esposti, M.D.2    Gilmore, A.P.3
  • 23
    • 84868567192 scopus 로고    scopus 로고
    • When autophagy meets cancer through p62/SQSTM1
    • [23] Puissant, A., Fenouille, N., Auberger, P., When autophagy meets cancer through p62/SQSTM1. Am. J. Cancer Res. 2 (2012), 397–413.
    • (2012) Am. J. Cancer Res. , vol.2 , pp. 397-413
    • Puissant, A.1    Fenouille, N.2    Auberger, P.3
  • 25
    • 84890118466 scopus 로고    scopus 로고
    • Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy
    • [25] Huang, L., Chen, T., Chen, C., Chen, S., Liu, Y., Wu, J., Shao, Z., Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy. World J. Surg. Oncol., 11, 2013, 307.
    • (2013) World J. Surg. Oncol. , vol.11 , pp. 307
    • Huang, L.1    Chen, T.2    Chen, C.3    Chen, S.4    Liu, Y.5    Wu, J.6    Shao, Z.7
  • 26
    • 84879478157 scopus 로고    scopus 로고
    • Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3 K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer
    • [26] Kavitha, K., Kowshik, J., Kishore, T.K., Baba, A.B., Nagini, S., Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3 K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer. Biochim. Biophys. Acta. Gen. Subj. 1830 (2013), 4433–4444.
    • (2013) Biochim. Biophys. Acta. Gen. Subj. , vol.1830 , pp. 4433-4444
    • Kavitha, K.1    Kowshik, J.2    Kishore, T.K.3    Baba, A.B.4    Nagini, S.5
  • 27
    • 0034648529 scopus 로고    scopus 로고
    • Activation of the NF-kappaB pathway by caspase 8 and its homologs
    • [27] Chaudhary, P.M., Eby, M.T., Jasmin, A., Kumar, A., Liu, L., Hood, L., Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene 19 (2000), 4451–4460.
    • (2000) Oncogene , vol.19 , pp. 4451-4460
    • Chaudhary, P.M.1    Eby, M.T.2    Jasmin, A.3    Kumar, A.4    Liu, L.5    Hood, L.6
  • 28
    • 84904755931 scopus 로고    scopus 로고
    • TCR-induced, PKC-θ-mediated NF-κB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade
    • [28] Zhao, Y., Lei, M., Wang, Z., Qiao, G., Yang, T., Zhang, J., TCR-induced, PKC-θ-mediated NF-κB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade. Biochem. Biophys. Res. Commun. 450 (2014), 526–531.
    • (2014) Biochem. Biophys. Res. Commun. , vol.450 , pp. 526-531
    • Zhao, Y.1    Lei, M.2    Wang, Z.3    Qiao, G.4    Yang, T.5    Zhang, J.6
  • 29
    • 84959158239 scopus 로고    scopus 로고
    • Improved transcription and translation with l-leucine stimulation of mTORC1 in Roberts syndrome
    • [29] Xu, B., Gogol, M., Gaudenz, K., Gerton, J.L., Improved transcription and translation with l-leucine stimulation of mTORC1 in Roberts syndrome. BMC Genom., 17, 2016, 25.
    • (2016) BMC Genom. , vol.17 , pp. 25
    • Xu, B.1    Gogol, M.2    Gaudenz, K.3    Gerton, J.L.4
  • 30
    • 84930929704 scopus 로고    scopus 로고
    • Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and Francois Baclesse Cancer Care Center between 1998 and 2008
    • [30] Cuny, F., Meunier, A., Heutte, N., Rame, J.P., de Raucourt, D., Babin, E., et al. Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and Francois Baclesse Cancer Care Center between 1998 and 2008. Eur. Ann. Otorhinolaryngol. Head Neck Dis. 132 (2015), 129–134.
    • (2015) Eur. Ann. Otorhinolaryngol. Head Neck Dis. , vol.132 , pp. 129-134
    • Cuny, F.1    Meunier, A.2    Heutte, N.3    Rame, J.P.4    de Raucourt, D.5    Babin, E.6
  • 31
    • 84891355009 scopus 로고    scopus 로고
    • State of the art in the treatment of laryngeal cancer
    • [31] Jenckel, F., Knecht, R., State of the art in the treatment of laryngeal cancer. Anticancer Res. 33 (2013), 4701–4710.
    • (2013) Anticancer Res. , vol.33 , pp. 4701-4710
    • Jenckel, F.1    Knecht, R.2
  • 32
    • 84941618262 scopus 로고    scopus 로고
    • Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter
    • [32] Kim, J.A., Lee, S., Kim, D.E., Kim, M., Kwon, B.M., Han, D.C., Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter. Carcinogenesis 36 (2015), 696–706.
