Genome-wide association and population genetic analysis of c-reactive protein in african american and hispanic american women

American Journal of Human Genetics

Volumn 91, Issue 3, 2012, Pages 502-512

  Reiner, Alex P ^a,b   Beleza, Sandra ^c   Franceschini, Nora ^d   Auer, Paul L ^a   Robinson, Jennifer G ^e   Kooperberg, Charles ^a   Peters, Ulrike ^a   Tang, Hua ^c  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c STANFORD UNIVERSITY   (United States)

^d IL   (United States)

^e UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN C1; C REACTIVE PROTEIN; CRYOPYRIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6 RECEPTOR; PROTEIN; TRIGGERING RECEPTOR EXPRESSED BY MYELOID CELL 2; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CHROMOSOME 1Q; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HISPANIC; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL;

EID: 84866070927     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2012.07.023     Document Type: Article

References (53)

1. Pearson, T.A., Mensah, G.A., Alexander, R.W., Anderson, J.L., Cannon, R.O., 3rd, Criqui, M., Fadl, Y.Y., Fortmann, S.P., Hong, Y., Myers, G.L., et al Centers for Disease Control and Prevention; American Heart Association. (2003). Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107, 499-511. (Pubitemid 36158056)
2. Ridker, P.M., Buring, J.E., Rifai, N., and Cook, N.R. (2007). Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds Risk Score. JAMA 297, 611-619.
3. Ridker, P.M., Paynter, N.P., Rifai, N., Gaziano, J.M., and Cook, N.R. (2008). C-reactive protein and parental history improve global cardiovascular risk prediction: The Reynolds Risk Score for men. Circulation 118, 2243-2251, 4p, 2251.
4. Ford, E.S., Giles,W.H., Myers, G.L., Rifai, N., Ridker, P.M., and Mannino, D.M. (2003). C-reactive protein concentration distribution among US children and young adults: Findings from the National Health and Nutrition Examination Survey, 1999-2000. Clin. Chem. 49, 1353-1357. (Pubitemid 36900622)
5. Albert, M.A., and Ridker, P.M. (2006). C-reactive protein as a risk predictor: Do race/ethnicity and gender make a difference? Circulation 114, e67-e74. (Pubitemid 44264805)
6. Lakoski, S.G., Cushman, M., Criqui, M., Rundek, T., Blumenthal, R.S., D'Agostino, R.B., Jr., and Herrington, D.M. (2006). Gender and C-reactive protein: Data from the Multiethnic Study of Atherosclerosis (MESA) cohort. Am. Heart J. 152, 593-598. (Pubitemid 44233418)
7. Khera, A., McGuire, D.K., Murphy, S.A., Stanek, H.G., Das, S.R., Vongpatanasin, W., Wians, F.H., Jr., Grundy, S.M., and de Lemos, J.A. (2005). Race and gender differences in C-reactive protein levels. J. Am. Coll. Cardiol. 46, 464-469. (Pubitemid 41040287)
8. Cushman, M., McClure, L.A., Howard, V.J., Jenny, N.S., Lakoski, S.G., and Howard, G. (2009). Implications of increased C-reactive protein for cardiovascular risk stratification in black and white men and women in the US. Clin. Chem. 55, 1627-1636.
9. Albert, M.A., Glynn, R.J., Buring, J., and Ridker, P.M. (2004). C-reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study). Am. J. Cardiol. 93, 1238-1242. (Pubitemid 38595677)
10. Mensah, G.A., Mokdad, A.H., Ford, E.S., Greenlund, K.J., and Croft, J.B. (2005). State of disparities in cardiovascular health in the United States. Circulation 111, 1233-1241. (Pubitemid 40389086)
11. Miller, M., Zhan, M., and Havas, S. (2005). High attributable risk of elevated C-reactive protein level to conventional coronary heart disease risk factors: The Third National Health and Nutrition Examination Survey. Arch. Intern. Med. 165, 2063-2068. (Pubitemid 41434580)
12. Wee, C.C., Mukamal, K.J., Huang, A., Davis, R.B., McCarthy, E.P., and Mittleman, M.A. (2008). Obesity and C-reactive protein levels among white, black, and hispanic US adults. Obesity (Silver Spring) 16, 875-880. (Pubitemid 351465646)
13. Shah, T., Newcombe, P., Smeeth, L., Addo, J., Casas, J.P., Whittaker, J., Miller, M.A., Tinworth, L., Jeffery, S., Strazzullo, P., et al. (2010). Ancestry as a determinant of mean population C-reactive protein values: Implications for cardiovascular risk prediction. Circ Cardiovasc Genet 3, 436-444.
