IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection

PLoS Pathogens

Volumn 13, Issue 10, 2017, Pages

  Wallet, Pierre ^a   Benaoudia, Sacha ^a   Mosnier, Amandine ^a   Lagrange, Brice ^a   Martin, Amandine ^a   Lindgren, Helena ^b   Golovliov, Igor ^b   Michal, Fanny ^a   Basso, Pauline ^c   Djebali, Sophia ^a   Provost, Angelina ^a   Allatif, Omran ^a   Meunier, Etienne ^d   Broz, Petr ^e   Yamamoto, Masahiro ^f   Py, Bénédicte F ^a   Faudry, Eric ^c   Sjöstedt, Anders ^b   Henry, Thomas ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIV GRENOBLE ALPES   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e UNIVERSITY OF BASEL   (Switzerland)

^f OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CRYOPYRIN; GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; WHEAT GERM AGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL LOAD; BACTERICIDAL ACTIVITY; BONE MARROW DERIVED MACROPHAGE; CELL DEATH; CELL VIABILITY ASSAY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FRANCISELLA NOVICIDA; GENE SILENCING; GENOTYPE; IMMUNOFLUORESCENCE; MOUSE; NITROSYLATION; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIME-LAPSE MICROSCOPY; TULAREMIA; ANIMAL; C57BL MOUSE; DISEASE MODEL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FRANCISELLA; FRANCISELLA TULARENSIS; GRAM NEGATIVE INFECTION; IMMUNOBLOTTING; IMMUNOLOGY; KNOCKOUT MOUSE; MALE;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FRANCISELLA; FRANCISELLA TULARENSIS; GENE KNOCKDOWN TECHNIQUES; GRAM-NEGATIVE BACTERIAL INFECTIONS; GTP-BINDING PROTEINS; IMMUNOBLOTTING; INFLAMMASOMES; INTERFERON-GAMMA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TULAREMIA;

EID: 85031698876     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006630     Document Type: Article

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