Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci

American Journal of Human Genetics

Volumn 100, Issue 6, 2017, Pages 954-959

  Hannon, Eilis ^a   Weedon, Mike ^a   Bray, Nicholas ^b   O'Donovan, Michael ^b   Mill, Jonathan ^a  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^b CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

blood; brain; complex trait; disease; DNA methylation; epigenetics; genetics; genome wide association study; GWAS; pleiotropy

Indexed keywords

CHOLESTEROL; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HEY2 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; BLOOD; BRAIN TISSUE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 15; CHROMOSOME 17; CHROMOSOME 6; DNA METHYLATION; FETUS BRAIN; GENE CONTROL; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MENDELIAN RANDOMIZATION ANALYSIS; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; BRAIN; CROHN DISEASE; EMBRYOLOGY; FETUS; GENETICS; METABOLISM; MIGRAINE; QUANTITATIVE TRAIT;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN; CROHN DISEASE; DNA METHYLATION; FETUS; GENETIC PLEIOTROPY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; MIGRAINE DISORDERS; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; REPRESSOR PROTEINS;

EID: 85019353394     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2017.04.013     Document Type: Article

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