14. Rodriguez, F., Peralta, C.A., Green, A.R., and López, L. (2012). Comparison of C-reactive protein levels in less versus more acculturated Hispanic adults in the United States (from the National Health and Nutrition Examination Survey 1999-2008). Am. J. Cardiol. 109, 665-669.
15. Carlson, C.S., Aldred, S.F., Lee, P.K., Tracy, R.P., Schwartz, S.M., Rieder, M., Liu, K., Williams, O.D., Iribarren, C., Lewis, E.C., et al. (2005). Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am. J. Hum. Genet. 77, 64-77. (Pubitemid 40848037)
16. Retterstol, L., Eikvar, L., and Berg, K. (2003). A twin study of C-Reactive Protein compared to other risk factors for coronary heart disease. Atherosclerosis 169, 279-282. (Pubitemid 37297474)
17. Pankow, J.S., Folsom, A.R., Cushman, M., Borecki, I.B., Hopkins, P.N., Eckfeldt, J.H., and Tracy, R.P. (2001). Familial and genetic determinants of systemic markers of inflammation: The NHLBI family heart study. Atherosclerosis 154, 681-689. (Pubitemid 32232166)
18. Dupuis, J., Larson, M.G., Vasan, R.S., Massaro, J.M., Wilson, P.W., Lipinska, I., Corey, D., Vita, J.A., Keaney, J.F., Jr., and Benjamin, E.J. (2005). Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: Evidence for susceptibility loci on 1q. Atherosclerosis 182, 307-314. (Pubitemid 41267199)
19. Fox, E.R., Benjamin, E.J., Sarpong, D.F., Rotimi, C.N., Wilson, J.G., Steffes, M.W., Chen, G., Adeyemo, A., Taylor, J.K., Samdarshi, T.E., and Taylor, H.A., Jr. (2008). Epidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study). Am. J. Cardiol. 102, 835-841.
20. Naitza, S., Porcu, E., Steri, M., Taub, D.D., Mulas, A., Xiao, X., Strait, J., Dei, M., Lai, S., Busonero, F., et al. (2012). A genomewide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 8, e1002480.
21. Dehghan, A., Dupuis, J., Barbalic, M., Bis, J.C., Eiriksdottir, G., Lu, C., Pellikka, N., Wallaschofski, H., Kettunen, J., Henneman, P., et al. (2011). Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-738.
22. Okada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., Hosono, N., Tsunoda, T., Matsuda, K., Tanaka, T., Kubo, M., et al. (2011). Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Hum. Mol. Genet. 20, 1224-1231.
23. Ridker, P.M., Pare, G., Parker, A., Zee, R.Y., Danik, J.S., Buring, J.E., Kwiatkowski, D., Cook, N.R., Miletich, J.P., and Chasman, D.I. (2008). Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: The Women's Genome Health Study. Am. J. Hum. Genet. 82, 1185-1192.
24. Doumatey, A.P., Chen, G., Tekola Ayele, F., Zhou, J., Erdos, M., Shriner, D., Huang, H., Adeleye, J., Balogun, W., Fasanmade, O., et al. (2012). C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Hum. Mol. Genet. 21, 3063-3072.
25. Johnson, N.A., Coram, M.A., Shriver, M.D., Romieu, I., Barsh, G.S., London, S.J., and Tang, H. (2011). Ancestral components of admixed genomes in a Mexican cohort. PLoS Genet. 7, e1002410.
26. Hays, J., Hunt, J.R., Hubbell, F.A., Anderson, G.L., Limacher, M., Allen, C., and Rossouw, J.E. (2003). The Women's Health Initiative recruitment methods and results. Ann. Epidemiol. 13 (9, Suppl), S18-S77. (Pubitemid 37324176)
27. Li, Y., Willer, C.J., Ding, J., Scheet, P., and Abecasis, G.R. (2010). MaCH: Using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet. Epidemiol. 34, 816-834.
28. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., Maller, J., Sklar, P., de Bakker, P.I., Daly, M.J., and Sham, P.C. (2007). PLINK: A tool set for wholegenome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575. (Pubitemid 47330214)
29. Thornton, T., and McPeek, M.S. (2010). ROADTRIPS: Casecontrol association testing with partially or completely unknown population and pedigree structure. Am. J. Hum. Genet. 86, 172-184.
30. Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A., and Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909. (Pubitemid 44141658)
31. Tang, H., Peng, J.,Wang, P., and Risch, N.J. (2005). Estimation of individual admixture: Analytical and study design considerations. Genet. Epidemiol. 28, 289-301. (Pubitemid 40559542)
