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Volumn 30, Issue 7, 2015, Pages 543-552

Using published data in Mendelian randomization: A blueprint for efficient identification of causal risk factors

Author keywords

Causal inference; Instrumental variable; Mendelian randomization; Published data; Summarized data; Two sample Mendelian randomization

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; GLUCOSE;

EID: 84943354221     PISSN: 03932990     EISSN: 15737284     Source Type: Journal    
DOI: 10.1007/s10654-015-0011-z     Document Type: Article
Times cited : (908)

References (38)
  • 1
    • 0037322022 scopus 로고    scopus 로고
    • Mendelian randomization: Can genetic epidemiology contribute to understanding environmental determinants of disease?
    • Davey Smith G, Ebrahim S. Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003; 32(1): 1-22. doi: 10. 1093/ije/dyg070.
    • (2003) Int J Epidemiol , vol.32 , Issue.1 , pp. 1-22
    • Davey Smith, G.1    Ebrahim, S.2
  • 2
    • 40849083720 scopus 로고    scopus 로고
    • Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
    • Lawlor D, Harbord R, Sterne J, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008; 27(8): 1133-63. doi: 10. 1002/sim. 3034.
    • (2008) Stat Med , vol.27 , Issue.8 , pp. 1133-1163
    • Lawlor, D.1    Harbord, R.2    Sterne, J.3    Timpson, N.4    Davey Smith, G.5
  • 3
    • 34547682094 scopus 로고    scopus 로고
    • Mendelian randomization as an instrumental variable approach to causal inference
    • Didelez V, Sheehan N. Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res. 2007; 16(4): 309-30. doi: 10. 1177/0962280206077743.
    • (2007) Stat Methods Med Res , vol.16 , Issue.4 , pp. 309-330
    • Didelez, V.1    Sheehan, N.2
  • 4
    • 0033853460 scopus 로고    scopus 로고
    • An introduction to instrumental variables for epidemiologists
    • Greenland S. An introduction to instrumental variables for epidemiologists. Int J Epidemiol. 2000; 29(4): 722-9. doi: 10. 1093/ije/29. 4. 722.
    • (2000) Int J Epidemiol , vol.29 , Issue.4 , pp. 722-729
    • Greenland, S.1
  • 5
    • 1942436221 scopus 로고    scopus 로고
    • Mendelian randomization: Prospects, potentials, and limitations
    • Davey Smith G, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol. 2004; 33(1): 30-42. doi: 10. 1093/ije/dyh132.
    • (2004) Int J Epidemiol , vol.33 , Issue.1 , pp. 30-42
    • Davey Smith, G.1    Ebrahim, S.2
  • 6
    • 84872042939 scopus 로고    scopus 로고
    • Use of Mendelian randomisation to assess potential benefit of clinical intervention
    • Burgess S, Butterworth A, Malarstig A, Thompson S. Use of Mendelian randomisation to assess potential benefit of clinical intervention. Br Med J. 2012; 345: e7325. doi: 10. 1136/bmj. e7325.
    • (2012) Br Med J , vol.345
    • Burgess, S.1    Butterworth, A.2    Malarstig, A.3    Thompson, S.4
  • 7
    • 67049167090 scopus 로고    scopus 로고
    • Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    • Kamstrup P, Tybjaerg-Hansen A, Steffensen R, Nordestgaard B. Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. J Am Med Assoc. 2009; 301(22): 2331-9. doi: 10. 1001/jama. 2009. 801.
    • (2009) J Am Med Assoc , vol.301 , Issue.22 , pp. 2331-2339
    • Kamstrup, P.1    Tybjaerg-Hansen, A.2    Steffensen, R.3    Nordestgaard, B.4
  • 8
    • 84859215358 scopus 로고    scopus 로고
    • The interleukin-6 receptor as a target for prevention of coronary heart disease: A Mendelian randomisation analysis
    • The Interleukin-6 Receptor Mendelian Randomisation Analysis Consortium. The interleukin-6 receptor as a target for prevention of coronary heart disease: a Mendelian randomisation analysis. Lancet. 2012; 379(9822): 1214-1224. doi: 10. 1016/s0140-6736(12)60110-x.
