Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood

PLoS Genetics

Volumn 11, Issue 9, 2015, Pages

  Burkhardt, Ralph ^a,b   Kirsten, Holger ^a,c   Beutner, Frank ^a,d   Holdt, Lesca M ^a,e   Gross, Arnd ^a   Teren, Andrej ^a,d   Tönjes, Anke ^a   Becker, Susen ^a,b   Krohn, Knut ^a,b   Kovacs, Peter ^a   Stumvoll, Michael ^a   Teupser, Daniel ^a,e   Thiery, Joachim ^a,b   Ceglarek, Uta ^a,b   Scholz, Markus ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^d UNIVERSITY OF LEIPZIG HEART CENTER   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYISOVALERYLCARNITINE; ACYLCARNITINE; AMINO ACID DERIVATIVE; ARGININE; ASPARTIC ACID; CARNITINE DERIVATIVE; JUNCTIONAL ADHESION MOLECULE C; MESSENGER RNA; ORGANIC CATION TRANSPORTER 6; PROPIONYLCARNITINE; STEAROYLCARNITINE; UNCLASSIFIED DRUG; AMINO ACID; CARNITINE;

ACYLCARNITINE BLOOD LEVEL; ADULT; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARG1 GENE; ARTICLE; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 21; CHROMOSOME 6; CHROMOSOME 8; COHORT ANALYSIS; CONTROLLED STUDY; DRIED BLOOD SPOT TESTING; EUROPEAN; GENE; GENE EXPRESSION PROFILING; GENE LOCUS; GENETIC ASSOCIATION; GENOME ANALYSIS; HEREDITY; HLCS GENE; HUMAN; HUMAN CELL; HUMAN GENOME; JAM3 GENE; LIPID BLOOD LEVEL; METABOLIC REGULATION; METABOLITE; MONONUCLEAR CELL; PPP1R16A GENE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SLC22A16 GENE; URINE LEVEL; ANALOGS AND DERIVATIVES; BLOOD; DISEASES; GENETICS; GENOME-WIDE ASSOCIATION STUDY;

AMINO ACIDS; CARNITINE; COHORT STUDIES; DISEASE; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 84943548355     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005510     Document Type: Article

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