Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: A mendelian randomization analysis

Journal of the American College of Cardiology

Volumn 60, Issue 25, 2012, Pages 2631-2639

  Ference, Brian A ^a,b   Yoo, Wonsuk ^c   Alesh, Issa ^a   Mahajan, Nitin ^a   Mirowska, Karolina K ^a   Mewada, Abhishek ^a   Kahn, Joel ^d   Afonso, Luis ^a   Williams Sr , Kim Allan ^a   Flack, John M ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d DETROIT MEDICAL CENTER   (United States)

Author keywords

cardiovascular disease; genetic polymorphism; low density lipoprotein cholesterol; myocardial infarction; prevention

Indexed keywords

APOLIPOPROTEIN E; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR;

ABCG8 GENE; APOE GENE; ARTICLE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; HMGCR GENE; HUMAN; ISCHEMIC HEART DISEASE; LDLR GENE; LONG TERM EXPOSURE; PCSK9 GENE; PRIORITY JOURNAL; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SORT1 GENE;

CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; FOLLOW-UP STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; MENDELIAN RANDOMIZATION ANALYSIS; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; WORLD HEALTH;

EID: 84871260146     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.09.017     Document Type: Article

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