    • (2012) Lancet , vol.379 , Issue.9822 , pp. 1214-1224
  • 10
    • 79951990503 scopus 로고    scopus 로고
    • Association between C reactive protein and coronary heart disease: Mendelian randomisation analysis based on individual participant data
    • CRP CHD Genetics Collaboration. Association between C reactive protein and coronary heart disease: Mendelian randomisation analysis based on individual participant data. Br Med J. 2011; 342: d548. doi: 10. 1136/bmj. d548.
    • (2011) Br Med J , vol.342
  • 11
    • 84881442965 scopus 로고    scopus 로고
    • Association of plasma uric acid with ischaemic heart disease and blood pressure: Mendelian randomisation analysis of two large cohorts
    • Palmer TM, Nordestgaard BG, Benn M, Tybjærg-Hansen A, Smith GD, Lawlor DA, Timpson NJ. Association of plasma uric acid with ischaemic heart disease and blood pressure: Mendelian randomisation analysis of two large cohorts. Br Med J. 2013; 347: f4262. doi: 10. 1136/bmj. f4262.
    • (2013) Br Med J , vol.347
    • Palmer, T.M.1    Nordestgaard, B.G.2    Benn, M.3    Tybjærg-Hansen, A.4    Smith, G.D.5    Lawlor, D.A.6    Timpson, N.J.7
  • 12
    • 63249089543 scopus 로고    scopus 로고
    • Mendelian randomization: How it can-and cannot-help confirm causal relations between nutrition and cancer
    • Schatzkin A, Abnet C, Cross A, Gunter M, Pfeiffer R, Gail M, Lim U, Davey Smith G. Mendelian randomization: how it can-and cannot-help confirm causal relations between nutrition and cancer. Cancer Prev Res. 2009; 2(2): 104-13. doi: 10. 1158/1940-6207. capr-08-0070.
    • (2009) Cancer Prev Res , vol.2 , Issue.2 , pp. 104-113
    • Schatzkin, A.1    Abnet, C.2    Cross, A.3    Gunter, M.4    Pfeiffer, R.5    Gail, M.6    Lim, U.7    Davey Smith, G.8
  • 15
    • 84884973036 scopus 로고    scopus 로고
    • Efficient design for Mendelian randomization studies: Subsample and two-sample instrumental variable estimators
    • Pierce B, Burgess S. Efficient design for Mendelian randomization studies: subsample and two-sample instrumental variable estimators. Am J Epidemiol. 2013; 178(7): 1177-84. doi: 10. 1093/aje/kwt084.
    • (2013) Am J Epidemiol , vol.178 , Issue.7 , pp. 1177-1184
    • Pierce, B.1    Burgess, S.2
  • 17
    • 77955148591 scopus 로고    scopus 로고
    • Two-sample instrumental variables estimators
    • Inoue A, Solon G. Two-sample instrumental variables estimators. Rev Econ Stat. 2010; 92(3): 557-61.
    • (2010) Rev Econ Stat , vol.92 , Issue.3 , pp. 557-561
    • Inoue, A.1    Solon, G.2
  • 18
    • 33748106661 scopus 로고    scopus 로고
    • Instruments for causal inference: An epidemiologist's dream?
    • Hernán M, Robins J. Instruments for causal inference: an epidemiologist's dream? Epidemiology. 2006; 17(4): 360-72. doi: 10. 1097/01. ede. 0000222409. 00878. 37.
    • (2006) Epidemiology , vol.17 , Issue.4 , pp. 360-372
    • Hernán, M.1    Robins, J.2
  • 19
    • 80053907554 scopus 로고    scopus 로고
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
    • The International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011; 478: 103-9. doi: 10. 1038/nature10405.
    • (2011) Nature , vol.478 , pp. 103-109
  • 20
    • 84885840876 scopus 로고    scopus 로고
    • Mendelian randomization analysis with multiple genetic variants using summarized data
    • Burgess S, Butterworth A, Thompson S. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013; 37(7): 658-65. doi: 10. 1002/gepi. 21758.
    • (2013) Genet Epidemiol , vol.37 , Issue.7 , pp. 658-665
    • Burgess, S.1    Butterworth, A.2    Thompson, S.3
  • 21
    • 84936778645 scopus 로고    scopus 로고
    • Accessed 2014/11/19. Technical Report, The Comprehensive R Archive Network