    • (2015) Carcinogenesis , vol.36 , pp. 696-706
    • Kim, J.A.1    Lee, S.2    Kim, D.E.3    Kim, M.4    Kwon, B.M.5    Han, D.C.6
  • 33
    • 84921321184 scopus 로고    scopus 로고
    • Polymeric micelles encapsulating fisetin improve the therapeutic effect in colon cancer
    • [33] Chen, Y., Wu, Q., Song, L., He, T., Li, Y., Li, L., et al. Polymeric micelles encapsulating fisetin improve the therapeutic effect in colon cancer. ACS Appl. Mater Interfaces 7 (2015), 534–542.
    • (2015) ACS Appl. Mater Interfaces , vol.7 , pp. 534-542
    • Chen, Y.1    Wu, Q.2    Song, L.3    He, T.4    Li, Y.5    Li, L.6
  • 35
    • 84946882376 scopus 로고    scopus 로고
    • Mobilization of copper ions by flavonoids in human peripheral lymphocytes leads to oxidative DNA breakage: a structure activity study
    • 26754-2669
    • [35] Arif, H., Rehmani, N., Farhan, M., Ahmad, A., Hadi, S.M., Mobilization of copper ions by flavonoids in human peripheral lymphocytes leads to oxidative DNA breakage: a structure activity study. Int. J. Mol. Sci., 16, 2015 26754-2669.
    • (2015) Int. J. Mol. Sci. , vol.16
    • Arif, H.1    Rehmani, N.2    Farhan, M.3    Ahmad, A.4    Hadi, S.M.5
  • 37
    • 79956080227 scopus 로고    scopus 로고
    • Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2
    • [37] Nagendraprabhu, P., Sudhandiran, G., Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Invest. New Drugs 29 (2011), 207–224.
    • (2011) Invest. New Drugs , vol.29 , pp. 207-224
    • Nagendraprabhu, P.1    Sudhandiran, G.2
  • 38
    • 84863011640 scopus 로고    scopus 로고
    • Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress
    • [38] Tentner, A.R., Lee, M.J., Ostheimer, G.J., Samson, L.D., Lauffenburger, D.A., Yaffe, M.B., Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol. Syst. Biol., 8, 2012, 568.
    • (2012) Mol. Syst. Biol. , vol.8 , pp. 568
    • Tentner, A.R.1    Lee, M.J.2    Ostheimer, G.J.3    Samson, L.D.4    Lauffenburger, D.A.5    Yaffe, M.B.6
  • 39
    • 84855576316 scopus 로고    scopus 로고
    • Different expression of extracellular signal-Regulated kinases (ERK) 1/2 and phospho-Erk proteins in MBA-MB-231 and MCF-7 cells after chemotherapy with doxorubicin or docetaxel
    • [39] Taherian, A., Mazoochi, T., Different expression of extracellular signal-Regulated kinases (ERK) 1/2 and phospho-Erk proteins in MBA-MB-231 and MCF-7 cells after chemotherapy with doxorubicin or docetaxel. Iran. J. Basic Med. Sci. 15 (2012), 669–677.
    • (2012) Iran. J. Basic Med. Sci. , vol.15 , pp. 669-677
    • Taherian, A.1    Mazoochi, T.2
  • 40
    • 84864094070 scopus 로고    scopus 로고
    • Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer
    • [40] Tekedereli, I., Alpay, S.N., Tavares, C.D., Cobanoglu, Z.E., Kaoud, T.S., Sahin, I., et al. Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. PLoS One, 7, 2012, e41171.
    • (2012) PLoS One , vol.7 , pp. e41171
    • Tekedereli, I.1    Alpay, S.N.2    Tavares, C.D.3    Cobanoglu, Z.E.4    Kaoud, T.S.5    Sahin, I.6
  • 41
    • 77953577584 scopus 로고    scopus 로고
    • The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy
    • [41] Abrams, S.L., Steelman, L.S., Shelton, J.G., Wong, E.W., Chappell, W.H., Bäsecke, J., et al. The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy. Cell Cycle 9 (2010), 1781–1791.
    • (2010) Cell Cycle , vol.9 , pp. 1781-1791
    • Abrams, S.L.1    Steelman, L.S.2    Shelton, J.G.3    Wong, E.W.4    Chappell, W.H.5    Bäsecke, J.6
  • 42
    • 27444440554 scopus 로고    scopus 로고
    • Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1
    • [42] Monje, P., Hernandez-Losa, J., Lyons, R.J., Castellone, M.D., Gutkind, J.S., Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. J. Biol. Chem. 280 (2005), 35081–35084.
