Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 16, 2014, Pages 6046-6051

  Pilla, Danielle M ^a   Hagar, Jon A ^b   Haldar, Arun K ^a   Mason, Ashley K ^c   Degrandi, Daniel ^d   Pfeffer, Klaus ^d   Ernst, Robert K ^c   Yamamoto, Masahiro ^e   Miao, Edward A ^b   Coers, Jörn ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

^c UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell death; Immunity related GTPases; Interferon; Nos2

Indexed keywords

CASPASE 11; FLAGELLIN; GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; INFLAMMASOME; INTERFERON; LIPOPOLYSACCHARIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ANIMAL CELL; ARTICLE; BACTERIAL LOAD; CHROMOSOME 3; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; CYTOTOXICITY; ENZYME ACTIVATION; ESCHERICHIA COLI; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; XENOPHAGY;

CELL DEATH; IMMUNITY-RELATED GTPASES; INTERFERON; NOS2;

ANIMALS; APOPTOSIS; CASPASES; CYTOPLASM; ENZYME ACTIVATION; GTP-BINDING PROTEINS; INTERFERON-GAMMA; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MUTATION; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE II; SALMONELLA TYPHIMURIUM;

EID: 84899098318     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321700111     Document Type: Article

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