Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk

American Journal of Human Genetics

Volumn 101, Issue 4, 2017, Pages 590-602

  Richardson, Tom G ^a   Zheng, Jie ^a   Davey Smith, George ^a   Timpson, Nicholas J ^a   Gaunt, Tom R ^a   Relton, Caroline L ^a   Hemani, Gibran ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

cardiovascular disease; causal inference; DNA methylation; epigenome wide association studies; Mendelian randomization

Indexed keywords

DNA; ADENYLATE CYCLASE; ADENYLATE CYCLASE 3; ADIPONECTIN; ADIPOQ PROTEIN, HUMAN;

ADCY3 GENE; ADIPOQ GENE; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE; GENE EXPRESSION; GENE MAPPING; GENETIC RISK; GENETIC VARIABILITY; HISTONE MODIFICATION; HUMAN; MENDELIAN RANDOMIZATION ANALYSIS; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; CARDIOVASCULAR DISEASES; CHILD; COHORT ANALYSIS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN GENOME; PATHOLOGY; PHENOTYPE; PREGNANCY; PROCEDURES; RISK FACTOR; UNITED KINGDOM;

ADENYLYL CYCLASES; ADIPONECTIN; CARDIOVASCULAR DISEASES; CHILD; COHORT STUDIES; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; QUANTITATIVE TRAIT LOCI; RISK FACTORS; UNITED KINGDOM;

EID: 85031708100     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2017.09.003     Document Type: Article

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