    • Johnson T. Efficient calculation for multi-SNP genetic risk scores. Technical Report, The Comprehensive R Archive Network 2013. http://cran. r-project. org/web/packages/gtx/vignettes/ashg2012. pdf. Accessed 2014/11/19.
    • (2013) Efficient calculation for multi-SNP genetic risk scores
    • Johnson, T.1
  • 22
    • 85066989975 scopus 로고    scopus 로고
    • Instrumental variables and GMM: Estimation and testing
    • Baum C, Schaffer M, Stillman S. Instrumental variables and GMM: estimation and testing. Stata J. 2003; 3(1): 1-31.
    • (2003) Stata J , vol.3 , Issue.1 , pp. 1-31
    • Baum, C.1    Schaffer, M.2    Stillman, S.3
  • 23
    • 84947411690 scopus 로고
    • On finite sample distributions of generalized classical linear identifiability test statistics
    • Basmann R. On finite sample distributions of generalized classical linear identifiability test statistics. J Am Stat Assoc. 1960; 55(292): 650-9.
    • (1960) J Am Stat Assoc , vol.55 , Issue.292 , pp. 650-659
    • Basmann, R.1
  • 24
    • 0001755034 scopus 로고
    • The estimation of economic relationships using instrumental variables
    • Sargan J. The estimation of economic relationships using instrumental variables. Econometrica. 1958; 26(3): 393-415.
    • (1958) Econometrica , vol.26 , Issue.3 , pp. 393-415
    • Sargan, J.1
  • 25
    • 0014358067 scopus 로고
    • Cations and the secretion of insulin from rabbit pancreas in vitro
    • Hales C, Milner R. Cations and the secretion of insulin from rabbit pancreas in vitro. J Physiol. 1968; 199(1): 177-87.
    • (1968) J Physiol , vol.199 , Issue.1 , pp. 177-187
    • Hales, C.1    Milner, R.2
  • 26
    • 0030813008 scopus 로고    scopus 로고
    • Glucose intolerance is associated with altered calcium homeostasis: A possible link between increased serum calcium concentration and cardiovascular disease mortality
    • Wareham NJ, Byrne CD, Carr C, Day NE, Boucher BJ, Hales CN. Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality. Metabolism. 1997; 46(10): 1171-7. doi: 10. 1016/s0026-0495(97)90212-2.
    • (1997) Metabolism , vol.46 , Issue.10 , pp. 1171-1177
    • Wareham, N.J.1    Byrne, C.D.2    Carr, C.3    Day, N.E.4    Boucher, B.J.5    Hales, C.N.6
  • 27
    • 84866353183 scopus 로고    scopus 로고
    • Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: Results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies
    • Forouhi N, Ye Z, Rickard A, Khaw K, Luben R, Langenberg C, Wareham N. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 2012; 55(8): 2173-82. doi: 10. 1007/s00125-012-2544-y.
    • (2012) Diabetologia , vol.55 , Issue.8 , pp. 2173-2182
    • Forouhi, N.1    Ye, Z.2    Rickard, A.3    Khaw, K.4    Luben, R.5    Langenberg, C.6    Wareham, N.7
  • 28
    • 80054698404 scopus 로고    scopus 로고
    • Design and cohort description of the InterAct Project: An examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
    • Langenberg C, Sharp S, Forouhi N, Franks P, Schulze M, Kerrison N, Ekelund U, Barroso I, Panico S, Tormo M, et al. Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia. 2011; 54(9): 2272-82. doi: 10. 1007/s00125-011-2182-9.
    • (2011) Diabetologia , vol.54 , Issue.9 , pp. 2272-2282
    • Langenberg, C.1    Sharp, S.2    Forouhi, N.3    Franks, P.4    Schulze, M.5    Kerrison, N.6    Ekelund, U.7    Barroso, I.8    Panico, S.9    Tormo, M.10
  • 29
    • 84865693929 scopus 로고    scopus 로고
    • Largescale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, et al. Largescale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012; 44(9): 991-1005. doi: 10. 1038/ng. 2385.
    • (2012) Nat Genet , vol.44 , Issue.9 , pp. 991-1005