32. Cann, H.M., de Toma, C., Cazes, L., Legrand, M.F., Morel, V., Piouffre, L., Bodmer, J., Bodmer, W.F., Bonne-Tamir, B., Cambon-Thomsen, A., et al. (2002). A human genome diversity cell line panel. Science 296, 261-262. (Pubitemid 34303653)
33. International HapMap Consortium. (2003). The International HapMap Project. Nature 426, 789-796.
34. Tang, H., Coram, M., Wang, P., Zhu, X., and Risch, N. (2006). Reconstructing genetic ancestry blocks in admixed individuals. Am. J. Hum. Genet. 79, 1-12. (Pubitemid 43927371)
35. Johnson, N.A. (2011). Efficient models and algorithms for problems in genomics. PhD thesis, Stanford University, Stanford, CA.
36. Pe'er, I., Yelensky, R., Altshuler, D., and Daly, M.J. (2008). Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet. Epidemiol. 32, 381-385. (Pubitemid 351656309)
37. Willer, C.J., Li, Y., and Abecasis, G.R. (2010). METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190-2191.
38. Zeller, T., Wild, P., Szymczak, S., Rotival, M., Schillert, A., Castagne, R., Maouche, S., Germain, M., Lackner, K., Rossmann, H., et al. (2010). Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS ONE 5, e10693.
39. González-Pérez, A., and López-Bigas, N. (2011). Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel. Am. J. Hum. Genet. 88, 440-449.
40. Ford, J.W., and McVicar, D.W. (2009). TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 21, 38-46.
41. Allcock, R.J., Barrow, A.D., Forbes, S., Beck, S., and Trowsdale, J. (2003). The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur. J. Immunol. 33, 567-577. (Pubitemid 36267623)
42. Paloneva, J., Manninen, T., Christman, G., Hovanes, K., Mandelin, J., Adolfsson, R., Bianchin, M., Bird, T., Miranda, R., Salmaggi, A., et al. (2002). Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71, 656-662. (Pubitemid 34970138)
43. Sharif, O., and Knapp, S. (2008). From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology 213, 701-713.
44. Crawford, D.C., Sanders, C.L., Qin, X., Smith, J.D., Shephard, C., Wong, M., Witrak, L., Rieder, M.J., and Nickerson, D.A. (2006). Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation 114, 2458-2465. (Pubitemid 44901518)
45. Livingstone, F.B. (1984). The Duffy blood groups, vivax malaria, and malaria selection in human populations: A review. Hum. Biol. 56, 413-425. (Pubitemid 14004835)
46. Hamblin, M.T., Thompson, E.E., and Di Rienzo, A. (2002). Complex signatures of natural selection at the Duffy blood group locus. Am. J. Hum. Genet. 70, 369-383. (Pubitemid 34112292)
47. Hamblin, M.T., and Di Rienzo, A. (2000). Detection of the signature of natural selection in humans: Evidence from the Duffy blood group locus. Am. J. Hum. Genet. 66, 1669-1679. (Pubitemid 30463085)
48. Hernandez, R.D., Kelley, J.L., Elyashiv, E., Melton, S.C., Auton, A., McVean, G., Sella, G., and Przeworski, M.; 1000 Genomes Project. (2011). Classic selective sweeps were rare in recent human evolution. Science 331, 920-924.
49. Roger, V.L., Go, A.S., Lloyd-Jones, D.M., Benjamin, E.J., Berry, J.D., Borden, W.B., Bravata, D.M., Dai, S., Ford, E.S., Fox, C.S., et al American Heart Association Statistics Committee and Stroke Statistics Subcommittee. (2012). Heart disease and stroke statistics-2012 update: A report from the American Heart Association. Circulation 125, e2-e220.
50. Chambless, L.E., Folsom, A.R., Sharrett, A.R., Sorlie, P., Couper, D., Szklo, M., and Nieto, F.J. (2003). Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. J. Clin. Epidemiol. 56, 880-890. (Pubitemid 37162663)
51. Chambless, L.E., Heiss, G., Shahar, E., Earp, M.J., and Toole, J. (2004). Prediction of ischemic stroke risk in the Atherosclerosis Risk in Communities Study. Am. J. Epidemiol. 160, 259-269. (Pubitemid 39006782)
52. DeBoer, M.D., Gurka, M.J., and Sumner, A.E. (2011). Diagnosis of the metabolic syndrome is associated with disproportionately high levels of high-sensitivity C-reactive protein in non-Hispanic black adolescents: An analysis of NHANES 1999-2008. Diabetes Care 34, 734-740.
53. Hingorani, A.D., and Casas, J.P.; Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium. (2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: A mendelian randomisation analysis. Lancet 379, 1214-1224.