Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

Science Translational Medicine

Volumn 8, Issue 369, 2016, Pages

  Suárez Calvet, Marc ^a,b   Caballero, Miguel Ángel Araque ^c   Kleinberger, Gernot ^b,d   Bateman, Randall J ^e   Fagan, Anne M ^e   Morris, John C ^e   Levin, Johannes ^a,b   Danek, Adrian ^a,b   Ewers, Michael ^c   Haass, Christian ^a,b,d  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d Germany 3 Munich Cluster for Systems Neurology   (Germany)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BIOLOGICAL MARKER; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TAU PROTEIN; TREM2 PROTEIN, HUMAN;

ADULT; ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL ACTIVATION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROGLIA; NERVE DEGENERATION; NERVE INJURY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; SIBLING; BRAIN; CASE CONTROL STUDY; CEREBROSPINAL FLUID; COHORT ANALYSIS; DISEASE EXACERBATION; DNA MUTATIONAL ANALYSIS; DOMINANT GENE; GENETICS; INNATE IMMUNITY; METABOLISM; MIDDLE AGED; MUTATION; NERVE CELL; PATHOLOGY; TIME FACTOR;

ADULT; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOIDOSIS; APOLIPOPROTEINS E; BIOMARKERS; BRAIN; CASE-CONTROL STUDIES; COHORT STUDIES; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; GENES, DOMINANT; HETEROZYGOTE; HUMANS; IMMUNITY, INNATE; MALE; MEMBRANE GLYCOPROTEINS; MICROGLIA; MIDDLE AGED; MUTATION; NEURONS; RECEPTORS, IMMUNOLOGIC; SIBLINGS; TAU PROTEINS; TIME FACTORS;

EID: 85006368840     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aag1767     Document Type: Article

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