Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Nature Communications

Volumn 7, Issue , 2016, Pages

  Kettunen, Johannes ^a,b,c,d   Demirkan, Ayse ^e,f   Würtz, Peter ^a   Draisma, Harmen H M ^g,h,i   Haller, Toomas ^j   Rawal, Rajesh ^k   Vaarhorst, Anika ^e   Kangas, Antti J ^a   Lyytikäinen, Leo Pekka ^l   Pirinen, Matti ^m   Pool, René ^g,h   Sarin, Antti Pekka ^b,m   Soininen, Pasi ^a,c   Tukiainen, Taru ^n,o,p   Wang, Qin ^a,c   Tiainen, Mika ^a,c   Tynkkynen, Tuulia ^a,c   Amin, Najaf ^f   Zeller, Tanja ^q,r   Beekman, Marian ^e   Deelen, Joris ^e   Van Dijk, Ko Willems ^e   Esko, Tõnu ^j   Hottenga, Jouke Jan ^g,h   Van Leeuwen, Elisabeth M ^f   Lehtimäki, Terho ^l   Mihailov, Evelin ^j   Rose, Richard J ^m,s   De Craen, Anton J M ^e   Gieger, Christian ^k   Kähönen, Mika ^l   Perola, Markus ^b,j,m   Blankenberg, Stefan ^q,r   Savolainen, Markku J ^d,t   Verhoeven, Aswin ^e   Viikari, Jorma ^u   Willemsen, Gonneke ^g,h   Boomsma, Dorret I ^g,h   Van Duijn, Cornelia M ^f   Eriksson, Johan ^b,m   Jula, Antti ^b   Järvelin, Marjo Riitta ^a,d,t,v   Kaprio, Jaakko ^b,m   Metspalu, Andres ^j   Raitakari, Olli ^u,w   Salomaa, Veikko ^b   Eline Slagboom, P ^e   Waldenberger, Melanie ^k   Ripatti, Samuli ^b,m,x   Ala Korpela, Mika ^a,c,d,t,y   more..

^a UNIVERSITY OF OULU   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d UNIVERSITY OF OULU   (Finland)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g VU UNIVERSITY AMSTERDAM   (Netherlands)

^h UNIVERSITY OF AMSTERDAM   (Netherlands)

ⁱ University of Tartu ^*  (Netherlands)

^j UNIVERSITY OF TARTU   (Estonia)

^k INSTITUTE OF EPIDEMIOLOGY   (Germany)

^l TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^m UNIVERSITY OF HELSINKI   (Finland)

ⁿ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^o BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^p HARVARD MEDICAL SCHOOL   (United States)

^q DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^r UNIVERSITY HEART CENTER HAMBURG   (Germany)

^s INDIANA UNIVERSITY   (United States)

^t OULU UNIVERSITY HOSPITAL   (Finland)

^u TURKU UNIVERSITY HOSPITAL   (Finland)

^v IMPERIAL COLLEGE LONDON   (United Kingdom)

^w UNIVERSITY OF TURKU   (Finland)

^x WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^y UNIVERSITY OF BRISTOL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; FATTY ACID; LIPOPROTEIN A; PYRUVIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

CARDIOVASCULAR DISEASE; ETIOLOGY; FATTY ACID; GENOME; HEALTH RISK; METABOLISM; METABOLITE; NUCLEAR MAGNETIC RESONANCE; PROTEIN;

ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; INDEL MUTATION; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MALE; MENDELIAN RANDOMIZATION ANALYSIS; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE IMAGING; PLEIOTROPY; RISK REDUCTION; ADULT; AGED; CARDIOVASCULAR DISEASE; CHROMOSOMAL MAPPING; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; YOUNG ADULT;

ADULT; AGED; CARDIOVASCULAR DISEASES; CHROMOSOME MAPPING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LIPOPROTEIN(A); LIPOPROTEINS, VLDL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; METABOLOMICS; MIDDLE AGED; TRIGLYCERIDES; YOUNG ADULT;

EID: 84962271039     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11122     Document Type: Article

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