    • (2005) J. Biol. Chem. , vol.280 , pp. 35081-35084
    • Monje, P.1    Hernandez-Losa, J.2    Lyons, R.J.3    Castellone, M.D.4    Gutkind, J.S.5
  • 43
    • 84921771740 scopus 로고    scopus 로고
    • Opisthorchis viverrini infection activates the PI3K/AKT/PTEN and wnt/beta-catenin signaling pathways in a cholangiocarcinogenesis model
    • [43] Yothaisong, S., Thanee, M., Namwat, N., Yongvanit, P., Boonmars, T., Puapairoj, A., et al. Opisthorchis viverrini infection activates the PI3K/AKT/PTEN and wnt/beta-catenin signaling pathways in a cholangiocarcinogenesis model. Asian Pac. J. Cancer Prev. 15 (2014), 10463–10468.
    • (2014) Asian Pac. J. Cancer Prev. , vol.15 , pp. 10463-10468
    • Yothaisong, S.1    Thanee, M.2    Namwat, N.3    Yongvanit, P.4    Boonmars, T.5    Puapairoj, A.6
  • 44
    • 84893744802 scopus 로고    scopus 로고
    • Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways
    • [44] Cheng, P., Dai, W., Wang, F., Lu, J., Shen, M., Chen, K., et al. Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways. Biochem. Biophys. Res. Commun. 443 (2014), 1162–1168.
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , pp. 1162-1168
    • Cheng, P.1    Dai, W.2    Wang, F.3    Lu, J.4    Shen, M.5    Chen, K.6
  • 46
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by akt and eif4e in oncogenesis and cancer therapy
    • [46] Wendel, H.G., de Stanchina, J.S., Fridman, A., Malina, S., Kogan, S., et al. Survival signalling by akt and eif4e in oncogenesis and cancer therapy. Nature 428 (2004), 332–337.
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1    de Stanchina, J.S.2    Fridman, A.3    Malina, S.4    Kogan, S.5
  • 47
    • 64849113485 scopus 로고    scopus 로고
    • Control of mitochondrial apoptosis by the Bcl-2 family
    • [47] Brunelle, J.K., Letai, A., Control of mitochondrial apoptosis by the Bcl-2 family. J. Cell Sci. 122 (2009), 437–441.
    • (2009) J. Cell Sci. , vol.122 , pp. 437-441
    • Brunelle, J.K.1    Letai, A.2
  • 48
    • 84903464142 scopus 로고    scopus 로고
    • Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry
    • [48] Lee, S., Braun, C.R., Bird, G.H., Walensky, L.D., Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods Enzymol. 544 (2014), 25–48.
    • (2014) Methods Enzymol. , vol.544 , pp. 25-48
    • Lee, S.1    Braun, C.R.2    Bird, G.H.3    Walensky, L.D.4
  • 49
    • 79952700828 scopus 로고    scopus 로고
    • Bcl-2 proteins and mitochondria—specificity in membrane targeting for death
    • [49] Lindsay, J., Esposti, M.D., Gilmore, A.P., Bcl-2 proteins and mitochondria—specificity in membrane targeting for death. Biochim. Biophys. Acta 1813 (2011), 532–539.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 532-539
    • Lindsay, J.1    Esposti, M.D.2    Gilmore, A.P.3
  • 50
    • 84872687503 scopus 로고    scopus 로고
    • Ellagic acid coordinately attenuates Wnt/beta-catenin and NF-kappaB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis
    • [50] Anitha, P., Priyadarsini, R.V., Kavitha, K., Thiyagarajan, P., Nagini, S., Ellagic acid coordinately attenuates Wnt/beta-catenin and NF-kappaB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis. Eur. J. Nutr. 52 (2013), 75–84.
    • (2013) Eur. J. Nutr. , vol.52 , pp. 75-84
    • Anitha, P.1    Priyadarsini, R.V.2    Kavitha, K.3    Thiyagarajan, P.4    Nagini, S.5
  • 51
    • 19644366033 scopus 로고    scopus 로고
    • Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation
    • [51] Farhana, L., Dawson, M.I., Fontana, J.A., Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation. Cancer Res. 65 (2005), 4909–4917.
    • (2005) Cancer Res. , vol.65 , pp. 4909-4917
    • Farhana, L.1    Dawson, M.I.2    Fontana, J.A.3
  • 52
    • 79953782203 scopus 로고    scopus 로고
    • NF-kappaB addiction and its role in cancer: one size does not fit allˮ
    • [52] Chaturvedi, M.M., Sung, B., Yadav, V.R., Kannappan, R., Aggarwal, B.B., NF-kappaB addiction and its role in cancer: one size does not fit allˮ. Oncogene 30 (2011), 1615–1630.
    • (2011) Oncogene , vol.30 , pp. 1615-1630
    • Chaturvedi, M.M.1    Sung, B.2    Yadav, V.R.3    Kannappan, R.4    Aggarwal, B.B.5
  • 53
    • 84904308807 scopus 로고    scopus 로고
    • MPT64 protein from Mycobacterium tuberculosis inhibits apoptosis of macrophages through NF-kB-miRNA21-Bcl-2 pathway
    • [53] Wang, Q., Liu, S., Tang, Y., Liu, Q., Yao, Y., MPT64 protein from Mycobacterium tuberculosis inhibits apoptosis of macrophages through NF-kB-miRNA21-Bcl-2 pathway. PLoS One, 9, 2014, e100949.
