TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

EMBO Reports

Volumn 18, Issue 7, 2017, Pages 1186-1198

  Mazaheri, Fargol ^a   Snaidero, Nicolas ^b,c   Kleinberger, Gernot ^d,e   Madore, Charlotte ^f   Daria, Anna ^e   Werner, Georg ^e   Krasemann, Susanne ^g   Capell, Anja ^e   Trümbach, Dietrich ^h   Wurst, Wolfgang ^a,d,h,i   Brunner, Bettina ^a   Bultmann, Sebastian ^e   Tahirovic, Sabina ^a   Kerschensteiner, Martin ^c,d   Misgeld, Thomas ^a,b,d   Butovsky, Oleg ^f   Haass, Christian ^a,d,e  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d Germany 3 Munich Cluster for Systems Neurology   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; chemotaxis; microglia; neurodegeneration; TREM2

Indexed keywords

APOLIPOPROTEIN E; CD68 ANTIGEN; CXCL16 CHEMOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTOME; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR; VASCULOTROPIN A; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN SLICE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; EX VIVO STUDY; GENE CLUSTER; GENE EXPRESSION; GENE EXPRESSION PROFILING; HOMEOSTASIS; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MALE; MICROGLIA; MOUSE; NERVE CELL LESION; NEURITE OUTGROWTH; NONHUMAN; PRIORITY JOURNAL; SOMATOSENSORY CORTEX; STABLE EXPRESSION; ALZHEIMER DISEASE; BONE MARROW CELL; CELL CULTURE; DEFICIENCY; DEGENERATIVE DISEASE; FRONTOTEMPORAL DEMENTIA; GENETICS; HUMAN; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PHYSIOLOGY;

ALZHEIMER DISEASE; CELLS, CULTURED; CHEMOTAXIS; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION PROFILING; HUMANS; LOSS OF FUNCTION MUTATION; MEMBRANE GLYCOPROTEINS; MICROGLIA; MYELOID CELLS; NEURODEGENERATIVE DISEASES; NEURONS; PHAGOCYTOSIS; RECEPTORS, IMMUNOLOGIC;

EID: 85019110538     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201743922     Document Type: Article

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