    • Scott, R.A.1    Lagou, V.2    Welch, R.P.3    Wheeler, E.4    Montasser, M.E.5    Luan, J.6    Mägi, R.7    Strawbridge, R.J.8    Rehnberg, E.9    Gustafsson, S.10
  • 32
    • 84884736257 scopus 로고    scopus 로고
    • Use of allele scores as instrumental variables for Mendelian randomization
    • Burgess S, Thompson S. Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol. 2013; 42(4): 1134-44. doi: 10. 1093/ije/dyt093.
    • (2013) Int J Epidemiol , vol.42 , Issue.4 , pp. 1134-1144
    • Burgess, S.1    Thompson, S.2
  • 33
    • 84878084956 scopus 로고    scopus 로고
    • Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: A meta-analysis from Atherosclerosis Risk in Communities and Cardiovascular Health Studies
    • Yu B, Barbalic M, Brautbar A, Nambi V, Hoogeveen RC, Tang W, Mosley TH, Rotter JI, O'Donnell CJ, Kathiresan S, et al. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from Atherosclerosis Risk in Communities and Cardiovascular Health Studies. Circ Cardiovasc Genet. 2013; 6(1): 82-8. doi: 10. 1161/circgenetics. 112. 963058.
    • (2013) Circ Cardiovasc Genet , vol.6 , Issue.1 , pp. 82-88
    • Yu, B.1    Barbalic, M.2    Brautbar, A.3    Nambi, V.4    Hoogeveen, R.C.5    Tang, W.6    Mosley, T.H.7    Rotter, J.I.8    O’Donnell, C.J.9    Kathiresan, S.10
  • 34
    • 79961177302 scopus 로고    scopus 로고
    • Avoiding bias from weak instruments in Mendelian randomization studies
    • Burgess S, Thompson S, CRP CHD genetics collaboration. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011; 40(3): 755-64. doi: 10. 1093/ije/dyr036.
    • (2011) Int J Epidemiol , vol.40 , Issue.3 , pp. 755-764
    • Burgess, S.1    Thompson, S.2
  • 35
    • 84887186450 scopus 로고    scopus 로고
    • Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: A note on Mendelian randomization studies
    • Würtz P, Kangas AJ, Soininen P, Lehtimäki T, Kähönen M, Viikari JS, Raitakari OT, Järvelin MR, Davey Smith G, Ala-Korpela M. Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies. J Am Coll Cardiol. 2013; 62(20): 1906-8. doi: 10. 1016/j. jacc. 2013. 07. 085.
    • (2013) J Am Coll Cardiol , vol.62 , Issue.20 , pp. 1906-1908
    • Würtz, P.1    Kangas, A.J.2    Soininen, P.3    Lehtimäki, T.4    Kähönen, M.5    Viikari, J.S.6    Raitakari, O.T.7    Järvelin, M.R.8    Davey Smith, G.9    Ala-Korpela, M.10
  • 36
    • 84936758183 scopus 로고    scopus 로고
    • Multivariable Mendelian randomization: The use of pleiotropic genetic variants to estimate causal effects
    • Burgess S, Thompson S. Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol. 2015; 181(4): 251-60.
    • (2015) Am J Epidemiol , vol.181 , Issue.4 , pp. 251-260
    • Burgess, S.1    Thompson, S.2
  • 37
    • 84958687567 scopus 로고    scopus 로고
    • Methods for meta-analysis of individual participant data from Mendelian randomization studies with binary outcomes
    • Burgess S, Thompson S, CRP CHD Genetics Collaboration. Methods for meta-analysis of individual participant data from Mendelian randomization studies with binary outcomes. Stat Methods Med Res. 2012; doi: 10. 1177/0962280212451882.
    • (2012) Stat Methods Med Res
    • Burgess, S.1    Thompson, S.2
  • 38
    • 84860592282 scopus 로고    scopus 로고
    • Expert Panel on Cardiovascular Health and Risk Reduction in Youth. Developing the 2011 integrated pediatric guidelines for cardiovascular risk reduction
    • Gidding S, Daniels S, Kavey R. Expert Panel on Cardiovascular Health and Risk Reduction in Youth. Developing the 2011 integrated pediatric guidelines for cardiovascular risk reduction. Pediatrics. 2012; 129(5): e1311-9. doi: 10. 1542/peds. 2011-2903.
    • (2012) Pediatrics , vol.129 , Issue.5 , pp. e1311-e1319
    • Gidding, S.1    Daniels, S.2    Kavey, R.3


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