    • (2014) PLoS One , vol.9 , pp. e100949
    • Wang, Q.1    Liu, S.2    Tang, Y.3    Liu, Q.4    Yao, Y.5
  • 54
    • 84905014915 scopus 로고    scopus 로고
    • IAP family of cell death and signaling regulators
    • [54] Silke, J., Vucic, D., IAP family of cell death and signaling regulators. Methods Enzymol. 545 (2014), 35–65.
    • (2014) Methods Enzymol. , vol.545 , pp. 35-65
    • Silke, J.1    Vucic, D.2
  • 55
    • 80053985362 scopus 로고    scopus 로고
    • Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death
    • [55] Hui, K.K., Kanungo, A.K., Elia, A.J., Henderson, J.T., Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death. Cell Death Differ. 18 (2011), 1780–1790.
    • (2011) Cell Death Differ. , vol.18 , pp. 1780-1790
    • Hui, K.K.1    Kanungo, A.K.2    Elia, A.J.3    Henderson, J.T.4
  • 56
    • 36148954336 scopus 로고    scopus 로고
    • Iap antagonists target ciap1 to induce TNFα-dependent apoptosis
    • [56] Vince, J.E., Wong, W.W., Khan, N., Feltham, R., Chau, D., Ahmed, A.U., et al. Iap antagonists target ciap1 to induce TNFα-dependent apoptosis. Cell 131 (2007), 682–693.
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1    Wong, W.W.2    Khan, N.3    Feltham, R.4    Chau, D.5    Ahmed, A.U.6
  • 57
    • 0032490670 scopus 로고    scopus 로고
    • Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis
    • [57] Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J.A., Binder, B.R., Lipp, J., Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis. J. Exp. Med. 188 (1998), 211–216.
    • (1998) J. Exp. Med. , vol.188 , pp. 211-216
    • Stehlik, C.1    de Martin, R.2    Kumabashiri, I.3    Schmid, J.A.4    Binder, B.R.5    Lipp, J.6
  • 58
    • 0037043329 scopus 로고    scopus 로고
    • Integrin (alpha 6 beta 4) regulation of eif-4e activity and vegf translation: a survival mechanism for carcinoma cells
    • [58] Chung, J., Bachelder, R.E., Lipscomb, E.A., Shaw, L.M., Mercurio, A.M., Integrin (alpha 6 beta 4) regulation of eif-4e activity and vegf translation: a survival mechanism for carcinoma cells. J. Cell. Biol. 158 (2002), 165–174.
    • (2002) J. Cell. Biol. , vol.158 , pp. 165-174
    • Chung, J.1    Bachelder, R.E.2    Lipscomb, E.A.3    Shaw, L.M.4    Mercurio, A.M.5
  • 59
    • 69449092724 scopus 로고    scopus 로고
    • Activation of the pi3k-akt-mtor signaling pathway promotes necrotic cell death via suppression of autophagy
    • [59] Wu, Y.T., Tan, H.L., Huang, Q., Ong, C.N., Shen, H.M., Activation of the pi3k-akt-mtor signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy 5 (2009), 824–834.
    • (2009) Autophagy , vol.5 , pp. 824-834
    • Wu, Y.T.1    Tan, H.L.2    Huang, Q.3    Ong, C.N.4    Shen, H.M.5
  • 60
    • 10344253840 scopus 로고    scopus 로고
    • Critical role of endogenous akt/iaps and mek1/erk pathways in counteracting endoplasmic reticulum stress-induced cell death
    • [60] Hu, P., Han, Z., Couvillon, A.D., Exton, J.H., Critical role of endogenous akt/iaps and mek1/erk pathways in counteracting endoplasmic reticulum stress-induced cell death. J. Biol. Chem. 279 (2004), 49420–49429.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49420-49429
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Exton, J.H.4
  • 61
    • 84855696465 scopus 로고    scopus 로고
    • Mtorc1 serves er stress-triggered apoptosis via selective activation of the ire1-jnk pathway
    • [61] Kato, H., Nakajima, S., Saito, Y., Takahashi, S., Katoh, R., Kitamura, M., Mtorc1 serves er stress-triggered apoptosis via selective activation of the ire1-jnk pathway. Cell Death Differ. 19 (2012), 310–320.
    • (2012) Cell Death Differ. , vol.19 , pp. 310-320
    • Kato, H.1    Nakajima, S.2    Saito, Y.3    Takahashi, S.4    Katoh, R.5    Kitamura, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.